scholarly journals Prevalence of Sarcopenia in Idiopathic Dropped Head Syndrome Patients is Similar to Healthy Volunteers

2021 ◽  
Author(s):  
Tatsuya Igawa ◽  
Norihiro Isogai ◽  
Akifumi Suzuki ◽  
Masahiro Ishizaka ◽  
Haruki Funao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Significant Loss ◽  
Trunk Muscle ◽  
Healthy Individuals ◽  
Healthy Elderly ◽  
Dropped Head Syndrome ◽  
Increased Risk ◽  
Appendicular Muscle Mass

Abstract Dropped head syndrome (DHS) exhibits cervical deformity due to weakness of the cervical extensor group, and sarcopenia is characterized by progressive and systemic reduction in skeletal muscle mass. These clinical finding are associated with reduced activity of daily living, reduced quality of life, and increased risk of mortality. We collected and reviewed prospective registry data for 16 consecutive female patients with idiopathic DHS and 32 healthy individuals who matched their gender and age. The prevalence of sarcopenia and body composition data were compared. There were no differences in the prevalence of sarcopenia, appendicular muscle mass, and leg muscle mass between DHS patients and the healthy elderly. Trunk muscle mass in DHS patients was significantly lower than that in healthy individuals. A significant correlation was found between appendicular muscle mass and trunk muscle mass in healthy subjects but not in DHS patients. Sarcopenia was not associated with the onset of idiopathic DHS. The prevalence of sarcopenia was not high in patients with idiopathic DHS due to the preservation of their appendicular skeletal muscle mass. Patients with DHS were characterized by a significant loss of trunk muscle mass that may be related to the disease but not aging.

scholarly journals Prevalence of sarcopenia in idiopathic dropped head syndrome patients is similar to healthy volunteers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tatsuya Igawa ◽  
Ken Ishii ◽  
Norihiro Isogai ◽  
Akifumi Suzuki ◽  
Masahiro Ishizaka ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Significant Loss ◽  
Trunk Muscle ◽  
Healthy Individuals ◽  
Healthy Elderly ◽  
Dropped Head Syndrome ◽  
Increased Risk ◽  
Appendicular Muscle Mass

AbstractDropped head syndrome (DHS) exhibits cervical deformity due to weakness of the cervical extensor group, and sarcopenia is characterized by progressive and systemic reduction in skeletal muscle mass. These clinical finding are associated with reduced activity of daily living, reduced quality of life, and increased risk of mortality. We collected and reviewed prospective registry data for 16 patients with idiopathic DHS continuously collected without dropping out and 32 healthy individuals who matched their gender and age. The prevalence of sarcopenia and body composition data were compared. There were no differences in the prevalence of sarcopenia, appendicular muscle mass, and leg muscle mass between DHS patients and the healthy elderly. Trunk muscle mass in DHS patients was significantly lower than that in healthy individuals. A significant correlation was found between appendicular muscle mass and trunk muscle mass in healthy subjects but not in DHS patients. Sarcopenia was not associated with the onset of idiopathic DHS. The prevalence of sarcopenia was not high in patients with idiopathic DHS due to the preservation of their appendicular skeletal muscle mass. Patients with DHS were characterized by a significant loss of trunk muscle mass that may be related to the disease but not aging.

scholarly journals Augmentation Index Is Inversely Associated with Skeletal Muscle Mass, Muscle Strength, and Anaerobic Power in Young Male Adults: A Preliminary Study

2021 ◽  
Vol 11 (7) ◽  
pp. 3146
Author(s):  
Dongmin Lee ◽  
Kyengho Byun ◽  
Moon-Hyon Hwang ◽  
Sewon Lee
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Arterial Stiffness ◽  
Muscle Mass ◽  
Muscular Strength ◽  
Skeletal Muscle Mass ◽  
Augmentation Index ◽  
Anaerobic Power ◽  
Negatively Associated ◽  
Increased Risk

Arterial stiffness is associated with an increased risk of cardiovascular disease. Previous studies have shown that there is a negative correlation between arterial stiffness and variables such as skeletal muscle mass, muscular strength, and anaerobic power in older individuals. However, little research has been undertaken on relationships in healthy young adults. This study presents a preliminary research that investigates the association between arterial stiffness and muscular factors in healthy male college students. Twenty-three healthy young males (23.9 ± 0.5 years) participated in the study. The participants visited the laboratory, and variables including body composition, blood pressure, arterial stiffness, blood parameters, grip strength, and anaerobic power were measured. Measurements of augmentation index (AIx) and brachial-ankle pulse wave velocity (baPWV) were performed to determine arterial stiffness. There were significant positive correlations among skeletal muscle mass, muscle strength, and anaerobic power in healthy young adult males. AIx was negatively associated with a skeletal muscle mass (r = −0.785, p < 0.01), muscular strength (r = −0.500, p < 0.05), and anaerobic power (r = −0.469, p < 0.05), respectively. Likewise, AIx@75 corrected with a heart rate of 75 was negatively associated with skeletal muscle mass (r = −0.738, p < 0.01), muscular strength (r = −0.461, p < 0.05), and anaerobic power (r = −0.420, p < 0.05) respectively. However, the baPWV showed no correlation with all muscular factors. Our findings suggest that maintaining high levels of skeletal muscle mass, muscular strength, and anaerobic power from relatively young age may lower AIx.

