Immunotherapy Using HistobulinTM In Psoriasis: A Case Report

2021 ◽  
Author(s):  
Hyuk Soon Kim ◽  
Geunwoong Noh
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Skin Biopsy ◽  
Clinical Symptoms ◽  
Psoriasis Patient ◽  
Basic Research ◽  
Case Presentation ◽  
The Third ◽  
Skin Manifestations ◽  
Symptoms And Signs

Abstract Background: There is no cure for psoriasis. Early treatment using biologics is recommended to improve skin manifestations and reduce systemic inflammation, which leads to comorbidities in various organs.Case Presentation: HistobulinTM therapy was performed on a psoriasis patient who developed the disorder due to allergic rhinitis. Psoriasis was confirmed pathologically by skin biopsy. The patient responded rapidly, and the skin manifestations began to improve after just the first injection. Although the patient showed some temporary aggravation after the third injection, the clinical symptoms and signs improved continuously thereafter and disappeared after the eighth injection. Remission was induced and was evident when the patient showed no symptoms and signs during the subsequent 4 weeks during which time the patient received 4 more injections; afterwards, HistobulinTM therapy was ceased. After treatment, psoriasis did not recur for more than 6 months.Conclusions: HistobulinTM is effective and induces remission in psoriasis patients. HistobulinTM is suggested for curative therapeutics in psoriasis patients, and further basic research and clinical evaluation are necessary.

scholarly journals Pregnancy with Atypical Pulmonary Tuberculosis During the COVID-19 Outbreak: A Case Report

2021 ◽  
Author(s):  
Ai-Ping ZHANG ◽  
Manman Liang ◽  
Zijian Wang ◽  
Weishun Hou ◽  
Jianghua Yang
Keyword(s):  
Case Report ◽  
Pulmonary Tuberculosis ◽  
Clinical Symptoms ◽  
Delayed Diagnosis ◽  
Third Trimester ◽  
Case Presentation ◽  
The Third ◽  
Standardized Treatment ◽  
Clinical Awareness ◽  
Physiological Reactions

Abstract Background: During pregnancy, due to reduced immunological resistance, the probability of tuberculosis infection is increased, easily leading to the occurrence of tuberculosis; thus, pregnancy with tuberculosis is a risk to the health of pregnant women with infectious diseases. However, the clinical symptoms of pregnancy with pulmonary tuberculosis are atypical, often confused with the physiological reactions of pregnancy, and there is a lack of clinical awareness, especially in the context of the global COVID-19 pandemic. Specifically, atypical lung lesions are prone to misdiagnosis or delayed diagnosis.Case presentation: A 21-year-old woman was infected with Mycobacterium tuberculosis during the third trimester of pregnancy. The diagnosis and treatment of the patient are reported.Conclusion: The interaction between tuberculosis and pregnancy is a double-edged sword. Increasing awareness of tuberculosis among doctors is essential, and early diagnosis and standardized treatment are key to improving the outcome of pregnancy.

scholarly journals Chilaiditi Syndrome: A Case Report Highlighting the Intermittent Nature of the Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Esha M. Kapania ◽  
Christina Link ◽  
Joshua M. Eberhardt
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Clinical Symptoms ◽  
Case Reports ◽  
Delayed Diagnosis ◽  
Spontaneous Resolution ◽  
Radiographic Evidence ◽  
Case Presentation ◽  
Chilaiditi Syndrome

Background. Chilaiditi syndrome is a phenomenon where there is an interposition of the colon between the liver and the abdominal wall leading to clinical symptoms. This is distinct from Chilaiditi sign for which there is radiographic evidence of the interposition, but is asymptomatic. Case Presentation. Here, we present the case of a patient who, despite having clinical symptoms for a decade, had a delayed diagnosis presumably due to the interposition being intermittent and episodic. Conclusions. This case highlights the fact that Chilaiditi syndrome may be intermittent and episodic in nature. This raises an interesting question of whether previous case reports, which describe complete resolution of the syndrome after nonsurgical intervention, are perhaps just capturing periods of resolution that may have occurred spontaneously. Because the syndrome may be intermittent with spontaneous resolution and then recurrence, patients should have episodic follow-up after nonsurgical intervention.

scholarly journals Case report: a 5-year-old with new onset nephrotic syndrome in the setting of COVID-19 infection

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kelsi M. Morgan ◽  
Peace D. Imani
Keyword(s):  
Nephrotic Syndrome ◽  
Case Report ◽  
Pediatric Patient ◽  
Corticosteroid Therapy ◽  
Clinical Remission ◽  
Laboratory Findings ◽  
Case Presentation ◽  
The Third ◽  
First Case ◽  
New Onset

