scholarly journals Extraction, Biological Activity, Formulation, and Evaluation of Bitter Herbs as Anti-Nail-Biting Lacquers

2021 ◽  
Author(s):  
Chutima Limmatvapirat ◽  
Sontaya Limmatvapirat ◽  
Siraprapa Chansatidkosol ◽  
Wantanwa Krongrawa ◽  
Napasorn Liampipat ◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Herbal Extracts ◽  
Film Property ◽  
Drying Time ◽  
Nail Biting ◽  
Film Forming ◽  
Human Volunteers ◽  
Phytochemical Constituents

Abstract Background: Nail biting can increase the risk of infection and abnormal-looking nails. The purpose of the present investigation was to formulate and evaluate anti-nail-biting lacquers consisting of bitter herbal extracts. Methods: The hydroalcoholic extracts obtained from Andrographis paniculata and Tinospora crispa were determined for phytochemical constituents, total phenolic contents, antioxidant activities, anti-inflammatory activities, and cytotoxicities. Anti-nail-biting lacquers were prepared by using herbal extracts (bittering agent), shellac (film forming polymer), ethanol (volatile solvent), and other indispensable additives with continuous stirring. Thus, attempts to enhance the film property and bitterness is accomplished by using polyvinylpyrrolidone K30 as a copolymer and varying concentrations of herbal extracts. Good accepted formulations were established for drying time, pH, viscosity, smoothness of film, film strength, water resistant, and solubility in simulated saliva and then evaluated their bitterness in human volunteers.Results: Phytochemical constituents including tannins, glycosides, reducing sugars, alkaloids, terpenoids, and flavonoids were found present in both extracts while saponins was only detected in A. paniculata extract. Although T. crispa extract exhibited a significantly higher (p < 0.05) total phenolic content and antioxidant activity than A. paniculata extract, it showed lower protein denaturation inhibition property than A. paniculata extract. Because of the potentials of both extracts without cytotoxicity, anti-nail-biting lacquers containing either A. paniculata extract or T. crispa extract were developed and evaluated. Drying time of formulations were 6-11 min with visually seen glossiness of formulation. Formulations of the nail lacquer showed good pH, viscosity, smoothness of film, film strength, water resistant, and solubility in simulated saliva. The formulations displaying no significant cytotoxicity effect on CRL-2076 cells were assessed on healthy human volunteers to compare bitterness and film characteristics. Conclusion: The optimized formulation containing A. paniculata extract could successfully achieve good film forming property and bitterness release which is considered promising for stopping nail biting.

scholarly journals Preparation and Properties of Anti-Nail-Biting Lacquers Containing Shellac and Bitter Herbal Extract

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Chutima Limmatvapirat ◽  
Sontaya Limmatvapirat ◽  
Siraprapa Chansatidkosol ◽  
Wantanwa Krongrawa ◽  
Napasorn Liampipat ◽  
...  
Keyword(s):  
Protein Denaturation ◽  
Herbal Extract ◽  
Total Phenolic ◽  
Herbal Extracts ◽  
Film Property ◽  
Drying Time ◽  
Nail Biting ◽  
Film Forming ◽  
Human Volunteers ◽  
Phytochemical Constituents

The purpose of the present investigation was to formulate and evaluate anti-nail-biting lacquers consisting of bitter herbal extracts. The hydroalcoholic extracts obtained from Andrographis paniculata and Tinospora crispa were determined for phytochemical constituents, total phenolic contents, antioxidant activities, anti-inflammatory activities, and cytotoxicities. Anti-nail-biting lacquers were prepared by using herbal extracts (bittering agent), shellac (film forming polymer), ethanol (volatile solvent), and other indispensable additives with continuous stirring. Thus, attempts to enhance the film property and bitterness are accomplished by using polyvinylpyrrolidone (PVP K30) as a copolymer and varying concentrations of herbal extracts. Good accepted formulations were established for drying time, pH, viscosity, smoothness of film, film strength, water resistant, and solubility in simulated saliva and evaluated their bitterness in human volunteers. The results revealed that phytochemical constituents including tannins, glycosides, reducing sugars, alkaloids, terpenoids, and flavonoids were found present in both extracts while saponins were only detected in A. paniculata extract. Although T. crispa extract exhibited a significantly higher ( p < 0.05 ) total phenolic content and antioxidant activity than A. paniculata extract, it showed lower protein denaturation inhibition property than A. paniculata extract. Because of the potentials of both extracts without cytotoxicity, anti-nail-biting lacquers containing either A. paniculata extract or T. crispa extract were developed and evaluated. Drying time of formulations was 6-11 min with visually seen glossiness of formulation. Formulations of the nail lacquer showed good pH, viscosity, smoothness of film, film strength, water resistant, and solubility in simulated saliva. The formulations displaying no significant cytotoxicity effect on CRL-2076 cells were assessed on healthy human volunteers to compare bitterness and film characteristics. The results revealed that the optimized formulation containing A. paniculata extract could successfully achieve good film forming property and bitterness release which is considered promising for stopping nail biting.

