scholarly journals Nutritional Status Related to Selenium in Patients With Ataxia-Telangiectasia - A Case Control Study: an Association With Oxidative Stress and Risk of Atherosclerosis

2020 ◽  
Author(s):  
Itana Gomes Alves Andrade ◽  
Fabíola Isabel Suano de Souza ◽  
Fernando Luiz Fonseca ◽  
Carolina Sanchez Aranda Lago ◽  
Roseli Oselka Saccardo Sarni
Keyword(s):  
Oxidative Stress ◽  
Food Intake ◽  
Liver Function ◽  
Glutathione Peroxidase ◽  
Nutritional Status ◽  
Lipid Profile ◽  
Ataxia Telangiectasia ◽  
Abdominal Circumference ◽  
Serum Selenium ◽  
Apo B

Abstract Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium (Se) is a trace element related to protection against damage caused by oxidative stress; it is postulated that adequate consumption reduces the risk of some chronic diseases. Objective: To describe the concentrations of Se and glutathione peroxidase (GPx) in patients with A-T, to relate them to markers of the lipid profile. Methods: We evaluated, through a controlled cross-sectional study, 22 A-T patients matched by sex and age with healthy individuals, conjointly evaluating: nutritional status, food intake, serum selenium, glutathione peroxidase (activity), lipid metabolism biomarkers, inflammation and lipid. Results: The median age in the A-T group was 12.2 years. A-T patients had greater impairment of lean body mass and GPx activity as well as lower abdominal circumference. A more atherogenic lipid profile was observed with higher concentrations of total cholesterol, non-HDL cholesterol, LDLox, Apo B, Apo B / Apo A-1 and LDL / HDL ratio; while a lower value was observed in the Apo A-1 / HDL ratio. It was also in the A-T group that statistical difference was detected in the three markers of liver function AST, ALT and GGT. In regard to food intake, A-T patients had lower values ​​of carbohydrate, protein, monounsaturated fat, trans fat, and Se. Conclusion: The study showed cardiovascular risk in A-T patients. A-T patients appear to be at increased risk of reduced nutritional status, impaired liver function, dyslipidemia and inflammation.

scholarly journals The Serum Selenium Level, the Activity of Some Selenodependent Enzymes and the Lipid Profile in Childhood Obesity

2021 ◽  
Vol 71 (12) ◽  
pp. 156-163
Author(s):  
Alexandra Gabriela Catianis ◽  
Bogdana Virgolici ◽  
Carmen Beatrice Dogaru ◽  
Laura Anca Popescu ◽  
Daniel Miricescu ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Glutathione Peroxidase ◽  
Lipid Profile ◽  
Normal Weight ◽  
Serum Selenium ◽  
Healthy Children ◽  
Obese Children ◽  
Free T4 ◽  
Apo B ◽  
Gpx Activity

Oxidative stress and dyslipidemia are present in childhood obesity. Selenoproteins are important antioxidants. Glutathione peroxidase and thioredoxin reduce the level of peroxides while the conversion of the tyroid hormon T4 to T3 needs also a selenoenzyme. Selenium deficiency can reduce the selenoproteins activity. The aim of this study was to determine the serum: selenium (Se), thioredoxin level (Trx) and activity of glutathione peroxidase (GPx) in obese children with dysmetabolism. The lipid profile, the hormones (free T4 and TSH), serum Se, serum Trx and GPx activity and atherogenic indexes (TG/HDLc, total cholesterol/HDLc, apoB/apoA-I ) were determined in 20 healthy children (10-16 years old) versus 41 overweight/obese children, same age, in an observational study. Spectro-photometer and ELISA methods were used. The GPx activity and the serum Se level had similar values in the studied groups , while the serum Trx level was lower in the obese children. The GPx activity was positively correlated with atherogenic indexes, negatively correlated with apo A-I (r= -0.74) and Se was positively correlated with apo B (r=0.52). The obese children had TSH and freeT4 in the normal range, but freeT4 was significantly higher in comparison with the values observed in the normal weight children. In conclusion, in childhood obesity, the normal serum range values for selenium or for selenium dependent proteins can �hide�a dysmetabolism of selenium because there are significant differences for the values of these parameters versus the ones from normal weight children. In childhood obesity, serum GPx activity and selenium values were strongly correlated with the atherogenic indexes.

scholarly journals Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Itana Gomes Alves Andrade ◽  
Fabíola Isabel Suano-Souza ◽  
Fernando Luiz Affonso Fonseca ◽  
Carolina Sanchez Aranda Lago ◽  
Roseli Oselka Saccardo Sarni
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Oxidized Ldl ◽  
Reference Value ◽  
Glutathione Peroxidase Activity ◽  
Oxidative Stress Biomarkers ◽  
Apo B ◽  
Lipid Status ◽  
And Oxidative Stress

