scholarly journals Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

2015 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Rahul Saxena ◽  
Shilpa Suneja ◽  
Raj Saxena ◽  
Dilutpal Sharma ◽  
Alok Milton Lal
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Patient Group ◽  
Systemic Inflammation ◽  
Apolipoprotein B ◽  
Healthy Controls ◽  
Cvd Risk ◽  
Apparent Paradox ◽  
Apo B ◽  
Group I

<p class="abstract"><strong>Background:</strong> Psoriasis is characterized by systemic increase of inflammation and oxidative stress. In addition, increased incidence of dyslipidemia in dermatological disorders is also in alarming phase. It is conceivable that association of inflammation, oxidative stress and dyslipidemia enhances the future the risk of cardiovascular disease (CVD) in psoriasis patients. The main of the study is to estimate the marker of systemic inflammation, oxidative stress, plasma lipid profile and apolipoprotein levels in psoriasis patients and to determine their role in predicting CVD risk in psoriasis.</p><p class="abstract"><strong>Methods:</strong> The study population consist of subjects categorized into two groups; Group I: Healthy controls and Group II: Psoriasis patients (n= 25 in each group). Erythrocyte malondialdehyde (MDA), plasma C-reactive protein (CRP) and lipid profile along with apolipoprotein B and A1 were measured and statistically analyzed using standard methods.</p><p class="abstract"><strong>Results:</strong> Plasma CRP, total cholesterol, triglycerides, LDL-cholesterol and MDA levels were significantly high (p&lt;0.05) in patient group as compared to healthy controls. HDL-cholesterol levels were altered insignificantly (p&lt;0.1) in patient group. Plasma Apo B/Apo A1 ratio were increased significantly (p&lt;0.01) in patient groups as compared to controls.</p><p><strong>Conclusions:</strong> Thus, enhanced inflammation, oxidative stress along with increase in Apo B, A1 and its ratio authenticates the fact that these markers are more efficient in prediction of CVD risk in psoriasis patients than conventional lipid profile parameters.</p>

scholarly journals Apolipoprotein A-I and Apolipoprotein B: Better Indicators of Dyslipidemia in Diabetic Retinopathy Patients?

2017 ◽  
Vol 21 (2) ◽  
pp. 142-146
Author(s):  
Aliya Nusrath ◽  
Dyavegowda Namitha ◽  
Arasegowda Rajeswari ◽  
Yeliyur D Shilpashree ◽  
N Asha Rani
Keyword(s):  
Diabetic Retinopathy ◽  
Lipid Profile ◽  
Plasma Glucose ◽  
Apolipoprotein B ◽  
Density Lipoprotein ◽  
Apo B ◽  
Postprandial Plasma Glucose ◽  
Apolipoprotein A ◽  
Group I ◽  
Group Ii

ABSTRACT Diabetic retinopathy (DR) remains the leading cause of mortality and disability in adults with diabetes. Recently apolipoprotein A-I (Apo A-I) and apolipoprotein B (Apo B) have been found to be associated with biophysiological changes of DR than traditional lipids. The objective of the present study was to evaluate the lipid profile including Apo A-I, Apo B, and Apo B/Apo A-I levels in diabetes patients with or without retinopathy. The present study was conducted at Adichunchanagiri Institute of Medical Sciences and Hospital, India. The total numbers of subjects were 90, divided into three groups. Group I included 30 healthy controls, group II included 30 cases of diabetes mellitus (DM) without retinopathy, and group III had 30 cases of DR. Blood samples were drawn under aseptic precautions from study subjects. The investigations carried out were fasting plasma glucose (FPG), postprandial plasma glucose (PPPG), and lipid profile including Apo A-I and Apo B in all subjects. The FPG, PPPG, lipid profile, and apolipoproteins (Apo A-I and Apo B) were estimated using autoanalyzer EM 200.There was significant increase in FPG, PPPG, total cholesterol, triglycerides (TGs), low-density lipoproteins (LDLs) and no significant decrease in high-density lipoprotein (HDL) levels in group II and III subjects. There was significant decrease in Apo A-I and increase in Apo B levels and Apo B/Apo A-I ratio in group II and III subjects. There is a suggestive association of TGs, LDL, and Apo B/Apo A-I ratio in diabetic subjects with and without retinopathy. The Apo A-I, Apo B, and ratio of Apo B/Apo A-I are strong indicators of dyslipidemia in diabetic and DR patients. The ratio of Apo B/Apo A-I is better associated with DR and may contribute to development and progression of DR. How to cite this article Namitha D, Nusrath A, Rajeswari A, Rani NA, Shilpashree YD. Apolipoprotein A-I and Apolipoprotein B: Better Indicators of Dyslipidemia in Diabetic Retinopathy Patients? Indian J Med Biochem 2017;21(2):142-146.

