scholarly journals Variation in Metabolic Characteristics of Chrysanthemum indicum from Different Habitats: Implications for cultivation and breeding

2021 ◽  
Author(s):  
Qingjun Zou ◽  
Qiaosheng Guo ◽  
Tao Wang ◽  
Jiamin Chen ◽  
Feng Yang ◽  
...  
Keyword(s):  
Single Species ◽  
Targeted Metabolomics ◽  
Multivariate Statistical ◽  
Metabolic Characteristics ◽  
Flavonoid Synthesis ◽  
Chrysanthemum Indicum ◽  
Widely Targeted Metabolomics ◽  
Application Potential ◽  
Different Populations ◽  
Chemical Products

Abstract Chrysanthemi Indici Flos (CIF), the capitulum of Chrysanthemum indicum, is widely used as Chinese medicine, spice, and tea in many areas, its extracts are also frequently used in daily chemical products and cosmetics. Although CIF-related products are becoming more abundant because of its excellent biological activity, its metabolic characteristics and the accumulation of metabolites are still unclear. A total of 802 metabolites were identified in CIF by widely targeted metabolomics, and significant differences were found in the accumulation of metabolites of CIF from different habitats. Particularly, the differences in metabolite accumulation in CIF were significantly correlated with the geographical distribution in mountainous areas, but not with climate. Through multivariate statistical analysis, the seven samples from different habitats could be divided into four categories, and the significantly changed metabolites between different categories were mainly concentrated in the flavonoid synthesis pathway. Judging from the metabolic level, it was supported to separate the Ch. nankingense (Juhuanao) into a single species. In addition, the corresponding candidate biomarkers were screened in this study to identify the origin of CIF and distinguish the Juhuanao. It can be inferred that widely targeted metabolomics has great application potential in authenticity identification, origin tracing and quality evaluation of CIF. There were abundant metabolic differences among different populations of Ch. indicum, which provided abundant materials for the selection and breeding of fine varieties.

scholarly journals Widely Targeted Metabolomics Analysis Reveals the Effect of Flooding Stress on the Synthesis of Flavonoids in Chrysanthemum morifolium

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3695 ◽  
Author(s):  
Tao Wang ◽  
Qingjun Zou ◽  
Qiaosheng Guo ◽  
Feng Yang ◽  
Liwei Wu ◽  
...  
Keyword(s):  
Chrysanthemum Morifolium ◽  
Growth Stages ◽  
Targeted Metabolomics ◽  
Flower Bud ◽  
Metabolomics Data ◽  
Flooding Stress ◽  
Flavonoid Synthesis ◽  
Key Enzyme ◽  
Widely Targeted Metabolomics ◽  
Different Growth Stages

Chrysanthemum morifolium. cv “Hangju” is an important medicinal material with many functions in China. Flavonoids as the main secondary metabolites are a major class of medicinal components in “Hangju” and its composition and content can change significantly after flooding. This study mimicked the flooding stress of “Hangju” during flower bud differentiation and detected its metabolites in different growth stages. From widely targeted metabolomics data, 661 metabolites were detected, of which 46 differential metabolites exist simultaneously in the different growth stages of “Hangju”. The top three types of the 46 differential metabolites were flavone C-glycosides, flavonol and flavone. Our results demonstrated that the accumulation of flavonoids in different growth stages of “Hangju” was different; however, quercetin, eriodictyol and most of the flavone C-glycosides were significantly enhanced in the two stages after flooding stress. The expression of key enzyme genes in the flavonoid synthesis pathway were determined using RT-qPCR, which verified the consistency of the expression levels of CHI, F3H, DFR and ANS with the content of the corresponding flavonoids. A regulatory network of flavonoid biosynthesis was established to illustrate that flooding stress can change the accumulation of flavonoids by affecting the expression of the corresponding key enzymes in the flavonoid synthesis pathway.

scholarly journals Extensive Metabolite Profiling in the Unexploited Organs of Black Tiger for Their Potential Valorization in the Pharmaceutical Industry

Life ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 544
Author(s):  
Jianfei Gao ◽  
Kangning Xiong ◽  
Wei Zhou ◽  
Weijie Li
Keyword(s):  
Acid Metabolism ◽  
Metabolite Profile ◽  
Industrial Applications ◽  
Targeted Metabolomics ◽  
Arginine Biosynthesis ◽  
Nutritional Values ◽  
Phenylpropanoid Biosynthesis ◽  
Tyrosine Metabolism ◽  
Organ Specific ◽  
Widely Targeted Metabolomics

Black tiger (Kadsura coccinea (Lem.)) has been reported to hold enormous pharmaceutical potential. The fruit and rhizome of black tiger are highly exploited in the pharmaceutical and other industries. However, the most important organs from the plant such as the leaf and stem are considered biowastes mainly because a comprehensive metabolite profile has not been reported in these organs. Knowledge of the metabolic landscape of the unexploited black tiger organs could help identify and isolate important compounds with pharmaceutical and nutritional values for a better valorization of the species. In this study, we used a widely targeted metabolomics approach to profile the metabolomes of the K. coccinea leaf (KL) and stem (KS) and compared them with the root (KR). We identified 642, 650 and 619 diverse metabolites in KL, KS and KR, respectively. A total of 555 metabolites were mutually detected among the three organs, indicating that the leaf and stem organs may also hold potential for medicinal, nutritional and industrial applications. Most of the differentially accumulated metabolites between organs were enriched in flavone and flavonol biosynthesis, phenylpropanoid biosynthesis, arginine and proline metabolism, arginine biosynthesis, tyrosine metabolism and 2-oxocarboxylic acid metabolism pathways. In addition, several important organ-specific metabolites were detected in K. coccinea. In conclusion, we provide extensive metabolic information to stimulate black tiger leaf and stem valorization in human healthcare and food.

