scholarly journals Clinical and Imaging Features of The Ovarian Cystadenofibroma or Adenofibroma and Their Correlation With Pathological Findings

2021 ◽  
Author(s):  
li liu ◽  
Jie Wang ◽  
Qingshu Li ◽  
Zhiwei Zhang ◽  
Ling Zhao ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Preoperative Diagnosis ◽  
Clinical Symptoms ◽  
Cystic Mass ◽  
Solid Component ◽  
Imaging Features ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Mri Features ◽  
Laboratory Results

Abstract Purpose To improve the accuracy of the preoperative diagnosis of ovarian cystadenofibroma (CAF) or adenofibroma (AF). Methods Clinical symptoms, laboratory results, imaging features, and pathological results of 11 patients with 11 histologically proven ovarian CAF/AF were reviewed retrospectively. The computed tomography (CT) and magnetic resonance imaging (MRI) features of the tumor including location, number, size, internal characteristics, CT density or MRI signal intensity, enhancement performance, lymphadenopathy, and amount of ascites were comprehensively evaluated. Results With regard to the clinical findings, results of serum cancer antigen 125 (CA125), cancer antigen 199 (CA199), and other laboratory tests were normal in most cases (81.8%, 9/11). The imaging features of the 11 lesions were as follows: unilateral occurrence, well-defined boundary, round or roundish, unilocular (63.6%, 7/11), cystic mass (81.8%, 9/11), multilocular (27.3%, 3/11), black sponge sign (18.2%, 2/11), carpet sign (81.8%, 9/11), residual ovary sign (45.5%, 5/11), papillary nodule clusters (45.5%, 5/11), and small vesicle with an acute angle to the inner cyst wall (18.2%, 2/11). The signal intensity of the solid component was isointense or hypointense on T2-weighted imaging and hypo intense on diffusion-weighted imaging. The CT value of the lesions ranged from 21 Hounsfield units (Hu) to 45 Hu. A slight to moderate enhancement degree occurred in more than half of the lesions (54.5%, 6/11). No or a small amount of ascites was present in these cases. Histologic examination revealed SCAF (45.5%, 5/11), SAF (27.3%, 3/11), and borderline CAF/AF (27.3%, 3/11). No necrosis, hemorrhage, or calcification was observed in any of these masses. Conclusion Ovarian CAF/AF usually mimics malignancy, demonstrating a cystic mass combined with solid component on CT or MR images. The integrity of case data including laboratory results and imaging features can help radiologists make an accurate preoperative diagnosis. No or a small amount of ascites may narrow the differential diagnosis.

scholarly journals ASSOCIATION BETWEEN SELECTED TUMOUR MARKERS AND CERVICAL INTRAEPITHELIAL NEOPLASM AMONG WOMEN IN BENIN CITY, NIGERIA

2020 ◽  
Vol 1 (1) ◽  
pp. 81-92
Author(s):  
K. Atoe ◽  
O. J. Idemudia
Keyword(s):  
Clinical Symptoms ◽  
Venous Blood ◽  
Histological Diagnosis ◽  
Premalignant Lesions ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Cross Sectional ◽  
Benin City ◽  
Serum Ca125 ◽  
Edo State

Female mortality rate due to cervical cancer is on the increase in developing countries like Nigeria. Early detection of premalignant lesions in the cervix is critical in increasing the chances of survival. This requires an effective primary screening mechanism before the onset of clinical symptoms. The purpose of this study was to investigate the capacity of three biomarkers; Cancer Antigen 125 (CA125), Cancer Antigen 15.3 (CA15.3) and Carcinoembryonic Antigen (CEA) in the diagnosis of Cervical Intraepithelial Neoplasm (CIN). The study, which was a cross-sectional prospective study, was carried out at the Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital Benin City and Department of Chemical Pathology, Edo University Iyamho, Edo state Nigeria, between August 2017 and January 2019. A total of 197 female participants were recruited and grouped into; Negative, CIN 1, CIN 2 and CIN 3 based on histological diagnosis. Venous blood was obtained from participants and serum CA125, CA15.3 and CEA levels were determined using standardized laboratory methods. The results showed a significant elevation in serum CA125, CA15.3 and CEA levels with CIN 3 lesions (17.81 ng/ml, 49.46 ng/ml and 17.43 ng/ml respectively) compared to their counterpart healthy individuals (8.89ng/ml, 32. 18ng/ml and 11.57ng/ml respectively). The markers presented low sensitivities (0 - 54.47 %) and high specificities (98.11 – 100.00 %) when compared with gold standard (histological diagnosis).