scholarly journals Potential role of apolipoprotein B/A1 ration in obese and non-obese female patients of coronary artery disease

2016 ◽  
Vol 7 (3) ◽  
pp. 18-22
Author(s):  
Sunita Mahto ◽  
Suman Bala Sharma ◽  
Shridhar Dwivedi ◽  
Mani Sethi ◽  
Rahul Saxena
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Apolipoprotein B ◽  
Obese Patients ◽  
Apo B ◽  
Group I ◽  
Group 3 ◽  
Group 2 ◽  
Artery Disease

Background: Obesity and hyperlipidemia are considered to be risk factor for cardiovascular diseases. Many patients who develop coronary artery disease (CAD) are non obese and have normal lipoprotein cholesterol. Assessment of apolipoproteins can improve future risk of cardiovascular complications.Aims and Objectives: We have investigated effect of weight in relation with lipoprotein and apolipoprotein levels as efficient marker of CAD in North Indian females.Materials and Methods: The study population consist of 90 subjects categorized into three groups:  Group I: Healthy controls; Group 2: Non obese patients of CAD and Group 3: Obese patients of CAD (n= 30 each group). Serum lipid profile along with apolipoprotein B and A1 were measured and apolipoprotein B/A1 ratio were calculated.Result: Total cholesterol and triglycerides levels were significantly high in obese patients as compared to non-obese and controls. LDL-C and HDL-C were altered insignificantly (p<0.1) in Group 2 and Group 3 as compared to Group 1. Apo B and apo A1 were significantly high in obese and non-obese CAD patients as compared to controls whereas insignificant difference was observed (p<0.1) when Group 3 patients were compared with Group 2. ApoB/Apo A1 ratio was increased significantly (p<0.01)) in patient groups as compared to controls. ­­­­­­­­­­­­­­­­­­­­­­­­­Conclusion: Although LDL-C and HDL-C were normal in subjects of CAD, increase in Apo B, A1 and its ratio authenticates the fact that these markers are more efficient in detection of CAD risk in obese and non obese patients than conventional lipid profile parameters.Asian Journal of Medical Sciences Vol. 7(3) 2016 18-22

scholarly journals Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes

2005 ◽  
Vol 62 (7-8) ◽  
pp. 529-536 ◽  
Author(s):  
Miroslava Zamaklar ◽  
Katarina Lalic ◽  
Natasa Rajkovic ◽  
Danijela Trifunovic ◽  
Mirjana Dragasevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Apo B ◽  
Significant Difference

Background. Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). Factors that contribute to endothelial cell dysfunction associated with the initiation of atherosclerosis include oxidative stress. The aim of this study was to investigate the relationship between lipid profile and oxidative stress in type 2 diabetics with and without ischemic heart disease (IHD). Methods. We studied 80 patients with T2D, 40 with IHD (group A1) and 40 without IHD (group A2). We also studied 51 non-diabetics, 31 with IHD (group B1), and 20 without IHD (group B2 - control group). Lipid profile was estimated by the total cholesterol, HDL cholesterol, LDL cholesterol, the level of triglyceride (Tg), lipoproteina a (Lp a), Apo A I, A II, B 100 and E. To evaluate the oxidative status we measured circulating oxidized LDL (ox LDL), erythrocyte antioxidative enzyme activity: superoxide dismutase (E-SOD), glutathione peroxidase (E-GPX), as well as the total antioxidative serum activity (TAS). Inflammatory reaction was estimated by C-reactive protein (CRP) and fibrinogen. Results. No significant difference was found in the lipid profile in groups A1, A2 and B1, but the group B2 had the lowest one. Lp a level was significantly higher in group B1 comparing to other groups (p < 0.05). There was no significant difference in the level of ox LDL between the groups. In diabetics, ox LDL positively correlated with the total cholesterol, LDL cholesterol, non HDL cholesterol, Apo B 100 and the relations between LDL/HDL and Tg/HDL (p < 0.001), as well as with Tg and fibrinogen (p < 0.05). In group B1, ox LDL positively correlated with total cholesterol, Tg (p < 0.01), LDL, and non HDL cholesterol (p < 0.05) and significantly with Apo B 100 (p < 0.001). There was no significant difference in the antioxidant enzyme activities between the groups of diabetics (A1 and A2), but fibrinogen was higher in the group with IHD (group A1, p < 0.05). Group B1 had lower ESOD activity than the groups A1 and A2 (p < 0.05), but CRP was higher (p < 0.05). There were no significant correlations between oxLDL and CRP in groups A1 and A2, but it was statistically significant in the group B1 (p < 0.05). Conclusion. In this study we demonstrated the increased oxidative stress in diabetics compared to non-diabetics regardless of the presence of IHD. Fibrinogen, but not CRP, was higher in diabetics with IHD, compared to diabetics without IHD. The increased oxidative stress, the reduced antioxidative activity E-SOD, and the higher level of CRP were found in non-diabetics with IHD compared to non-diabetics without IHD.

