scholarly journals Space Time Trends of Community Onset Staphylococcus Aureus Infections in Children Living in Southeastern United States: 2002-2010

2020 ◽  
Author(s):  
Lilly Immergluck ◽  
Ruijin Geng ◽  
Chaohua Li ◽  
Mike Edelson ◽  
Lance Waller ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Census Tract ◽  
Metropolitan Statistical Area ◽  
Infection Group ◽  
Census Tracts ◽  
Mrsa Infection ◽  
Very High ◽  
Community Onset ◽  
The U.S ◽  
Mssa Infection

Abstract Background Staphylococcus aureus (S. aureus) remains a serious cause of infections in the U.S. and worldwide. Non antibiotic resistant Staphylococcus aureus (methicillin susceptible or MSSA) is the cause of half of all health care–associated staphylococcal infections, and methicillin resistant Staphylococcus aureus (MRSA) still is the leading cause of community onset skin and soft tissue infections in the U.S. This is the first study to spatially look at trends of both community onset MRSA and MSSA infections over nine years and determine ‘best’ to ‘worst’ infection trends over a nine year period (2002-2010),which spanned when community onset MRSA infections were occurring in epidemic proportions across the U.S. MethodsRetrospective study from 2002-2010, using electronic health records of children living in the southeastern U.S. (Atlanta, Georgia) with S. aureus infections and relevant U.S. census data (at the census tract level). The Proc Traj for SAS was applied to generate community onset MRSA and MSSA trajectory infection groups (low, high, very high, or deviant trends), and then, mapping of these trajectory groups using census tract boundaries.ResultsFrom community onset MRSA infection trend patterns (low, high, very high), only 0.8% of the census tracts showed a dramatic increase from 2002-2007 and then a gradual decline from 2008 to 2010. From community onset MSSA infection trend patterns (low and high), 85.7% of ‘high infection’ group persisted throughout the nine year period, compared to 14.3% of ‘low infection’ group over this same period. Low community onset MRSA and MSSA trend patterns were seen throughout the 20 counties of Atlanta, Georgia’s metropolitan statistical area, but more often seen in those counties less densley populated. Census tracts reflecting Atlanta’s ‘innercity’ had the highest proportion of the worst infection trend pattern (community onset MRSA-Very High-CO-MSSA-High or community onset MRSA-High-CO-MSSA-High). The deviant trend of community onset MRSA Very High- CO-MSSA Low infection were in census tracts east of downtown Atlanta. Conclusions ‘Trends’ of S. aureus infection patterns, stratified by antibiotic resistance, over geographic areas and time identify communities with higher risks for community onset MRSA infection compared to community onset MSSA infection.

scholarly journals 2. Space Time Trends of Community Onset Staphylococcus aureus Infections in Children Living in Southeastern United States: 2002-2016

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S1-S2
Author(s):  
Lilly Immergluck ◽  
Ruijin geng ◽  
Chaohua Li ◽  
Mike Edelson ◽  
Lance Waller ◽  
...  
Keyword(s):  
United States ◽  
Staphylococcus Aureus ◽  
Infection Rate ◽  
Census Tract ◽  
Metropolitan Statistical Area ◽  
Census Tracts ◽  
Mrsa Infection ◽  
Very High ◽  
Community Onset ◽  
Mssa Infection