scholarly journals Additive effect of low skeletal muscle mass and abdominal obesity on coronary artery calcification

2021 ◽  
Author(s):  
Ji Eun Jun ◽  
Mira Kang ◽  
Sang-Man Jin ◽  
Kyunga Kim ◽  
You-Cheol Hwang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Coronary Artery ◽  
Muscle Mass ◽  
Abdominal Obesity ◽  
Coronary Artery Calcification ◽  
Skeletal Muscle Mass ◽  
Reference Group ◽  
Sarcopenic Obesity ◽  
Cvd Risk ◽  
Increased Risk

Objective We aimed to investigate the interaction of reduced skeletal muscle mass and abdominal obesity on coronary artery calcification (CAC). Design and methods A total of 19,728 adults free of cardiovascular disease (CVD) who contemporaneously underwent cardiac tomography and bioelectrical impedance analysis were enrolled in a cross-sectional and longitudinal cohort. Skeletal muscle mass index (SMI) was calculated the following formula: SMI (%) = total appendicular muscle mass (kg)/body weight (kg) x 100 according to sex. CAC presence or incidence was defined as CAC score>0, and CAC progression was defined as √CAC score (follow-up) − √CAC score (baseline)>2.5. Pre-sarcopenia was defined as SMI ≤ –1.0 standard deviation of the sex-specific mean of a young reference group. Abdominal obesity was defined as waist circumference ≥90cm for men and ≥85cm for women. All individuals were further classified into four groups: normal, abdominal obesity alone, pre-sarcopenia alone, and pre-sarcopenic obesity. Results Individuals with pre-sarcopenic obesity showed the highest adjusted odds ratio (AOR) for CAC presence (AOR 2.16, 95% confidence interval [CI]: 1.98–2.36, P<0.001) as well as total CAC incidence and progression (adjusted hazard ratio 1.54, 95% CI: 1.37–1.75, P<0.001), compared with normal individuals. Pre-sarcopenic obesity significantly increased CAC incidence and progression compared to either pre-sarcopenia or abdominal obesity alone. Conclusion Pre-sarcopenia and abdominal obesity together were significantly associated with a higher CAC presence and increased risk of CAC incidence and progression, independent of traditional CVD risk factors.

Low Skeletal Muscle Mass Independently Predicts Mortality in Patients with Chronic Heart Failure after an Acute Hospitalization

Cardiology ◽  
2019 ◽  
Vol 142 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Persio D. Lopez ◽  
Pankaj Nepal ◽  
Adedoyin Akinlonu ◽  
Divya Nekkalapudi ◽  
Kwon Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Psoas Muscle ◽  
Exercise Intolerance ◽  
Cox Regression Analysis ◽  
Acute Hospitalization ◽  
Increased Risk ◽  
All Cause Mortality

Background: Heart failure (HF) is a syndrome associated with exercise intolerance, and its symptoms are more common in patients with low skeletal muscle mass (SMM). Estimation of muscle mass can be cumbersome and unreliable, particularly in patients with varying body weight. The psoas muscle area (PMA) can be used as a surrogate of sarcopenia and has been associated with poor outcomes in other populations. Objectives: The aim of this study was to assess if sarcopenia is associated with the survival of patients with HF after an acute hospitalization. Method: We retrospectively studied a cohort of 160 patients with HF who had abdominopelvic computed tomography during an acute hospitalization. We obtained standardized measurements of their PMA and defined sarcopenia as the lowest gender-based tertile of the said area. The patients were followed until death or discontinuation of care. We used Kaplan-Meier estimates and Cox regression analysis to assess the relationship between sarcopenia and all-cause mortality. Results: We found that the 52 patients with sarcopenia had 4.5 times the risk of all-cause mortality at 1 year compared to the rest of the cohort (CI 1.784–11.765; p = 0.0016) after adjusting for significant covariates. Stratification by age and sex revealed that this association could be limited to males and patients < 75 years old. Conclusion: The PMA, used as a surrogate of low SMM, is independently associated with an increased risk of late mortality after an acute hospitalization in patients with HF.

Decreased Skeletal Muscle Mass is Associated with an Increased Risk of Mortality after Radical Nephrectomy for Localized Renal Cell Cancer

2016 ◽  
Vol 195 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Sarah P. Psutka ◽  
Stephen A. Boorjian ◽  
Michael R. Moynagh ◽  
Grant D. Schmit ◽  
Brian A. Costello ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Skeletal Muscle Mass ◽  
Cell Cancer ◽  
Risk Of Mortality ◽  
Increased Risk

scholarly journals Selecting Appropriate Sarcopenia Screening Methods for Asian Populations

2020 ◽  
Vol 9 (8) ◽  
pp. 2333
Author(s):  
Yu-Ching Lin ◽  
Yi-Chien Lu ◽  
Fang-Ping Chen ◽  
Ying Chin Lin ◽  
Yun-Chung Cheung ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Fat Mass ◽  
Skeletal Muscle Mass ◽  
Healthy Individuals ◽  
Community Based ◽  
Skeletal Muscle Index ◽  
Asian Populations ◽  
Age Dependent ◽  
Total Fat

