scholarly journals Association Between the Triglyceride Glucose Index and Alanine Aminotransferase Levels: a Cross-sectional Study

2021 ◽  
Author(s):  
Yu Hua ◽  
Haiyue Yu ◽  
Shuang Chen ◽  
Xueyao Zhang ◽  
Xingang Zhang ◽  
...  
Keyword(s):  
Alanine Aminotransferase ◽  
Cardiovascular Health ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: The triglyceride glucose index (TyG) has been proposed as a marker of insulin resistance or type 2 diabetes mellitus (T2DM). Risk of serum alanine aminotransferase (ALT) levels is increased in T2DM patients. We aimed to evaluate the association between TyG index and elevated ALT. Methods: A multicenter, cross-sectional study was conducted in China from Northeast China Rural Cardiovascular Health Study (NCRCHS), and 11,573 adults with complete data were included in our final analysis.Results: TyG index was positively associated with the prevalence of elevated ALT. Frequency of elevated ALT increased from the lowest to the top quartile of TyG in both sexes (p for trend <0.001). Compared with the participants in the lowest quartile of TyG, the adjusted odds ratio and 95% CIs for elevated ALT were 1.71 (1.32-2.21) and 2.46 (1.90-3.19) for those in the third and the fourth quartile of TyG (p<0.001). Compared with the first quartile of TyG, participants in the top quartile of TyG had more than 2 times risk for elevated ALT (2.38-times for men and 2.22-times for women, respectively, p<0.001). According to the ROC analysis, the optimal cut-off point of TyG for elevated ALT was 8.69 and 8.96 for men and women, respectively. Conclusions: TyG index is effective to identify individuals at risk for elevated ALT. TyG thresholds of 8.69 for men and 8.96 for women was highly sensitive for detecting elevated ALT subjects. Findings from this study underscore that TyG index may be suitable as a surrogate marker for abnormal liver enzymes in Chinese adults.

scholarly journals Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

2021 ◽  
Author(s):  
Jin Sun ◽  
Yongkang Su ◽  
Man Li ◽  
Shouyuan Ma ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Mediation Effect ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
The Relationship

Abstract Background and Aims: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Methods and Results： A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

scholarly journals The triglyceride-glucose index (TyG) and Nonalcoholic fatty liver in the Japanese population: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Enqian Liu ◽  
Yaping Weng ◽  
Aiming Zhou ◽  
Chunlai Zeng
Keyword(s):  
Logistic Regression ◽  
Japanese Population ◽  
Inflection Point ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background: Evidences regarding the association between triglyceride-glucose index (TyG) and Nonalcoholic fatty liver (NAFLD) are controversial. Therefore, the goals of this research are to evaluate whether TyG is independently associated with NAFLD and the ability of TyG index to detect NAFLD in the Japanese population. Methods: The present study was a cross-sectional study. The data was downloaded from the DATADRYAD website. A total of 13178 participants was involved in a hospital in Japan from 2004 to 2015. The correlation between TyG and NAFLD was detected by using binary logistic regression and Generalized additive models. The likelihood ration test was used to examine the modification and interaction of subgroups. Furthermore, the ability of TyG to predict NAFLD was evaluated by using receiver operating characteristic (ROC) curves. The formula for the TyG index was ln [fasting triglyceride level (mg / dl) × fasting blood glucose level (mg / dl) / 2] Results: The average age of the selected participants was 43.36±8.89 years old, and about 51.02% of them were male. In fully-adjusted binary logistic regression model, TyG was positively related with the risk of NAFLD (Odds ratio (OR)=2.45, 95%CI 2.12-2.82). The relationship between TyG and NAFLD was a non-linear relationship, and its inflection point was 8.22. The effect sizes and the confidence intervals of the left and right sides of inflection point were 3.26(2.44 - 4.35) and 2.09 (1.72 - 2.54), respectively. By subgroup analysis, the stronger association was found in females, low GGT, non-obesity, non-visceral fat obesity (P for interaction <0.05). Among the total population, the AUC for TyG [0.810 (0.804 - 0.817)] was worse than ALT [ 0.829 (0.822 - 0.835)] but better than TG [ 0.799 (0.792 - 0.805)] and FPG [ 0.715 (0.707 - 0.722)]. A similar result was found for men. In the women, the AUC for the TyG was superior to ALT, FPG, and TG. Conclusion: The association between TyG and NAFLD is non-linear. TyG is stronger positively correlated to the risk of NAFLD when TyG is less than 8.22. TyG is helpful to identify individuals with NAFLD.

