scholarly journals Synthesis And Characterization of Vancomycin-Loaded Chitosan Nanoparticles For Drug Delivery

2021 ◽  
Author(s):  
Tajuddin Hafizi ◽  
Mehrnoosh Hasan Shahriari ◽  
Majid Abdouss ◽  
Shafiq Ahmad Kahdestani
Keyword(s):  
Biomedical Applications ◽  
Bacterial Infections ◽  
Chitosan Nanoparticles ◽  
Biological Properties ◽  
Food Industries ◽  
Hemostatic Activity ◽  
Average Size ◽  
To Receive ◽  
Nano Size

Abstract Chitosan is a linear polysaccharide with and prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, non-immunogenicity, bioadhesion, antibacterial, antifungal and hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, and food industries; agriculture; biotechnology; pharmaceutical industry and medicine; specially in biomedical applications. The special chemical structure of chitosan allows some specific modifications and by reducing the size of chitosan particles to Nano size, it becomes an excellent drug nanocarrier. Vancomycin is a typical antibiotic used for bacterial infections caused by geram positive bacteria. In this work, chitosan nanoparticles (CSNPs) were prepared via ionotropic gelation using tripolyphosphate (TPP) as crosslinker. The effect of chitosan and TPP concentration on the size of chitosan nanoparticles was studied and CS:TPP ratio of 1:1 with average size of nanoparticle about 100 nm were selected. The prepared samples were characterized using DLS, FTIR, TGA, DSC, and SEM techniques. The results confirmed that vancomycin has been loaded successfully on chitosan nanoparticles and there was not any interaction between vancomycin and chitosan. Also, it is observed that 40% of vancomycin is released burstly in the first 9 h and after that the drug release is continued gradually to receive 90% at 100 h.

scholarly journals Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1375
Author(s):  
María J. Moreno-Vásquez ◽  
Maribel Plascencia-Jatomea ◽  
Saúl Sánchez-Valdes ◽  
Judith C. Tanori-Córdova ◽  
Francisco J. Castillo-Yañez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Food Packaging ◽  
Inhibitory Concentration ◽  
Antioxidant Activities ◽  
Bacterial Species ◽  
Chitosan Nanoparticles ◽  
Epigallocatechin Gallate ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power

Nanoparticles based on chitosan modified with epigallocatechin gallate (EGCG) were synthetized by nanoprecipitation (EGCG-g-chitosan-P). Chitosan was modified by free-radical-induced grafting, which was verified by Fourier transform infrared (FTIR). Furthermore, the morphology, particle size, polydispersity index, and zeta potential of the nanoparticles were investigated. The grafting degree of EGCG, reactive oxygen species (ROS) production, antibacterial and antioxidant activities of EGCG-g-chitosan-P were evaluated and compared with those of pure EGCG and chitosan nanoparticles (Chitosan-P). FTIR results confirmed the modification of the chitosan with EGCG. The EGCG-g-chitosan-P showed spherical shapes and smoother surfaces than those of Chitosan-P. EGCG content of the grafted chitosan nanoparticles was 330 μg/g. Minimal inhibitory concentration (MIC) of EGCG-g-chitosan-P (15.6 μg/mL) was lower than Chitosan-P (31.2 μg/mL) and EGCG (500 μg/mL) against Pseudomonas fluorescens (p < 0.05). Additionally, EGCG-g-chitosan-P and Chitosan-P presented higher Staphylococcus aureus growth inhibition (100%) than EGCG at the lowest concentration tested. The nanoparticles produced an increase of ROS (p < 0.05) in both bacterial species assayed. Furthermore, EGCG-g-chitosan-P exhibited higher antioxidant activity than that of Chitosan-P (p < 0.05) in 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric-reducing antioxidant power assays. Based on the above results, EGCG-g-chitosan-P shows the potential for food packaging and biomedical applications.

Preparation and Characterization of Gelatin/Oligomeric Proanthocyanidins Composite Microspheres

2011 ◽  
Vol 287-290 ◽  
pp. 132-135
Author(s):  
Ching Wen Lou ◽  
Jin Jia Hu ◽  
Chao Chiung Huang ◽  
Shih Yu Huang ◽  
Hsiu Hui Yeh ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Air Permeability ◽  
Wound Dressings ◽  
Water Contact ◽  
Composite Microsphere ◽  
Oligomeric Proanthocyanidins ◽  
Composite Microspheres ◽  
Hemostatic Activity ◽  
Potential Use

Gelatin is a heterogeneous mixture of single or multi-stranded polymers made of amino acids. Its film formability, air permeability, biocompatibility, and hemostatic activity render it appropriate for wound dressing. In this study, we used a syringe to drop gelatin solution into oligomeric proanthocyanidins solution to prepare the composite microspheres. Physical properties of the composite microsphere, such as swelling, stability in water, contact angle, and Fourier transform infrared spectroscopy were examined. We aimed at investigating its potential use in promoting wound healing along with wound dressings. The greatest swelling (1480 %) of the gelatin/OPC composite microsphere was achieved in 10 min. The composite microspheres dissolved 90% in the first 60 min during water stability test. Therefore, the developed composite microsphere has great hydrophilic and can be used in biomedical applications.

