Effect of 6 months intense Yoga practice on lipid profile, thyroxine medication and serum TSH level in women suffering from hypothyroidism: A pilot study

2016 ◽  
Vol 13 (2) ◽  
Author(s):  
Savitri Nilakanthan ◽  
Kashinath Metri ◽  
Nagaratna Raghuram ◽  
Nagendra Hongasandra
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Rank Test ◽  
Autonomous Nervous System ◽  
Signed Rank ◽  
Medication Score ◽  
Signed Rank Test ◽  
History Of ◽  
Artery Disease ◽  
Age Range

Abstract: A significant number of women in India are suffering from hypothyroidism. Hypothyroidism is characterized by elevated lipid profiles and thyroid stimulation hormone (TSH). It leads many comorbid conditions such as coronary artery disease, obesity, depression, osteoporosis, sleep apnea, and etc. Yoga is proven to be effective in reducing weight, dyslipidemia, depression and it brings the balance in autonomous nervous system. We aimed to study the effect of 6 months: Twenty-two household women suffering from hypothyroidism between the age range of 30 and 40 (mean±SD; 36.7±3.2) years, with average 4±1.12-year history of hypothyroidism were included in this study. Subjects with known cardiac issues, hypertension, history, recent surgery, slip disc and low back pain were excluded from this study. None of the subjects were on any other medication except thyroxine which was kept during the intervention phage (mean 65.78±22.74 mcg). All the subjects underwent 6 months of: The paired sample t-test showed significant reduction in total cholesterol (p=0.006; –8.99 %), low-density lipoprotein (LDL) (p=0.002; –9.81 %) and triglycerides (p=0.013; –7.6 %), and there was a significant improvement in high-density lipoprotein (HDL) (p=0.02; +9.65 %) along with nonsignificant reduction in TSH level (p=0.452; –9.72 %). Wilcoxon signed-rank test showed significant reduction in thyroxine medication score (p=0.029; –15.30 %) from.: 6 months practice of

Impact of One-Rod Levonorgestrel Implant on Blood Chemistry Profile

2021 ◽  
Author(s):  
Eka R. Gunardi ◽  
Raymond Surya ◽  
Inayah Syafitri ◽  
Yogi Pasidri
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Chemistry ◽  
Rank Test ◽  
Bivariate Analysis ◽  
Signed Rank ◽  
Before And After ◽  
Signed Rank Test ◽  
Aspartate Transferase

Abstract Objective: The aim of this study is to investigate the effect of one-rod levonorgestrel implant on the blood chemistry profile which include random blood glucose (RBG), hemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and lipid profile such as total cholesterol, High-density lipoprotein (HDL), Low-density lipoprotein (LDL), and triglycerideMethods: This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated for 6 months and the blood chemistry profile was followed up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. The p <0.05 was considered as a significant value. Results: The level of Hb, RBG, AST, and lipid profile was different significantly before and after 6-months one-rod implant insertion (p<0.05). However, in 24 months, all of parameters were still on normal limit and not different clinically. Conclusion: One-rod levonorgestrel implant insertion shows minimal effect to all blood chemistry profiles.

scholarly journals Impact of one-rod levonorgestrel implant on the blood chemistry profile

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eka R. Gunardi ◽  
Raymond Surya ◽  
Inayah Syafitri ◽  
Yogi Pasidri
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Chemistry ◽  
Rank Test ◽  
Bivariate Analysis ◽  
Normal Limits ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Aspartate Transferase

AbstractThe aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles.

