scholarly journals Reduced 25-Hydroxyvitamin D Concentration in the Aqueous Humor of Cataract Patients with Open-Angle Glaucoma

2021 ◽  
Author(s):  
Yongwun Cho ◽  
Seung Pil Yun ◽  
Woong-Sun Yoo ◽  
Rock-Bum Kim ◽  
Min-Chul Cho ◽  
...  
Keyword(s):  
Vitamin D ◽  
Aqueous Humor ◽  
Open Angle Glaucoma ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Epidemiological Studies ◽  
Open Angle ◽  
Fiber Layer ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Abstract Previous epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigated the relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor and OAG. We measured 25(OH)D concentrations in aqueous humor and serum of 126 patients who underwent cataract surgery. The 25(OH)D concentrations were measured using Elecsys Vitamin D Total Kits with the Cobas e602 module (Roche Diagnostics, Mannheim, Germany), an electrochemiluminescence assay. Multiple linear regression analysis was performed to investigate factors associated with serum and aqueous humor 25(OH)D concentrations.Patients with OAG had significantly lower 25(OH)D concentrations in aqueous humor than control patients. Serum 25(OH)D concentrations were higher in patients with OAG than in the control, but this was not statistically significant. 25(OH)D concentrations in aqueous humor of patients with OAG were significantly associated with axial length but not with glaucoma severity, which was determined by the retinal nerve fiber layer thickness or mean deviation.Vitamin D concentrations in aqueous humor of patients with OAG were significantly lower than those in patients without OAG.

scholarly journals Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yongwun Cho ◽  
Seung Pil Yun ◽  
Woong-Sun Yoo ◽  
Rock-Bum Kim ◽  
Min-Chul Cho ◽  
...  
Keyword(s):  
Vitamin D ◽  
Aqueous Humor ◽  
Open Angle Glaucoma ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Mean Deviation ◽  
Open Angle ◽  
Fiber Layer ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractPrevious epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigated the relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor and OAG. We measured 25(OH)D concentrations in aqueous humor and serum of 126 patients who underwent cataract surgery. 36 were patients with OAG and 90 were control patients. The 25(OH)D concentrations were measured using Elecsys Vitamin D Total Kits with the Cobas e602 module (Roche Diagnostics, Mannheim, Germany), an electrochemiluminescence assay. Multiple linear regression analysis was performed to investigate factors associated with serum and aqueous humor 25(OH)D concentrations. Patients with OAG had significantly lower 25(OH)D concentrations in aqueous humor than control patients. Serum 25(OH)D concentrations were higher in patients with OAG than in the control, but this was not statistically significant. 25(OH)D concentrations in aqueous humor of patients with OAG were significantly associated with axial length but not with glaucoma severity, which was determined by the retinal nerve fiber layer thickness or mean deviation. Vitamin D concentrations in aqueous humor of patients with OAG were significantly lower than those in patients without OAG.

scholarly journals Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Min-Chul Cho ◽  
Rock-Bum Kim ◽  
Ja-Young Ahn ◽  
Woong-Sun Yoo ◽  
Seong-Jae Kim
Keyword(s):  
Vitamin D ◽  
Regression Analysis ◽  
Aqueous Humor ◽  
Linear Regression Analysis ◽  
Senile Cataract ◽  
Multivariate Linear Regression Analysis ◽  
Diabetic Cataract ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D

