scholarly journals Multi-omics Analysis of Redox Imbalance-Related Mild Health Problems in Monkeys

2021 ◽  
Author(s):  
Fumie Hamano ◽  
Suzumi M Tokuoka ◽  
Megumi Ishibashi ◽  
Yasuto Yokoi ◽  
Dieter M Tourlousse ◽  
...  
Keyword(s):  
Water Content ◽  
Macaca Fascicularis ◽  
Bacterial Species ◽  
Redox Balance ◽  
Health Problems ◽  
Single Individual ◽  
Comprehensive Understanding ◽  
Metabolomics Data ◽  
The Relationship ◽  
Oxidized Fatty Acids

Abstract Certain symptoms associated with mild sickness and lethargy have not been categorized as definitive diseases. Confirming such symptoms in captive monkeys (Macaca fascicularis) can be difficult; however, it is possible to observe and analyze their feces. Even among monkeys that are housed under carefully monitored conditions, some monkeys occasionally have poor stool conditions. In this study, we investigated the relationship between stool state and various omics data by considering objective and quantitative values of stool water content as a phenotype for analysis. By examining the food intake of the monkeys, the stool and urine they expel, and the plasma circulating in their bodies, we attempted to obtain a comprehensive understanding of the health status of a single individual and understand its relationship with stool condition. Our metabolomics data strongly suggested an association between lipids and stool water content. Lipidomic analysis revealed the involvement of saturated and oxidized fatty acids, metallomics revealed the contribution of selenium (a bio-essential trace element), and intestinal microbiota analysis revealed the association of several bacterial species with the stool water content. Taken together, these results suggest that selenium-induced disturbance in redox balance may cause minor health problems.

scholarly journals Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys

Metabolites ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 701
Author(s):  
Fumie Hamano ◽  
Suzumi M. Tokuoka ◽  
Megumi Ishibashi ◽  
Yasuto Yokoi ◽  
Dieter M. Tourlousse ◽  
...  
Keyword(s):  
Water Content ◽  
Macaca Fascicularis ◽  
Bacterial Species ◽  
Health Problems ◽  
Comprehensive Understanding ◽  
Metabolomics Data ◽  
Cynomolgus Monkeys ◽  
Lipidomic Analysis ◽  
The Relationship ◽  
Oxidized Fatty Acids

Certain symptoms associated with mild sickness and lethargy have not been categorized as definitive diseases. Confirming such symptoms in captive monkeys (Macaca fascicularis, known as cynomolgus monkeys) can be difficult; however, it is possible to observe and analyze their feces. In this study, we investigated the relationship between stool state and various omics data by considering objective and quantitative values of stool water content as a phenotype for analysis. By examining the food intake of the monkeys and assessing their stool, urine, and plasma, we attempted to obtain a comprehensive understanding of the health status of individual monkeys and correlate it with the stool condition. Our metabolomics data strongly suggested that many lipid-related metabolites were correlated with the stool water content. The lipidomic analysis revealed the involvement of saturated and oxidized fatty acids, metallomics revealed the contribution of selenium (a bio-essential trace element), and intestinal microbiota analysis revealed the association of several bacterial species with the stool water content. Based on our results, we hypothesize that the redox imbalance causes minor health problems. However, it is not possible to make a definite conclusion using multi-omics alone, and other hypotheses could be proposed.

scholarly journals Mitochondrial Sirtuins in Reproduction

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1047
Author(s):  
Giovanna Di Emidio ◽  
Stefano Falone ◽  
Paolo Giovanni Artini ◽  
Fernanda Amicarelli ◽  
Anna Maria D’Alessandro ◽  
...  
Keyword(s):  
Stress Responses ◽  
Metabolic Pathways ◽  
Redox Balance ◽  
Antioxidant Defenses ◽  
Metabolic Abnormalities ◽  
Female Reproduction ◽  
Mitochondrial Dysfunctions ◽  
Early Embryos ◽  
The Relationship

Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria. They catalyze NAD+-dependent deacylation and the ADP-ribosylation of mitochondrial proteins, thereby modulating gene expression and activities of enzymes involved in oxidative metabolism and stress responses. In this context, mitochondrial sirtuins (mtSIRTs) act in synergistic or antagonistic manners to protect from aging and aging-related metabolic abnormalities. In this review, we focus on the role of mtSIRTs in the biological competence of reproductive cells, organs, and embryos. Most studies are focused on SIRT3 in female reproduction, providing evidence that SIRT3 improves the competence of oocytes in humans and animal models. Moreover, SIRT3 protects oocytes, early embryos, and ovaries against stress conditions. The relationship between derangement of SIRT3 signaling and the imbalance of ROS and antioxidant defenses in testes has also been demonstrated. Very little is known about SIRT4 and SIRT5 functions in the reproductive system. The final goal of this work is to understand whether sirtuin-based signaling may be taken into account as potential targets for therapeutic applications in female and male infertility.

Attachment to God and Quest as Moderators of the Relationship between Religious Doubt and Mental Health

2021 ◽  
pp. 009164712199240
Author(s):  
Noah S. Love ◽  
Cassidy A. Merlo ◽  
M. Elizabeth Lewis Hall ◽  
Peter C. Hill
Keyword(s):  
Mental Health ◽  
Positive Relationship ◽  
Mental Health Problems ◽  
Negative Relationship ◽  
Health Problems ◽  
Positive Mental Health ◽  
Attachment To God ◽  
Religious Doubt ◽  
Avoidant Attachment ◽  
The Relationship

The present study examined attachment to God and quest as potential moderators of the relationship between religious doubt and mental health. A sample of Christian participants ( N = 235) completed a survey which included measures of attachment to God, quest, religious doubt, and mental health. As hypothesized, attachment to God and quest significantly moderated an individual’s experience of religious doubt. Low avoidant attachment to God (i.e., a more secure attachment) was associated with a more negative relationship between cognitive religious doubt and positive mental health than high avoidant attachment. In contrast, low avoidant attachment to God also ameliorated the positive relationship between affective religious doubt and mental health problems. Low anxious attachment was associated with a stronger negative relationship between both measures of religious doubt (i.e., cognitive and affective) and positive mental health. In addition, high soft quest weakened all four of the relationships between measures of religious doubt and mental health. High hard quest ameliorated the positive relationship between both measures of religious doubt and mental health problems. These results indicate that an individual’s attachment to God and the way an individual is oriented toward religion each play a role in the mental health outcomes associated with religious doubt.

scholarly journals Trauma, Sleep and Mental Health Problems in Low-Income Young Adults

2021 ◽  
Vol 18 (3) ◽  
pp. 1145
Author(s):  
Rachel A. Fusco ◽  
Yan Yuan ◽  
Hyunji Lee ◽  
Christina E. Newhill
Keyword(s):  
Mental Health ◽  
Young Adults ◽  
Low Income ◽  
Mental Health Problems ◽  
Trauma Exposure ◽  
Health Problems ◽  
Equation Modeling ◽  
Poor Sleep ◽  
Depression And Anxiety ◽  
The Relationship

Low-income young adults are more likely to have exposure to trauma, which increases risk for mental health problems. Although adequate sleep promotes good health, people with histories of trauma are more likely to have sleep problems. The current study explored whether poor sleep mediated the relationship between trauma exposure and mental health. A sample of 143 low-income 18–24-year-old young adults completed depression, anxiety, and trauma exposure measures and wore sleep monitors for four nights. Structural equation modeling (SEM) was used to examine both direct and indirect effects of variables. Results showed that higher trauma exposure was associated with depression and anxiety. Mean sleep hours per night was fewer than six, far below recommended guidelines for optimal health and functioning. Fewer sleep hours partially mediated the relationship between both trauma exposure and depression and anxiety, and the direct effect from trauma remained significant after adjusting for the partial mediation from sleep.