scholarly journals Phytochemical assessment of Iphiona aucheri (Bioss.) Anderb. and its cytotoxic, antioxidant and antidiabetic activities

2020 ◽  
Vol 49 (4) ◽  
pp. 913-918
Author(s):  
Muhammad Abdur Rehman Shah ◽  
Rahmat Ali Khan ◽  
Mushtaq Ahmed
Keyword(s):  
Brine Shrimp ◽  
Methanolic Extract ◽  
Antioxidant Activities ◽  
Hexane Fraction ◽  
Total Phenolic ◽  
Aqueous Fraction ◽  
Phenolic Contents ◽  
Total Phenolic Contents ◽  
Total Antioxidant ◽  
Phytochemical Constituents

The presence of phytochemical constituents and estimation of total phenolic contents in Iphiona aucheri (Bioss.) Anderb. stem and assessment of their cytotoxic, total antioxidant and anti-diabetic activity were investigated. All fractions were assessed for phytochemicals, cytotoxic activity, total phenolic contents, antioxidant and anti-diabetic characteristics. Saponins, glycosides, protein and amino acids, carbohydrates and flavonoids were found in aqueous fraction and methanolic extract while they were absent in n-hexane fraction except glycosides and protein. The crude methanolic extract (70.3 ± 1.9%) revealed highest brine shrimp mortalities. Except n-hexane fraction others indicated considerable antioxidant activities via DPPH, ABTS•+ and H2O2 assays. Crude methanolic extract expressed higher inhibition of α-amylase (60.71 ± 0.89%) than glucophage (54.92 ± 0.56%). Non significant correlation of total phenolic contents with percentage antioxidant and anti-diabetic activities of crude methanolic extract and its various fractions was observed in all cases.

scholarly journals Effects of Pretreatments and Drying Temperatures on Drying Characteristics, Antioxidant Properties and Color of Ginger Slice

2014 ◽  
Vol 62 (5) ◽  
pp. 1125-1134 ◽  
Author(s):  
Ratiya Thuwapanichayanan ◽  
Charotorn Phowong ◽  
Donludee Jaisut ◽  
Jiří Štencl
Keyword(s):  
Ascorbic Acid ◽  
Acid Solution ◽  
Antioxidant Activities ◽  
Antioxidant Properties ◽  
Color Difference ◽  
Total Phenolic ◽  
Drying Time ◽  
Drying Characteristics ◽  
Ascorbic Acid Solution ◽  
Total Color Difference

To reduce the adverse effects of hot air drying, ginger slices were pretreated prior to drying. The effects of 2 pretreatment methods (blanching versus dipping in 0.1% ascorbic acid solution) and drying temperatures (60, 70 and 80 °C) on the drying characteristics and the qualities of the dried ginger slices in terms of total phenolic content (TPC), antioxidant activities (DPPH and ABTS methods) and color were investigated. It was noted that the moisture content for both un-pretreated and pretreated samples decreased more rapidly when drying was performed at higher drying temperatures. However, the drying time of un-pretreated and pretreated samples was not significantly different. The TPC and antioxidant activities of the ginger slices increased markedly after drying. The increase in these values was higher for pretreated samples. The dried ascorbic acid solution dipped sample exhibited the highest values of TPC and antioxidant activity. Moreover, the total color difference of the ascorbic acid solution dipped ginger was slightly lower than the total color difference of the un-pretreated ginger. However, the tested drying temperatures, ranging from 60 to 80 °C, did not affect the final TPC, antioxidant activities, and color of the ginger samples.

scholarly journals Impact of Roasting to Total Phenolic, Flavonoid and Antioxidant Activities in Root, Bark and Leaf of Polyscias fruticosa