Abstract Background Staphylococcus aureus (S. aureus) remains a serious cause of infections in the United States and worldwide. Methicillin susceptible S. aureus (MSSA) is the cause of half of all health care–associated staphylococcal infections, and Methicillin Resistant S. aureus (MRSA) is the leading cause of community onset skin and soft tissue infections in the US. This study looks at a 15-year trend of community onset (CO)-MRSA and MSSA infections and determines ‘best’ to ‘worst’ infection trends. We identified distinct groups of CO-MRSA and MSSA infection rate trajectories by grouping census tracts of the 20 county Atlanta Metropolitan Statistical Area (MSA) between 2002 to 2016 with similar temporal trajectories. Methods This is a retrospective study from 2002-2016, using electronic health records of children living in Atlanta, Georgia with S. aureus infections and relevant US census data (at the census tract level). A group based trajectory model was applied to generate community onset S. aureus trajectory infection groups (low, high, very high) by census tract and were mapped using ArcGIS. Results Three CO-MSSA infection groups (low, high, very high) and two CO-MRSA infection groups (low, high) were detected among 909 census tracts in the 20 counties. We found ~74% of all the census tracts with S.aureus occurrence during this time period belonged to low infection rate groups for both MRSA and MSSA, with a higher proportion occurring in the less densely populated counties. Census tracts in DeKalb County, one of Atlanta’s most densely populated areas, had the highest proportion of the worst infection trend patterns (CO-MRSA high or very high, CO-MSSA high or very high). Trends of Community-Onset MRSA and MSSA Infection Rates Based on Group-based Trajectory Models Spatial patterns for CO-MRSA and CO-MSSA Trajectory Trends in the Atlanta Metropolitan Area Between 2002 to 2016 Conclusion Trends of S. aureus infection patterns, stratified by antibiotic resistance over geographic areas and time, identify communities with higher risks for MRSA infection compared to MSSA infection. Further investigation of the determinants of the trajectory groupings and the geographic outliers identified by this study may be a way to target prevention strategies aimed to prevent S. aureus infections. Disclosures All Authors: No reported disclosures

scholarly journals The rise of methicillin resistant Staphylococcus aureus: now the dominant cause of skin and soft tissue infection in Central Australia

2017 ◽  
Vol 145 (13) ◽  
pp. 2817-2826 ◽  
Author(s):  
E. MACMORRAN ◽  
S. HARCH ◽  
E ATHAN ◽  
S LANE ◽  
S TONG ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Treatment Outcomes ◽  
Univariate Analysis ◽  
Methicillin Resistant ◽  
Dominant Phenotype ◽  
Mrsa Infection ◽  
Central Australia ◽  
Healthcare Associated ◽  
Community Onset

SUMMARYThis study aimed to examine the epidemiology and treatment outcomes of community-onset purulent staphylococcal skin and soft tissue infections (SSTI) in Central Australia. We performed a prospective observational study of patients hospitalised with community-onset purulent staphylococcal SSTI (n = 160). Indigenous patients accounted for 78% of cases. Patients were predominantly young adults; however, there were high rates of co-morbid disease. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was the dominant phenotype, accounting for 60% of cases. Hospitalisation during the preceding 6 months, and haemodialysis dependence were significant predictors of CA-MRSA infection on univariate analysis. Clinical presentation and treatment outcomes were found to be comparable for methicillin-susceptible S. aureus (MSSA) and methicillin-resistant cases. All MRSA isolates were characterised as non-multi-resistant, with this term used interchangeably with CA-MRSA in this analysis. We did not find an association between receipt of an active antimicrobial agent within the first 48 h, and progression of infection; need for further surgical debridement; unplanned General Practitioner or hospital re-presentation; or need for further antibiotics. At least one adverse outcome was experienced by 39% of patients. Clindamycin resistance was common, while rates of trimethoprim–sulfamethoxazole resistance were low. This study suggested the possibility of healthcare-associated transmission of CA-MRSA. This is the first Australian report of CA-MRSA superseding MSSA as the cause of community onset staphylococcal SSTI.

Excess Costs and Utilization Associated with Methicillin Resistance for Patients with Staphylococcus aureus Infection

2010 ◽  
Vol 31 (4) ◽  
pp. 365-373 ◽  
Author(s):  
Gregory A. Filice ◽  
John A. Nyman ◽  
Catherine Lexau ◽  
Christine H. Lees ◽  
Lindsay A. Bockstedt ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Medical Center ◽  
Patient Characteristics ◽  
Veterans Affairs ◽  
Department Of Veterans Affairs ◽  
Accounting Systems ◽  
Excess Costs ◽  
Mrsa Infection ◽  
Mssa Infection