Abstract Background Serum 25-hydroxyvitamin D (25 (OH) D) levels are associated with various pathologic ocular conditions. Few studies have assessed 25 (OH) D concentrations in non-serum specimens, and none to date has assessed 25 (OH) D concentrations in human aqueous humor and their association with ocular diseases. This study investigated the possible correlations between 25 (OH) D concentrations in aqueous humor and serum and whether vitamin D concentrations in aqueous humor were associated with cataract. Methods This study prospectively enrolled 136 patients, including 87 with senile cataract and 49 with diabetic cataract, who underwent cataract surgery from January to November 2017. 25 (OH) D was measured in aqueous humor and serum specimens collected from all patients, and their correlation was analyzed statistically. Clinical and laboratory data, including the results of ophthalmologic examinations, were compared in the two groups of cataract patients. Results No correlation was observed between 25 (OH) D concentrations in aqueous humor and serum (P = 0.381). 25 (OH) D concentrations in aqueous humor were significantly higher in patients with diabetic than senile cataract (P = 0.006). Multivariate logistic regression analysis showed that the adjusted odds ratio for diabetic cataract for the highest compared with the lowest quartile of 25 (OH) D concentration in aqueous humor was 4.36 ng/ml (95% confidence interval [CI]: 1.33–14.34 ng/ml; P = 0.015). Multivariate linear regression analysis showed that 25(OH) D concentration in aqueous humor was 2.68 ng/ml (95% CI: 0.34–5.01 ng/ml; P = 0.025) higher in patients with diabetic than senile cataract. Conclusions 25(OH) D concentrations in aqueous humor and serum did not correlate with each other. Higher 25(OH) D level in aqueous humor was associated with diabetic cataract. These findings suggest that studies of vitamin D levels in patients with ocular conditions should include measurements of vitamin D levels in aqueous humor.

scholarly journals Vitamin D Binding Protein Affects the Correlation of 25(OH)D and Frailty in the Older Men

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yi Wang ◽  
Yan-Jiao Wang ◽  
Jun-Kun Zhan ◽  
Zhi-Yong Tang ◽  
Wu Huang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Linear Regression Analysis ◽  
Older Men ◽  
Joint Effect ◽  
Hunan Province ◽  
Multivariate Linear Regression Analysis ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Vitamin D binding protein (DBP) may alter the biologic activity of 25-hydroxyvitamin D [25(OH)D]. The objective of our present study was to determine the joint effect of serum 25(OH)D and DBP on the risk of frailty. Five hundred sixteen male participants aged 70 years or older were recruited in Changsha city and its surrounding area in Hunan province of China. Frailty was defined as the presence of at least three of the five following criteria: weakness, low physical activity, slow walking speed, exhaustion, and weight loss. Multivariate linear regression analysis was performed to assess the relationship between 25(OH)D and DBP levels. Odds ratios (ORs) for frailty were evaluated across quartiles of 25(OH)D and DBP levels, adjusted age, education, and body mass index. The results showed that participants in the lowest quartile of 25(OH)D and the highest quartile of DBP levels, the lowest quartile of 25(OH)D and the lowest quartile of DBP levels, and those in the the lower quartile of 25(OH)D and lowest quartile of DBP levels had significantly higher OR of being frail compared with those in the highest quartile of 25(OH)D and lowest quartile of DBP, with OR of 3.18 (95% CI: 1.46–4.56,P<0.05), 2.63 (95% CI: 1.31–3.68,P<0.01), and 2.52 (95% CI: 1.22–3.52,P<0.05), respectively. The results indicate that the joint effect of serum 25(OH)D and DBP levels is associated with the risk of frailty, and serum DBP levels affects 25(OH)D-frailty relationship in the older men.

scholarly journals Healthy changes in some cardiometabolic risk factors accompany the higher summertime serum 25-hydroxyvitamin D concentrations in Iranian children: National Food and Nutrition Surveillance

2018 ◽  
Vol 21 (11) ◽  
pp. 2013-2021 ◽  
Author(s):  
Bahareh Nikooyeh ◽  
Zahra Abdollahi ◽  
Majid Hajifaraji ◽  
Hamid Alavi-Majd ◽  
Forouzan Salehi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Total Cholesterol ◽  
Cardiometabolic Risk ◽  
Linear Regression Analysis ◽  
Cardiometabolic Risk Factors ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo investigate seasonal variations of vitamin D status at different latitudes and if these changes are accompanied by corresponding variations in certain health parameters in children living in a broad latitudinal range in Iran.DesignLongitudinal study.SubjectsIn total, 530 apparently healthy children aged 5–18 years were randomly selected from six regions of Iran with a latitudinal gradient from 29°N to 37·5°N. All anthropometric and biochemical assessments were performed twice during a year (summer, winter). High BMI (Z-score >1), low HDL cholesterol (<40 mg/dl, males; <50 mg/dl, females) and high TAG (>150 mg/dl) were considered cardiometabolic risk factors.ResultsSerum 25-hydroxyvitamin D (25(OH)D) showed between-season variation, with significantly higher concentrations (mean (sd)) in summer v. winter (43 (29) v. 27 (18) nmol/l; P<0·001). Change of circulating 25(OH)D between summer and winter was negatively correlated with change of BMI (r=−0·16; P<0·001), TAG (r=−0·09; P=0·04) and total cholesterol (r=−0·10; P=0·02) and directly correlated with change of height-for-age Z-score (r=0·09; P=0·04). Multiple stepwise linear regression analysis (β; 95 % CI) showed that winter serum 25(OH)D (−0·3; −0·4, −0·2; P<0·001), gender (boys v. girls: 9·7; 5·2, 14·1; P<0·001) and latitude (>33°N v. <33°N: 4·5; 0·09, 9·0; P=0·04) were predictors of change of serum 25(OH)D between two seasons.ConclusionsSummertime improvement of vitamin D status was accompanied by certain improved cardiometabolic risk factors, notably serum TAG, total cholesterol and BMI, in children.