2020 ◽  
pp. 13-17
Author(s):  
Minh Phuoc Nguyen
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Root Bark ◽  
Antioxidant Power ◽  
Medical Plant ◽  
Ferric Reducing Antioxidant Power ◽  
Phytochemical Constituents ◽  
Radical Scavenging Ability ◽  
The Stability

Polyscias fruticosa belongs to Araliaceae family widely cultivated in Vietnam. It is a medical plant highly valued recently owing to its diversified therapeutic functions. It’s exploited in all parts including root, bark and leaf for medicinal purposes. In the herbal tea production, the final step is normally ended with the roasting in order to improve its flavor and aroma. There’s a concern about the detrimental effect of thermal roasting to the stability of phytochemical constituents. In this research, we attempted to evaluate the reduction of total phenolic (mg GAE/100 g), total flavonoid (mg QE/100 g), DPPH radical-scavenging ability (mM TE/100 g), FRAP ferric reducing antioxidant power assay (mM TE/100 g) in root, bark and leaf of Polyscias fruticosa under different roasting conditions. All samples were steamed in vapor for 30 seconds before being dried by convective dryer at 45°C for 6 hours to final moisture content around 12%. Then these samples would be roasted in different conditions (125/15; 130/12, 135/9, 140/6, 145/3, °C/minutes). Our results revealed that roasting at 135/9°C/minutes was appropriate to preserve the most phytochemical constituents.

Comparative Studies on the Phytochemical Constituents and in vitro Antioxidant Activities of Methanol and Ethyl Acetate Leaf Extracts of Talium Trangulare

2021 ◽  
Vol 7 (1) ◽  
pp. 18-23
Author(s):  
Oyedotun Oyeleke ◽  
Mutiat Bamigboye ◽  
Boyede Olowookere ◽  
Kehinde Alabi ◽  
Samuel Oladele ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Comparative Studies ◽  
Methanol Extract ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Leaf Extracts ◽  
Phytochemical Content ◽  
Phytochemical Constituents

Medicinal herbs have been known for their use as an alternative medicine in the management and treatment of different categories of diseases. The present study was designed to assess the phytochemical constituents present in methanol and ethylacetate leaves extract of Talium trangulare and its antioxidant potentials against free radicals comparatively. The functional groups of the phytochemicals were carried out using FTIR techniques while the phytochemical component of the extract was determined by standard methods. The comparative studies of antioxidant abilities of methanol and ethylacetate leaves extracts of Talium trangulare were evaluated by various antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide, hydroxyl radicals, scavenging activities. These different antioxidant activities were compared with standard antioxidants compounds such as ascorbic acid and Gallic acid. The total phenolic content in ethylacetate extract is higher than what was obtained from methanol extract of Talium trangulare, however, methanol extract has higher tannins and flavonoids content. The methanol extract was found to have demonstrated high reduction capability and powerful free radical scavenging, especially against DPPH radical and hydrogen peroxide as compared with the ethylacetate leaves extract. The results that was obtained in the present study clearly established the antioxidant potency of both ethylacetate and methanol leaf extracts of Talium trangulare. The methanol extract shows better antioxidant activities and more flavonoids and tannin than the ethylacetate extract. In conclusion, the methanol leaf extract of Talium trangulare has comparatively better in vitro antioxidant potentials with corresponding phytochemical content than ethylacetate extract.

Comparative Study of Antioxidant Activities and Total Phenolic Content of Selected Edible Wild Mushrooms

2011 ◽  
Vol 13 (3) ◽  
pp. 245-255 ◽  
Author(s):  
Hip Seng Yim ◽  
Fook Yee Chye ◽  
Mee Yee Lee ◽  
Patricia Matanjun ◽  
Siew Eng How ◽  
...  
Keyword(s):  
Comparative Study ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Wild Mushrooms ◽  
Edible Wild Mushrooms

Phytochemical composition and antioxidant activity of Malus baccata (L.) Borkh. fruits

2020 ◽  
Vol 3 (1) ◽  
pp. 47
Author(s):  
Nadezhda Petkova ◽  
Manol Ognyanov ◽  
Blaga Inyutin ◽  
Petar Zhelev ◽  
Panteley Denev
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Activities ◽  
Ethanol Extract ◽  
Titratable Acidity ◽  
Total Phenolic ◽  
Total Phenolic Compounds ◽  
Frap Assay ◽  
Phytochemical Composition ◽  
Malus Baccata