scholarly journals Minority stress, resilience, and health in Italian and Taiwanese LGB+ people: A cross-cultural comparison

2021 ◽  
Author(s):  
Roberto Baiocco ◽  
Cristiano Scandurra ◽  
Fausta Rosati ◽  
Jessica Pistella ◽  
Salvatore Ioverno ◽  
...  
Keyword(s):  
Minority Stress ◽  
Online Survey ◽  
Health Problems ◽  
Sexual Stigma ◽  
Common Path ◽  
Mediating Role ◽  
Cross Cultural Comparison ◽  
Moderated Mediation Model ◽  
The Relationship

AbstractThe present study, using a moderated mediational model, explored levels of distal/proximal stressors, rumination, resilience, and health in a group of Italian and Taiwanese LGB+ people. The study also examined the role of internalized sexual stigma (ISS) and rumination as mediators between discrimination and health, and resilience as a moderator of the relationship between discrimination and ISS, rumination, and health, respectively. An online survey was administered to 508 LGB+ participants (270 Italian and 238 Taiwanese) whose age ranged from 18 to 70 years (M = 37.93, SD = 13.53). The moderated mediation model was tested through a series of path analyses stratified by group nationality. Italian participants reported higher discrimination and resilience, but lower ISS, rumination, and health problems compared to their Taiwanese counterparts. The only common path between groups was the direct effect of discrimination on health problems. The mediating role of ISS and rumination in the relationship between discrimination and health, as well as the moderating role of resilience, were partly significant only for the Italian group. Conclusions: The findings suggest that mediators and moderators used to evaluate the effects of minority stress on health may differ between groups; further culturally sensitive research in the field of LGB+ health is needed.

A Test of Contextual Theory: The Relationship Among Relational Ethics, Marital Satisfaction, Health Problems, and Depression

2008 ◽  
Vol 30 (4) ◽  
pp. 183-198 ◽  
Author(s):  
Heath A. Grames ◽  
Richard B. Miller ◽  
W. David Robinson ◽  
Derrel J. Higgins ◽  
W. Jeff Hinton
Keyword(s):  
Marital Satisfaction ◽  
Health Problems ◽  
Relational Ethics ◽  
Contextual Theory ◽  
The Relationship

Relationship between self-care and comprehensive understanding of heart failure and its signs and symptoms

2017 ◽  
Vol 17 (6) ◽  
pp. 496-504 ◽  
Author(s):  
Kyoung Suk Lee ◽  
Debra K Moser ◽  
Kathleen Dracup
Keyword(s):  
Heart Failure ◽  
Confidence Interval ◽  
Self Care ◽  
Signs And Symptoms ◽  
Comprehensive Understanding ◽  
Behavior Scale ◽  
Heart Failure Exacerbation ◽  
The Relationship ◽  
Different Levels ◽  
Care Behavior

Background: Although incomplete understanding of heart failure and its signs and symptoms appears to be a barrier to successful self-care, there are few studies examining the relationship between self-care and levels of comprehensive understanding of heart failure and its signs and symptoms. Aim: To determine whether incomplete understanding of heart failure and its signs and symptoms is associated with self-care in heart failure patients who were recently discharged from the hospital due to heart failure exacerbation. Methods: Patients completed the nine-item European Heart Failure Self-care Behavior scale and questionnaire to assess knowledge of heart failure and its signs and symptoms. Three groups were formed by their different levels of understanding of heart failure and its signs and symptoms. Multivariable linear regression was used to determine whether these three levels of understanding groups predicted self-care after controlling for demographic and clinical variables. Results: Of 571 patients 22.1%, 40.1% and 37.8% had poor, moderate, and complete understanding, respectively. Compared with patients in the poor understanding group, patients in complete and moderate understanding groups were more likely to have better adherence to self-care activities (standardized β = −0.14, 95% confidence interval −3.41, −0.47; standardized β = −0.19, 95% confidence interval −4.26, −1.23, respectively). Conclusions: Fewer than half of the patients had a comprehensive understanding of heart failure and its signs and symptoms, which was associated with poor self-care. Our study suggests that patient education should include contents to promote comprehensive understanding of heart failure and its symptoms, as well as the importance of self-care behaviors.

