scholarly journals Disinfection effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro

2021 ◽  
Author(s):  
Keda Chen ◽  
Feike Ma ◽  
Ying Wang ◽  
Xinyi Zhuang ◽  
Xuning Zhang ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Vero Cells ◽  
Inhibitory Effect ◽  
Control Measures ◽  
World Health ◽  
The Novel ◽  
Pyridinium Chloride ◽  
Infection Control Measures ◽  
Novel Coronavirus

Abstract The novel coronavirus (COVID-19 or 2019-nCoV) is a respiratory virus that can exist in the mouth and saliva of patients and spreads through aerosol dispersion. In the face of such a serious epidemic, the World Health Organization (who) recommends that governments and individuals take necessary infection control measures. The novel coronavirus (severe acute respiratory syndrome coronavirus; SARS-CoV-2) spread rapidly, causing varying degrees of respiratory disease and, in severe cases. SARS-CoV-2 is a respiratory disease that can be transmitted through direct transmission, aerosol transmission, or contact. Therefore, stomatological hospitals and departments have become high-infection-risk environments. Accordingly, oral disinfectants that can effectively inactivate the virus have become a highly active area of research. Hexadecyl pyridinium chloride, povidone-iodine, and other common oral disinfectants are the natural primary choices for stomatological hospitals. Therefore, this study investigated the inhibitory effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro. Vero cells infected with SARS-CoV-2 were used to determine the disinfection effect; the CCK-8 method was used to determine cytotoxicity, and viral load was determined by real-time PCR. The results showed that hexadecyl pyridinium chloride has no obvious cytotoxic effect on Vero cells in the concentration range 0.0125–0.05 mg/mL. The in vitro experiments showed that hexadecyl pyridinium chloride significantly inhibits the virus at concentrations of 0.1 mg/mL or above at 2 min of action. Thus, the results provide experimental support for the use of hexadecyl pyridinium chloride in stomatological hospitals.

scholarly journals Disinfection Effect of Hexadecyl Pyridinium Chloride on SARS-CoV-2 in vitro.

2021 ◽  
Author(s):  
Keda Chen ◽  
Feike Ma ◽  
Ying Wang ◽  
Xinyi Zhuang ◽  
Xuning Zhang ◽  
...  
Keyword(s):  
Vero Cells ◽  
Inhibitory Effect ◽  
The Novel ◽  
Pyridinium Chloride ◽  
Risk Environments ◽  
Highly Active ◽  
High Infection ◽  
Aerosol Dispersion ◽  
Novel Coronavirus

Abstract The novel coronavirus (COVID-19 or 2019-nCoV) is a respiratory virus that can exist in the mouth and saliva of patients and spreads through aerosol dispersion. Therefore, stomatological hospitals and departments have become high-infection-risk environments. Accordingly, the search for oral disinfectants that can effectively inactivate the virus has become a highly active area of research. Hexadecyl pyridinium chloride, povidone-iodine, and other common oral disinfectants are the natural primary choices for stomatological hospitals. Therefore, this study investigated the inhibitory effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro. Vero cells infected with SARS-CoV-2 were used to determine disinfection effect; the CCK-8 method was used to determine cytotoxicity; and viral load was determined by real-time PCR. The results showed that hexadecyl pyridinium chloride has no obvious cytotoxic effect on Vero cells in the concentration range 0.0125–0.05 mg/mL. The in vitro experiments showed that hexadecyl pyridinium chloride significantly inhibits the virus at concentrations of 0.1 mg/mL or above at 2 min of action. Thus, the results provide experimental support for the use of hexadecyl pyridinium chloride in stomatological hospitals.

scholarly journals Just the Facts: Recommendations on point-of-care ultrasound use and machine infection control during the coronavirus disease 2019 pandemic

CJEM ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 445-449 ◽  
Author(s):  
Daniel J. Kim ◽  
Tomislav Jelic ◽  
Michael Y. Woo ◽  
Claire Heslop ◽  
Paul Olszynski
Keyword(s):  
Infection Control ◽  
Point Of Care ◽  
Control Measures ◽  
World Health ◽  
Point Of Care Ultrasound ◽  
The Novel ◽  
Infection Control Measures ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Widespread Interest

The World Health Organization declared the novel coronavirus disease 2019 (COVID-19) to be a pandemic on March 11, 2020, and, currently, there are over 10,000 confirmed cases in Canada, with this number expected to grow exponentially. There has been widespread interest in the use of point-of-care ultrasound (POCUS) in the management of patients with suspected COVID-19. The CAEP Emergency Ultrasound Committee has developed recommendations on the use of POCUS in these patients, with an emphasis on machine infection control measures.