Abstract 14606: Endothelial Injury Biomarkers and Risk Factors Associated With Discordant Risk of Acute Coronary Syndrome Despite Controlled Low-density Lipoprotein Cholesterol Identified by a Novel Coronary Artery Disease Predictive Algorithm

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Ned Premyodhin ◽  
WENJUN FAN ◽  
Masood Younus ◽  
Douglas S Harrington ◽  
Nathan D Wong
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
Predictive Algorithm ◽  
Coronary Syndrome ◽  
History Of ◽  
Artery Disease

Background: Individuals with no history of coronary artery disease can develop acute coronary syndrome (ACS), often in the absence of major risk factors including low-density lipoprotein cholesterol (LDL-C). We identified risk factors and biomarkers that can help identify those at discordantly high risk of ACS who have normal LDL-C using a novel coronary artery disease predictive algorithm (CADPA) incorporating biomarkers of endothelial injury validated in the Multi-Ethnic Study of Atherosclerosis cohort. Methods: Five-year predicted ACS risk was calculated using the CADPA for 8589 patients. Common risk factors and serum levels of 9 biomarkers utilized by the CADPA were tracked. We identified a “discordant high ACS” risk group with serum LDL-C < 130 mg/dL but 5-year CADPA predicted risk ≥ 7.5% and a “discordant low ACS” risk group defined as LDL-C ≥ 130 mg/dL but 5-year CADPA risk of < 7.5%. Multiple logistic regression identified risk factors and biomarkers that predicted discordance in two separate models. Results: The average age and percent male of the high ACS discordant group was higher compared to non-discordant (68±10 vs 54±13 years and 61% vs 43%, respectively). Diabetes (OR 2.84 [2.21-3.66]), male sex (OR 2.83 [2.40-3.35]), family history (OR 2.23 [1.88-2.64]) and active smoking (OR 1.99 [1.50-2.62]) exhibited greatest odds of high ACS discordance compared to other risk factors (all p < 0.01). Increased serum soluble FAS (OR 2.12 [1.97-2.29]), Hemoglobin A1c (OR 1.60 [1.48-1.72]) and interleukin-16 (OR 1.40 [1.32-1.48]) were the biomarkers most associated with discordant risk, independent of global risk factors. Conclusion: Men with diabetes and family history of myocardial infarction who are actively smoking may be at highest risk of developing ACS despite controlled LDL-C. Future studies should examine whether using the CADPA can help identify such individuals that could benefit from earlier targeting of risk factor modification for prevention of ACS.

scholarly journals Immediate Role of Two Yoga Based Mantra Recitation on Selective Attention in Undergraduate Students

2019 ◽  
Vol 13 ◽  
pp. 01-07
Author(s):  
NAROTTAM KUMAR
Keyword(s):  
Selective Attention ◽  
Undergraduate Students ◽  
Rank Test ◽  
Group Comparison ◽  
Signed Rank ◽  
Percentage Improvement ◽  
Wilcoxon Signed Rank Test ◽  
Signed Rank Test ◽  
Age Range

Aim of the present study was to evaluate the effect of Gayatri mantra recitation and Om recitation on selective attention as measured by color stroop. The study was performed on undergraduate students (Male=30) with age range of 18 to 30 years. All students were trained for reciting Gayatri mantra for 3 days. The baseline data were used. The participants participated in Gayatri mantra and Om recitation about 15 min for two consecutive days. The sequence of the session was assigned randomly to the participants. The attention was assessed using color stroop test before and immediately after each session. Within-group comparison showed that due to GM recitation and Om recitation, Stroop scores improved or significant improvement of Stroop scores in both groups (P < 0.001;Wilcoxon signed rank test). The percentage improvement of Stroop score was 16.16 % after GM recitation whereas 9.26 % after Om recitation. This pilot study shows that both Gayatri mantra and simply sitting led to improvement in attention, as measured by Stroop Task. But the influence of Gayatri mantra was significantly higher than Om recitation.

scholarly journals A retrospective analysis with quality of life assessment of nasal surgery for nasal obstruction

2018 ◽  
Vol 5 (1) ◽  
pp. 5
Author(s):  
Mehmet Fatih Karakus ◽  
Suleyman Emre Karakurt ◽  
Mustafa Colak
Keyword(s):  
Quality Of Life ◽  
Nasal Obstruction ◽  
Life Assessment ◽  
Rank Test ◽  
Signed Rank ◽  
Symptom Evaluation ◽  
Signed Rank Test ◽  
The Difference ◽  
Age Range