scholarly journals 25-Hydroxyvitamin D and matrix metalloproteinases-2, -9 level in patients with primary open angle glaucoma and pseudoexfoliative glaucoma/syndrome

2017 ◽  
Vol 10 (1) ◽  
pp. 10-16
Author(s):  
Inessa S Beletskaya ◽  
Tatiana L Karonova ◽  
Sergey Yu Astakhov
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Study Groups ◽  
Control Group ◽  
Open Angle ◽  
Hydroxyvitamin D ◽  
Study Results ◽  
Clinically Significant

Aim. To determine serum 25(OH)D and plasma MMP-2 and MMP-9 levels in patients with primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEG), and pseudoexfoliation syndrome (PES) - to assess potential associations between vitamin D status and these diseases. Methods. We included 238 patients (105 males and 133 females) aged from 55 to 75 years. One hundred twenty two patients had PEG, 46 patients had POAG, 32 had PES. 38 subjects were healthy, and were considered as the control group. Cases with clinically significant systemic diseases and concomiatant eye diseases were excluded, if there was a confirmed pathogenic impact of vitamin D and MMP. The serum 25(OH)D level was investigated by immunochemiluminescence method, plasma MMP-2 and MMP-9 levels - by ELISA. Results. Serum 25(OH)D level was between 4.6 and 82.25 nM/l (mean 41.7 nM/l), so most participants showed vitamin D deficiency. It was shown that mean serum 25(OH)D level in patients with PEG, POAG and PES was similar (39.3 ± 1.2, 38.8 ± 2.1 and 40.51 ± 2.4 nM/l, p > 0.05), but it was lower than that in the control group (52.7 ± 2.1 nM/l, p < 0.01). Plasma MMP-2 concentration was the same in all study groups. Plasma MMP-9 level was higher in POAG and PES patients (48.23 ± 3.26 and 54.01 ± 3.57 ng/ml) than in the control group (32.60 ± 2.34 ng/ml, p < 0.001) and PEG patients (40.86 ± 3.60 ng/ml, p < 0.05). We found positive correlations between MMP-2 and MMP-9 levels in patients with PEG (r = 0.48, p = 0.001) and patients with POAG (r = 0.43, p = 0.003). The correlation analysis showed also a negative relation between 25(OH)D and MMP-9 (r = -0.32, p = 0.02), MMP-2 (r = -0.33, p = 0.02) in patients with POAG. Summary. Study results confirmed a potential role of vitamin D in apoptosis regulation and tissue remodeling in patients with POAG and PES. Hence, vitamin D deficiency can be considered as a risk factor for glaucoma development.

Cytokine profile in tear and aqueous humor of primary open-angle patients as a prognostic factor for trabeculectomy outcome

2021 ◽  
pp. 112067212110559
Author(s):  
Barbara Burgos-Blasco ◽  
Beatriz Vidal-Villegas ◽  
Federico Saenz-Frances ◽  
Jose I Fernandez-Vigo ◽  
Vanessa Andres-Guerrero ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cytokine Profile ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Cytokine Levels ◽  
Surgical Failure ◽  
One Year