Objective.To determine differences in healthcare costs between cases of methicillin-susceptible Staphylococcus aureus (MSSA) infection and methicillin-resistant S. aureus (MRSA) infection in adults.Design.Retrospective study of all cases of S. aureus infection.Setting.Department of Veterans Affairs hospital and associated clinics.Patients.There were 390 patients with MSSA infections and 335 patients with MRSA infections.Methods.We used medical records, accounting systems, and interviews to identify services rendered and costs for Minneapolis Veterans Affairs Medical Center patients with S. aureus infection with onset during the period from January 1, 2004, through June 30, 2006. We used regression analysis to adjust for patient characteristics.Results.Median 6-month unadjusted costs for patients infected with MRSA were $34,657, compared with $15,923 for patients infected with MSSA. Patients with MRSA infection had more comorbidities than patients with MSSA infection (mean Charlson index 4.3 vs 3.2; P < .001). For patients with Charlson indices of 3 or less, mean adjusted 6-month costs derived from multivariate analysis were $51,252 (95% CI, $46,041–$56,464) for MRSA infection and $30,158 (95% CI, $27,092–$33,225) for MSSA infection. For patients with Charlson indices of 4 or more, mean adjusted costs were $84,436 (95% CI, $79,843–$89,029) for MRSA infection and $59,245 (95% CI, $56,016–$62,473) for MSSA infection. Patients with MRSA infection were also more likely to die than were patients with MSSA infection (23.6% vs 11.5%; P < .001). MRSA infection was more likely to involve the lungs, bloodstream, and urinary tract, while MSSA infection was more likely to involve bones or joints; eyes, ears, nose, or throat; surgical sites; and skin or soft tissue (P < .001).Conclusions.Resistance to methicillin in S. aureus was independently associated with increased costs. Effective antimicrobial stewardship and infection prevention programs are needed to prevent these costly infections.

scholarly journals MRSA Infection and Mortality Rate in California

2018 ◽  
Author(s):  
Haydar Witwit
Keyword(s):  
Staphylococcus Aureus ◽  
Mortality Rate ◽  
Bacterial Infection ◽  
Female Patient ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
P Value ◽  
Mortality Incidence ◽  
Mrsa Infection ◽  
Males And Females ◽  
Mssa Infection

Average of 41,900 patients are diagnosed annually with staphylococcus bacterial infection in California, 24,089 patients have Methicillin-resistant Staphylococcus Aureus (MRSA) and 17,810 patients have Methicillin-Sensitive Staphylococcus (MSSA). This paper demonstrates that there is a difference in mortality rate due to staphylococcus infection between males and females (P-value&lt;0.05, CI 95%). Male patient diagnosed with S. aureus has 1.3 chance of mortality incidence than female patient. In addition, MRSA infection rate is 1.4 times MSSA infection (P-value&lt;0.05, CI 95%), but the gap of infection is decreasing; however, mortality of both infections combined are more than threefold greater compared to three decades ago.

scholarly journals Multidrug and Mupirocin Resistance in Environmental Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates from Homes of People Diagnosed with Community-Onset MRSA Infection

2017 ◽  
Vol 83 (22) ◽  
Author(s):  
J. H. Shahbazian ◽  
P. D. Hahn ◽  
S. Ludwig ◽  
J. Ferguson ◽  
P. Baron ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Health Risk ◽  
Home Environment ◽  
One Health ◽  
Increased Risk ◽  
Mrsa Infection ◽  
Mupirocin Resistance ◽  
Mrsa Strains ◽  
Community Onset

