scholarly journals Isolation of Nannocystis species from Iran and exploring their natural products

2021 ◽  
Author(s):  
Azam Moradi ◽  
Mohammad Yaghoubi-Avini ◽  
Joachim Wink
Keyword(s):  
Natural Products ◽  
New Species ◽  
Secondary Metabolites ◽  
Fibroblast Cell ◽  
Fibroblast Cell Line ◽  
Active Metabolites ◽  
Gram Positive Bacteria ◽  
Depth Analysis ◽  
L929 Fibroblast ◽  
A New Species

Abstract Several different techniques were employed for the isolation of Nannocystis from various sources. A polyphasic approach was used for identification. Twelve strains of N. pusilla, N. exedens, and N. konarekensis with distinctive distribution between climates were identified. The bioactivity was examined against a panel of eight bacteria, two yeasts, and one fungus; cytotoxicity was tested on the L929 fibroblast cell line. Eleven strains mainly inhibit Gram-positive bacteria, and only one isolate was cytotoxic. The extracts analysis by HPLC and LC-MS were compared to Myxobase, and eight different compounds were detected; a correlation was observed between compounds and producing species. 70% of strains had the potential to produce structurally diverse compounds. Nannochelins and althiomycin were the most abundant metabolites. The discovery of a new species of Nannocystis and the high potentiality of strains to produce secondary metabolites encourage further sampling and in-depth analysis of extracts to find new active metabolites.

Penicillium kananaskense, a new species from Alberta soil

1994 ◽  
Vol 72 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Keith A. Seifert ◽  
J. C. Frisvad ◽  
Mary Ann McLean
Keyword(s):  
New Species ◽  
Secondary Metabolites ◽  
Key Words ◽  
Rapid Growth ◽  
Preliminary Data ◽  
Pinus Contorta ◽  
The Many ◽  
A New Species

The new species Penicillium kananaskense is described based on an isolate from soil in a Pinus contorta forest from Alberta, Canada. Colonies are characterized by their relatively rapid growth, velutinous texture, white to slightly pink conidial masses, growth at 5 °C, and absence of growth at 37 °C. The conidiophores are monoverticillate or have one metula, are up to 300 μm tall, smooth walled or with slightly roughened walls, vesiculate, and bear ampulliform phialides, 8–11.5(−14.5) × 2.5–4 μm, that produce disordered chains of ellipsoidal conidia, 3–5 × 2.5–4 μm, with smooth or finely roughened walls. The species is compared with previously described taxa and its subgeneric affinities are discussed. Preliminary data on the many secondary metabolites produced by the ex-type culture are presented. Key words: Penicillium kananaskense, soil, Pinus contorta var. latifolia, mycotoxins.

scholarly journals Novel Metabolites from the Stem Bark of Brombya sp. Nova (Gap Creek) (Rutaceae)

2006 ◽  
Vol 1 (5) ◽  
pp. 1934578X0600100
Author(s):  
Clynton W. Halstead ◽  
Paul I. Forster ◽  
Peter G. Waterman
Keyword(s):  
New Species ◽  
Secondary Metabolites ◽  
Stem Bark ◽  
Aerial Parts ◽  
Coumarin 6 ◽  
A New Species

Two piperonyl derivatives, seven coumarins and two furoquinoline alkaloids were isolated from the aerial parts of a new species of Brombya [Brombya sp. nov. (Gap Creek) (Rutaceae)]. Three of the compounds were new natural metabolites; 7-(3,4-methylenedioxyphenyl)octene-2-one (7,8-dehydromoskachen D), the coumarin 6-(1ξ,2ξ,3-trihydroxy-3-methylbutyl)-7-hydroxy-2H-1-benzopyran-2-one, and the furoquinoline alkaloid 4,5,6,7-tetramethoxyfuro[2,3-b]quinoline (5,6,7-trimethoxydictamnine). The secondary metabolites isolated in this study are typical of the Rutaceae, contrasting with earlier studies on the only other species of Brombya, B. platynema, which yielded only brombyins, for which 7,8-dehydromoskachen D is a possible precursor.

Toxicity evaluation of ZnO nanostructures on L929 fibroblast cell line using MTS assay

2015 ◽  
Author(s):  
Siti Khadijah Mohd Bakhori ◽  
Shahrom Mahmud ◽  
Ling Chuo Ann ◽  
Azman Seeni Mohamed ◽  
Siti Nazmin Saifuddin ◽  
...  
Keyword(s):  
Cell Line ◽  
Fibroblast Cell ◽  
Fibroblast Cell Line ◽  
Zno Nanostructures ◽  
Toxicity Evaluation ◽  
L929 Fibroblast ◽  
Mts Assay

scholarly journals Momordica and Pycnogenol Can Tolerate Imazamox Induced Toxicity in L929 Cells Line: In Vitro Study

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1584
Author(s):  
Ali Taghizadehghalehjoughi ◽  
Betul Cicek
Keyword(s):  
Protective Effect ◽  
Cell Line ◽  
Low Dose ◽  
Antioxidant Activities ◽  
Fibroblast Cell ◽  
High Dose ◽  
Protective Effects ◽  
Fibroblast Cell Line ◽  
Cell Viability Assay ◽  
L929 Fibroblast

