scholarly journals Adenomyosis: Is It A Confounder Or An Innocent Companion In Patients With Endometrial Hyperplasia?

2021 ◽  
Author(s):  
Fatma Nurgül Taşgöz ◽  
Nergis Kender Erturk ◽  
Gulnur Tanrıverdi Kılıç ◽  
Gulay Gokce
Keyword(s):  
Risk Factor ◽  
Multivariate Regression ◽  
Endometrial Hyperplasia ◽  
Independent Risk Factor ◽  
Fold Increase ◽  
Multivariate Regression Analysis ◽  
Demographic Characteristics ◽  
Endometrial Sampling ◽  
Significant Independent Risk Factor ◽  
Pathologic Findings

Abstract Purpose: To evaluate the effect of adenomyosis on the discordance of pathologic findings in patients with endometrial hyperplasia (EH) before hysterectomy.Methods: Two hundred seventeen patients who were diagnosed as having EH via endometrial sampling and underwent hysterectomy within 3 months were included in this retrospective study. The patients’ preoperative and postoperative pathologic findings were compared and discordant results were defined as overdiagnosed and underdiagnosed.Results: The rate of concurrent endometrial carcinoma (EC) among all EH was 22.11%, whereas this rate was 41.4% in EH with atypia. There was no difference between EH subtypes in terms of demographic characteristics and coexisting myometrial lesions. The discordance between preoperative endometrial sampling and final hysterectomy specimen results was evaluated, and patients with underdiagnosis were older (60.5 years, p<0.001), had a higher BMI (30.84 kg/m2, p<0.001), were mostly postmenopausal (p<0.001), had lower parity numbers (median=2, p=0.002), and had a lower rate of co-existing adenomyosis (p=0.009). The rates of co-existing leiomyomas between the groups were not different. No effect of other demographic characteristics was observed in the multivariate regression analysis; however, the presence of adenomyosis was a significant independent risk factor affecting a 5.8-fold increase in overdiagnosis (-1.50; OR: 0.17 (0.05-0.50) p=0.002) and 4.5-fold increase in underdiagnosis (-1.50; p=0.005).Conclusion: Co-existing adenomyosis could lead to discordance of the pathologic findings in women with EH diagnoses before hysterectomy.

scholarly journals High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Beili Shi ◽  
Zhaohui Ni ◽  
Hong Cai ◽  
Minfang Zhang ◽  
Shan Mou ◽  
...  
Keyword(s):  
Risk Factor ◽  
Multivariate Regression ◽  
Ventricular Hypertrophy ◽  
Independent Risk Factor ◽  
High Sensitivity ◽  
Multivariate Regression Analysis ◽  
Left Ventricular ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.Methods. 287 LN patients (age: 38.54 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.Results. The prevalence of LVH in this cohort was 21.25% (). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, , and correlated with left ventricular mass index (LVMI) (, ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (, ) for LVH in patients with LN.Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.

scholarly journals CT scores predict mortality in 2019-nCoV pneumonia

2020 ◽  
Author(s):  
Yun Xie ◽  
Luyu Yang ◽  
Hui Dong ◽  
Hu Peng ◽  
Yuetian Yu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Multivariate Regression ◽  
Independent Risk Factor ◽  
Laboratory Data ◽  
Ground Glass Opacity ◽  
Multivariate Regression Analysis ◽  
Rt Pcr ◽  
Absolute Count ◽  
Single Center Study ◽  
Worse Prognosis

Abstract Background: While 2019-nCoV nucleic acid swab tests has high false positives rate, How to diagnose 2019-nCoV pneumonia and predict prognosis by CT is very important. Methods: In this retrospective single-center study, we consecutively included suspected 2019-nCoV pneumonia critical cases in the intensive care unit of Wuhan third hospital from January 31, 2020 to February 16, 2020. The cases were confirmed by real-time RT-PCR, and all patients were evaluated with CT, cutoff values were obtained according to the Yoden index, and were divided into high CT score group and low CT score group. Epidemiological, demographic, clinical, and laboratory data were collected. Results: The major imaging feature of 2019-nCoV pneumonia is the ground glass opacity (GGO). Multivariate regression analysis found that CT score and absolute count of lymphocytes were independent risk factor for death, and CT score predicted mortality AUC-ROC =0.7, cutoff=1.45. When the absolute count of lymphocytes decreased, the patient's CT also deteriorated. Conclusion: CT score and absolute count of lymphocytes were independent risk factor for death, and patients with high CT score may have a worse prognosis. Lower absolute count of lymphocytes may indicated the patient's CT also deteriorated.