<p class="abstract"><strong>Background:</strong> Nasal obstruction is a common health problem that disrupts a person’s quality of life (QoL). The Nasal Obstruction Symptom Evaluation scale (NOSE) is a QoL scale with questions specific to nasal obstruction symptoms. This study aimed to evaluate surgical success in patients who underwent nasal septal deviation surgery by using a NOSE assessment, thus determining the importance and efficacy of surgery in this group of patients.</p><p class="abstract"><strong>Methods:</strong> This study was conducted in between January 2016 and June 2017, including a total of 60 patients. The age range of the patients was 18–57 (mean, 34.4±9.9 years). The preoperative and postoperative scoring and surgeries were performed by the same investigator. The surgeries were septoplasty and radiofrequency applied to the inferior concha to overcome conchal hypertrophy. Preoperative mean scores were compared with postoperative second-month values. The importance of difference was evaluated with the Wilcoxon signed-rank test.  </p><p class="abstract"><strong>Results:</strong> Preoperative minimum, maximum and mean scores were 65.0, 100.0 and 83.4 (83.41±8.15), respectively. Postoperative minimum, maximum and mean scores were 10.0, 35.0 and 21.6 (21.66±8.06), respectively. The difference in mean scores was significant (Z=−6.778; p&lt;0.001).</p><p class="abstract"><strong>Conclusions:</strong> The difficulty in evaluating patient satisfaction and postoperative success stems from differences in each surgeon’s approach and the comparison of preoperative and postoperative findings. This study, which was carried out by the same researcher for all steps, differs it from similar studies.</p>

scholarly journals Effectiveness of Subliminal Stimuli in Lie Detection: Use of Physical Countermeasures

2018 ◽  
Vol 3 (4) ◽  
pp. 320-325
Author(s):  
Mandeep Sharma ◽  
Amrita Yadava ◽  
Nov Rattan Sharma
Keyword(s):  
Lie Detection ◽  
Rank Test ◽  
Friedman Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Signed Rank Test ◽  
Age Range ◽  
Non Parametric

The objective of the present investigation was to study the effectiveness of subliminal stimuli in reducing the probability of use of countermeasures during polygraph was considered. Further, use of countermeasures (physical) would be more for supraliminal stimuli as compared to subliminal stimuli. Purposive total samples of 79 adults with (age range between 20-28 years) were selected for the present study. Windows Based Computerised Lie Detector (CLD-118) and Aversion Therapy Instrument (MBT-498) were used in present study. For analyses of the data, Friedman Test (non-parametric) followed by Wilcoxon Signed-Rank Test (non-parametric), were applied. In the present investigation the effectiveness of subliminal stimuli in deterring the execution of countermeasures was studied, revealed that subliminal stimuli acted as a deterrent to physical countermeasures. The present findings indicate that subliminal stimuli can be used as a deterrent to countermeasures (Physical) in Lie Detection.

Safety and efficacy of eculizumab in paroxysmal nocturnal hemoglobinuria evolving from patients with myelodysplastic syndrome and aplastic anemia

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7033-7033
Author(s):  
R. A. Brodsky ◽  
P. Hillmen ◽  
J. Schubert ◽  
L. Luzzatto ◽  
G. Socié ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndrome ◽  
Aplastic Anemia ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Bone Marrow Failure ◽  
Rank Test ◽  
Point Increase ◽  
Signed Rank ◽  
Signed Rank Test ◽  
History Of

