scholarly journals The Association Between Parity and Metabolically Unhealthy Normal-Weight in Chinese Postmenopausal Women

2020 ◽  
Author(s):  
Mengte Shi ◽  
Xinhe Zhou ◽  
Chao Zheng ◽  
Youjin Pan
Keyword(s):  
Postmenopausal Women ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Smoking Status ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Age At Menarche ◽  
Patients With Diabetes ◽  
Drinking Status ◽  
Chinese Postmenopausal Women

Abstract BackgroundStudies analyzing the association between parity and metabolically unhealthy normal-weight (MUHNW) individuals in postmenopausal women remain limited, this study aimed to explore the association between parity and MUHNW among Chinese postmenopausal women.MethodsIn total, 776 normal-weight undiagnosed type 2 diabetes postmenopausal women who visited the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University for a routine health check-up between 1 January 2017 and 31 December 2019 were included in the study. All individuals had fully completed information records encompassing standardized electronic medical records, physical examinations, and biochemical measurements. The association between parity and MUHNW was analyzed using multivariate logistic regression.ResultsCompared to women with a parity of one, the odds ratios (OR) [95% confidence interval (CI)] of the parity 2, 3, and ≥4 groups were observed to be 1.40 (0.89, 2.20), 2.00 (1.16, 3.44) and 1.87 (0.96, 3.62), respectively, with P for trend < 0.05 after adjusting for potential confounding factors. Women with a higher parity (≥3) had an increased OR of abdominal obesity, while the OR (95% CI) of the parity 3 group was 2.54 (1.46, 4.40) and that of the parity 4 group was 4.25 (2.11, 8.56), the P for trend < 0.001 after adjusting for age, body mass index (BMI), education level, first-degree relatives of patients with diabetes, smoking status, alcohol drinking status, physical activity, pregnancy losses, age at menarche, and duration of reproductive years. No significant differences were detected for other metabolic disorders including high levels of triglycerides (TG), blood pressure, fasting plasma glucose (FPG), and decreased high-density lipoprotein cholesterol (HDL-C) in different parity groups.ConclusionHigher parity was associated with a higher risk of MUHNW in Chinese postmenopausal women. Accordingly, it may be plausible that parity serves as a risk factor for metabolic disorders irrespective of BMI, and abdominal obesity may play an important role in metabolic disorders.

scholarly journals The risk of cardiovascular death in type 2 diabetes

2017 ◽  
Vol 95 (1) ◽  
pp. 57-59
Author(s):  
N. V. Zeinalova ◽  
Yagub Ziyaddin Kurbanov ◽  
V. A. Mirzazade ◽  
R. A. Rzayeva ◽  
M. S. Novruzova
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Disorders ◽  
Density Lipoprotein ◽  
Cardiovascular Death ◽  
Control Group ◽  
Average Risk ◽  
Virtual Control ◽  
Framingham Risk ◽  
Patients With Diabetes

Aim. To evaluate effects of metabolic disorders on the risk of cardiovascular death in patients with type II diabetes based on Framingham risk score. We analyzed results of examination of 210 men and 210 women with type 2 diabetes who applied for medical care to the VM center of Endocrinology during 1997-2014. A virtual control group was formed matching real patients in terms of the number, sex, age, and height having ideal body mass index, total cholesterol and high-density lipoprotein cholesterol levels. The average risk of cardiovascular death in patients with type 2 diabetes was equal to 4,56±0,254% compared with 0,6±1,028% in the virtual control group. The differences was significant (p <0,001). The minimum risk for the patients of the two groups was estimated at 0,001% and 0,01% respectively. The maximum risk of cardiovascular death is 34,17% in patients with diabetes and 8,24% in controls. It is concluded that type 2 diabetes and related metabolic disorders significantly increase the risk of cardiovascular death.

scholarly journals Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2883
Author(s):  
Inés Domínguez-López ◽  
Isabella Parilli-Moser ◽  
Camila Arancibia-Riveros ◽  
Anna Tresserra-Rimbau ◽  
Miguel Angel Martínez-González ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Postmenopausal Women ◽  
Tartaric Acid ◽  
Cardiovascular Health ◽  
Ldl Cholesterol ◽  
Smoking Status ◽  
Strong Association ◽  
Density Lipoprotein ◽  
P Value ◽  
Wine Consumption

Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60–80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (−3.13 μg/mg (−5.54, −0.71), p-value = 0.016 and −3.03 μg/mg (−5.62, −0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.

scholarly journals Metabolic syndrome in middle-aged and older women: A cross-sectional study

2022 ◽  
Vol 18 ◽  
pp. 174550652110706
Author(s):  
Mayle Andrade Moreira ◽  
Saionara Maria Aires da Câmara ◽  
Sabrina Gabrielle Gomes Fernandes ◽  
Ingrid Guerra Azevedo ◽  
Álvaro Campos Cavalcanti Maciel
Keyword(s):  
Metabolic Syndrome ◽  
Older Women ◽  
Abdominal Obesity ◽  
Menopausal Status ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Age At Menarche ◽  
Middle Aged ◽  
Cross Sectional

Objective: This study aims to compare the prevalence of metabolic syndrome between different age groups of middle-aged and older women and to assess whether these differences are independent of potential covariates. Methods: Study conducted with 510 women divided into three age groups: 45–54, 55–64 and 65–74 years. Socioeconomic, reproductive and lifestyle variables were self-reported. We defined metabolic syndrome using the National Cholesterol Education Program Adult Treatment Panel III criteria (abdominal obesity, diabetes, reduced high-density lipoprotein, elevated triglycerides, and hypertension). Logistic regression assessed the association between age groups, and metabolic syndrome was adjusted for covariates (socioeconomic variables, age at menarche and at first childbirth, parity, menopausal status, physical activity variables and smoking). Results: Women aged 55–64 years presented higher prevalence of all metabolic syndrome criteria than the other groups, except for abdominal obesity, which was higher in the oldest group. In the fully adjusted analysis, the 55–64 years age group continues to exhibit significantly higher odds of presenting metabolic syndrome when compared to the youngest group (45–54 years) (OR = 2.257; 95% CI = 1.20:4.24). There was no statistical difference in the odds of presenting metabolic syndrome when comparing the oldest and the youngest groups (OR = 1.500; 95% CI = 0.85:2.65). Conclusion: The higher prevalence of metabolic syndrome among those aged 55–64 years may indicate that middle-aged women become unhealthy earlier in the life course and that many of them may die prematurely. This result highlights the importance of screening metabolic syndrome earlier in the midlife and the need for public health policies aimed at reducing adverse effects in later years.

scholarly journals Heterogeneity of abdominal obesity in patients with cardiovascular diseases

2022 ◽  
Vol 17 (6) ◽  
pp. 867-872
Author(s):  
S. V. Miklishanskaya ◽  
L. V. Solomasova ◽  
A. A. Orlovsky ◽  
S. N. Nasonova ◽  
N. A. Mazur
Keyword(s):  
Adipose Tissue ◽  
Abdominal Obesity ◽  
Metabolic Disorders ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Anthropometric Parameters ◽  
Weight Calculation ◽  
Total Adipose Tissue ◽  
Dimensional Echocardiography ◽  
Visceral Adipose

Aim: To assess the content of visceral adipose tissue (VAT) in patients with abdominal obesity and its relationship with metabolic disorders.Material and methods. Patients with abdominal obesity (n=107) were included in the study. All participants had an assessment of anthropometric parameters (height, weight), calculation of body mass index (BMI), proportion of total adipose tissue and VAT (bioimpedance analyzer), high-density lipoprotein cholesterol (HDL-c) levels, triglycerides, fasting blood glucose, epicardial thickness adipose tissue (two-dimensional echocardiography).Results. The median share of VAT (bioimpedance method) was 13%. Patients with abdominal obesity are divided by VAT into 2 groups: ≥14% or ≤13%. Patients with VAT≥14% had significantly higher levels of triglycerides (1.76 [1.27; 2.38] mmol / L) and glucose (6.33 [5.78; 7.87] mmol / L), and below HDL-c levels (0.95 [0.85; 1.21] mmol / L) compared with patients with VAT≤13% (1.32 [1.02; 1.50], 5.59 [5, 11; 6.16] and 1.31 [1.07; 1.58] mmol / L, respectively; p<0.001 for all three comparisons). A significant correlation was found between VAT and triglyceride, glucose and HDL-c levels (r=0.40; r=0.40; r=-0.31, respectively; p<0.001).Conclusion. Persons with abdominal obesity are heterogeneous in the proportion of VAT. The proportion of VAT above the median is associated with metabolic disorders that are significant for the development and progression of atherosclerosis. An increase in BMI in obese individuals is not associated with an increase in VAT and an increase in the severity of metabolic disorders.