ABSTRACT Patients with community-onset (CO) methicillin-resistant Staphylococcus aureus (MRSA) infections contribute to MRSA contamination of the home environment and may be reexposed to MRSA strains from this reservoir. This study evaluates One Health risk factors, which focus on the relationship between humans, animals, and the environment, for the increased prevalence of multiple antimicrobial-resistant MRSA isolates in the home environment. During a trial of patients with CO-MRSA infection, MRSA was isolated from the household environment at the baseline and 3 months later, following randomization of patients and household members to mupirocin-based decolonization therapy or an education control group. Up to two environmental MRSA isolates collected at each visit were tested. MRSA isolates were identified in 68% (65/95) of homes at the baseline (n = 104 isolates) and 51% (33/65) of homes 3 months later (n = 56 isolates). The rates of multidrug resistance (MDR) were 61% among isolates collected at the baseline and 55% among isolates collected at the visit 3 months later. At the baseline, 100% (14/14) of MRSA isolates from rural homes were MDR. While antimicrobial use by humans or pets was associated with an increased risk for the isolation of MDR MRSA from the environment, clindamycin use was not associated with an increased risk for the isolation of MDR MRSA. Incident low-level mupirocin-resistant MRSA strains were isolated at 3 months from 2 (5%) of 39 homes that were randomized to mupirocin treatment but none of the control homes. Among patients recently treated for a CO-MRSA infection, MRSA and MDR MRSA were common contaminants in the home environment. This study contributes to evidence that occupant use of antimicrobial drugs, except for clindamycin, is associated with MDR MRSA in the home environmental reservoir. (This study has been registered at ClinicalTrials.gov under registration no. NCT00966446.) IMPORTANCE MRSA is a common bacterial agent implicated in skin and soft tissue infections (SSTIs) in both community and health care settings. Patients with CO-MRSA infections contribute to environmental MRSA contamination in these settings and may be reexposed to MRSA strains from these reservoirs. People interact with natural and built environments; therefore, understanding the relationships between humans and animals as well as the characteristics of environmental reservoirs is important to advance strategies to combat antimicrobial resistance. Household interactions may influence the frequency and duration of exposure, which in turn may impact the duration of MRSA colonization or the probability for recurrent colonization and infection. Therefore, MRSA contamination of the home environment may contribute to human and animal recolonization and decolonization treatment failure. The aim of this study was to evaluate One Health risk factors that may be amenable to intervention and may influence the recovery of MDR and mupirocin resistance in CO-MRSA isolates.

scholarly journals Meticillin-resistant Staphylococcus aureus infection in diabetic mice enhanced inflammation and coagulation

2006 ◽  
Vol 55 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Shyh-Ming Tsao ◽  
Cheng-Chin Hsu ◽  
Mei-Chin Yin
Keyword(s):  
Staphylococcus Aureus ◽  
Protein C ◽  
Interleukin 2 ◽  
Endothelial Injury ◽  
Diabetic Mice ◽  
Plasminogen Activator Inhibitor 1 ◽  
At Iii ◽  
Mrsa Infection ◽  
Pai 1 ◽  
Mssa Infection

BALB/cA mice were used to study the interaction of diabetes and meticillin-resistant Staphylococcus aureus (MRSA) infection on pathogen distribution, cytokine profile and inflammatory and endothelial-injury markers, as well as coagulation and anticoagulation factors. Meticillin-susceptible S. aureus (MSSA) infection did not cause death within the experimental period. MRSA-infected nondiabetic and diabetic mice died on 19·1±1·4 and 10·6±0·7 days post-infection (p.i.), respectively. MRSA and MSSA infection in diabetic mice did not result in symptomatic bacteraemia; however, MRSA infection in diabetic mice significantly reduced glucose levels (P<0·05). Diabetic mice showed significantly higher levels of C-reactive protein, fibrinogen, fibronectin and von Willebrand factor than nondiabetic mice (P<0·05), and MRSA infection further elevated the plasma levels of these inflammatory and endothelial markers (P<0·05). Before infection, diabetic mice had significantly higher plasminogen activator inhibitor-1 (PAI-1) activity, lower antithrombin III (AT-III) and protein C activities (P<0·05), and MRSA infection significantly increased PAI-1 activity further and reduced the activity of AT-III and protein C (P<0·05). MRSA infection increased the production of three Th1 cytokines, interleukin 2 (IL-2), tumour necrosis factor alpha and gamma interferon, in diabetic mice (P<0·05); however, three Th2 cytokines, IL-4, IL-6, IL-10, were elevated at 2 and 4 days p.i., and then dropped gradually. MRSA infection in diabetic mice accelerated the inflammation process, endothelial injury and blood coagulation in diabetic mice. Therefore, the development of proper infection diagnosis and timely use of effective treatments for MRSA-infected diabetic individuals is important and necessary.

scholarly journals Staphylococcal Infection in California: Strain Dominancy and Trends, a Good Day Against Superbug