Marine ecosystem assessment in a fisheries management context

2002 ◽  
Vol 59 (9) ◽  
pp. 1429-1440 ◽  
Author(s):  
Jason S Link ◽  
Jon K.T Brodziak ◽  
Steve F Edwards ◽  
William J Overholtz ◽  
David Mountain ◽  
...  
Keyword(s):  
Fisheries Management ◽  
Marine Ecosystem ◽  
Single Species ◽  
Reference Points ◽  
System Level ◽  
Multivariate Statistical Methods ◽  
Multivariate Statistical ◽  
Management Context ◽  
Ecosystem Level ◽  
Ecosystem Based Fisheries Management

We examined a suite of abiotic, biotic, and human metrics for the northeast U.S. continental shelf ecosystem at the aggregate, community, and system level (>30 different metrics) over three decades. Our primary goals were to describe ecosystem status, to improve understanding of the relationships between key ecosystem processes, and to evaluate potential reference points for ecosystem-based fisheries management (EBFM). To this end, empirical indicators of ecosystem status were examined and standard multivariate statistical methods were applied to describe changes in the system. We found that (i) a suite of metrics is required to accurately characterize ecosystem status and, conversely, that focusing on a few metrics may be misleading; (ii) assessment of ecosystem status is feasible for marine ecosystems; (iii) multivariate points of reference can be determined for EBFM; and (iv) the concept of reference directions could provide an ecosystem level analog to single-species reference points.

scholarly journals Changes in Metabolome and Nutritional Quality of Lycium barbarum Fruits from Three Typical Growing Areas of China as Revealed by Widely Targeted Metabolomics

Metabolites ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 46 ◽  
Author(s):  
Yajun Wang ◽  
Xiaojie Liang ◽  
Yuekun Li ◽  
Yunfang Fan ◽  
Yanlong Li ◽  
...  
Keyword(s):  
Soil Moisture ◽  
Light Intensity ◽  
Nutritional Quality ◽  
Climatic Factors ◽  
Northwest China ◽  
High Light Intensity ◽  
Climatic Conditions ◽  
Targeted Metabolomics ◽  
Lycium Barbarum ◽  
Widely Targeted Metabolomics

This study aimed at assessing the climatic factors influencing the wolfberry fruit morphology, and the composition of its nutritious metabolites. The cultivar Ningqi1, widely grown in Northwest China was collected from three typical ecological growing counties with contrasting climatic conditions: Ningxia Zhongning (NF), Xinjiang Jinghe (XF) and Qinghai Nomuhong (QF). During the ripening period, 45 fruits from different plantations at each location were sampled. A total of 393 metabolites were detected in all samples through the widely targeted metabolomics approach and grouped into 19 known classes. Fruits from QF were the biggest followed by those from XF and NF. The altitude, relative humidity and light intensity had negative and strong correlations with most of the metabolites, suggesting that growing wolfberry in very high altitudes and under high light intensity is detrimental for the fruit nutritional quality. Soil moisture content is highly and negatively correlated with vitamins, organic acids and carbohydrates while moderately and positively correlated with other classes of metabolites. In contrast, air and soil temperatures exhibited positive correlation with majority of the metabolites. Overall, our results suggest high soil and air temperatures, low altitude and light intensity and moderate soil moisture, as the suitable conditions to produce Lycium fruits with high content of nutritious metabolites.

scholarly journals Extensive Metabolic Profiles of Leaves and Stems from the Medicinal Plant Dendrobium officinale Kimura et Migo

Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 215 ◽  
Author(s):  
Cao ◽  
Ji ◽  
Li ◽  
Lu ◽  
Tian ◽  
...  
Keyword(s):  
Genomic Research ◽  
Dendrobium Officinale ◽  
Metabolic Profiles ◽  
Asian Countries ◽  
Targeted Metabolomics ◽  
Medicinal Species ◽  
Metabolomic Data ◽  
Metabolite Profiles ◽  
Widely Targeted Metabolomics ◽  
Metabolic Data

Dendrobium officinale Kimura et Migo is a commercially and pharmacologically highly prized species widely used in Western Asian countries. In contrast to the extensive genomic and transcriptomic resources generated in this medicinal species, detailed metabolomic data are still missing. Herein, using the widely targeted metabolomics approach, we detect 649 diverse metabolites in leaf and stem samples of D. officinale. The majority of these metabolites were organic acids, amino acids and their derivatives, nucleotides and their derivatives, and flavones. Though both organs contain similar metabolites, the metabolite profiles were quantitatively different. Stems, the organs preferentially exploited for herbal medicine, contained larger concentrations of many more metabolites than leaves. However, leaves contained higher levels of polyphenols and lipids. Overall, this study reports extensive metabolic data from leaves and stems of D. officinale, providing useful information that supports ongoing genomic research and discovery of bioactive compounds.

Identification of key taste components in loquat using widely targeted metabolomics

2020 ◽  
Vol 323 ◽  
pp. 126822 ◽  
Author(s):  
Shicheng Zou ◽  
Jincheng Wu ◽  
Muhammad Qasim Shahid ◽  
Yehua He ◽  
Shunquan Lin ◽  
...  
Keyword(s):  
Targeted Metabolomics ◽  
Widely Targeted Metabolomics
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