Abstract Introduction Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 μg/L (43.2–57.0) vs 54.6 (45.2–62.6) μg/dL, p = 0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I1, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p = 0.029] and lower Apo-A-I1/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p = 0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC = 0.849) and ALT (AUC = 0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

scholarly journals Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes

2005 ◽  
Vol 62 (7-8) ◽  
pp. 529-536 ◽  
Author(s):  
Miroslava Zamaklar ◽  
Katarina Lalic ◽  
Natasa Rajkovic ◽  
Danijela Trifunovic ◽  
Mirjana Dragasevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Apo B ◽  
Significant Difference

Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 - control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD.

scholarly journals Assessment of Plasma Malondialdehyde in Acne Patients on Isotretinoin Therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M A Saleh ◽  
K M A Alzawahry ◽  
R E M Gad
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Side Effects ◽  
Serum Level ◽  
Liver Function ◽  
Lipid Profile ◽  
Acne Vulgaris ◽  
Liver Function Tests ◽  
Severe Acne ◽  
Function Tests

Abstract Background Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects predominantly adolescents and young adults. Oral isotretinoin is a highly effective treatment agent for patients with nodulocystic acne and moderate to severe acne resistant to conventional therapy, isotretinoin might have side effects of oxidative stress and lipid peroxidation. . Malondialdehyde is the end product of lipid peroxidation and is a good marker of free radical-mediated damage and oxidative stress. Objective The purpose of this study to estimate malondialdehyde level in patients on Isotretinoin treatment for moderate to severe acne and compare them with healthy control group. Patients and Methods The case-control study was conducted at Ain. Shams University Faculty of Medicine, Egypt, from October 2017 to April 2017, and comprised male or non-pregnant female patients more than 18 years of age. 88 participants were included in the study; 44 cases, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne in comparison to equal healthy matching group. Isotretinoin was started in a dosage of 0.5mg/kg/day, and1.0mg/kg/day in patients with moderate and severe acne vulgaris respectively. Malondialdehyde, liver function tests, lipid profile and CBC were tested at the baseline for all participants and after 3 months for the patients who started isotretnoin therapy. Results In the current study, the mean baseline level malondialdehyde among all cases was 141.39 µmo1/m1±88.90, (range: 34.5 -360) and in controls it was 40 [µmo1/m1 ±11.3, (range: 9.5-90.4) this difference was statistically highly significant (P = 0.001). There was highly significant difference in malondialdehyde serum level (p = 0.0001) among all cases after 3 months of isotretnoin therapy, also there was a significant increase in MDA serum level among moderate cases (p = 0.021) and highly significant increase of MDA in severe cases (p=.001).ALP, ALT, serum cholesterol and triglyceride significant increases were seen in all cases. Conclusion low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and Malondialdehyde serum levels than high dose.

scholarly journals STATISTICAL DATA ANALYSIS WHICH RESULT FROM THE BIO-DIAGNOSIS AND BIO-TREATMENT OF INJURED RATS WITH THE HYPERLIPIDEMIA AND HYPERGLYCEMIA DISEASES

2016 ◽  
Vol 9 (9) ◽  
pp. 122
Author(s):  
Hanan Farouk Aly Abduallah ◽  
Howaida I Abdalla ◽  
Sanaa A Ali ◽  
Mohamed M Mamdooh ◽  
Reda Abo Alez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Liver Function ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Ipomoea Tricolor ◽  
And Oxidative Stress

ABSTRACTObjective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymesactivity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-inducedhyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactatedehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-densitylipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant,glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significantdecrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters underinvestigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathologicalexamination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobularhepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showednormal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HGrats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats withI. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs.Conclusion: The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicatingrelieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be acandidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to beapplied effectively to reduce perturbation in HC associated diabetes.Keywords: Ipomoea tricolor, Sophora tomentosa, Lipid profile and liver function enzymes, Endothelial dysfunction markers, Statistics and imagerecognition, Histopathological analysis.

scholarly journals Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

2021 ◽  
Author(s):  
Itana Gomes Alves Andrade ◽  
Fabiola Isabel Suano de Souza ◽  
Fernando Luiz Fonseca ◽  
Carolina Sanchez Aranda Lago ◽  
Roseli Oselka Saccardo Sarni
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Oxidized Ldl ◽  
Reference Value ◽  
Glutathione Peroxidase Activity ◽  
Oxidative Stress Biomarkers ◽  
Apo B ◽  
Lipid Status ◽  
And Oxidative Stress