scholarly journals A Cross-Sectional Study on the Association between Body Mass Index and Frailty According to Sex in Elderly Patients with Disabilities from an Elderly Day-Care Center

Geriatrics ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Tsuyoshi Asai ◽  
Masanori Wakida ◽  
Ryo Kubota ◽  
Yoshihiro Fukumoto ◽  
Haruhiko Sato ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Elderly Patients ◽  
Body Mass ◽  
Care Center ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Sectional Study ◽  
Cross Sectional

The association between body mass index (BMI) and frailty in elderly patients with disabilities is unclear. We aimed to investigate the association between BMI and frailty in the elderly with disabilities according to sex. This cross-sectional study included 280 elderly patients with disabilities from an elderly daycare center. BMI classification for the Asian population was used to categorize the patients into four groups: underweight, normal, overweight, and obese. Frailty score was based on the phenotypic definition of frailty and consisted of five criteria derived from the revised Japanese version of the Cardiovascular Health Study. Those who had three or more criteria were considered frail. Logistic regression models were constructed to investigate the associations between frailty and BMI in each group (males and females). In females, being underweight was significantly associated with frailty after adjusting for confounders (age and Mini-Mental State Examination score); after adding medical history as a confounder, the aforementioned association was not significant. In males, BMI was not significantly associated with frailty. The association between BMI and frailty differed according to sex among the elderly with disabilities. This finding provides important information regarding frailty risk to workers in daycare facilities.

scholarly journals Mediation Effect of Obesity on the Association Between Triglyceride-glucose Index and Hyperuricemia in Chinese Hypertension Adults.

2021 ◽  
Author(s):  
Jin Sun ◽  
Yongkang Su ◽  
Man Li ◽  
Shouyuan Ma ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Surrogate Marker ◽  
Cross Sectional Study ◽  
Han Chinese ◽  
Mediation Effect ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Relationship Of

Abstract Background: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship of TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Method：A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. Body mass index (BMI), waist (WC) and hip circumference (HC) were regarded as obesity indexes, to evaluate the mediation effect of the association between TyG index and hyperuricemia.Result：The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), the third (8.67-9.07) and the highest quartile (≥9.08) of TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index were associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

scholarly journals Prevalence and determinants of ideal cardiovascular health in a latin women cohort: a cross-sectional study

2021 ◽  
Vol 4 ◽  
pp. 100071
Author(s):  
Mónica Acevedo ◽  
Paola Varleta ◽  
Carolina Casas-Cordero ◽  
Amalia Berríos ◽  
Carlos Navarrete ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health

Abstract P001: LGB Health Disparities: Examining the Status of Ideal Cardiovascular Health From the 2011-2012 NHANES Survey

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Anshul Saxena ◽  
Muni Rubens ◽  
Sankalp Das ◽  
Tanuja Rajan ◽  
Gowtham Grandhi ◽  
...  
Keyword(s):  
Sexual Orientation ◽  
Cardiovascular Health ◽  
Cross Sectional Study ◽  
Minority Populations ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ideal Cardiovascular Health ◽  
The Status ◽  
Nationally Representative ◽  
And Bisexual

Objectives: Extensive data suggests that lesbian, gay and bisexual (LGB) adults are more likely to experience adverse cardiovascular outcomes relative to heterosexuals. However, evidence regarding cardiovascular health (CVH) disparities and sexual orientation is scarce. The aim of this study was to examine the distribution of CVH metrics in a US nationally representative population of heterosexual (HT), and LGB adults. Methods: This cross-sectional study analyzed 2445 participants (representing 115 million) adults aged 18 or over years in the 2011-2012 NHANES survey. The CVH factors of smoking, body mass index (BMI), physical activity (PA), diet, blood pressure (BP), total cholesterol (TC) and glucose (GLU) were measured. Each CVH factor was then classified as ideal; intermediate; or poor. Ideal CVH was defined as presence of >=5 ideal CVH metrics. Results: 95.1% of the weighted sample self-identified as HT (95% CI: 93.5%, 96.6%) compared to 4.9% (95%: 3.3%, 6.5%) LGB. The figure illustrates the distribution of each of the 7 CVH categories according to sexual orientation. In age, gender, and race adjusted analysis, LGB individuals were 36% (AOR: 0.64; 95%: 0.29, 1.4; p > 0.05) less likely to have ideal CVH compared to HT. These proportions go higher after adjusting for age. Conclusions: The results suggest that LGB individuals face a higher risk of being in the category for poor cardiovascular health compared to heterosexuals. Evidence suggests that there are sexual orientation disparities among adults. If confirmed in other studies, results point towards disproportionately higher risk for cardiovascular disease among sexual-minority populations. Figure

scholarly journals Relationship between Ratio of Second and Fourth Digit and Obesity Traits among Different Ethnic Groups in Ilorin, North Central Nigeria