Coronavirus: Towards controlling of the pandemic - Indian scenario

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal
Keyword(s):  
Control Measures ◽  
The Novel ◽  
Medical Treatments ◽  
Health Crisis ◽  
The Public ◽  
Infection Control Measures ◽  
The Social ◽  
Asking Questions ◽  
The Government ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.

scholarly journals Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine

2020 ◽  
Vol 99 (5) ◽  
pp. 481-487 ◽  
Author(s):  
L. Meng ◽  
F. Hua ◽  
Z. Bian
Keyword(s):  
Public Health ◽  
Infection Control ◽  
Control Measures ◽  
World Health ◽  
Infection Control Measures ◽  
Dental Practitioners ◽  
The World ◽  
Essential Knowledge ◽  
Novel Coronavirus ◽  
Health Organization

The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major public health challenge for not only China but also countries around the world. The World Health Organization announced that the outbreaks of the novel coronavirus have constituted a public health emergency of international concern. As of February 26, 2020, COVID-19 has been recognized in 34 countries, with a total of 80,239 laboratory-confirmed cases and 2,700 deaths. Infection control measures are necessary to prevent the virus from further spreading and to help control the epidemic situation. Due to the characteristics of dental settings, the risk of cross infection can be high between patients and dental practitioners. For dental practices and hospitals in areas that are (potentially) affected with COVID-19, strict and effective infection control protocols are urgently needed. This article, based on our experience and relevant guidelines and research, introduces essential knowledge about COVID-19 and nosocomial infection in dental settings and provides recommended management protocols for dental practitioners and students in (potentially) affected areas.

scholarly journals Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong

2020 ◽  
Vol 258 (5) ◽  
pp. 1049-1055 ◽  
Author(s):  
Tracy H. T. Lai ◽  
Emily W. H. Tang ◽  
Sandy K. Y. Chau ◽  
Kitty S. C. Fung ◽  
Kenneth K. W. Li
Keyword(s):  
Hong Kong ◽  
Infection Control ◽  
Control Measures ◽  
The Novel ◽  
Infection Control Measures ◽  
Novel Coronavirus

scholarly journals The IMPDH inhibitor merimepodib provided in combination with the adenosine analogue remdesivir reduces SARS-CoV-2 replication to undetectable levels in vitro

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 361
Author(s):  
Natalya Bukreyeva ◽  
Rachel A. Sattler ◽  
Emily K. Mantlo ◽  
Timothy Wanninger ◽  
John T. Manning ◽  
...  
Keyword(s):  
Disease Burden ◽  
Vero Cells ◽  
The United States ◽  
The Novel ◽  
Infectious Titer ◽  
Adenosine Analogue ◽  
Pre Treatment ◽  
Novel Coronavirus ◽  
Dose Dependent

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing COVID-19 pandemic, which has resulted in over 2.5 million confirmed cases and 170,000 deaths worldwide as of late April 2020. The pandemic currently presents major public health and economic burdens worldwide. No vaccines or therapeutics have been approved for use to treat COVID-19 cases in the United States despite the growing disease burden, thus creating an urgent need for effective treatments. The adenosine analogue remdesivir (REM) has recently been investigated as a potential treatment option, and has shown some activity in limiting SARS-CoV-2 replication. We previously reported that the IMPDH inhibitor merimepodib (MMPD) provides a dose-dependent suppression of SARS-CoV-2 replication in vitro. Here, we report that a 4-hour pre-treatment of Vero cells with 2.5µM MMPD reduces the infectious titer of SARS-CoV-2 more effectively than REM at the same concentration. Additionally, pre-treatment of Vero cells with both REM and MMPD in combination reduces the infectious titer of SARS-CoV-2 to values below the detectable limit of our TCID50 assay. This result was achieved with concentrations as small as 1.25 µM MMPD and 2.5 µM REM. At concentrations of each agent as low as 0.31 µM, significant reduction of viral production occurred. This study provides evidence that REM and MMPD administered in combination might be an effective treatment for COVID-19 cases.

scholarly journals Community grid management is an important measure to contain the spread of novel coronavirus pneumonia (COVID-19)

2020 ◽  
Vol 148 ◽  
Author(s):  
Chen Ling ◽  
Xianjie Wen
Keyword(s):  
Control Measures ◽  
World Health ◽  
The Novel ◽  
Source Of Infection ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control ◽  
Grid Management

Abstract The outbreak of novel coronavirus pneumonia (coronavirus disease 2019 (COVID-19)), declared as a ‘global pandemic’ by the World Health Organization (WHO), is a public health emergency of international concern (PHEIC). The outbreak in multiple locations shows a trend of accelerating spread around the world. China has taken a series of powerful measures to contain the spread of the novel coronavirus. In response to the COVID-19 pandemic, in addition to actively finding effective treatment drugs and developing vaccines, it is more important to identify the source of infection at the community level as soon as possible to block the transmission path of the virus to prevent the spread of the pandemic. The implementation of grid management in the community and the adoption of precise management and control measures to reduce unnecessary personnel movement can effectively reduce the risk of pandemic spread. This paper mainly describes that the grid management mode can promote the refinement and comprehensiveness of community management. As a management system with potential to improve the governance ability of community affairs, it may be helpful to strengthen the prevention and control of the epidemic in the community.