2019 ◽  
Author(s):  
Haydar Witwit
Keyword(s):  
Staphylococcus Aureus ◽  
Bacterial Infection ◽  
Infection Rate ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Staphylococcal Infection ◽  
P Value ◽  
Infection Rates ◽  
Significant Difference ◽  
Mrsa Infection ◽  
Mssa Infection

In California, an average of 41,900 patients are diagnosed annually with Staphylococcus bacterial infection; out of these, 24,090 patients have methicillin-resistant Staphylococcus aureus (MRSA) infection and 17,810 patients have methicillin-sensitive Staphylococcus aureus (MSSA) infection. The aim of this paper is to find out whether there is a significant difference in strain dominancy and in what direction. The paper gathered and analyzed data for period of five years of infection rate due to Staphylococcus aureus. This study indicates that a significant difference in dominancy exists, the MRSA infection rate (an average of five years period) is 1.35 times higher than the MSSA infection rate (P-value &lt; 0.05, CI: 95%), but the gap between the two infection rates is decreasing. The infection rate of both MRSA and MSSA is in a path of decline.

scholarly journals Are Lactational Breast Abscesses caused by Methicillin-resistant Staphylococcus aureus Special?

2020 ◽  
Author(s):  
Yan Li ◽  
Xiangjun Ma ◽  
Xiangping He
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Duration ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Manifestations ◽  
Antibiotic Use ◽  
Needle Aspiration ◽  
Methicillin Resistant ◽  
Chi Squared ◽  
Mrsa Infection ◽  
Mssa Infection

Abstract Background: This study aimed to identify the differences in clinical characteristics, puncture efficacy, antibiotic use, treatment duration, breastfeeding postillness, and recurrence of patients with breast abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA) infection during lactation.Methods: The clinical data of patients with breast abscesses during lactation who were treated in our hospital from January 2014 to February 2017 were reviewed. According to bacterial culture results, they were divided into MRSA (n = 260) and MSSA (n = 962) groups. Hospitalization (whether or not the patients were hospitalized), postpartum time, age, location of abscess cavities, number of abscess cavities, amount of pus, frequency of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration, delactation and recurrence were compared between the two groups using a t-test and a chi-squared test.Results: We noted that only delactation was statistically significantly different between the two groups (P = 0.018). Hospitalization, postpartum time, age, location of abscess cavities, number of abscess cavities, amount of pus, frequency of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration and recurrence showed no statistically significant differences (P = 0.488, P = 0.328, P = 0.494, P = 0.218, P = 0.088, P = 0.102, P = 0.712, P = 0.336, P = 0.512, P = 0.386 and P = 0.359, respectively). Conclusion: Patients with breast abscesses caused by MRSA infection during lactation presented no significant differences in the clinical manifestations, needle aspiration efficacy, antibiotic use or treatment duration compare with those caused by MSSA infection. However, patients with MRSA infected were more susceptible to delectation.

scholarly journals Prior Vancomycin Use Is a Risk Factor for Reduced Vancomycin Susceptibility in Methicillin-Susceptible but Not Methicillin-Resistant Staphylococcus aureus Bacteremia

2012 ◽  
Vol 33 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Kara B. Mascitti ◽  
Paul H. Edelstein ◽  
Neil O. Fishman ◽  
Knashawn H. Morales ◽  
Andrew J. Baltus ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Medical Center ◽  
Tertiary Care ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia ◽  
Tertiary Care Medical Center ◽  
Healthcare Acquired Infections ◽  
Mrsa Infection ◽  
Substantial Morbidity ◽  
Mssa Infection