scholarly journals The effects of tubal sterilization on menopausal age in a cohort of postmenopausal women

2021 ◽  
Vol 38 (4) ◽  
pp. 589-593
Author(s):  
Utku AKGÖR ◽  
Samet KİRAT ◽  
C. Ekrem TOK
Keyword(s):  
Postmenopausal Women ◽  
Smoking Status ◽  
Statistical Significance ◽  
Intrauterine Device ◽  
Age At Menarche ◽  
Tubal Sterilization ◽  
Age At Menopause ◽  
Secondhand Smoking ◽  
Significant Difference ◽  
Mother’S Age

To evaluate whether tubal sterilization (TS) has an adverse effect on menopausal age in a cohort of postmenopausal women. The medical records on TS were gathered from 1,228 postmenopausal women in menopause clinic at a tertiary hospital. The age at menarche, the parity, smoking and secondhand smoking status and mother’s age at menopause did not show any significant difference between the groups. Likewise, marital status, educational and yearly income levels were comparable (P > 0.01). Although the mean BMI (P = 0.06) and the rate of oral contraceptive use (P = 0.09) were tended to be higher in non-TS women than in TS group, the difference did not reach statistical significance. The ever use of intrauterine device rate was significantly lower in TS group than in non-TS group (P <0.001). The TS women, in comparison with the non-TS women had undergone earlier natural menopause (P <0.001). The age at menopause had an inverse correlation with TS, and positive correlation with mother’s age at menopause in univariate analyses. However, there was marginally significant correlation between secondhand smoking and age at menopause. Linear stepwise regression analyses revealed that TS and mother’s age at menopause were independent predictors of age at menopause (P < 0.05). We found an earlier age at menopause in women with TS in this study. In this regard, this is the first report about the age at menopause in women with TS, as far as we know.

scholarly journals Biochemical Data and Metabolic Profiles of Male Exclusive Narghile Smokers (ENSs) Compared With Apparently Healthy Nonsmokers (AHNSs)

2019 ◽  
Vol 13 (1) ◽  
pp. 155798831982575 ◽  
Author(s):  
Yosra Hasni ◽  
Sabrine Bachrouch ◽  
Mohamed Mahjoub ◽  
Amel Maaroufi ◽  
Sonia Rouatbi ◽  
...  
Keyword(s):  
Smoking Status ◽  
Low Density Lipoprotein ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Lower Percentage ◽  
Metabolic Profiles ◽  
The Metabolic Syndrome ◽  
Low Hdl ◽  
History Of

