scholarly journals Meta-analysis of Salt Valproate Prevent Switch Associated with Antidepressants in Chinese Depressive Patients

2021 ◽  
Author(s):  
Dong Shen ◽  
Wangqiang Lv ◽  
Fengli Sun ◽  
Jin Weidong
Keyword(s):  
Social Sciences ◽  
Sodium Valproate ◽  
Citation Index ◽  
Meta Analysis ◽  
Combination Group ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Switch Rate ◽  
Depressive Patients ◽  
Social Sciences Citation Index

Abstract Objective: to study the efficacy of valproate in preventing switch rate related to antidepressant in depressive patients. Methods: The related literature were searched in Chinese Biomedical Database(CBM), China National Knowledge Infrastructure(CNKI) , WANFANG database,and Chinese Social Sciences Citation Index(CSSCI) from 1 January 2005 to 1 January 2020 The rate of switch between groups was synthesized and discussed.Result:A total of 549 subjects were included in 7 studies,in which in 279 cases are in combination group and 270 cases are in group of monotherapy by antidepressant . The results showed switch rate of valproate group was 0.11%,switch rate of antidepressant group was 11.11%, which was very different (OR=0.13 ,95% CI: 0.05–0.35) and also indicated that valproate reduced switch rate was 99%[ (11.11%-0.11%)/11.11%]. In sodium valproate group, switch rate was 0%，while switch rate in antidepressant was 5.7%( OR=0.18,95%CI=0.04-0.84,Z=2.18,P=0.03). In magnesium valproate group, switch rate was 2.2%,while switch rate in antidepressant was16.92% ( OR=0.11,95%CI=0.03-0.39,Z=3.47, P=0.0005).Conclusion:The salt valproate can reduced switch rate related to antidepressant in depressive patients.

Can Salt Valproate Prevent Switch Associated With Antidepressants in Depressive Patients?Meta-analysis From Chinese Data (Preprint)

2021 ◽  
Author(s):  
Shen Dong ◽  
Wangqiang Lv ◽  
Fengli Sun ◽  
Weidong Jin
Keyword(s):  
Combination Treatment ◽  
Case Reports ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Mood Stabilizer ◽  
Combination Group ◽  
China National Knowledge Infrastructure ◽  
Switch Rate ◽  
Depressive Patients

BACKGROUND There are many ways to strengthen the effects of treatment for depressive patients,in which, add on mood stabilizer is one of these many ways. And at same time,it was very common that antidepressant induce switch to mania.Does the mood stabilizer can prevent the switch?This study is that assessment the difference between combination treatment of valproate and antidepressant and monotherapy antidepressant. OBJECTIVE to assess the preventing switch effect of valproate in depressive patients treated by antidepressant METHODS We searched Chinese Biomedical Database(CBM), China National Knowledge Infrastructure(CNKI) , WANFANG database,and Chinese Social Sciences Citation Index(CSSCI) in Chinese to find literature from 1 January 2005 to 1 January 2020 related to the study in model of “comparison of switch rate between combination treatment of valproate and antidepressant and monotherapy of antidepressant in depressive patients” ,among which results such as comments, letters, reviews and case reports were excluded. The rate of switch between groups was synthesized and discussed. RESULTS A total of 549 subjects were included in 7 studies,in which in 279 cases are in combination group and 270 cases are in group of monotherapy by antidepressant . Random effect model is used to account for the data by Revman 5.2. The results showed that the switch rate of valproate group was 0.11%(3/279),switch rate of antidepressant group was 11.11%( 30/270), which was very different in switch rate(OR=0.13 ,95% CI: 0.05–0.35) and also indicated that valproate reduced switch rate was 99%[ (11.11%-0.11%)/11.11%]. In sodium valproate group, switch rate was 0%，while switch rate in antidepressant was 5.7%( OR=0.18,95%CI=0.04-0.84),which was significantly different(Z=2.18,P=0.03). In magnesium valproate group, switch rate was 2.2%,while switch rate in antidepressant was16.92%( OR=0.11,95%CI=0.03-0.39),which was significantly different(Z=3.47,P=0.0005). CONCLUSIONS The salt valproate can reduced switch rate related to antidepressant in depressive patients. In this study, salt valproate reduce 99% switch rate. CLINICALTRIAL NO

Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis

2021 ◽  
Vol 53 (07) ◽  
pp. 425-434
Author(s):  
Jie Fu ◽  
Tao Tao ◽  
Zuoxiao Li ◽  
Yangmei Chen ◽  
Xiu Chen ◽  
...  
Keyword(s):  
Sodium Valproate ◽  
Early Stage ◽  
Meta Analysis ◽  
Group Versus ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Asian Patients ◽  
Knowledge Infrastructure ◽  
Patients With Epilepsy

AbstractWe conducted this meta-analysis to assess the effects of sodium valproate (VPA) monotherapy on blood liver enzymes in patients with epilepsy. PubMed, Web of Science, EBSCO, Cochrane Library, Wanfang, China national knowledge infrastructure databases were searched. Nine studies were included. Results showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA monotherapy group versus control group were 0.70 (95% CI=0.31 to 1.09, Z=3.52, p=0.0004), 0.47 (95% CI=− 0.01 to 0.95, Z=1.91, p=0.06), 0.44 (95% CI=0.29 to 0.60, Z=5.55, p<0.00001), respectively. (2) In subgroup meta-analysis, increased blood AST and GGT levels were observed in epileptic minors (AST: total SMD=0.85, 95% CI=0.40 to 1.30, Z=3.69, p=0.0002; GGT: total SMD=0.46, 95% CI=0.29 to 0.63, Z=5.25, p<0.00001). Elevated blood ALT level was observed in Asian patients receiving VPA monotherapy (total SMD=0.70, 95% CI=0.51 to 0.90, Z=7.01, p<0.00001), and the early stage of VPA monotherapy (total SMD=0.93, 95% CI=0.57 to 1.29, Z=5.09, p<0.00001). Overall, our results indicated that blood AST and GGT were significantly increased in epileptic minors receiving VPA monotherapy. The elevation of blood ALT was observed in Asian patients and the early stage of VPA monotherapy. However, due to the small number of included studies, our results should be considered with caution.

scholarly journals Influencing Factors of Academic Entrepreneurship-Based Knowledge Mapping: A Comparative Analysis of Chinese and International Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Liu Ziyu ◽  
Zhao Lixia
Keyword(s):  
Social Sciences ◽  
Comparative Analysis ◽  
Influencing Factors ◽  
Academic Entrepreneurship ◽  
Citation Index ◽  
Organizational Factors ◽  
Knowledge Mapping ◽  
Personal Factors ◽  
China National Knowledge Infrastructure ◽  
Social Sciences Citation Index

In order to analyze the hot frontier of academic entrepreneurship and study the influencing factors of academic entrepreneurship, By using citespace V information visualization software and content analysis, 32 papers in CNKI (China National Knowledge Infrastructure) database are retrieved which are indexed by CSSCI (Chinese Social Sciences Citation Index), and 66 papers are retrieved in Web of Science database which are indexed by SSCI (Social Sciences Citation Index); the Chinese and international sample papers were compared and analyzed, and a comparative analysis between Chinese and international papers was made. The results show that the influencing factors of academic entrepreneurship are divided into personal, environmental, and organizational factors. There are many researches on personal factors in China and external factors such as environment, organization, and system in international countries. Chinese research tends to the macrolevel, while international research pays more attention to the microlevel. The research frontier at home and abroad is the research of academic entrepreneurial process at microlevel. Finally, some suggestions are given to academic entrepreneurship: academic exchanges should be strengthened, more support platforms should be set up in university institutions, and the state should introduce incentive policies to enhance the strength and level of academic entrepreneurship.

Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis

Angiology ◽  
2021 ◽  
pp. 000331972110044
Author(s):  
Hongling Xu ◽  
Hongye Wang ◽  
Chuang Zhang ◽  
Jun Xiao ◽  
Ning Hua ◽  
...  
Keyword(s):  
Meta Analysis ◽  
China National Knowledge Infrastructure ◽  
Contrast Induced Nephropathy ◽  
Serum Cystatin ◽  
Assessment Development ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Knowledge Infrastructure ◽  
Evidence Evaluation ◽  
Biological Medicine ◽  
Neutrophil Gelatinase

This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 µg/d alprostadil or 20 µg/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 µg/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.

scholarly journals Effect of somatometric parameters on the prevalence and severity of varicocele: a systematic review and meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Runqing Li ◽  
Junjie Liu ◽  
Yushan Li ◽  
Quanxian Wang
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Random Effects Models ◽  
Knowledge Infrastructure ◽  
Regression Test ◽  
Mean Differences ◽  
Q Statistic ◽  
The Relationship

Abstract Background Published studies have shown contradictory results regarding the relationship between somatometric parameters and varicoceles. We performed a systematic review and meta-analysis to investigate the possible effects of age, height, weight, and body mass index (BMI) on the presence and severity of varicoceles. Methods Databases including EMBASE, MEDLINE, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Web of Science, and Google Scholar were systematically searched to identify relevant articles published up to March 2020. Two researchers independently identified eligible articles and extracted data. Cochran’s Q statistic and I2 statistics were used to assess heterogeneity. Meta-analysis was performed using StataSE 12.0 software (StataCorp LP, USA). Random-effects models were used to obtain the weighted mean differences (WMDs) and 95% confidence intervals (CIs). Publication bias was assessed using Begg’s funnel plot and Egger’s regression test. Results The search strategy produced 272 articles, of which 18 articles were eligible according to the inclusion/exclusion criteria. A total of 56,325 patients with varicocele and 1,334,694 patients without varicocele were included in the meta-analysis to evaluate the effect of somatometric parameters on the presence and severity of varicocele. The overall results demonstrated that the presence of varicoceles was significantly associated with height (WMD = 1.41, 95% CI = 1.07 to 1.74, P < 0.001) and inversely correlated with BMI (WMD = − 1.35, 95% CI = -1.67 to − 1.03, P < 0.001) but not with age (WMD = -0.93, 95% CI = -2.19 to 0.33, P = 0.149) or weight (WMD = 0.24, 95% CI = -2.24 to 2.72, P = 0.850). The severity of varicocele was inversely correlated with increased BMI but not with age. Conclusion The presence of varicoceles was significantly associated with height and inversely correlated with BMI.

scholarly journals Individual or combined transcatheter arterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma: a time-to-event meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chuang Jiang ◽  
Gong Cheng ◽  
Mingheng Liao ◽  
Jiwei Huang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Transcatheter Arterial Chemoembolization ◽  
Meta Analysis ◽  
Combined Treatment ◽  
Similar Rate ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Arterial Chemoembolization

Abstract Background There is still some debate as to whether transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA) is better than TACE or RFA alone. This meta-analysis aimed to compare the efficacy and safety of TACE plus RFA for hepatocellular carcinoma (HCC) with RFA or TACE alone. Methods We searched PubMed, MEDLINE, Embase, Cochrane Library, and CNKI (China National Knowledge Infrastructure) for all relevant randomized controlled trials and retrospective studies reporting overall survival (OS), recurrence-free survival (RFS), and complications of TACE plus RFA for HCC, compared with RFA or TACE alone. Results Twenty-one studies involving 3413 patients were included. TACE combined with RFA was associated with better OS (hazard ratio [HR]=0.62, 95% confidence intervals [CI] = 0.55–0.71, P < 0.001) and RFS (HR = 0.52, 95% CI = 0.39–0.69, P < 0.001) than TACE alone; compared with RFA alone, TACE plus RFA resulted in longer OS (HR = 0.63, 95% CI = 0.53–0.75, P < 0.001) and RFS (HR = 0.60, 95% CI = 0.51–0.71, P < 0.001). Subgroup analyses by tumor size also showed that combined treatment resulted in better OS and RFS compared with RFA alone in patients with HCC larger than 3 cm. Combined treatment resulted in similar rate of major complications compared with TACE or RFA alone (OR = 1.78, 95% CI = 0.99–3.20, P = 0.05; OR = 1.00, 95% CI = 0.42–2.38, P = 1.00, respectively). Conclusions TACE combined with RFA was more effective for HCC than TACE alone. For patients with a tumor larger than 3 cm, the combined treatment also achieved a better effect than RFA alone.