Undesirable side effects that result from the random use of herbicides in developing countries are widespread. Imazamox is a widely used herbicide and has toxic effect on humans. Momordica charantia has been reported to possess many benefits and medicinal properties. Pycnogenol (PYC) is a natural plant extract from the bark of Pinus pinaster Aiton and has potent antioxidant activities. The aim of this study was to evaluate the protective effects of pycnogenol and momardica on induced imazamox toxicity effects on L929 fibroblast cell line. L929 fibroblast cells were cultured in the appropriate culture medium. Toxic concentration of imazamox 250 μM, were administered 30 min prior to momordica and pycnogenol (10−1–10−5 concentration) on L929 fibroblast cell line for 24 h. The cell viability assay was determined by using MTT test. TAC-TOS analysis were used to evaluate antioxidant and oxidant status. According to our study pycnogenol high dose showned protective effect whereas momordica low dose showned protective effect p < 0.05. In current study pycnogenol increased TAC capacity in high dose but in lower dose pycnogenol did not show any promise (p < 0.05). Momordica results showed correlation with MTT result. According to this analyse momordica only in low dose increased anti oxidant capacity and in addition, only in low dose TOS level were decreased (p > 0.05). In conclusion momordica and pycnogenol showed promise to reduced imazamox toxicity.

scholarly journals Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 249 ◽  
Author(s):  
Subramani ◽  
Sipkema
Keyword(s):  
Natural Products ◽  
New Species ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Marine Environment ◽  
Present Knowledge ◽  
Bioactive Natural Products ◽  
Rare Actinomycetes ◽  
Promising Source

Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and novel bioactive compounds. In this review, we aim to summarize the present knowledge on the isolation, diversity, distribution and natural product discovery of marine rare actinomycetes reported from mid-2013 to 2017. A total of 97 new species, representing 9 novel genera and belonging to 27 families of marine rare actinomycetes have been reported, with the highest numbers of novel isolates from the families Pseudonocardiaceae, Demequinaceae, Micromonosporaceae and Nocardioidaceae. Additionally, this study reviewed 167 new bioactive compounds produced by 58 different rare actinomycete species representing 24 genera. Most of the compounds produced by the marine rare actinomycetes present antibacterial, antifungal, antiparasitic, anticancer or antimalarial activities. The highest numbers of natural products were derived from the genera Nocardiopsis, Micromonospora, Salinispora and Pseudonocardia. Members of the genus Micromonospora were revealed to be the richest source of chemically diverse and unique bioactive natural products.

scholarly journals III. On the resin of ficus rubiginosa, and a new homologue of benzylic alcohol

1860 ◽  
Vol 150 ◽  
pp. 43-56
Keyword(s):  
Natural Products ◽  
New Species ◽  
New South ◽  
Chemical Properties ◽  
Gutta Percha ◽  
South Wales ◽  
Benzylic Alcohol ◽  
British Colonies ◽  
A New Species ◽  
Made In

Among the interesting collection of natural products contributed to the Paris Universal Exhibition of 1855 by the British Colonies, was a gum presenting some remarkable qualities. This substance was stated by the exhibitor to be a new species of gutta percha, in consequence of its becoming plastic when masticated, and on this account it attracted considerable attention. It had been contributed by Dr. Stephenson, of Manning River, N. S. W., who had obtained it from a species of Ficus , known as F. rubiginosa . The zealous Commissioner for New South Wales, Mr. (now Sir William) M c Arthur, brought this gum under our notice with the view of obtaining some information respecting its chemical properties. A few preliminary experiments, which were made in Paris, at once showed us that this substance had very little in common with gutta percha, and, moreover, its chemical properties were found to be entirely different from those of that gum. Although our experiments did not allow us to hold out hopes to Mr. M c Arthur of the gum becoming a valuable article of exportation from the colony, they offered some inducement to us to make a more rigorous investigation of it on purely scientific grounds. On communicating this view to Mr. M c Arthur, he liberally placed at our disposal the remainder of the specimen exhibited.

Ophiocordyceps flavida sp. nov. (Ophiocordycipitaceae), a new species from Thailand associated with Pseudogibellula formicarum (Cordycipitaceae), and their bioactive secondary metabolites

2021 ◽  
Vol 20 (4) ◽  
pp. 477-492
Author(s):  
Suchada Mongkolsamrit ◽  
Wasana Noisripoom ◽  
Siraphop Pumiputikul ◽  
Chollaratt Boonlarppradab ◽  
Robert A. Samson ◽  
...  
Keyword(s):  
New Species ◽  
Secondary Metabolites ◽  
Bioactive Secondary Metabolites ◽  
A New Species

scholarly journals Cytotoxicity evaluation of a new fast set highly viscous conventional glass ionomer cement with L929 fibroblast cell line

2011 ◽  
Vol 14 (4) ◽  
pp. 406 ◽  
Author(s):  
Hany Mohamed Aly Ahmed ◽  
Norhayati Luddin ◽  
Deepti Saini ◽  
NorShamsuria Omar ◽  
Rajan Saini
Keyword(s):  
Cell Line ◽  
Glass Ionomer Cement ◽  
Fibroblast Cell ◽  
Fibroblast Cell Line ◽  
Glass Ionomer ◽  
L929 Fibroblast ◽  
Ionomer Cement

scholarly journals Natural Products from Actinomycetes Associated with Marine Organisms

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 629
Author(s):  
Jianing Chen ◽  
Lin Xu ◽  
Yanrong Zhou ◽  
Bingnan Han
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Critical Role ◽  
Ecological Status ◽  
Marine Organisms ◽  
Chemical Defenses ◽  
Microbial Infection ◽  
Active Metabolites ◽  
Marine Animals

The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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