scholarly journals Carbohydrate Antigen 125 Supplements Carbohydrate Antigen 19-9 for the Prediction of Invasive Intraductal Papillary Mucinous Neoplasms of the Pancreas

2021 ◽  
Author(s):  
Yunzhen Qian ◽  
Yitao Gong ◽  
Guopei Luo ◽  
Yu Liu ◽  
Ruijie Wang ◽  
...  
Keyword(s):  
Roc Curves ◽  
Serum Levels ◽  
Carbohydrate Antigen ◽  
Serum Biomarkers ◽  
Cancer Center ◽  
Carbohydrate Antigen 125 ◽  
Diagnostic Indices ◽  
Preoperative Serum ◽  
Malignant Group ◽  
Serological Biomarkers

Abstract BackgroundIntraductal papillary mucinous neoplasm (IPMN) is a disease with malignant potential. IPMNs of the pancreas are mainly managed according to radiographic indications, which lack accuracy in defining grades of IPMNs. Therefore, other indications such as serological biomarkers should be employed to predict the invasiveness of IPMNs.MethodsWe investigated preoperative serum levels of CA19-9, CA125 and CEA of 381 surgical patients with a definite pathological diagnosis of IPMN from July 2010 to December 2019 at Shanghai Cancer Center. We calculated the Youden indices of each point of receiver operating characteristic (ROC) curves to find the most appropriate cut-off values of CA19-9, CA125 and CEA in recognizing malignant IPMNs. Serological biomarker differences were correlated with grades and biological behaviours of IPMNs. Diagnostic indices of these serum biomarkers were calculated.ResultsMalignant group had higher serum levels of CA19-9, CA125 and CEA. According to ROC curves, the most appropriate cut-off value of CA125 were readjusted to 13.5 U/ml while the cut-off values of CA19-9 and CEA remained 37 U/ml and 5.3 ng/l as them mostly be employed. Besides, CA19-9 elevation was significantly associated with vascular invasion and perineural infiltration. We found CA125 may predict invasive IPMN in CA19-9 negative subgroup according to ROC curve. ConclusionsSerological biomarkers are useful and sensitive indications for recognizing invasive IPMNs. CA19-9 has the upmost diagnostic indices among all regularly used serum biomarkers in differentiating malignant and benign IPMNs. CA19-9 should be combined with CA125 to form a more favourable biomarker panel for IPMNs malignancy prediction.

scholarly journals Assessment of the Value of Preoperative Serum Levels of CA 242 and CEA in the Staging and Postoperative Survival of Colorectal Adenocarcinoma Patients

2003 ◽  
Vol 18 (3) ◽  
pp. 182-187 ◽  
Author(s):  
S.B. Kim ◽  
L.C. Fernandes ◽  
S.S. Saad ◽  
D. Matos
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Radical Surgery ◽  
Roc Curves ◽  
Serum Levels ◽  
Control Group ◽  
Significance Level ◽  
Ca 242 ◽  
Preoperative Serum ◽  
Significant Difference

Introduction CEA is the most frequently used tumor marker in colorectal cancer. There may be an improvement in its efficacy when used in association with CA 242. Aim The purpose of this study was to evaluate the efficacy of preoperative serum levels of the tumor markers CA 242 and CEA in the staging and postoperative follow-up of colorectal adenocarcinoma patients. Patients and Methods Of a series of 134 patients with colorectal adenocarcinomas 90 underwent radical surgery and 44 palliative surgery. The control group consisted of 22 organ donors. The cutoff serum levels utilized were 5 ng/mL for CEA and 20 U/mL for CA 242. The mortality during follow-up was recorded in order to determine the duration of survival. The data were submitted to statistical analysis using diagnostic tests, the chi-square test, survival analysis (Kaplan and Meier) and ROC curves. A significance level of p ≤ 0.05 was applied. Results The sensitivity of CEA in Dukes’ stages A, B, C and D was 27.8%, 32.4%, 32.1% and 66.7%, respectively. The sensitivity of CA 242 was 11.1%, 16.2%, 30.8% and 50%. When both markers were combined, the sensitivity was 33.3%, 48.6%, 40.7% and 72.5%. In the group of patients who underwent radical surgery the mean survival was 60.47 months for those with high preoperative CEA levels, 52.22 months for those with high preoperative CA 242 levels, and 44.80 months for those with elevated levels of both markers. There was a statistically significant difference in survival between patients undergoing radical surgery with elevated CA 242 levels, especially when CEA was also elevated, and patients without elevated CA 242. Conclusion Preoperative serum levels of CA 242 showed less efficacy than CEA levels for the staging of colorectal adenocarcinoma patients. Elevated preoperative serum levels of CA 242 alone were related to poor survival, especially in association with high levels of CEA.