We aimed to determine the most appropriate sarcopenia screening method for Asian populations. We retrospectively studied the physiological differences between the sexes in healthy individuals and prospectively compared using skeletal muscle mass versus handgrip strength (HS) to screen for sarcopenia in a community-based population. Skeletal muscle mass was determined using dual-energy X-ray absorptiometry. Of 5881 healthy individuals recruited, 101 were from urban populations and 349 from a community-based population. The sexes were comparable in total lean muscle mass declines after peaking around 20 years of age. An age-dependent decline in total fat mass was found only among men;a persistent increase in total fat mass was observed only among women. The prevalence of low skeletal muscle mass significantly increased with age in both sexes only when applying the weight-adjusted skeletal muscle index (wSMI); it was significant only among men when applying the height-adjusted skeletal muscle index (hSMI). Using HS resulted in a much higher prevalence of sarcopenia in both sexes. A significant age-dependent increase in fat mass in women showed that the most appropriate adjustment method is wSMI for women and hSMI for men. Nevertheless, a primary HS survey is recommended for both sexes in Asian populations.

Skeletal muscle loss after total gastrectomy, exacerbated by adjuvant chemotherapy.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 168-168
Author(s):  
Kazumasa Fujitani ◽  
Yusuke Yamaoka ◽  
Toshimasa Tsujinaka ◽  
Kazuyoshi Yamamoto ◽  
Motohiro Hirao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Adjuvant Chemotherapy ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Significant Loss ◽  
Muscle Loss ◽  
Clinical Factors ◽  
Improved Outcomes ◽  
Skeletal Muscle Loss

168 Background: Skeletal muscle loss is associated with physical disability, nosocomial infections, postoperative complications, and decreased survival. Preventing the loss of skeletal muscle mass after gastrectomy may lead to improved outcomes. The aims of this study were to assess changes in skeletal muscle mass after total gastrectomy (TG) and to clarify the clinical factors affecting significant loss of skeletal muscle after TG. Methods: One hundred and two patients undergoing TG for primary gastric cancer underwent abdominal computed tomography (CT) before and 1 year after TG to precisely quantify postoperative changes in skeletal muscle and adipose tissue. Univariate and multivariate logistic regression analyses identified clinical factors contributing to significant loss of skeletal muscle after TG. Results: At 1 year after TG, the mass of both skeletal muscle and adipose tissue was reduced by 6.20±6.80% and 65.8±36.1% of the preoperative values, respectively, and 26 patients (25.5%) showed a significant loss of skeletal muscle of more than 10%. Adjuvant chemotherapy with S-1 for ≥6 months (hazard ratio 26.75, 95% confidence interval 3.511 to 203.9) was identified as the single independent risk factor for a significant loss of skeletal muscle. Conclusions: Skeletal muscle loss was exacerbated by extended adjuvant chemotherapy after TG. Further research should identify appropriate nutritional interventions for maintaining skeletal muscle mass and leading to improved outcomes.

scholarly journals Total Skeletal Muscle Mass, Appendicular Muscle Mass, Strength And Power In Master Athletes

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S220
Author(s):  
Louisa D. Raisbeck ◽  
Jonathon L. Stickford ◽  
Colleen M. McCracken ◽  
Sandra Tecklenberg ◽  
Jeanne D. Johnston ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Master Athletes ◽  
Appendicular Muscle Mass

scholarly journals Effect of Low Skeletal Muscle Mass and Sarcopenic Obesity on Chronic Kidney Disease in Patients with Type 2 Diabetes

2021 ◽  
Author(s):  
Da Hea Seo ◽  
Young Ju Suh ◽  
Yongin Cho ◽  
Seong Hee Ahn ◽  
Seongha Seo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Bioelectrical Impedance ◽  
Sarcopenic Obesity ◽  
Increased Risk

Abstract The causal relationship between low muscle mass and development of chronic kidney disease (CKD) is uncertain in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the association between low muscle mass or sarcopenic obesity and the risk of incident CKD in patients with T2DM. A total of 3,123 patients with T2DM with preserved renal function were followed up for incident CKD. Skeletal muscle mass was estimated from bioelectrical impedance analysis. CKD was defined as an estimated glomerular filtration rate < 60 mL/min/1.73m2. Sarcopenic obesity was defined as the coexistence of sarcopenia and abdominal obesity. During 8.9 years of follow-up, 530 (17.0%) patients developed incident CKD. When subjects were divided into three groups based on sex-specific tertiles, lower muscle mass was not associated with an increased risk of incident CKD after adjustment for risk factors. However, when patients were divided into four groups according to the presence of sarcopenia and obesity, sarcopenic obesity was associated with an increased risk of incident CKD (adjusted hazard ratio 1.77; 95% confidence interval 1.24-2.51; p=0.001) compared to the other groups. Sarcopenic obesity, but not low muscle mass alone, may increase the risk of CKD in patients with T2DM.

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