Studies evaluating the metabolic profiles of ENSs are scarce and presented controversial conclusions. This study aimed to compare the metabolic profiles of ENSs’ and AHNSs’ groups. Males aged 25–45 years and free from a known history of metabolic and/or cardiovascular diseases were included. According to the smoking status, two groups of ENSs and AHNSs were identified. Body mass index (BMI, kg/m2), waist circumference (WC, cm), systolic and diastolic blood pressures (SBP, DBP, mmHg), fasting blood data in mmol/L (blood glycemia [FBG], triglycerides [TG], total cholesterol [TC], high- and low- density lipoprotein cholesterol [HDL-C, LDL-C]) and obesity status were evaluated. The metabolic syndrome (MetS) was defined according to the 2006 International Diabetes Federation (IDF) recommendations. Data were expressed as mean ± standard deviation ( SD) or percentages. Compared to the AHNSs’ group ( n = 29), the ENSs’ one ( n = 29) had (a) higher values of BMI (26.5 ± 2.3 vs. 28.2 ± 3.6), WC (95 ± 7 vs. 100 ± 10), and TG (1.22 ± 0.40 vs. 1.87 ± 0.85); and (b) included a lower percentage of males having low HDL-C (82.7% vs. 62.0%), and higher percentages of males having obesity (6.9% vs. 37.9%) or hypertriglyceridemia (10.7% vs. 51.7%). Both the ENSs’ and AHNSs’ groups: (a) had similar values of FBG (5.38 ± 0.58 vs. 5.60 ± 0.37), TC (4.87 ± 1.16 vs. 4.36 ± 0.74), HDL-C (0.92 ± 0.30 vs. 0.82 ± 0.21), LDL-C (3.09 ± 0.98 vs. 2.92 ± 0.77), SBP (117 ± 9 vs. 115 ± 8), and DBP (76 ± 6 vs. 73 ± 7); and (b) included similar percentages of males having normal weight (17.2% vs. 31.0%); overweight (44.8% vs. 62.1%); android obesity (79.3% vs. 59.6%), hypertension (10.3% vs. 10.3%), hyperglycemia (37.9% vs. 48.2%), and MetS (51.7% vs. 34.5%). There is a need to monitor narghile use among male metabolic patients since it alters some components of the MetS.

scholarly journals Differences in body composition between metabolically healthy and unhealthy midlife women with respect to obesity status

2021 ◽  
Vol 84 (1) ◽  
pp. 59-71
Author(s):  
Lenka Vorobeľová ◽  
Darina Falbová ◽  
Daniela Siváková
Keyword(s):  
Body Composition ◽  
Smoking Status ◽  
Menopausal Status ◽  
Sport Activity ◽  
Density Lipoprotein ◽  
Logistic Models ◽  
Normal Weight ◽  
Metabolic Health ◽  
Midlife Women ◽  
Metabolically Healthy

Abstract Body composition (BC) characteristics across metabolic health-by-body mass index categories were examined. Metabolic health (MH) was defined by five biomarkers: waist circumference, blood pressure, levels of triglycerides, high density lipoprotein cholesterol, and fasting glucose. Potential differences in BC characteristics between metabolically healthy obese (MH-O) and metabolically unhealthy obese (MUH-O) women, and between MH normal weight (MH-NW) and MUH normal weight (MUH-NW) women were explored in 276 Slovak midlife women (39-65 years). Body composition parameters were measured with bioimpedance analyzer (BIA 101, Akern, S. r. l.). A simple comparison of the BC data between the subgroups showed significant differences in resistance (Rz, ohm) (p=0.035), muscle mass (MM, kg) (p=0.044), and total body water (TBW, kg) (p=0.047) between MH-O and MUH-O women. However, we did not observe any significant differences in BC characteristics between MH-NW and MUHNW. Specific logistic regression models were used to determine differences in BC characteristics between various obesity phenotypes, with controlling for age, menopausal status, smoking status and sport activity. Our results indicated that increasing age and decreasing Rz were statistically significantly associated with an increased likelihood of exhibiting MUH-O (p=0.031 for age; p=0.032 for Rz). Moreover, other logistic models which included age, menopausal status, biochemical variables and life style factors such as covariates, showed that increasing alanine aminotransferase (ALT) and uric acid (UA) were statistically significantly associated with an increased likelihood of exhibiting MUH-O (p=0.023 for ALT, p=0.010 for UA). In conclusion, MUH-O and MH-O cardiometabolic profiles are characterized by differences in the value of resistance and plasma levels of ALT and UA.

scholarly journals The association between parity and metabolic syndrome and its components in normal-weight postmenopausal women in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mengte Shi ◽  
Xinhe Zhou ◽  
Chao Zheng ◽  
Youjin Pan
Keyword(s):  
Metabolic Syndrome ◽  
Postmenopausal Women ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Confounding Factors ◽  
Continuous Variables ◽  
Hip Circumference ◽  
Cross Sectional ◽  
Statistical Software ◽  
Normally Distributed