Abstract P376: Cardiometabolic Abnormalities, Systemic Inflammation, and Oxidative Stress in Children

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Stephanie J Frisbee ◽  
Jefferson C Frisbee ◽  
Alan Ducatman
Keyword(s):  
Oxidative Stress ◽  
Regression Analysis ◽  
Systemic Inflammation ◽  
Linear Regression Analysis ◽  
Univariate Analysis ◽  
Class Action ◽  
Large Sample Size ◽  
Metabolic Disturbances ◽  
Cvd Risk ◽  
Age Related

The increasing prevalence of childhood obesity has been well documented & is predictive of increased severity in obesity-related CVD risk factors & metabolic disorders, such as systemic inflammation & oxidative stress. While the poor long-term vascular consequences of these conditions are better understood in adults, the consequences of these obesity-associated metabolic disturbances are less studied in children. This study utilized the 12,476 children (<18 years) enrolled in the C8 Health Project, which resulted from the pretrial settlement of a class action lawsuit pursuant to contamination of the drinking water supply; we have recently published a complete description of this study (Frisbee et al, 2009). The current analysis used the large sample size available from this study to determine the severity of chronic inflammation & oxidative stress associated with cardiometabolic abnormalities, including obesity, dyslipidemia, & hyperglycemia, present either singly or in combination, in children. In this population, median age was 11.6 years, 48% were female, 40% were overweight or obese (OWT-OB; BMI≥85th percentile), 2% had glucose ≥126 mg/dL (HypGly), & 34% had total cholesterol ≥170 mg/dL or LDL cholesterol ≥110 mg/dL (DysLip), Additionally, median CRP, a biomarker of systemic inflammation, was 0.4 mg/L with 16% having CRP≥2 mg/L, & median GGT, a biomarker of oxidative stress, was 12.0 IU/L with 1.7% having GGT≥35 IU/L. In univariate analysis: CRP & GGT were statistically significantly higher in participants with OWT-OB; GGT but not CRP was higher in children with HypGly or DysLip; & both CRP & GGT were higher in children with any cardiometabolic abnormality. In linear regression analysis controlling for age, gender, SES (household income), a regular exercise program, & while simultaneously considering OWT-OB, HypGly, & DysLip: OWT-OB statistically significantly predicted CRP (b-coefficient±SE/adj R-square; 1.0±0.1/1.4%) though HypGly & DysLip were not, ceteris paribus, associated with CRP; OWT-OB (3.5±0.2/16.6%), HypGly (1.2±0.6/16.6%), & DysLip (2.1±0.2/16.6%) were all simultaneously predictive of GGT. In logistic regression analysis controlling for the same covariates & also simultaneously considering the same cardiometabolic abnormalities: OWT-OB (OR (95%CI); 3.8 (3.4-4.4)) & DysLip (1.2 (1.0=1.3)) but not HypGly increased the risk for CRP≥2 mg/L; similarly, OWT-OB (5.6 (3.5-8.7)) & DysLip (3.4 (2.3-5.0)) but not HypGly were associated with increased for oxidative stress (GGT≥35 IU/L). This study suggests that different cardiometabolic abnormalities have different associations with systemic inflammation & oxidative stress; obesity & dyslipidemia rather than hyperglycemia are more strongly associated with systemic inflammation & oxidative stress in children. Futher study is needed to elucidate gender & age-related differences in these associations.

scholarly journals Role of Apo B and Apo A1 Levels in Relation to Conventional Lipid Profile in Patients of Ischaemic Heart Disease with or without Type II Diabetes Mellitus