Crab apple (Malus baccata (L.) Borkh.) was mainly distributed in Europe as an ornamental plant, but the nutritional properties of its edible fruits were not fully revealed. The aim of the current study was to characterize the phytochemical composition of ripen carb apple fruits and to evaluate their nutritional and antioxidant potentials. The fruits were assayed for moisture and ash content, proteins, lipids, carbohydrates, titratable acidity (TA), pH, total phenolic compounds and natural pigments. Among the analyzed carbohydrates cellulose was found in the highest content (6% dw), followed by sugars (sucrose, glucose and fructose) and 1.8 % dw uronic acids. The total chlorophylls and carotenoids contents in their fruits were 6.51 and 4.80 μg/g fw, respectively. Total monomeric anthocyanins were not detected. The highest content of total phenolic compounds (2.67 mg GAE/g fw) was found in 95 % ethanol extract from fruits, while the total flavonoids were relatively low – 0.1 mg QE/g fw. DPPH assay (17.27 mM TE/g fw) and FRAP assay (14.34 mM TE/g fw) demonstrated in vitro antioxidant activities of crabapple. Malus baccata fruits were evaluated as a rich source of dietary fibers and phenolic compounds with significant antioxidant potential that could be used in human nutrition.

SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN DAN ANTITUMOR 20 TUMBUHAN OBAT ASAL KABUPATEN MANOKWARI

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Bimo Budi Santoso
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Antitumor Activity ◽  
Traditional Method ◽  
Extraction Efficiency ◽  
Phenolic Content ◽  
Antioxidant Activities ◽  
Total Phenolic ◽  
Phenolic Contents ◽  
Total Phenolic Contents

<strong><em>Flavanoid, steroid, and terpenoid contents of 20 Manokwari medicinal plants were analyzed.  The antioxidant activity, total phenolic contents and antitumor activity of 20 Manokwari medicinal plants were also evaluated. The result shows that 83% positif to flavanoid test, 59% positif to terpenoid test and only 25% positif steroid. Antioxidant activity and total phenolic contents evaluated using Ferric Thiocianate (FTC) and Folin-Ciocalteu methods respectively. Antioxidant activity and total phenolic contents of medicinal plants were extracted by the traditional method, boiling in water and also in 80% methanol. Twenty plants evaluated in both exstracts have significantly varies of antioxidant activities and phenolic contents,  A significant and linier correlation coefficient between the antioxidant activity and the total phenolic content was found in both aqueous (R<sup>2</sup>= 0,77) and methanol (R<sup>2</sup> = 0,85). Antitumor activity was tested using cell maurine P-388 and only 2 of medicinal plants are active to inhibit cell maurine P-388. Comparing extraction efficiency of the two methods, the methanol extracted phenolic compounds more efficiently, and antioxidant activity of the extract was higher.</em></strong>

Survey of Chinese Cowpea Cultivars for Phenolic Compounds and Antioxidant Activity

2018 ◽  
Vol 17 (4) ◽  
pp. 337-348
Author(s):  
Bai Zhouya ◽  
Huang Xiaojun ◽  
Meng Jinxia ◽  
Kan Lijiao ◽  
Nie Shaoping
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Content ◽  
Antioxidant Activities ◽  
Jiangxi Province ◽  
Total Phenolic ◽  
Total Flavonoid Content ◽  
Flavonoid Content ◽  
Comprehensive Investigation ◽  
Cowpea Cultivars ◽  
P Distribution

Distribution of phenolic compounds and antioxidant activities was surveyed in 24 varieties of Chinese cowpea from 4 provinces. Identity of phytochemicals were determined by UPLC-ESIQTOF-MS/MS and quantified by HPLC-ESI-QqQ-MS/MS. Seven phenolic acids, 16 flavonoids and 9 other compounds were identified and several of these were quantified. Quercetin-3-glucoside and kaempferol-glucoside were the major phenolic compounds. In addition, our study indicated that OJYDH cultivar from Jiangxi province had the highest total phenolic content, total flavonoid content and stronger antioxidant activities than other cowpea cultivars. This study made a comprehensive investigation on antioxidants from cowpea and provided the useful data to support its function.

Sign in / Sign up

Export Citation Format

Share Document