Abstract Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective: To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods: This is a cross-sectional and contolled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results: Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 ug/L (43.2-57.0) vs 54.6 (45.2-62.6) ug/dL, p = 0.242]. Nine/22 (41%) of A-T patients had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p=0.029] and lower Apo-A-I/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p=0.005]. Selenium levels were influenced, in both groups, independently, only by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC=0.849) and ALT (AUC=0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion: In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

scholarly journals Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

2015 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Rahul Saxena ◽  
Shilpa Suneja ◽  
Raj Saxena ◽  
Dilutpal Sharma ◽  
Alok Milton Lal
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Patient Group ◽  
Systemic Inflammation ◽  
Apolipoprotein B ◽  
Healthy Controls ◽  
Cvd Risk ◽  
Apparent Paradox ◽  
Apo B ◽  
Group I

<p class="abstract"><strong>Background:</strong> Psoriasis is characterized by systemic increase of inflammation and oxidative stress. In addition, increased incidence of dyslipidemia in dermatological disorders is also in alarming phase. It is conceivable that association of inflammation, oxidative stress and dyslipidemia enhances the future the risk of cardiovascular disease (CVD) in psoriasis patients. The main of the study is to estimate the marker of systemic inflammation, oxidative stress, plasma lipid profile and apolipoprotein levels in psoriasis patients and to determine their role in predicting CVD risk in psoriasis.</p><p class="abstract"><strong>Methods:</strong> The study population consist of subjects categorized into two groups; Group I: Healthy controls and Group II: Psoriasis patients (n= 25 in each group). Erythrocyte malondialdehyde (MDA), plasma C-reactive protein (CRP) and lipid profile along with apolipoprotein B and A1 were measured and statistically analyzed using standard methods.</p><p class="abstract"><strong>Results:</strong> Plasma CRP, total cholesterol, triglycerides, LDL-cholesterol and MDA levels were significantly high (p&lt;0.05) in patient group as compared to healthy controls. HDL-cholesterol levels were altered insignificantly (p&lt;0.1) in patient group. Plasma Apo B/Apo A1 ratio were increased significantly (p&lt;0.01) in patient groups as compared to controls.</p><p><strong>Conclusions:</strong> Thus, enhanced inflammation, oxidative stress along with increase in Apo B, A1 and its ratio authenticates the fact that these markers are more efficient in prediction of CVD risk in psoriasis patients than conventional lipid profile parameters.</p>

scholarly journals Decrease in Antioxidant Status of Plasma and Erythrocytes from Geriatric Population

2012 ◽  
Vol 33 (6) ◽  
pp. 303-308 ◽  
Author(s):  
Manjulata Kumawat ◽  
Tarun Kumar Sharma ◽  
Ishwar Singh ◽  
Neelima Singh ◽  
Sanjeev Kumar Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Cardiovascular Diseases ◽  
Glutathione Peroxidase ◽  
Glutathione Reductase ◽  
Lipid Profile ◽  
Reduced Glutathione ◽  
Elderly Subjects ◽  
Geriatric Population ◽  
Free Radical Damage

Background: Ageing is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. The study aims to find out the status of lipid profile, antioxidant enzymes, malondialdehyde in geriatric population.Patients/methods: The study was conducted on 150 subjects (75 healthy control between the ages of 20–30 years and 75 elderly subjects between ages of 50–70 years as cases). The following parameters were analyzed using the standard reference methods: lipid profile, reduced glutathione, glutathione peroxidase, glutathione reductase, catalase, superoxide dismutase and malondialdehyde.Results: The present study was conducted to estimate the oxidative stress parameters in geriatric population. Highly significant increase in total cholesterol (TC), triglyceride (TG), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), malondialdehyde, catalase and decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase was observed in geriatrics when compared with their younger counterparts.Conclusion: This study concluded that there is enhanced oxidative stress and decreased antioxidant defence in geriatrics as compared to younger subjects which could play an important role in ageing. Dyslipidemia has become one of the important risk factors for the increasing prevalence of cardiovascular diseases. There is lack of awareness on the relationship between blood lipids and the risk of cardiovascular diseases in geriatric population. The strategy of early prevention should be adopted against dyslipidemia.

scholarly journals Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

2021 ◽  
Author(s):  
Itana Gomes Alves Andrade ◽  
Fabiola Isabel Suano-Souza ◽  
Fernando Luiz Fonseca ◽  
Carolina Sanchez Aranda Lago ◽  
Roseli Oselka Saccardo Sarni
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Oxidized Ldl ◽  
Reference Value ◽  
Glutathione Peroxidase Activity ◽  
Oxidative Stress Biomarkers ◽  
Apo B ◽  
Lipid Status ◽  
And Oxidative Stress

Abstract Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective: To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods: This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results: Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 ug/L (43.2-57.0) vs 54.6 (45.2-62.6) ug/dL, p=0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p=0.029] and lower Apo-A-I/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p=0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC=0.849) and ALT (AUC=0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion: In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

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