7033 Background: Myelodysplastic syndrome (MDS) and aplastic anemia (AA) have been reported to be associated with the development of the acquired clonal hemolytic and bone marrow failure disorder, paroxysmal nocturnal hemoglobinuria (PNH). Two recent phase 3 clinical studies have demonstrated significant benefit of the complement inhibitor eculizumab (Soliris) in a heterogeneous population of patients with PNH (n=140). Methods: To investigate whether eculizumab was safe and effective in PNH patients with a history of MDS or AA (n=37), efficacy parameters were examined in the MDS/AA patient subpopulation. Results: Intravascular hemolysis, as assessed by plasma levels of the enzyme lactate dehydrogenase (LDH), was reduced from a mean of 1871 ± 159 U/L at baseline to 300 ± 21 U/L at week 26 in patients with a history of MDS or AA (p<0.001, signed rank test; normal range 103–223 U/L). Anemia was improved as packed RBC transfusion requirements were substantially reduced with eculizumab in these patients from a median of 8 units per patient in the 6 months before treatment to 0 units per patient during eculizumab treatment (p<0.001, signed rank test). Despite history of bone marrow failure, eculizumab treatment markedly improved fatigue with an 11.6 point increase over baseline using the FACIT-Fatigue instrument (p<0.001, signed rank test; a 3 or more point increase in this instrument has been shown to be clinical meaningful). Fatigue was similarly improved with the fatigue scale of the EORTC QLQ-C30 instrument (p<0.001, signed rank test). Eculizumab appeared to be well tolerated when administered to PNH patients with a history of MDS or AA. The significant clinical improvements in hematologic and quality of life outcomes with eculizumab treatment in PNH patients with a history of MDS or AA were similar to the clinical improvements demonstrated the overall PNH patient population. Conclusions: These analyses show that eculizumab treatment may provide important clinical benefit when administered to PNH patients with a history of bone marrow failure. No significant financial relationships to disclose.

scholarly journals Safety of Prescribing Statins in Childhood Dyslipidemia

2020 ◽  
Vol 10 (01) ◽  
pp. e119-e125
Author(s):  
Mohammed Khaled Al-Alaili ◽  
Abdikarim Mohamed Abdi ◽  
Bilgen Basgut
Keyword(s):  
Randomized Clinical Trials ◽  
Drug Class ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Heart Association ◽  
Cochrane Library ◽  
Low Density Lipoprotein Cholesterol ◽  
The Past ◽  
Artery Disease ◽  
Age Range

AbstractHyperlipidemia is on the rise in pediatrics, leading to early coronary artery disease complications. Familial hypercholesterolemia is an important risk factor, with the homozygous subtype being more dangerous, yet less prevalent than the heterozygous subtype. Statins are shown to be an effective treatment in this population. This systematic review will emphasize the safety of such drug class in pediatrics, while taking into consideration the latest cholesterol guideline. Cochrane Library, Clinicaltrials.gov, and PubMed were reviewed systematically in June 2019 and rechecked in November 2019 for the past 5 years with keywords like child, safety, hyperlipidemia, and statins, which resulted in nine randomized clinical trials. In short, statins are shown to be intermediately effective—median decrease of low-density lipoprotein cholesterol was 32% achieving the target of < 160 mg/dL in 67% of patients—in lowering lipid levels yet preventing early complications. They are also considered safely tolerated in most cases, even when taken for extended periods, but still not evidently permissible for children below 8 years old, which was the average age of all participants in the trials. Statins should not be given generally for pediatrics of less than 8 years old, in contrast to what was mentioned in the American Heart Association guideline (0–19 age range), since there is no evidence supporting their safety within this age group.

Low Density Lipoprotein Cholesterol/Apolipoprotein B-100 Ratio: Interaction of Family History of Premature Atherosclerotic Coronary Artery Disease With Race and Gender in 7 to 11 Year Olds

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 494-499
Author(s):  
Syed Islam ◽  
Bernard Gutin ◽  
Tina Manos ◽  
Clayton Smith ◽  
Frank Treiber
Keyword(s):  
Family History ◽  
Apolipoprotein B ◽  
Low Density Lipoprotein ◽  
Positive Family History ◽  
Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
White Girls ◽  
History Of ◽  
Artery Disease

