scholarly journals CSDVP: Compressed Sensing for Drug-Virus Prediction

2021 ◽  
Author(s):  
Milad Besharatifard ◽  
Arshia Gharagozlou
Keyword(s):  
Compressed Sensing ◽  
Performance Improvement ◽  
Matrix Factorization ◽  
Drug Repositioning ◽  
Model Performance ◽  
The World ◽  
Coronavirus Infection ◽  
Factorization Methods ◽  
The Relationship

Abstract The 2019 Coronavirus (COVID-19) epidemic has recently hit most countries hard. Therefore, many researchers around the world are looking for a way to control this virus. Examining existing medications and using them to prevent this epidemic can be helpful. Drug repositioning solutions can be effective because designing and discovering a drug can be very time-consuming. Although no drug has been definitively approved for the treatment of this disease, the effectiveness of a few drugs for the treatment of the disease has been observed. In this study, with the help of computational matrix factorization methods, the associations between drugs and viruses have been predicted. By combining the similarities between the drugs and the similarities between the viruses and using the compressed sensing technique, we investigated the association between the drug and the virus. The Compressed Sensing approach to Drug-Virus Prediction (CSDVP) can work well. We compared the proposed method with other methods in this field and found its accuracy is more desirable than other methods. In fact, the CSDVP approach with the Human drug virus database (HDVD) and evaluation through 5-fold CV, with AUC = 0.87 and AUPR = 0.37, can identify the relationship between drugs and viruses. We also investigated the effect of drug properties on model performance improvement using autoencoder. Thus, with each decrease in the size of the characteristics in different sizes, we examined the performance of the CSDVP model in predicting the drug-virus relationship. The relationship between drugs and coronavirus infection is also analyzed, and the results are presented.

scholarly journals CSDVP: Compressed Sensing for Drug-Virus Prediction

2021 ◽  
Author(s):  
Milad Besharatifard ◽  
Arshia Gharagozlou
Keyword(s):  
Compressed Sensing ◽  
Performance Improvement ◽  
Matrix Factorization ◽  
Drug Repositioning ◽  
Model Performance ◽  
The World ◽  
Coronavirus Infection ◽  
Factorization Methods ◽  
The Relationship

Abstract The 2019 Coronavirus (COVID-19) epidemic has recently hit most countries hard. Therefore, many researchers around the world are looking for a way to control this virus. Examining existing medications and using them to prevent this epidemic can be helpful. Drug repositioning solutions can be effective because designing and discovering a drug can be very time-consuming. Although no drug has been definitively approved for the treatment of this disease, the effectiveness of a few drugs for the treatment of the disease has been observed. In this study, with the help of computational matrix factorization methods, the associations between drugs and viruses have been predicted. By combining the similarities between the drugs and the similarities between the viruses and using the compressed sensing technique, we investigated the association between the drug and the virus. The Compressed Sensing approach to Drug-Virus Prediction (CSDVP) can work well. We compared the proposed method with other methods in this field and found its accuracy is more desirable than other methods. In fact, the CSDVP approach with the HDVD dataset and evaluation through 5-fold CV, with AUC = 0.96 and AUPR = 0.85, can identify the relationship between drugs and viruses. We also investigated the effect of drug properties on model performance improvement using autoencoder. Thus, with each decrease in the size of the characteristics in different sizes, we examined the performance of the CSDVP model in predicting the drug-virus relationship. The relationship between drugs and coronavirus infection is also analyzed, and the results are presented.

scholarly journals Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1737 ◽  
Author(s):  
Ana H. A. Morais ◽  
Thais S. Passos ◽  
Bruna L. L. Maciel ◽  
Juliana K. da Silva-Maia
Keyword(s):  
Immune Modulation ◽  
Nutritional Therapy ◽  
World Health ◽  
Adequate Intake ◽  
Lactobacillus Gasseri ◽  
The World ◽  
Coronavirus Infection ◽  
Health Organization ◽  
The Relationship

Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.

Kazakhstan’s Economic Growth in the Context of the World Economy

2006 ◽  
pp. 133-146 ◽  
Author(s):  
K. Arystanbekov
Keyword(s):  
Economic Growth ◽  
Economic Policy ◽  
World Economy ◽  
World Ocean ◽  
Direct Access ◽  
Crude Petroleum ◽  
Nation States ◽  
The World ◽  
The Relationship

Kazakhstan’s economic policy results in 1995-2005 are considered in the article. In particular, the analysis of the relationship between economic growth and some indicators of nation states - population, territory, direct access to the World Ocean, and extraction of crude petroleum - is presented. Basic problems in the sphere of economic policy in Kazakhstan are formulated.