Myxofibrosarcoma: clinical and prognostic value of MRI features

2020 ◽  
Vol 16 ◽  
Author(s):  
Paolo Spinnato ◽  
Andrea Sambri ◽  
Tomohiro Fujiwara ◽  
Luca Ceccarelli ◽  
Roberta Clinca ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Contrast Enhancement ◽  
Imaging Modality ◽  
Soft Tissue Sarcomas ◽  
The Elderly ◽  
High Rate ◽  
Imaging Features ◽  
High Grade ◽  
Mri Features

: Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma and plays a key role in the preoperative setting of these patients.MRI features associated with high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement, presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful to stratify the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features

scholarly journals Head and neck osteosarcoma: CT and MR imaging features

2020 ◽  
Vol 49 (2) ◽  
pp. 20190202
Author(s):  
Zhendong Luo ◽  
Weiguo Chen ◽  
Xinping Shen ◽  
Genggeng Qin ◽  
Jianxiang Yuan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Giant Cell ◽  
High Signal ◽  
Imaging Features ◽  
Matrix Mineralization ◽  
Imaging Characteristics ◽  
Mri Features ◽  
Signal Intensities ◽  
Ct And Mri

Objective: This study aims to assess the CT and MRI features of head and neck osteosarcoma (HNO). Methods: 37 HNOs were identified, and the following imaging characteristics were reviewed on CT and MRI. Results: A total of 37 patients(age 41.5 ± 15.0 years old; 16 males, 21 females) were included in the study. Tumours occurred in the maxilla (16, 43.2%), mandible (8, 21.6%), skull base (6, 16.2%), calvarium (5, 13.5%), paranasal sinuses (1, 2.7%) and cervical soft tissue (1, 2.7%). 16 patients received radiotherapy for nasopharyngeal carcinoma. Three patients (8.1%) developed osteosarcomas related to a primary bone disease. 16 of the (43.2%) tumours demonstrated lytic density on CT scans, followed by 13 (35.1%) showing mixed density and 7 (18.9%) with sclerotic density. Matrix mineralization was present in 32 (86.5%). 3 out of 24 (12.5%) tumours showed lamellar periosteal reactions, 21 out of 24 (87.5%) showed spiculated periosteal reactions. 12 tumours showed low signal intensities on T1WI, with 16 having heterogeneous signal intensities. 10 tumours showed high signal intensities on T2WI, and 18 showed heterogeneous signal intensities. With contrast-enhanced images, 3 tumours showed homogeneous enhancement (2 osteoblastic and 1 giant cell-rich), 18 tumours showed heterogeneous enhancement (13 osteoblastic, 4 fibroblastic and 1 giant cell-rich), and 7 tumours showed peripheral enhancement (6 chondroblastic and 1 osteoblastic). These tumours were characterized by soft tissue masses with a diameter of 5.6 ± 1.8 cm. Conclusions: HNO is a rare condition and is commonly associated with previous radiation exposure. This study provides age, sex distribution, location, CT and MRI features of HNO.

scholarly journals Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jinyao Ni ◽  
Junwu Zhang ◽  
Yanxia Chen ◽  
Weizhong Wang ◽  
Jinlin Liu
Keyword(s):  
Information System ◽  
Lichen Planus ◽  
Hospital Information System ◽  
Clinical Characteristics ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Ivig Treatment ◽  
Good’S Syndrome ◽  
Laboratory Results