Background. In adults, a low density lipoprotein cholesterol (LDL-C)/apolipoprotein B-100 (ApoB) ratio is an indicator of ApoB-enriched small dense LDL, which is associated with premature coronary artery disease (CAD). Since this LDL subclass may be inherited, we investigated whether a low LDL-C/ApoB ratio was associated with a positive family history of premature CAD in young children. Methods. Subjects were 66 children aged 7 to 11 years who were recruited through a school-based family history survey, flyers, and hospital newspaper advertisements. They were divided according to family history and assessed for fatness, blood pressure, lipids, lipoproteins, and apoproteins. Results. Family history interacted with gender such that girls with a positive family history had a lower LDL-C/ApoB ratio than girls with a negative family history, while the opposite was true in boys; ie, family history-positive boys had a higher ratio than family history-negative boys. The association of a low ratio with a positive family history was seen most clearly in white girls. Family history-positive whites had higher ApoB than family history-negative whites, whereas the pattern was reversed in the blacks. The LDL-C/ApoB ratio and ApoB were not related to other CAD risk factors such as fatness, blood pressure, or other lipids and lipoproteins. Conclusion. In young children, a low LDL-C/ApoB ratio and high ApoB levels were associated with a positive family history of CAD only in the white girls, suggesting that this group is at increased risk of genetically mediated CAD.

scholarly journals Improvement in Metabolic Co-Morbidities after Implantation of CardioMEMS in Patients with Heart Failure with Preserved Ejection Fraction Phenotype

2021 ◽  
Vol 10 (19) ◽  
pp. 4308
Author(s):  
Amit Alam ◽  
Johanna Van Zyl ◽  
Navdeep Nayyar ◽  
Shelley Hall ◽  
Rita Jermyn
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Ejection Fraction ◽  
Density Lipoprotein ◽  
Rank Test ◽  
Preserved Ejection Fraction ◽  
The Metabolic Syndrome ◽  
Signed Rank ◽  
Signed Rank Test ◽  
Blood Pressures

Background: Heart failure with preserved ejection fraction (HFpEF) patients often have other comorbidities, including obesity, dyslipidemia, hypertension, and diabetes, comprising the metabolic syndrome. The impacts of hemodynamic monitoring via CardioMEMS on these co-morbidities remain unknown. Methods: A retrospective analysis of 29 patients with HFpEF (EF 45% or greater) and CardioMEMS was performed at a single center. Weight, body mass index (BMI), systolic blood pressures (SBP), high-density lipoprotein (HDL), triglycerides (TGL), hemoglobin A1C (HbA1c), and pulmonary artery diastolic pressures (PADP) were assessed at baseline and six months post-implant. Paired t-tests and the Wilcoxon signed-rank test were used, as appropriate, to test differences between time points. Results: These patients were 69% female, with a mean age of 73 years, and 62% had non-ischaemic cardiomyopathies (NICM). At the time of CardioMEMS implantation, average PADP was 20.1 mmHg ± 5.7, weight was 102.6 kg ± 22.7, BMI was 38.0 kg/m2 ± 8.3, SBP was 135 mmHg ± 19, HDL was 42.4 mg/dL ± 11.3, and median TGL was 130 mg/dL (100, 180). At six months we witnessed a decrease by 20.9% in PADP to 15.9 mmHg ± 5.8, (p < 0.001). In addition, the following was noted: weight decreased by 2.5% to 100.0 kg ± 23.2, (p = 0.006), BMI reduced by 2.6% to 37.0 ± 8.2, (p = 0.002), SBP decreased by 6.7% to 126 mmHg ± 16 (p < 0.001), HDL increased by 10.8% to 47 mg/dL ± 11.9 (p < 0.001), and TGL decreased by 15.4% to 110 mg/dL (105, 135) (p = 0.001). 62% of patients were diabetic with no significant improvements in HbA1C values at the 6-month follow-up. Conclusion: The utilization of CardioMEMS to optimize PADP results in an improvement in the comorbidities associated with the metabolic syndrome. Further studies are warranted to validate these findings and delineate clinical significance.

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