COVID-19 Vaccination Efficacy and Safety Literature Review

2021 ◽  
Author(s):  
Michael Halim
Keyword(s):  
Active Immunization ◽  
Control Measures ◽  
World Health ◽  
The Novel ◽  
The Past ◽  
The Subject ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Guidelines And Recommendations ◽  
Roll Out

Since the emergency of the novel coronavirus disease (COVID-19) that is caused by SARS-Cov-2 in 2019, researchers have been on the move to find solutions to mitigate the spread of the virus. Various control measures have been put in place by governments under guidelines and recommendations of key global agencies with the world health organization (WHO) leading in providing information to help fight the pandemic. Multi-agency research efforts have been geared towards developing vaccines for active immunization to prevent COVID-19 infection. This paper is geared towards providing a detailed review and analysis of developments of the current vaccines in terms of safety and efficacy. Approaches that have been taken by different researchers and their findings are the subject of this work. Based on the mechanism by which a vaccine protects an individual against COVID-19 infection, it has been found that the already rolled out vaccines are mRNA (Pfizer and Moderna) and vector (Astrazeneca) vaccine structured. There is also China's Sinovac vaccine which has been in place for the past few years. The four vaccines reviewed here are administered in two doses some days apart. Currently, no vaccine has a safety threat and the efficacies are 95% for COVID-19 mRNA vaccine BNT162b2 (Pfizer), 94.1% for mRNA-1273 vaccine (Moderna), 70.4%forChAdOx1 nCoV-19 vaccine / AZD1222 (AstraZeneca) vaccine and 78% for sinovac respectively. Findings of this paper show that other vaccines are awaiting clinical roll out for trials. Even though these efficacies imply that the vaccines offer significant protection against the infection, further research and evaluation should go on to achieve higher efficacies while addressing any safety concerns that may go beyond local and systemic reactions that occur on patients after vaccination. This study concludes that even with the protection of the present vaccines, individuals must continue wearing personal protective equipment (PPEs) such as masks.

COVID-19-Pandemie: Sicherheitsrichtlinien bei nicht-chirurgischen ästhetischen Eingriffen im Gesichtsbereich

2021 ◽  
pp. 1-2
Author(s):  
Andrea Schulz
Keyword(s):  
Infection Control ◽  
Current Knowledge ◽  
Clinic Visit ◽  
Control Measures ◽  
The Novel ◽  
Infection Control Measures ◽  
Virtual Meeting ◽  
Facial Plastic ◽  
Novel Coronavirus ◽  
Aesthetic Procedures

<b>Background:</b> The novel coronavirus (COVID-19) pandemic is expected to last for an extended time, making strict safety precautions for office procedures unavoidable. The lockdown is going to be lifted in many areas, and strict guidelines detailing the infection control measures for aesthetic clinics are going to be of particular importance. <b>Methods:</b> A virtual meeting was conducted with the members (n = 12) of the European Academy of Facial Plastic Surgery Focus Group to outline the safety protocol for the nonsurgical facial aesthetic procedures for aesthetic practices in order to protect the clinic staff and the patients from SARS-CoV-2 infection. The data analysis was undertaken by thematic and iterative approach. <b>Results:</b> Consensus guidelines for nonsurgical facial aesthetic procedures based on current knowledge are provided for three levels: precautions before visiting the clinic, precautions during the clinic visit, and precautions after the clinic visit. <b>Conclusions:</b> Sound infection control measures are mandatory for nonsurgical aesthetic practices all around the world. These may vary from country to country, but this logical approach can be customized according to the respective country laws and guidelines.

scholarly journals A Physicist View of COVID-19 Airborne Infection through Convective Airflow in Indoor Spaces

2020 ◽  
Vol 2 ◽  
pp. 68-72
Author(s):  
Luis Alfredo Anchordoqui ◽  
Eugene M. Chudnovsky
Keyword(s):  
Control Measures ◽  
General Idea ◽  
Public Health Issue ◽  
The Novel ◽  
Major Public Health Issue ◽  
Airborne Infection ◽  
Confined Spaces ◽  
Infection Control Measures ◽  
Novel Coronavirus ◽  
Indoor Spaces

General Idea: Naturally produced droplets from humans (such as those produced by breathing, talking, sneezing, and coughing) include several types of cells (e.g., epithelial cells and cells of the immune system), physiological electrolytes contained in mucous and saliva (e.g. Na+, K+, Cl-), as well as, potentially, several infectious agents (e.g. bacteria, fungi, and viruses). In response to the novel coronavirus SARS-CoV-2 epidemic, which has become a major public health issue worldwide, we provide a concise overview of airborne germ transmission as seen from a physics perspective. We also study whether coronavirus aerosols can travel far from the immediate neighbourhood and get airborne with the convective currents developed within confined spaces. Methodology: Methods of fluid dynamics are utilized to analyse the behavior of various-size airborne droplets containing the virus. Study Findings: We show that existing vortices in the air can make a location far away from the source of the virus be more dangerous than a nearby (e.g., 6 feet away) location. Practical Implications: Our study reveals that it seems reasonable to adopt additional infection-control measures to the recommended 6 feet social distancing. We provide a recommendation that could help to slow down the spread of the virus.

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