Abstract Background This is a case report of an asymptomatic SARS-CoV-2 infection associated with new-onset nephrotic syndrome in a pediatric patient. This is the third case of new-onset nephrotic syndrome in children associated with SARS-CoV-2 infection, but is the first case report describing a new-onset nephrotic syndrome presentation in a patient who had asymptomatic COVID-19 infection. Case presentation This is a case of a previously healthy 5 year old female who presented with new-onset nephrotic syndrome in the setting of an asymptomatic COVID-19 infection. She presented with progressive edema, and laboratory findings were significant for proteinuria and hypercholesterolemia. She was treated with albumin, diuretics, and corticosteroid therapy, and achieved clinical remission of her nephrotic syndrome within 3 weeks of treatment. Though she was at risk of hypercoagulability due to her COVID-19 infection and nephrotic syndrome, she was not treated with anticoagulation, and did not develop any thrombotic events. Conclusions Our case report indicates that SARS-CoV-2 infection could be a trigger for nephrotic syndrome, even in the absence of overt COVID-19 symptoms.

scholarly journals Isolated nausea and vomiting as the cardinal presenting symptoms of clozapine-induced myocarditis: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
M. Z. van der Horst ◽  
F. van Houwelingen ◽  
J. J. Luykx
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Clinical Symptoms ◽  
Early Recognition ◽  
Nausea And Vomiting ◽  
Resonance Imaging ◽  
Treatment Resistant ◽  
Laboratory Examination ◽  
Case Presentation ◽  
Presenting Symptoms

Abstract Background Clozapine is an atypical antipsychotic proven to be superior in the treatment of treatment-resistant schizophrenia. Myocarditis is a rare, but well-known complication of treatment with clozapine. Only few cases have been reported in which nausea and vomiting were prominent symptoms. This is the first described report in which nausea and vomiting were the only presenting symptoms of clozapine-induced myocarditis. Case presentation We report a case of a 58-year-old woman, suffering from schizoaffective disorder, who is being treated with clozapine. Two weeks after initiation of clozapine, she developed nausea and vomiting, in absence of any other clinical symptoms. Laboratory examination and magnetic resonance imaging confirmed the diagnosis of clozapine-induced myocarditis. Clozapine was discontinued and the patient recovered fully. Conclusions This case emphasizes the importance of recognizing myocarditis as a cause of isolated nausea and vomiting in patients treated with clozapine. Early recognition improves clinical outcome and reduces mortality.

scholarly journals A man with recurrent fever, arthritis, and rashes-brucellosis? A case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Wang ◽  
Xu Lu ◽  
Chengbo Li ◽  
Myong Jun Ri ◽  
Wei Cui
Keyword(s):  
Infectious Disease ◽  
Bone Marrow ◽  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Skin Biopsy ◽  
Rare Case ◽  
Glucocorticoid Therapy ◽  
Recurrent Fever ◽  
Neutrophilic Dermatosis ◽  
Case Presentation

Abstract Background We report a rare case of chronic brucellosis accompanied with myelodysplastic syndrome and neutrophilic dermatosis, which to the best of our knowledge, has never been reported. Case presentation A young man was admitted to our hospital complaining of recurrent fever, arthritis, rashes and anemia. He had been diagnosed with brucellosis 6 years prior and treated with multiple courses of antibiotics. He was diagnosed with myelodysplastic syndrome and neutrophilic dermatosis following bone marrow puncture and skin biopsy. After anti-brucellosis treatment and glucocorticoid therapy, the symptoms improved. Conclusions Clinicians should consider noninfectious diseases when a patient who has been diagnosed with an infectious disease exhibits changing symptoms.

scholarly journals An itchy erythematous papular skin rash as a possible early sign of COVID-19: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Alice Serafini ◽  
Peter Konstantin Kurotschka ◽  
Mariabeatrice Bertolani ◽  
Silvia Riccomi
Keyword(s):  
Case Report ◽  
Skin Rash ◽  
Early Stage ◽  
Situational Factors ◽  
Intermittent Fever ◽  
Case Presentation ◽  
Case Identification ◽  
Skin Manifestations ◽  
Remote Assessment ◽  
Multiple Patients

Abstract Background Several recent studies suggest the possibility of a skin rash being a clinical presentation of coronavirus disease 2019 (COVID-19). The purpose of this case report is to bring attention to skin manifestations in the early stage of COVID-19 in order to support frontline physicians in their crucial activity of case identification. Case presentation The patient is an Italian 32-year-old female nurse who had several close contacts with multiple patients with COVID-19 as part of her professional workload. On March 13, 2020, the patient developed an itchy, erythematous papular rash (sparing only her face, scalp, and abdomen), which lasted for 10 days. The rash was accompanied by a feeling of general fatigue that gradually worsened over the following days and has continued for 5 months (until the end of July 2020). During the first week of remote assessment carried out by her general practitioner, the patient gradually developed a dry cough, intermittent fever, and diarrhoea and then had a positive test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Her skin manifestations disappeared completely 48 days after the onset of the disease, followed by the disappearance of the dry cough. Conclusions In light of recent studies, this case report suggests that skin manifestations, when taken into account with other situational factors (such as profession and patient history) should be taken into proper consideration by frontline physicians as possibly being caused by SARS-CoV-2. Early identification of COVID-19 is a key part of the strategy of case detection and case isolation. To enhance this activity, further research is needed to establish frequency, symptoms, signs, and pathogenesis of skin manifestations in patients with COVID-19.