scholarly journals Identifying Stress Landscapes in Boston Neighborhoods

2018 ◽  
Vol 7 ◽  
pp. 216495611880305 ◽  
Author(s):  
F. Garrett Conyersm ◽  
Helene M Langevin ◽  
Gary J Badger ◽  
Darshan H Mehta
Keyword(s):  
Health Problems ◽  
Aggressive Driving ◽  
Negative Behaviors ◽  
Unequal Treatment ◽  
Policy Interventions ◽  
Medical Centers ◽  
Academic Medical ◽  
The Relationship ◽  
The City ◽  
Neighborhood Level

Background Chronic stress plays a role in the development of health disparities. However, the relationship between neighborhood stressors and stress-related health problems and behaviors is unknown. In the city of Boston, Massachusetts, 3 neighborhoods, while within a 3 mile radius, have widely divergent life expectancies. This work aims to investigate and compare perceived neighborhood-level stressors, stress-related negative behaviors, and stress-related health problems in these neighborhoods. Methods Three hundred twenty-six participants were surveyed from the neighborhoods. Participants were asked to rate (1) 27 neighborhood stressors, (2) 16 stress-related negative behaviors, and (3) 13 stress-related health problems using a 1 to 5 Likert-type scale. Differences in responses between neighborhoods were analyzed using Kruskal–Wallis and χ2 tests. Results The highest neighborhood stressors overall were related to finance, unequal treatment, and unsafe bike/pedestrian access. The highest stress-related health problems were related to substance abuse and obesity, and the largest stress-related behaviors were related to poor diet, intolerance, and aggressive driving. There were significant differences across neighborhoods ( P < .05) for 18 of the 27 neighborhood stressors, 8 of the 10 stress-related health problems, and 12 of the 15 stress-related behaviors. Conclusions There is marked contrast in stress landscapes between the 3 neighborhoods in Boston despite their geographical proximity. This finding potentially serves as an explanation for the drastic differences in health outcomes, even though these neighborhoods are equidistant from academic medical centers. Strategies for improving the health of individuals should incorporate the unique stressors at the neighborhood level. Further research is needed to investigate how specifically neighborhood stressors influence the health of residents, thereby informing what policy interventions might be useful.

scholarly journals Objective measurement of physical activity in Macaca fascicularis

1982 ◽  
Vol 16 (3) ◽  
pp. 240-243
Author(s):  
Wayne T. Corbett ◽  
Harry M. Schey ◽  
A. W. Green
Keyword(s):  
Physical Activity ◽  
Standard Deviation ◽  
Macaca Fascicularis ◽  
Living Environment ◽  
Activity Levels ◽  
Free Living ◽  
Activity Measurements ◽  
Active Intermediate ◽  
The Mean ◽  
The Relationship

The mean and standard deviation over 24 h for 3 groups of animals - active, intermediate and inactive - in physical activity units were 10948 ± 3360, 2611 ± 1973 and 484 ± 316 respectively. The differences were significant ( P = 0·004), demonstrating the ability of the method to distinguish between groups that can be visibly differentiated. The small within-animal physical activity standard deviation (18·85 PAU) obtained in another group, suggests that it also yields reliable physical activity measurements for non-human primates. The monitoring device used can discriminate between individual nonhuman primate physical activity levels in a free-living environment and does not alter daily behaviour. This makes possible the study of the relationship between physical activity and atherosclerosis in nonhuman primates.

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