Objective To evaluate the cytokine profile in tear and aqueous humor in primary open-angle glaucoma before trabeculectomy and correlate preoperative cytokine levels with the surgical outcome. Methods Prospective study. Twenty-nine patients with primary open-angle glaucoma undergoing primary trabeculectomy were included. Levels of 27 cytokines were measured in tear an aqueous humor using the Bio-Plex Pro Human Cytokine 27-Plex Immunoassay kit (Bio-Rad Laboratories, Hercules, CA, USA). Results 29 patients who underwent trabeculectomy were included and their first-year follow-up visits were recorded. Mean age was 76.0 ± 7.0 years (range 56–84), mean intraocular pressure was 18.2 ± 3.6 mmHg and mean number of topical medications was 2.3 ± 0.9. At the one-year visit, 5 patients were classified as surgical failure. In aqueous humor, preoperative cytokine levels of regulated on activation normal T cell expressed and secreted (RANTES) were significantly higher in those patients with surgical failure at one year. IL-8 in tear and interferon gamma-induced protein (IP-10) in aqueous humor correlated positively with one-year IOP reduction. No statistically significant correlations were found with changes in visual field mean defect or global peripapillary retinal nerve fiber layer thickness (all, p >0.05). Conclusions Preoperative RANTES levels in aqueous humor as well as other cytokines could serve as useful biomarkers for trabeculectomy outcome.

scholarly journals Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts

2012 ◽  
Vol 108 (10) ◽  
pp. 1889-1896 ◽  
Author(s):  
Kimberly A. Bertrand ◽  
Edward Giovannucci ◽  
Yan Liu ◽  
Susan Malspeis ◽  
A. Heather Eliassen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Prediction Models ◽  
Epidemiological Studies ◽  
Health Study ◽  
Control Analysis ◽  
Vitamin D Status ◽  
Blood Draw ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Hormone Use

Epidemiological and other evidence suggests that vitamin D may be protective against several chronic diseases. Assessing vitamin D status in epidemiological studies, however, is challenging given finite resources and limitations of commonly used approaches. Using multivariable linear regression, we derived predicted 25-hydroxyvitamin D (25(OH)D) scores based on known determinants of circulating 25(OH)D, including age, race, UV-B radiation flux at residence, dietary and supplementary vitamin D intakes, BMI, physical activity, alcohol intake, post-menopausal hormone use (women only) and season of blood draw, in three nationwide cohorts: the Nurses' Health Study, Nurses' Health Study II and the Health Professionals Follow-up Study. The model r2 for each cohort ranged from 0·25 to 0·33. We validated the prediction models in independent samples of participants from these studies. Mean measured 25(OH)D levels rose with increasing decile of predicted 25(OH)D score, such that the differences in mean measured 25(OH)D between the extreme deciles of predicted 25(OH)D were in the range 8·7–12·3 ng/ml. Substituting predicted 25(OH)D scores for measured 25(OH)D in a previously published case–control analysis of colorectal cancer yielded similar effect estimates with OR of approximately 0·8 for a 10 ng/ml difference in either plasma or predicted 25(OH)D. We conclude that these data provide reasonable evidence that a predicted 25(OH)D score is an acceptable marker for ranking individuals by long-term vitamin D status and may be particularly useful in research settings where biomarkers are not available for the majority of a study population.

Proposal and Validation of a Quick Question to Rate the Influence of Diet in Geriatric Epidemiological Studies on Vitamin D

2013 ◽  
Vol 83 (4) ◽  
pp. 254-258 ◽  
Author(s):  
Gaëlle Chevallereau ◽  
Xavier Gleyses ◽  
Laurène Roussel ◽  
Sarah Hamdan ◽  
Olivier Beauchet ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hypovitaminosis D ◽  
Epidemiological Studies ◽  
Hydroxyvitamin D ◽  
Background Diet ◽  
Simple Question ◽  
25 Hydroxy Vitamin D ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements ◽  
Exogenous Source

Background: Diet is a major exogenous source of vitamin D. The objective of this analysis was to determine whether the yes/no answer to a simple question exploring diet (“Do you eat fatty fish at least once a week and/or eggs several times per week?”) could be associated with serum 25-hydroxy-vitamin D status among 261 older in- and outpatients (mean ± standard deviation, 83.5 ± 8.1 years). Methods: Two groups were distinguished based on the binary yes/no answer. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D ≤ 75 nmol/L. Results: More participants with hypovitaminosis D answered “No” to the question on diet compared to their counterparts (p = 0.002). Answering “No” was associated with hypovitaminosis D (OR = 3.22, p = 0.001) after adjustment for potential confounders, with a positive predictive value = 79 %. Conclusion: A simple dietary question may identify older patients with hypovitaminosis D who should receive vitamin D supplements.