Objective.Staphylococcus aureus is a cause of community- and healthcare-acquired infections and is associated with substantial morbidity, mortality, and costs. Vancomycin minimum inhibitory concentrations (MICs) among S. aureus have increased, and reduced vancomycin susceptibility (RVS) may be associated with treatment failure. We aimed to identify clinical risk factors for RVS in S. aureus bacteremia.Design.Case-control.Setting.Academic tertiary care medical center and affiliated urban community hospital.Patients.Cases were patients with RVS S. aureus isolates (defined as vancomycin E-test MIC >1.0 μg/mL). Controls were patients with non-RVS S. aureus isolates.Results.Of 392 subjects, 134 (34.2%) had RVS. Fifty-eight of 202 patients (28.7%) with methicillin-susceptible S. aureus (MSSA) isolates had RVS, and 76 of 190 patients (40.0%) with methicillin-resistant S. aureus (MRSA) isolates had RVS (P = .02). In unadjusted analyses, prior vancomycin use was associated with RVS (odds ratio [OR], 2.08; 95% confidence interval [CI], 1.00–4.32; P = .046). In stratified analyses, there was significant effect modification by methicillin susceptibility on the association between vancomycin use and RVS (P = .04). In multivariate analyses, after hospital of admission and prior levofloxacin use were controlled for, the association between vancomycin use and RVS was significant for patients with MSSA infection (adjusted OR, 4.02; 95% CI, 1.11–14.50) but not MRSA infection (adjusted OR, 0.87; 95% CI, 0.36–2.13).Conclusions.A substantial proportion of patients with S. aureus bacteremia had RVS. The association between prior vancomycin use and RVS was significant for patients with MSSA infection but not MRSA infection, suggesting a complex relationship between the clinical and molecular epidemiology of RVS in S. aureus.Infect Control Hosp Epidemiol 2012;33(2):160-166

scholarly journals 1717. Relationship between Neighborhood Census-tract Level Poverty and Respiratory Syncytial Virus (RSV)-associated Hospitalizations in U.S. adults, 2015-2017

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S842-S843
Author(s):  
Jenna Holmen ◽  
Art Reingold ◽  
Erica Bye ◽  
Lindsey Kim ◽  
Evan J Anderson ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Census Tract ◽  
Case Fatality ◽  
Demographic Characteristics ◽  
Emerging Infections ◽  
Poverty Level ◽  
Catchment Areas ◽  
Syncytial Virus ◽  
Four Levels ◽  
The U.S

Abstract Background In the U.S., RSV is increasingly recognized as a cause of hospitalization for adults with respiratory illness. In adults &gt; 50 years of age, it accounts for up to 12% of medically-attended acute respiratory illnesses and has a case fatality proportion of ~ 6–8%. Poverty can have important influences on health on both the individual level as well as the community level. Few studies have evaluated the relationship of RSV and poverty level, and no identified studies have evaluated this relationship among adults. We evaluated the incidence of RSV-associated hospitalizations in adults across multiple sites in the U.S. by census-tract (CT) level poverty. Methods Medical record data abstraction was conducted for all adults with a laboratory-confirmed RSV infection admitted to a hospital within the Centers for Disease Control and Prevention’s Emerging Infections Program catchment areas within California, Georgia, Maryland, Minnesota, New York, and Tennessee during the 2015–2017 RSV seasons (October-April). Patient addresses were geocoded to their corresponding CT. CTs were divided into four levels of poverty, as selected in prior publications, based on American Community Survey data of percentage of people living below the poverty level: 0–4.9%, 5–9.9%, 10-19.9%, and ³20%. Incidence rates were calculated by dividing the number of RSV cases in each CT poverty-level (numerator) by the number of adults living in each CT poverty level (denominator), as determined from the 2010 US census, and standardized for age. Results There were 1713 RSV case-patients with demographic characteristics (Table 1). The incidence of RSV-associated hospitalizations of adults increased with increasing CT level poverty (Figure 1 and Table 2). The risk of RSV-associated hospitalization was 2.58 times higher in census tracts with the highest (20%) versus the lowest (&lt; 5%) percentages of individuals living below the poverty level. Table 1: Demographic characteristics of adults with an RSV-associated hospitalization, 2015-2017. Figure 1. Age-adjusted incidence rate of RSV-associated hospitalizations of adults by census-tract poverty level, 2015-2017 Table 2. Incidence rate ratios for RSV-associated hospitalizations of adults by census-tract poverty level, 2015-2017. Conclusion The incidence rate of RSV-associated hospitalization in adults appears to have a positive association with increasing CT level of poverty; however, this trend reached significance only among cases living in CTs with higher percentages of poverty (≥ 10%). Disclosures Evan J. Anderson, MD, Sanofi Pasteur (Scientific Research Study Investigator)

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