scholarly journals COVID vaccine related lower limb gangrene: the first case report

2021 ◽  
Vol 8 (10) ◽  
pp. 3204
Author(s):  
Nishant Lal ◽  
Shafy Ali Khan ◽  
Aiswarya R. Pillai ◽  
Shafy Ali Khan
Keyword(s):  
Case Report ◽  
Lower Limb ◽  
Arterial Thrombosis ◽  
Clinical Symptoms ◽  
Limb Ischemia ◽  
Lower Limb Ischemia ◽  
First Case ◽  
Symptoms And Signs

Though there have been multiple cases of arterial thrombosis and gangrene of limbs reported following COVID-19 infections, there has not been any case reported following COVID-19 vaccinations. Here we reported a case of acute lower limb ischemia following COVID-19 vaccination in a 32 year male with no co-morbidities. The clinical symptoms and signs related to lower limb ischemia started 2 weeks after COVID-19 vaccination. Despite anticoagulation, thrombo embolectomy and intraluminal catheter guided thrombolysis, patient’s left forefoot became gangrenous and had to be amputated.

TRICHILEMMAL CYST OF THE THIRD FINGERTIP: A CASE REPORT

Hand Surgery ◽  
2014 ◽  
Vol 19 (01) ◽  
pp. 131-133 ◽  
Author(s):  
Cenk Melikoglu ◽  
Fikret Eren ◽  
Barış Keklik ◽  
Cem Aslan ◽  
Mustafa Sutcu ◽  
...  
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Hair Follicles ◽  
Nodular Lesion ◽  
Case Presentation ◽  
The Third ◽  
Trichilemmal Cyst ◽  
Common Skin

Introduction: Trichilemmal cysts (TCs) are common skin lesions that occur in hairy areas. A TC involving a fingertip has not been previously described in the literature. We herein report a case of a TC occupying a fingertip region. Case presentation: A 43-year-old woman presented with a 1.5 × 1.5 cm nodular lesion on the third fingertip. The lesion was completely excised, and histopathological examination revealed a TC. Conclusion: TCs may involve atypical locations, such as fingertips, where there are no hair follicles. After surgical excision, a careful histopathological examination should be performed to differentiate TCs from proliferating pilar tumors.

scholarly journals First report of Bickerstaff’s brainstem encephalitis caused by Salmonella Dublin: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiangbo Xie ◽  
Tingting Zhang ◽  
Tao Liu
Keyword(s):  
Case Report ◽  
Clinical Symptoms ◽  
Invasive Infection ◽  
Suspected Case ◽  
Brainstem Encephalitis ◽  
Limb Weakness ◽  
Case Presentation ◽  
Salmonella Dublin ◽  
First Case ◽  
Bickerstaff’S Brainstem Encephalitis

Abstract Background Diseases caused by nontyphoid Salmonella can range from mild, to self-limiting gastroenteritis and severe invasive infection. Relatively rarely, Salmonella may cause severe encephalopathy. Case presentation We report a suspected case of Bickerstaff’s brainstem encephalitis caused by Salmonella Dublin. A young man presented with impaired consciousness, ataxia, dysarthria, limb weakness, and restricted eyeball abduction. His clinical symptoms were consistent with Bickerstaff’s brainstem encephalitis. Conclusions This is the first case report of Bickerstaff’s brainstem encephalitis caused by Salmonella Dublin in the literature. After treatment, he recovered and was discharged. Early antibiotic treatment of sepsis may control the disease and avoid serious encephalopathy.

scholarly journals Pregnancy With Atypical Pulmonary Tuberculosis in COVID-19 Outbreak:A Case Report

2021 ◽  
Author(s):  
Aiping ZHANG ◽  
Manman Liang ◽  
Zijian Wang ◽  
Weishun Hou ◽  
Jianghua Yang
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Pulmonary Tuberculosis ◽  
Infectious Diseases ◽  
Clinical Symptoms ◽  
Third Trimester ◽  
The Third ◽  
Standardized Treatment ◽  
Clinical Awareness ◽  
Physiological Reactions

Abstract BackgroundPregnant women due to reduced resistance, the probability of tuberculosis infection increased, easy to lead to the occurrence of tuberculosis, so pregnancy with tuberculosis is a risk to the health of pregnant women infectious diseases. However, the clinical symptoms of pregnancy with pulmonary tuberculosis are atypical, confused with the physiological reactions of pregnancy, and lack of clinical awareness, especially under the influence of the global COVID-19 epidemic, lung atypical lesions are prone to misdiagnosis or delayed diagnosis.Case presentationA 21-year-old woman was infected with Mycobacterium tuberculosis during the third trimester of pregnancy. The diagnosis and treatment of the patient were reported.ConclusionThe interaction between tuberculosis and pregnancy is like a double-edged sword. Reaising doctors’awareness on tuberculosis is fundamental, and early diagnosis and standardized treatment are the key to improve the outcome of pregnancy.

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