Impact of One-Rod Levonorgestrel Implant on Blood Chemistry Profile
Abstract Objective: The aim of this study is to investigate the effect of one-rod levonorgestrel implant on the blood chemistry profile which include random blood glucose (RBG), hemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and lipid profile such as total cholesterol, High-density lipoprotein (HDL), Low-density lipoprotein (LDL), and triglycerideMethods: This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated for 6 months and the blood chemistry profile was followed up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. The p <0.05 was considered as a significant value. Results: The level of Hb, RBG, AST, and lipid profile was different significantly before and after 6-months one-rod implant insertion (p<0.05). However, in 24 months, all of parameters were still on normal limit and not different clinically. Conclusion: One-rod levonorgestrel implant insertion shows minimal effect to all blood chemistry profiles.