scholarly journals Low manganese and high iron levels in amniotic fluid correlate with fetal chromosomal abnormalities in pregnant women

2021 ◽  
Author(s):  
J Suliburska ◽  
Jakub Pankiewicz ◽  
Adam Sajnóg ◽  
Magdalena Paczkowska ◽  
Beata Nowakowska ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Pregnant Women ◽  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Chromosomal Abnormalities ◽  
Karyotype Analysis ◽  
Principal Component ◽  
Inductively Coupled ◽  
Essential And Toxic Elements ◽  
Caucasian Women

Abstract This study aimed to check the association of essential and toxic elements in amniotic fluid (AF) with chromosomal abnormalities. A total of 156 pregnant Polish white Caucasian women between the age of 20 and 43 years participated in the study. AF samples were collected during routine diagnostic and treatment procedures in pregnant women. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine the levels of various elements in AF. Genomic hybridization and cytogenic karyotype analysis were used. The results of the karyotype analysis indicated chromosomal abnormalities in 19 fetuses (over 12% of the total population) and it was mainly trisomy 21 (N=11), trisomy 18 (N=2), triploidy (N=2) and other chromosomal aberrations. It was found that a low concentration of manganese in AF was associated with chromosomal abnormalities in the foetus. High levels of iron and advanced age of the mother increased the risk of aneuploidy in the fetus. Principal component analysis (PCA) and Spearman correlation showed a strong correlation between essential and toxic elements in AF, especially in groups with chromosomal abnormalities. The results of this exploratory study indicate that the levels of essential and toxic elements in AF are associated with chromosomal abnormalities in the human fetus.

scholarly journals Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 328 ◽  
Author(s):  
Rafal Kocylowski ◽  
Mariusz Grzesiak ◽  
Zuzanna Gaj ◽  
Wiktor Lorenc ◽  
Ewa Bakinowska ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Fetal Development ◽  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Maternal Serum ◽  
Growth Disorders ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
Spectrometry Technique ◽  
Essential And Toxic Elements

Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic elements on fetal development has not yet been fully investigated, and the results of recent research indicate that these elements may be crucial in the assessment of the risk of malformations in neonates. We determined the association between essential and toxic elements and the level of folate in maternal serum (MS) and amniotic fluid (AF), along with neonatal abnormalities. A total of 258 pregnant Polish women in the age group of 17–42 years participated in this study. AF and MS were collected during vaginal delivery or during cesarean section. An inductively coupled plasma mass spectrometry technique was used to determine the levels of various elements in AF and MS. The results of this exploratory study indicate that the levels of essential and toxic elements are associated with fetal and newborn anatomical abnormalities and growth disorders.

scholarly journals Determination of essential and toxic elements in products of milling wheat

2016 ◽  
Vol 70 (6) ◽  
pp. 707-715 ◽  
Author(s):  
Gordana Ludajic ◽  
Lato Pezo ◽  
Jelena Filipovic ◽  
Vladimir Filipovic ◽  
Nenad Kosanic
Keyword(s):  
Principal Components ◽  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Principal Component ◽  
Data Representation ◽  
Important Variable ◽  
Raw Material ◽  
Content Quality ◽  
Inductively Coupled ◽  
Essential And Toxic Elements

In the production bread wheat bran is used as a raw material rich in dietary fiber. Therefore, it is necessary to monitor the content of essential and toxic elements in the flour and bran. This paper investigates essential (Zn, Cu, Fe and Mn) and toxic (Pb, Cd, Hg and As) elements in products of milling wheat grown in the whole territory of Banat, the region in Serbia. Inductively Coupled Plasma Mass Spectrometry was used for analysis. The mean contents of the following elements Pb, Cd, Hg, As, Fe, Mn and Zn in wheat kernels were 0.143 mg/kg, 0.007 mg/kg, 0.017 mg/kg, 35.7643 mg/kg, 50.865 mg/kg, and 21.174 mg/kg, respectively. Cluster Analysis (CA) and Principal component analysis (PCA) was applied to discriminate and to group the different samples, according to element content. Quality results show that the first two principal components, accounting for 80.17% of the total variance, can be considered sufficient for data representation and the first two principal components of toxic elements and essential microelements. Cd (15.28%), Zn (17.91%), Cu (17.08), Fe (16.91%) and Mn (17.54%), have been found the most influential for the first factor coordinate calculation, while the contribution of Pb (27.93%) and Hg (61.86%) has been the most important variable for the second factor coordinate calculation.

scholarly journals Determination of Essential and Toxic Elements in Cattle Blood: Serum vs Plasma

Animals ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 465 ◽  
Author(s):  
Diego Luna ◽  
Marta López-Alonso ◽  
Yolanda Cedeño ◽  
Lucas Rigueira ◽  
Víctor Pereira ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Serum Samples ◽  
Element Analysis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Essential And Toxic Elements ◽  
High Concentrations

This study was designed to evaluate the influence of type of blood sample (serum or plasma) on essential and toxic element analysis in cattle. Paired plasma and serum samples (n = 20) were acid digested, and the concentrations of As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn. Mo, Ni, P, Pb, Sb, Se, Sr and Zn were determined by inductively coupled plasma mass spectrometry (ICP-MS). The study findings indicate that plasma and serum samples appear suitable and interchangeable for the determination of most of the essential and toxic elements in blood in cattle. The only exceptions are Cu and Se, the concentrations of which were significantly lower (40.9 and 29.9% respectively) in serum than in plasma. Some of the Cu in blood samples from bovine ruminants is known to be sequestered during clotting. However, further research on Se in ruminants and other animal species is warranted. Finally, the significantly higher Mn (9.9%) concentrations in serum than in plasma may have been caused by haemolysis of some samples. Special attention should be paid to preventing haemolysis of samples during collection and processing, in order to prevent overestimation of elements present at high concentrations inside erythrocytes (i.e., Fe, Mn and Zn).

scholarly journals Patterns and Determinants of Essential and Toxic Elements in Chinese Women at Mid-Pregnancy, Late Pregnancy, and Lactation

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 668
Author(s):  
Yubo Zhou ◽  
Lailai Yan ◽  
Hongtian Li ◽  
Xiucui Li ◽  
Yaqiong Liu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Late Pregnancy ◽  
Dietary Factors ◽  
Feeding Practice ◽  
Delivery Mode ◽  
Area Element ◽  
Lactating Women ◽  
Essential And Toxic Elements

Maternal status of essential and toxic elements affects the health of the mother, developing fetus, or breastfeeding infant. However, few studies have examined the patterns of these elements and their determinants in pregnant or lactating women. Plasma samples of 1211 healthy mid-pregnant, late pregnant, and lactating women enrolled in coastland, lakeland, and inland areas of China from May–July 2014, were analyzed for concentrations of 15 elements, using inductively coupled plasma mass spectrometry. The adjusted median concentrations of elements varied by physiologic stage and region. Lactating versus pregnant women showed higher concentrations of Zn, Cr, Mo, Ni, Sb, Cd and Pb, but lower concentrations of Cu, I, Al and Hg. In pregnant women, the concentrations of Fe, Zn, I, Mo, Ni, Al, Hg and Cd were higher in mid- versus late-pregnancy. Overall, the highest concentrations were observed in Zn, I, Mn, Al, and Pb in coastland, in Hg in lakeland, and in Fe in inland area. Element concentrations varied by maternal age, pre-pregnancy BMI, education, parity, delivery mode, feeding practice, and intakes of aquatic products and mutton. In conclusion, essential and toxic elements coexisted in pregnant and lactating women, and their concentrations varied by physiologic stages, regions, maternal socio-demographic characteristics and dietary factors.

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