scholarly journals P1493CORRELATION BETWEEN END-DIALYSIS OVER-WEIGHT IN INITIAL STAGE OF HEMODIALYSIS AND PROGNOSIS IN INCIDENT HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ping Zhang ◽  
Ying Wang ◽  
Xi Yao ◽  
Shaohua Chen ◽  
Chunping Xu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Mortality ◽  
Multivariate Regression ◽  
Independent Risk Factor ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Interdialytic Weight Gain ◽  
The Relationship

Abstract Background and Aims The volume factor of maintenance hemodialysis patients is closely related to the prognosis. We hypothesized that the excess weight after dialysis (end-dialysis over-weight, edOW) is an important factor of volume impact survival in hemodialysis (HD) patients. The purpose of this study was to analyze the relationship between edOW and long-term prognosis of patients with maintenance hemodialysis. Method This retrospective study observed incident hemodialysis patients who treated in Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University from January 1, 2008 to April 30, 2017, three times a week for at least one year. The end point of follow-up was death, abdominal dialysis, kidney transplantation, transfer or until April 30, 2018. The general data of the patients included age, gender, BMI, primary renal disease, CVD, first hemodialysis access, albumin(Alb), Haemoglobin(Hb), blood pressure, heart rate, ultrafiltration rate(UFR), interdialytic weight gain IDWG, end -dialysis overweight (edOW). Cox multivariate regression was used to analyze the relationship between edow and all-cause mortality and cardiovascular mortality. Results Totally 469 patients male, 64% were enrolled, with an average age of 56.9 ± 17.1 years. During the follow-up period, 102 patients died. The main cause of death was cardiovascular and cerebrovascular events, accounting for 44.7%. The mean value of edow was 0.28 ± 0.02 kg. Kaplan-Meier(Log-rank test) survival analysis showed that the long-term survival rate of the group with edow ≤ 0.28kg was better than that of the group with edow &gt; 0.28kg (P = 0.042), and the cardiovascular mortality of the group with edow &gt; 0.28kg was significantly higher than that of the group with edow ≤ 0.28kg (P = 0.001). Cox multivariate regression analysis showed that edow was an independent risk factor for all-cause death in hemodialysis patients (P = 0.025, AhR = 1.541, 95% CI 1.057-2.249), and also an independent risk factor for CVD death in hemodialysis patients (P = 0.007, AhR = 1.929, 95% CI 1.198-3.107). Conclusion EdOW is an independent risk factor of long-term all-cause and cardiovascular death in hemodialysis patients.

scholarly journals Lymphopenic community acquired pneumonia, an unnoticed phenotype associated to mortality in non immuno-suppressed patients: a retrospective cohort study

2017 ◽  
Author(s):  
Jesus F Bermejo-Martin ◽  
Catia Cilloniz ◽  
Raul Mendez ◽  
Raquel Almansa ◽  
Albert Gabarrus ◽  
...  
Keyword(s):  
Multivariate Regression ◽  
Fold Increase ◽  
Multivariate Regression Analysis ◽  
Community Acquired Pneumonia ◽  
Post Discharge ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Immunological Phenotype ◽  
Hospital Clinic

AbstractBackgroundThe role of neutrophil and lymphocyte counts as predictors of prognosis in Community Acquired Pneumonia (CAP) has not been appropriately studied.MethodsThis was a retrospective study to evaluate by multivariate regression analysis, the association between neutrophil and lymphocyte counts with mortality at 30-days post discharge in two large cohorts of hospitalized patients with CAP and no prior immunosupression: a multicentric with 1550 patients recruited at 14 hospitals in Spain and a unicentric with 2840 patients recruited at the Hospital Clinic-Barcelona.FindingsThe unicentric cohort accounted with a higher proportion of critically ill patients: 586 (20·6%) vs 131 (8·5%) and non survivors 245 (8·6%) vs 74 (4·8%). Lymphopenia (< 1000 lymphocytes/mm3) was present in the 52·8% of the patients in both cohorts. A sub-group of lymphopenic patients, those with lymphocyte counts below decil 3 (677 lymphocytes/mm3 in the multicentric cohort and 651 lymphocytes/mm3 in the unicentric one), showed > 2-fold increase in the risk of mortality, independently of the CURB-65 score, critical illness and receiving an appropriated antibiotic treatment: (OR [CI95%], p) (2·18 [1·21- 3·92], 0·009) and (2·33 [1·61-3·33], <0·001) respectively. Neutrophil counts were not associated with mortality risk.InterpretationLymphopenia is present in a half of the patients with CAP needing of hospitalization, in absence of antecendents of immunosupression. Lymphopenic CAP with lymphocyte counts < 664 lymphocytes/mm3 constitutes a particular immunological phenotype of the disease which is associated to an increased risk of mortality.FundingCibeRes, 2009 Support to Research Groups of Catalonia 911, IDIBAPS, SEPAR, SVN

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