Abstract Background Studies analyzing the association between parity and normal-weight metabolic syndrome (MetS) in postmenopausal women of normal weight remain limited, this study aimed to explore the association between parity and MetS among Chinese normal-weight postmenopausal women. Methods In total, 776 normal-weight undiagnosed type 2 diabetes postmenopausal women who visited the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University for a routine health check-up between 1 January 2017 and 31 December 2019 were included in the cross-sectional study. All individuals had fully completed information records encompassing standardized electronic medical records, physical examinations, and biochemical measurements. Metabolic health was defined as fewer than 2 parameters of the MetS were present, in combination with normal weight. Continuous variables which were normally distributed were expressed as means and standard deviation. Comparisons among normally distributed continuous variables were made using one-way ANOVA while that among non-normal distribution parameters were made using Kruskal-Wallis. The association between parity and MetS was analyzed using multivariate logistic regression. All of the analyses were performed with SPSS statistical software (Version 23.0, SPSS, Inc., Chicago, IL, USA) and the statistical software package EmpowerStats (http://www.empowerstats.com, X&Y Solutions, Inc., Boston, MA). Results After adjusting for potential confounding factors including hip circumference, parity was failed to show a significantly relationship with MetS in normal-weight women(P=0.054). Women with a higher parity (≥3) had an increased OR of abdominal obesity, while the OR (95% CI) of the parity 3 group was 2.06 (1.13, 3.77) and that of the parity ≥4 group was 3.08(1.42, 6.66) the P for trend was 0.002 after adjusting for potential confounding factors. No significant differences were detected for other metabolic disorders including high levels of triglycerides (TG), blood pressure, fasting plasma glucose (FPG), and decreased high-density lipoprotein cholesterol (HDL-C) in different parity groups. Conclusions Higher parity was not associated with a higher risk of MetS in normal weight Chinese postmenopausal women. As for the components of MetS, only waist circumference was associated with multiparity even after controlling for hip circumference.

scholarly journals Gut microbiota markers associated with obesity and overweight in Italian adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vanessa Palmas ◽  
Silvia Pisanu ◽  
Veronica Madau ◽  
Emanuela Casula ◽  
Andrea Deledda ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Relative Abundance ◽  
Smoking Status ◽  
16S Rrna Gene Sequencing ◽  
Normal Weight ◽  
Activity Level ◽  
Rrna Gene ◽  
Illumina Platform ◽  
Obesity And Overweight ◽  
Rrna Gene Sequencing

AbstractIn the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ± 6.0; F/M = 40/6) was analyzed and compared to that of 46 NW subjects (BMI = 21.6 ± 2.1; F/M = 41/5), matched for sex, age and smoking status, by using 16S rRNA gene sequencing on MiSeq Illumina platform. The gut microbial community of OB patients exhibited a significant decrease in the relative abundance of several Bacteroidetes taxa (i.e. Flavobacteriaceae, Porphyromonadaceae, Sphingobacteriaceae, Flavobacterium, Rikenella spp., Pedobacter spp., Parabacteroides spp., Bacteroides spp.) when compared to NW; instead, several Firmicutes taxa were significantly increased in the same subjects (Lachnospiraceae, Gemellaceae, Paenibacillaceae, Streptococcaceae, Thermicanaceae, Gemella, Mitsuokella, Streptococcus, Acidaminococcus spp., Eubacterium spp., Ruminococcus spp., Megamonas spp., Streptococcus, Thermicanus, Megasphaera spp. and Veillonella spp.). Correlation analysis indicated that body fatness and waist circumference negatively correlated with Bacteroidetes taxa, while Firmicutes taxa positively correlated with body fat and negatively with muscle mass and/or physical activity level. Furthermore, the relative abundance of several bacterial taxa belonging to Enterobacteriaceae family, known to exhibit endotoxic activity, was increased in the OB group compared to NW. The results extend our knowledge on the GM profiles in Italian OB, identifying novel taxa linking obesity and intestine.

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