2021 ◽  
Author(s):  
Hardik N Javia ◽  
Milav H Bhavsar ◽  
Bhavesh R Sadariya ◽  
Amitkumar V Maheshwari ◽  
Hariom Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type Ii ◽  
Apo B ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Introduction: Ischaemic Heart Disease (IHD) or Coronary Artery Disease (CAD) is the most prevalent chronic disease and the main leading cause of death in the world, with more than half a million newly diagnosed IHD patients each year. Central to this are disorders of lipoprotein metabolism. Apolipoprotein B (Apo B) and Apolipoprotein A1 (Apo A1) are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. Apo B and Apo A1 are among the emerging markers for Cardiovascular Diseases (CVD). Routine conventional lipid profile does not incorporate these markers. Aim: To determine the level of Apo A1 and Apo B in patients of IHD with or without Type II Diabetes Mellitus (T2DM) and analyse the significance of these parameters over the conventional lipid profile. Materials and Methods: The case-control study was conducted at Government Medical College, Bhavnagar, Gujarat, India from July 2013 to December 2013. The study consists of 100 participants including 50 having IHD only (Group I), 50 having IHD with T2DM (Group II) as study groups and 50 healthy individuals (Group III) as control. Various biochemical parameters including Apo B and Apo A1 were analysed and statistically evaluated to come to conclusion. Results: The demographic details of the participants which shows no significant different in age and gender among groups I, II and III. Apo B and A1 were elevated in group I and II and were found highly significant (p-value <0.0001) as compared to the group III. There was positive correlation of serum Apo B levels with total cholesterol (r=0.495, p-value <0.0001), Low-Density Lipoproteins (LDL-C) (r=0.526, p-value <0.0001) and Apo A1 (r=0.685, p-value <0.0001) in group I and LDL-C (r=0.468, p-value=0.001) and Apo A1 (r=0.754, p-value <0.0001) in group II. Similarly, Apo A1 levels were positively correlated with Apo B (r=0.685, p<0.0001) in group I and LDL-C (r=0.305, p-value=0.031) and Apo B (r=0.754, p-value <0.0001) in group II. Conclusion: As the Apo B and Apo A1 cover both atherogenic and antiatherogenic lipid parameters respectively, it can be used as a better predictor of development of IHD with and without T2DM in comparison to conventional parameters of lipid profile.

STUDIES ON APOLIPOPROTEINS (APO A1 & APO B) AND LIPOPROTEIN (A) ALONG WITH LIPID PROFILE IN THE PATIENTS OF TYPE II DIABETES MELLITUS AND METABOLIC SYNDROME

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Arpita Rohit ◽  
N. Haridas
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Apolipoprotein B ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Apo B ◽  
Lipoprotein A ◽  
The Metabolic Syndrome

Patients with Type II diabetes mellitus or the metabolic syndrome have unique dyslipidemia characterized by hypertriglyceridemia; elevated blood levels of apolipoprotein B; small, dense low-density lipoprotein (LDL) cholesterol; and low levels of high-density lipoprotein (HDL) cholesterol. Treatment of dyslipidemia associated with these disorders should focus on correcting the abnormal lipoprotein levels as well as LDL and HDL heterogeneity. Statins and fibrates are useful for treating elevated LDL in patients with and without diabetes or the metabolic syndrome. There are few researches on Apolipoprotein A and Apolipoprotein B, Lipoprotein (a) in India, in comparison to foreign countries. So this study is aimed to evaluate Apo lipoproteins (Apo A1 & Apo B) and Lipoprotein (a) levels along with Lipid profile in Type II Diabetes Mellitus and in patients with Metabolic Syndrome which can be correlated with the risk of cardiovascular disease. Conclusion: Apo lipoprotein A1, Apolipoprotein B and Lipoprotein (a) can be important marker for the risk developing of heart disease. Statistical relationships between LDL and HDL and their respective Apo lipoproteins, Apo B and Apo A-1, in diabetic and metabolic syndrome can be established. Keywords:  Lipid profile, Type II Diabetes Mellitus, Apo lipoproteins (Apo A & Apo B), Lipoprotein (a) and Metabolic Syndrome.

scholarly journals Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl4

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Mohamed M. Hafez ◽  
Othman A. Al-Shabanah ◽  
Naif O. Al-Harbi ◽  
Mohamed M. Al-Harbi ◽  
Salim S. Al-Rejaie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Lipid Profile ◽  
Hepatoprotective Effect ◽  
Paraoxonase 1 ◽  
Antioxidant Genes ◽  
Expression Levels ◽  
Group I ◽  
Genes Expression