Abstract Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.

scholarly journals CTNI-03. IMAGING FEATURES OF LEPTOMENINGEAL METASTASES OF NON-SMALL CELL LUNG CANCER: A SINGLE-CENTER REAL-WORLD STUDY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii41-ii41
Author(s):  
Junjie Zhen ◽  
Lei Wen ◽  
Shaoqun Li ◽  
Mingyao Lai ◽  
Changguo Shan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Type A ◽  
Brain Parenchyma ◽  
Imaging Features ◽  
Type B ◽  
Type D ◽  
Mri Examination ◽  
Mri Features ◽  
Brain And Spinal Cord ◽  
The Brain

Abstract BACKGROUND According to EANO-ESMO clinical practice guidelines, the MRI findings of LM are divided into 4 types, namely linear enhancement (type A), nodular enhancement (type B), linear combined with nodular enhancement (type C), and sign of hydrocephalus (type D). METHODS The MRI features of brain and spinal cord in patients diagnosed with NSCLC-LM in Guangdong Sanjiu Brain Hospital from 2010 until 2019 were investigated, and then were classified into 4 types. The imaging features were analyzed. RESULTS A total of 80 patients were enrolled in the study. The median age of the patients was 53.5 years old, and the median time from the initial diagnosis to the confirmed diagnosis of LM was 11.6 months. The results of enhanced MRI examination of the brain in 79 cases showed that the number of cases with enhancements of type A, B, C and D were 50 (63.3%), 0, 26 (32.9%) and 3 (3.8%), respectively, and that LM with metastases to the brain parenchyma was found in 42 cases (53.2%). The results of enhanced MRI examination of spinal cord in 59 cases showed that there were only enhancements of type A and C in 40 cases (67.8%) and 3 cases (5.0%), and no enhancement sign in the other 16 cases (27.2%). CONCLUSION MRI examination of brain and spinal cord will improve the detection rate of LM. The MRI features of NSCLC-LM in real world are mainly characterized by the linear enhancements of brain and spinal cord, followed by linear combined with nodular enhancement. The enhancements of type B and type D are rare in clinic. Almost half of the patients have LM and metastases to the brain parenchyma. Therefore, the differentiation of tumor metastases is needed to be paid attention to for the early diagnosis and the formulation of reasonable treatment plans.

scholarly journals The triangular fibrocartilage complex on high-resolution 3 T MRI in healthy adolescents: the thin line between asymptomatic findings and pathology

2021 ◽  
Author(s):  
Anne-Sophie van der Post ◽  
Sjoerd Jens ◽  
Frank F. Smithuis ◽  
Miryam C. Obdeijn ◽  
Roelof-Jan Oostra ◽  
...  
Keyword(s):  
Signal Intensity ◽  
Sagittal Plane ◽  
Articular Surface ◽  
Triangular Fibrocartilage Complex ◽  
Ulnar Variance ◽  
Observer Agreement ◽  
Mri Findings ◽  
Mri Features ◽  
Triangular Fibrocartilage ◽  
The Individual