scholarly journals Meta-analysis reveals significant association between FOXP3 polymorphisms and susceptibility to Graves’ disease

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110041
Author(s):  
Guiqin Tan ◽  
Xin Wang ◽  
Guangbing Zheng ◽  
Juan Du ◽  
Fangyu Zhou ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Pooled Analysis ◽  
Case Control ◽  
Graves Disease ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
China National Knowledge Infrastructure ◽  
Asian Populations ◽  
Knowledge Infrastructure ◽  
Independent Case

Objective This meta-analysis aimed to determine the associations between the rs3761547, rs3761548, and rs3761549 single-nucleotide polymorphisms (SNPs) of the forkhead box P3 ( FOXP3) gene and susceptibility to Graves’ disease (GD). Methods Case–control studies with information on the associations between the rs3761547, rs3761548, and rs3761549 FOXP3 SNPs and GD published before 01 May 2020 were identified in the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases. Data from the studies were analyzed using RevMan version 5.3. Results Seven independent case–control studies including 4051 GD patients and 4569 controls were included in the meta-analysis. The overall pooled analysis indicated that FOXP3/rs3761548 and FOXP3/rs3761549 polymorphisms were significantly associated with GD susceptibility (rs3761548: A vs. C, odds ratio [OR] = 1.32, 95% confidence interval [CI] 1.05–1.67; rs3761549: TT vs. CC, OR = 1.98, 95%CI 1.49–2.65; (TT + TC) vs. CC, OR = 1.44, 95%CI 1.11–1.88). In contrast, the FOXP3/rs3761547 polymorphism was not associated with GD susceptibility. Subgroup analysis according to ethnicity showed that rs3761548 was associated with GD in Asians but not in Caucasians, whereas rs3761549 was associated in both Asians and Caucasians. Conclusion This meta-analysis demonstrated that FOXP3/rs3761548 and FOXP3/rs3761549 SNPs were significantly associated with susceptibility to GD, at least in Asian populations.

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

scholarly journals Efficacy and Safety of Topical Timolol Eye Drops in the Treatment of Myopic Regression after Laser In Situ Keratomileusis: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Xiaochen Wang ◽  
Guiqiu Zhao ◽  
Jing Lin ◽  
Nan Jiang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Treated Group ◽  
Laser In Situ Keratomileusis ◽  
Control Group ◽  
Eye Drops ◽  
Efficacy And Safety ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Significant Difference

Aims. The aim of this study was to assess the efficacy and safety of timolol in the treatment of myopic regression after laser in situ keratomileusis (LASIK).Methods. We searched MEDLINE, CENTRAL, EMBASE, China National Knowledge Infrastructure (CNKI), and Chinese Biological Medicine (CBM) from the inception to July 2015 for relevant randomized controlled trials that examined timolol therapy for myopic regression. The methodological quality of the studies included was assessed using the Revman 5.3 software.Results. We included six clinical trials involving 483 eyes in this review, including 246 eyes in treated group and 237 eyes in controlled group. We observed statistically significant improvements on the postoperative SE in the 3 months. However, the change of CCT was not statistically different between the control group and the experimental group. There were fewer cases of IOP, UDVA, and CDVA in treated group having significant difference from the controlled group.Conclusions. Topical timolol could be an effective treatment for reduction of myopic regression especially the spherical errors after myopic LASIK. Further RCTs with larger sample sizes for these trials are warranted to determine the efficacy and limitation for myopic regression after LASIK.

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