Objectives. The purpose of the study is to evaluate the hepatoprotective effect of rutin in carbon tetrachloride- (CCl4-) induced liver injuries in rat model.Methods. Forty male Wistar albino rats were divided into four groups. Group I was the control group and received dimethyl sulphoxide (DMSO) and olive oil. Group II received rutin. Groups III was treated with CCl4. Group IV was administered rutin after 48 h of CCl4treatment. Liver enzymes level, lipid profile, lipid peroxidation, and hydrogen peroxide were measured. The genes expression levels were monitored by real time RT-PCR and western blot techniques.Results. CCl4group showed significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), thiobarbituric acid reactive substances (TBAR), hydrogen peroxide (H2O2), and lipid profile and a significant decrease in glutathione peroxidase (GPx), glutathione S transferase (GST), catalase (CAT), paraoxonase-1 (PON-1), paraoxonase-3 (PON-3), peroxisome proliferator activated receptor delta (PPAR-δ), and ATP-binding cassette transporter 1 (ABAC1) genes expression levels. Interestingly, rutin supplementation completely reversed the biochemical and gene expression levels induced by CCl4to control values.Conclusion. CCl4administration causes aberration of genes expression levels in oxidative stress pathway resulting in DNA damage and hepatotoxicity. Rutin causes hepatoprotective effect through enhancing the antioxidant genes.

scholarly journals Oxidative Stress, Inflammation And Apolipoprotein B (Apo B): Risk Indicators of Cardiovascular Disease in Non Diabetic Obese Males

2017 ◽  
Vol 16 (04) ◽  
pp. 31-39
Author(s):  
Dr. Sucheta Panda ◽  
Dr. Sharmistha Swain ◽  
Dr. Srikrushna Mahapatra ◽  
Dr. Pramila Kumari Mishra ◽  
Dr. Nirupama Devi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Apolipoprotein B ◽  
Risk Indicators ◽  
Apo B

scholarly journals Serum apolipoprotein B increased among tuberculosis patients compared to healthy subjects

2021 ◽  
Vol 40 (1) ◽  
pp. 45
Author(s):  
Augustine Chinedu Ihim ◽  
Samuel Chukwuemeka Meludu ◽  
Charles Chinedum Onyenekwe ◽  
Arthur Ebelenna Anyabolu ◽  
Comfort N Akujiobi
Keyword(s):  
Cardiovascular Disease ◽  
Apolipoprotein B ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Mantoux Test ◽  
Sputum Smear ◽  
Smear Microscopy ◽  
Healthy Controls ◽  
Apo B ◽  
Latent Tb

Background<br />The burden of tuberculosis (TB) and cardiovascular disease (CVD) is enormous worldwide. Public health programs have been challenged with the overlapping of TB and CVD epidemics.Mycobacterium tuberculosis (MTB) is also a main driver of atherogenesis, suggesting a potential pathogenic role of tuberculosis in cardiovascular disease. The objective of this study was to compare the serum levels of apolipoprotein B (apo B), apolipoprotein B48 (apo B48) and apolipoprotein B100 (apo B100) between patients with tuberculosis and healthy subjects. <br /><br />Methods <br />A cross-sectional study was conducted involving 251 subjects consisting of 120 treatment naïve active TB patients [26 HIV co infected (TB+HIV+) and 82 TB+), 12 malaria parasite co-infected (TB+MP+)], 26 latent TB infected (LTB) and 105 healthy controls. Their body mass index (BMI) was calculated. Mycobacterium tuberculosis infection was determined by Ziehl-Nelseen (ZN) sputum smear microscopy and confirmed positive using GeneXpert. Latent TB was determined by Mantoux test, MP was evaluated by microscopy while HIV by immunochromatographic techniques using serial algorithm. Apolipoproteins were determined using spectrophotometry. A one-way ANOVA test and LSD’s post hoc multiple comparisons were used for statistical analyses. <br /><br />Results<br />Significantly lower mean levels of BMI were observed in LTB, TB+, TB+HIV+ and TB+MP+ compared with the controls (p&lt;0.005). The mean serum levels of apo B, apo B48 and B100 were significantly higher in LTB, TB+, HIV+TB+ and TB+MP+ compared with apparently healthy controls (p&lt;0.05). <br /><br />Conclusion <br />Elevated levels of apolipoproteins among infected TB individuals might predispose them to cardiovascular disease.

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