scholarly journals Is 25-Hydroxyvitamin D Associated with Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus in Saudi Arabia? A Population Based Study

2021 ◽  
Vol 18 (6) ◽  
pp. 2805
Author(s):  
AlJohara M AlQuaiz ◽  
Abdullah A Alrasheed ◽  
Ambreen Kazi ◽  
Mohammad Ali Batais ◽  
Khaled M Alhabeeb ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Saudi Arabia ◽  
Glycosylated Hemoglobin ◽  
Linear Regression Analysis ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Hba1c Levels

Background: Saudi Arabia has a high burden of diabetes mellitus and vitamin D deficiency. The objective of this study was to explore the association between glycosylated hemoglobin and 25-hydroxyvitamin D in patients with type 2 diabetes mellitus (T2DM) in Riyadh, Saudi Arabia. Methods: An interview based cross-sectional study was conducted on 606 patients with type 2 diabetes, aged 30–75 years, visiting primary health care centers. Blood samples were collected for measuring HbA1c, 25(OH)D and bone and lipid markers. Multivariable linear regression analysis was conducted to explore the association between HbA1c and 25(OH)D. Results: The mean (±SD) levels for HbA1c and 25(OH) D were 7.69 (±1.77) and 44.28 (±23.06), respectively. Around 55% of patients had uncontrolled HbA1c (>7.0), whereas vitamin D deficiency (<50 nmol/L) was found in 52.3% (=317). Multiple linear regression analysis found that a unit increase in vitamin D levels and parathyroid hormone levels was associated with −0.17 (−0.02, −0.01, p < 0.001) and −0.20 (−2.66, −1.18, p < 0.001) unit decrease in levels of HbA1c, respectively. Similarly, increasing age was associated with −0.15 (−0.01, −0.04, p = 0.002) unit decrease in HbA1c levels, whereas unit increases in serum alkaline phosphatase, calcium and diabetes duration were associated with 0.22 (0.01, 0.02, p < 0.001), 0.14 (1.03, 3.88, p = 0.001) and 0.26 (0.42, 0.78, p < 0.001) unit increase in HbA1c levels, respectively. Conclusion: HbA1c levels are associated with 25-hydroxyvitamin D levels. For better control of HbA1c levels, it is important to maintain 25-hydroxyvitamin D level and bone markers within normal range.

scholarly journals Vitamin D and Incidence of Prediabetes or Type 2 Diabetes: A Four-Year Follow-Up Community-Based Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yun Gao ◽  
Tianpeng Zheng ◽  
Xingwu Ran ◽  
Yan Ren ◽  
Tao Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Community Based ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Aim. To examine whether the baseline 25-hydroxyvitamin D [25(OH)D] level was predictive of the onset of prediabetes or type 2 diabetes (T2DM) in the Chinese population. Methods. This was a 4-year follow-up study that was conducted in the Chengdu region of China as part of the China National Diabetes and Metabolic Disorders Study. The study included 490 participants that were free of prediabetes and type 2 diabetes mellitus (T2DM) at baseline and had complete data by follow-up examinations. Glucose, insulin, and 25(OH)D levels were measured at baseline and at 4 years later. Prediabetes and T2DM were defined by results obtained from an oral glucose tolerance test. Results. Over a 4-year follow-up, 95 (48.5‰) developed prediabetes and 31 (15.8‰) individuals developed diabetes. Low 25(OH)D status was significantly associated with the risk of developing prediabetes [OR 3.01 (95% CI: 1.50–6.06), P=0.002] and T2DM [OR 5.61 (95% CI: 1.73–18.27), P=0.004] after adjustment for multiple potential confounders. In a multiple linear regression analysis, low baseline levels of 25(OH)D were an independent predictor of increased insulin resistance over a 4-year period (P<0.05). Conclusions. The current prospective study suggests that low 25(OH)D levels might have contributed to the incidence of prediabetes or T2DM in Chinese individuals. This trial is registered with TR-CCH-ChiCTR-OCS-09000361.

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