scholarly journals Synthesis and Characterization of an Amphiphilic Linoleic Acid-g-Quaternary Chitosan with Low Toxicity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaobin Fang ◽  
Yingqi Xu ◽  
Jinming Zhang ◽  
Xianghong Lu ◽  
Yitao Wang ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
H Nmr ◽  
Low Toxicity ◽  
Low Cytotoxicity ◽  
Average Size ◽  
Novel Drug

A novel amphiphilic derivative of chitosan, namely, a linoleic acid-g-quaternary chitosan (LA-g-QC), was designed and synthesized as low toxic material for biomedical applications in this study. The chemical structure of LA-g-QC was characterized by Fourier transform infrared spectroscopy (FTIR),1H nuclear magnetic resonance (1H-NMR), and elemental analysis. LA-g-QC could form nanosized micelles with self-assembly, which was confirmed by the results of critical micelle concentration (CMC) via fluorescence spectroscopy. The average size of LA-g-QC was 140 nm and its zeta potential was approximately +35.50 mV. CMC value was 31.00 mg/mL. Furthermore, LA-g-QC micelles, at final concentrations between 0.94 μg/mL and 30 μg/mL, did not inhibit the proliferation of HepG2 or SMMC 7721 cell lines. Taken together, LA-g-QC has low cytotoxicity and high potential for the preparation of novel drug-delivery micelles.

scholarly journals Preparation and Characterization of Silica-Coated Iron Oxide Nanoparticles (Fe3O4@SiO2 NPs)

2021 ◽  
Vol 18 (1) ◽  
pp. 161
Author(s):  
Nurul Izza Taib ◽  
Famiza Abdul Latif ◽  
Nur Diyana Syazwani Zambri
Keyword(s):  
Iron Oxide ◽  
Alkaline Medium ◽  
Biomedical Applications ◽  
Tetraethyl Orthosilicate ◽  
Oxide Nanoparticles ◽  
Hydrolysis And Condensation ◽  
Average Size ◽  
Superparamagnetic Properties ◽  
Fe3o4 Core

In this study, this SiO2 has been coated on the surface of Fe3O4 (Fe3O4@SiO2) by hydrolysis and condensation of tetraethyl orthosilicate (TEOS) under alkaline medium at 80oC. It was found that only 500  mL TEOS is required to obtain the best coated Fe3O4 core structures which has been confirmed from its TEM micrograph. FTIR analyses revealed the formation of Si-O-Si bonds at 1084.2–1101.4 cm-1 hence confirmed that SiO2 has been successfully coated the Fe3O4 core. From the FESEM analyses, the average size of silica was ~ 50 -70 nm.  EDX of the Fe3O4@SiO2 showed that silica had been effectively bonded onto the surface of Fe3O4. The VSM measurements confirmed the superparamagnetic properties of Fe3O4@SiO2 that is desirable for biomedical applications.

Characterization of Portuguese Propolis: Unraveling Biological Properties

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
CA Aguiar ◽  
AM Ferreira ◽  
R Oliveira ◽  
F Baltazar ◽  
A Cunha
Keyword(s):  
Biological Properties

Optimization and Physicochemical Characterization of Chitosan and Chitosan Nanoparticles Extracted from the Crayfish Procambarus clarkii Wastes

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  
Keyword(s):  
Procambarus Clarkii ◽  
Chitosan Nanoparticles ◽  
Physicochemical Characterization

Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

2019 ◽  
Vol 56 (2) ◽  
pp. 396-398
Author(s):  
Georgeta Zegan ◽  
Daniela Anistoroaei ◽  
Elena Mihaela Carausu ◽  
Eduard Radu Cernei ◽  
loredana Golovcencu
Keyword(s):  
Drug Delivery ◽  
Clavulanic Acid ◽  
Bacterial Infections ◽  
Drug Delivery Systems ◽  
Intracellular Transport ◽  
Oral Treatment ◽  
Chitosan Nanoparticles ◽  
Well Being ◽  
Cell Penetrating ◽  
Novel Drug

Amoxicillin and clavulanic acid are two of the most commonly prescribed antibacterial worldwide for treating oral infectious diseases. Oral health is of big importance for well-being and general health. A few novel drug delivery systems were designed for oral treatment and prophylaxis of different diseases in the oral cavity. This work focused on the latest drug delivery development of the most common oral pathologies, namely, periodontitis, oral mucosal infections, dental caries and oral cancer. Herein we reveal the synthesis, characterization and application of chitosan nanoparticles for intracellular transport of the weakly cell-penetrating amoxicillin and clavulanic acid in order to improve their efficacy on bacterial infections.

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