Urine MACC1 Plays an Indicative Role in Diagnosing Bladder Cancer
Abstract Background: Present study aimed to estimate the diagnostic efficacy of urine Metastasis-associated in colon cancer 1 (MACC1) for bladder cancer patients.Methods: Urine MACC1 expression was measured in bladder cancer patients and controls via quantitative real-time polymerase chain reaction (qRT-PCR) assay. Chi-square test was used to assess the correlation of urine MACC1 levels with clinicopathological features of the patients. The diagnostic performance of urine MACC1 was evaluated by receiver operating characteristics (ROC) curve.Results: Urine MACC1 was obviously elevated in bladder cancer patients compared with controls (P<0.001). What’s more, abnormal urine MACC1 expression was significantly correlated with differentiation (P=0.013), tumor stage (P=0.023), lymph node metastasis (P=0.033) and distant metastasis (P=0.026). Furthermore, according to ROC analysis, urine MACC1 could distinguish bladder cancer patients from controls with an AUC (the areas under the ROC curve) of 0.909. The cut-off value of urine MACC1 for bladder cancer diagnosis was 1.275, with 79.8% specificity and 87.3% sensitivity.Conclusion: Urine MACC1 may be act as a biomarkers for diagnosis of bladder cancer.