Abstract Objective The objective of the study is to provide a reference for morphology, homogeneity, and signal intensity of triangular fibrocartilage complex (TFCC) and TFCC-related MRI features in adolescents. Materials and methods Prospectively collected data on asymptomatic participants aged 12–18 years, between June 2015 and November 2017, were retrospectively analyzed. A radiograph was performed in all participants to determine skeletal age and ulnar variance. A 3-T MRI followed to assess TFCC components and TFCC-related features. A standardized scoring form, based on MRI definitions used in literature on adults, was used for individual assessment of all participants by four observers. Results per item were expressed as frequencies (percentages) of observations by all observers for all participants combined (n = 92). Inter-observer agreement was determined by the unweighted Fleiss’ kappa with 95% confidence intervals (95% CI). Results The cohort consisted of 23 asymptomatic adolescents (12 girls and 11 boys). Median age was 13.5 years (range 12.0–17.0). Median ulnar variance was −0.7 mm (range − 2.7–1.4). Median triangular fibrocartilage (TFC) thickness was 1.4 mm (range 0.1–2.9). Diffuse increased TFC signal intensity not reaching the articular surface was observed in 30 (33%) observations and a vertical linear increased signal intensity with TFC discontinuation in 19 (20%) observations. Discontinuation between the volar radioulnar ligament and the TFC in the sagittal plane was seen in 23 (25%) observations. The extensor carpi ulnaris was completely dislocated in 10 (11%) observations, more frequent in supinated wrists (p = 0.031). Inter-observer agreement ranged from poor to fair for scoring items on the individual TFCC components. Conclusion MRI findings, whether normal variation or asymptomatic abnormality, can be observed in TFCC and TFCC-related features of asymptomatic adolescents. The rather low inter-observer agreement underscores the challenges in interpreting these small structures on MRI. This should be taken into consideration when interpreting clinical MRIs and deciding upon arthroscopy.

Cancer Antigen 125 Associated With Multiple Benign and Malignant Pathologies

2003 ◽  
Vol 10 (2) ◽  
pp. 150-154 ◽  
Author(s):  
C. Miralles ◽  
M. Orea ◽  
P. Espa�a ◽  
M. Provencio ◽  
A. S�nchez ◽  
...  
Keyword(s):  
Cancer Antigen 125 ◽  
Cancer Antigen

Variability of effluent cancer antigen 125 and interleukin-6 determination in peritoneal dialysis patients

2011 ◽  
Vol 26 (11) ◽  
pp. 3739-3744 ◽  
Author(s):  
D. Lopes Barreto ◽  
A. M. Coester ◽  
M. Noordzij ◽  
W. Smit ◽  
D. G. Struijk ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Interleukin 6 ◽  
Dialysis Patients ◽  
Cancer Antigen 125 ◽  
Cancer Antigen

scholarly journals Clinical characteristics and surgical treatments of primary hepatic angiosarcoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lei Jiang ◽  
Lijun Xie ◽  
Ge Li ◽  
Hang Xie ◽  
Zhao Fang ◽  
...  
Keyword(s):  
Malignant Tumor ◽  
Transarterial Chemoembolization ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Past History ◽  
Hepatic Lobectomy ◽  
Hepatic Angiosarcoma ◽  
Mri Features ◽  
Primary Hepatic Angiosarcoma ◽  
Surgical Treatments

Abstract Purpose Primary hepatic angiosarcoma is a very rare and highly malignant tumor with poor prognosis. It is difficult to diagnose because of the lack of typical clinical features, and the treatment protocols for PHA are also not clear. Therefore, this study wants to find out the clinical characteristics and surgical treatments of primary hepatic angiosarcoma. Methods Among 8990 patients diagnosed with primary malignant tumor of the liver from January 2000 to December 2019 in our hospital, only four patients were diagnosed with primary hepatic angiosarcoma. The demographics, clinical manifestation, past history, serology test results, MRI features, pathology, treatment modality and prognosis of four patients were collected and analyzed. Results Three of four patients had no clinical symptoms, while one patient's symptom was abdominal pain. The levels of tumor markers of all four patients were within the normal reference range and serological tests were negative for hepatitis B and C virus. The MRI imaging findings of all four patients were mixed mass with highly disordered vascular characteristics. All four patients were misdiagnosed preoperatively. One patient who underwent hepatic lobectomy was still alive for about 18 months after surgery. One patient who underwent hepatic lobectomy has survived for only 6 months due to severe pneumonia. The other two patients who received transarterial chemoembolization survived 16 months and 11 months respectively. Conclusion The clinical symptoms of primary hepatic angiosarcoma are not typical, and primary hepatic angiosarcoma is easily misdiagnosed. The typical imaging manifestations are structural disorder and heterogeneous tumor. Hepatic lobectomy and transarterial chemoembolization may be important surgical treatments to improve the prognosis of patients.

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