Virginia Woolf and Being-in-the-world

2017 ◽  
Author(s):  
Emma Simone
Keyword(s):  
Virginia Woolf ◽  
Historical Context ◽  
The Political ◽  
Cartesian Dualism ◽  
Self And Other ◽  
The World ◽  
Binary Oppositions ◽  
The Individual ◽  
The Relationship ◽  
Existential Perspective

Virginia Woolf and Being-in-the-world: A Heideggerian Study explores Woolf’s treatment of the relationship between self and world from a phenomenological-existential perspective. This study presents a timely and compelling interpretation of Virginia Woolf’s textual treatment of the relationship between self and world from the perspective of the philosophy of Martin Heidegger. Drawing on Woolf’s novels, essays, reviews, letters, diary entries, short stories, and memoirs, the book explores the political and the ontological, as the individual’s connection to the world comes to be defined by an involvement and engagement that is always already situated within a particular physical, societal, and historical context. Emma Simone argues that at the heart of what it means to be an individual making his or her way in the world, the perspectives of Woolf and Heidegger are founded upon certain shared concerns, including the sustained critique of Cartesian dualism, particularly the resultant binary oppositions of subject and object, and self and Other; the understanding that the individual is a temporal being; an emphasis upon intersubjective relations insofar as Being-in-the-world is defined by Being-with-Others; and a consistent emphasis upon average everydayness as both determinative and representative of the individual’s relationship to and with the world.

A Māori Girl Watches, Listens, and Learns – Coming of Age from an Indigenous Viewpoint: Mauri (Merata Mita, 1988)

2018 ◽  
Author(s):  
Alistair Fox
Keyword(s):  
Indigenous People ◽  
Coming Of Age ◽  
Natural World ◽  
Feature Film ◽  
Indigenous Woman ◽  
Spiritual Dimension ◽  
The World ◽  
Life Force ◽  
Relationship Of ◽  
The Relationship

This chapter examines Merata Mita’s Mauri, the first fiction feature film in the world to be solely written and directed by an indigenous woman, as an example of “Fourth Cinema” – that is, a form of filmmaking that aims to create, produce, and transmit the stories of indigenous people, and in their own image – showing how Mita presents the coming-of-age story of a Māori girl who grows into an understanding of the spiritual dimension of the relationship of her people to the natural world, and to the ancestors who have preceded them. The discussion demonstrates how the film adopts storytelling procedures that reflect a distinctively Māori view of time and are designed to signify the presence of the mauri (or life force) in the Māori world.

On Metaphysics and the Political: A Polemics of Reading Baudelaire in the 1930s

2019 ◽  
Vol 58 (2) ◽  
pp. 249-259
Author(s):  
Joseph Acquisto
Keyword(s):  
Twentieth Century ◽  
Political Crisis ◽  
The Political ◽  
Modern Poetry ◽  
Progressive Politics ◽  
The World ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

This essay examines a polemic between two Baudelaire critics of the 1930s, Jean Cassou and Benjamin Fondane, which centered on the relationship of poetry to progressive politics and metaphysics. I argue that a return to Baudelaire's poetry can yield insight into what seems like an impasse in Cassou and Fondane. Baudelaire provides the possibility of realigning metaphysics and politics so that poetry has the potential to become the space in which we can begin to think the two of them together, as opposed to seeing them in unresolvable tension. Or rather, the tension that Baudelaire animates between the two allows us a new way of thinking about the role of esthetics in moments of political crisis. We can in some ways see Baudelaire as responding, avant la lettre, to two of his early twentieth-century readers who correctly perceived his work as the space that breathes a new urgency into the questions of how modern poetry relates to the world from which it springs and in which it intervenes.

Mechanisms of liver damage in COVID-19

2020 ◽  
Vol 1 (19) ◽  
pp. 39-46
Author(s):  
T. V. Pinchuk ◽  
N. V. Orlova ◽  
T. G. Suranova ◽  
T. I. Bonkalo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Risk Factor ◽  
Liver Disease ◽  
Liver Function ◽  
Liver Damage ◽  
The World ◽  
Coronavirus Infection ◽  
The Impact ◽  
Analyze Data

At the end of 2019, a new coronavirus (SARS-CoV-2) was discovered in China, causing the coronavirus infection COVID-19. The ongoing COVID-19 pandemic poses a major challenge to health systems around the world. There is still little information on how infection affects liver function and the significance of pre-existing liver disease as a risk factor for infection and severe COVID-19. In addition, some drugs used to treat the new coronavirus infection are hepatotoxic. In this article, we analyze data on the impact of COVID-19 on liver function, as well as on the course and outcome of COVID-19 in patients with liver disease, including hepatocellular carcinoma, or those on immunosuppressive therapy after liver transplantation.

ADDRESSING THE ISSUE OF СOVID-19, SARS-COV-2 VIRUS AND THE DISEASE

2020 ◽  
Vol 99 (6) ◽  
pp. 15-31
Author(s):  
A.A. Korenkova ◽  
◽  
E.M. Mayorova ◽  
V.V. Bahmetjev ◽  
M.V. Tretyak ◽  
...  
Keyword(s):  
Public Health ◽  
Immune Responses ◽  
Molecular Mechanisms ◽  
Herd Immunity ◽  
Significant Problem ◽  
Prevention Measures ◽  
Optimal Therapy ◽  
The World ◽  
Public Health Challenge ◽  
Coronavirus Infection

The new coronavirus infection has posed a major public health challenge around the world, but new data on the disease raises more questions than answers. The lack of optimal therapy is a significant problem. The article examines the molecular mechanisms of SARS-CoV-2 infection and the pathogenesis of COVID-19, special attention is paid to features of pathological processes and immune responses in children. COVID-19 leads to a wide diversity of negative outcomes, many of which can persist for at least months. Many of the consequences have yet to be identified. SARS-CoV-2 may provoke autoimmune reactions. Reinfection, herd immunity, vaccines and other prevention measures are also discussed in this review.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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