2016 ◽  
Vol 8 (4) ◽  
pp. 396-400 ◽  
Author(s):  
Bolaji Fatai OYEYEMI ◽  
John Oluwafemi ADEBAYO ◽  
Abass Toba ANIFOWOSHE ◽  
Oluyinka Ajibola IYIOLA
Keyword(s):  
Ethnic Groups ◽  
Pearson Correlation ◽  
Standard Procedure ◽  
Surrogate Marker ◽  
Relative Length ◽  
Cross Sectional Study ◽  
Digit Ratio ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference

Digit ratio (2D:4D) denotes the relative length of the second and fourth digits. There are contradicting reports on its relationship with ethnicity/race, whereas convincing studies show it is related to obesity. This cross-sectional study was undertaken to demystify ethnic difference in 2D:4D ratio and to analyze its relationship with obesity among adults in Ilorin Nigeria. The cross-sectional study included 701 individuals. Finger lengths were measured with electronic calipers and other anthropometric traits were measured with standard procedure. Student t test and one-way ANOVA were used to detect differences among groups and relationship was computed with Pearson correlation. The receiver operator characteristic curves were used to detect the diagnostic effect of 2D:4D for obesity. The obtained results showed sexual dimorphism in 2D:4D ratio and other anthropometrics at p < 0.01. Obesity was associated with significantly higher mean of 2D:4D in both genders (female 0.9814 ± 0.012:0.9700 ± 0.012; male 0.9700 ± 0.010:0.9592 ± 0.010 at p < 0.001). The area under the curve was 0.753 (95% CI 0.677-0.829, p < 0.01) and 0.798 (95% CI 0.756-0.804, p < 0.01) in female and male R2D:4D respectively for obesity, implying that 2D:4D might be a surrogate marker for obesity in future.  No significant difference was found in 2D:4D among different ethnic groups studied (p >0.05); this result proved that there was no ethnic specificity in 2D:4D ratio among study’ participants. Thus, it can be reported that the digit ratio was related to high 2D:4D, but this cannot be said for different ethnic groups. The results imply that 2D:4D might be a good surrogate indicator for obesity, but not ethnicity.  

scholarly journals Are soluble ST2 levels influenced by vitamin D and/or the seasons?

2019 ◽  
Vol 8 (6) ◽  
pp. 691-700
Author(s):  
Vito Francic ◽  
Martin Keppel ◽  
Verena Schwetz ◽  
Christian Trummer ◽  
Marlene Pandis ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Risk ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Disease Manifestation ◽  
Cross Sectional ◽  
Soluble St2 ◽  
Vitamin D Levels ◽  
Cardiovascular Biomarker

Objective Cardiovascular disease manifestation and several associated surrogate markers, such as vitamin D, have shown substantial seasonal variation. A promising cardiovascular biomarker, soluble ST2 (sST2), has not been investigated in this regard – we therefore determined if systemic levels of sST2 are affected by seasonality and/or vitamin D in order to investigate their clinical interrelation and usability. Design sST2 levels were measured in two cohorts involving hypertensive patients at cardiovascular risk, the Styrian Vitamin D Hypertension Trial (study A; RCT design, 8 weeks 2800 IU cholecalciferol daily) and the Ludwigshafen Risk and Cardiovascular Health Study (LURIC; study B; cross-sectional design). Methods The effects of a vitamin D intervention on sST2 levels were determined in study A using ANCOVA, while seasonality of sST2 levels was determined in study B using ANOVA. Results The concentrations of sST2 remained unchanged by a vitamin D intervention in study A, with a mean treatment effect (95% confidence interval) of 0.1 (−0.6 to 0.8) ng/mL; P = 0.761), despite a rise in 25(OH)D (11.3 (9.2–13.5) ng/mL; P < 0.001) compared to placebo. In study B, seasonal variations were present in 25(OH)D levels in men and women with or without heart failure (P < 0.001 for all subgroups), while sST2 levels remained unaffected by the seasons in all subgroups. Conclusions Our study provides the first evidence that systemic sST2 levels are not interrelated with vitamin D levels or influenced by the seasons in subjects at cardiovascular risk.

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