scholarly journals Carbohydrate antigen-125, calcium, and hemoglobin as predictive clinical indicator for ocular metastasis in male liver cancer patients

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Qian-Hui Xu ◽  
Pei-Wen Zhu ◽  
Biao Li ◽  
Wen-Qing Shi ◽  
Qi Lin ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Carbohydrate Antigen ◽  
Serum Biomarkers ◽  
Ca 125 ◽  
Carbohydrate Antigen 125 ◽  
Male Patients ◽  
Ocular Metastasis ◽  
Relationship Of ◽  
The Relationship

Abstract Background Primary liver cancer (PLC) is a common type of cancer among men worldwide. Little is known regarding the relationship of liver cancer with ocular metastasis (OM). Drinking has been also reported to be related not only to the occurrence of liver cancer but also to the causes of some ocular lesions. Purpose A diagnostic standard for the levels of serum biomarkers associated with OM derived from liver cancer in men is urgently needed. Material and methods We examined the association between OM in liver cancer and its serum biomarkers. A total of 1254 male patients with liver cancer were recruited in this retrospective study between July 2002 and December 2012. We assessed the relationship between drinking preference and OM in male patients with liver cancer, and aimed to identify an independent prognostic factor or establish a quantitative indicator for OM. Results By assessing the potential indicators, carbohydrate antigen-125 (CA-125), calcium, and hemoglobin (Hb) were found to be most valuable in the diagnosis of OM in male patients with liver cancer. Conclusion CA-125, calcium, and Hb are independent risk factors of OM in patients with liver cancer who consume alcohol.

Comparison of Serum Tumor Markers for Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma

2010 ◽  
Vol 76 (11) ◽  
pp. 1210-1213 ◽  
Author(s):  
Lian-Yuan Tao ◽  
Lei Cai ◽  
Xiao-Dong He ◽  
Wei Liu ◽  
Qiang Qu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Intrahepatic Cholangiocarcinoma ◽  
High Specificity ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Carbohydrate Antigen ◽  
Serum Tumor Markers ◽  
Preoperative Serum

Serum tumor markers such as alpha-fetoprotein (AFP), carcinoembryonic antigen, carbohydrate antigen (CA) 19-9, CA242, and CA50 were analyzed to evaluate their diagnostic values in single and combined tests for distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). Preoperative serum levels of AFP, carcinoembryonic antigen, CA19-9, CA242, and CA50 were measured in 45 ICC and 76 HCC patients. The serum levels and the positive rate of AFP, CA19-9, and CA242 were significantly different between the ICC patients and HCC patients. Although AFP (—) was the most sensitive assay for distinguishing ICC from HCC (91.1%), its specificity was significantly lower than that of CA242 (+) and CA19-9 (+). The combination of AFP (-) and CA242 (+) afforded a high specificity of 94.3 per cent and showed highest accuracy (78.5%). Evaluation of patients without liver cirrhosis also showed similar results. The diagnostic value of CA242 (+) is better than that of CA19-9 (+) and AFP (-) in distinguishing ICC from HCC. Combined detection of AFP (—) and CA242 (+) can improve the specificity and accuracy of diagnosing ICC.

scholarly journals TO ACESS LEVEL OF CA 19.9( CARBOHYDRATE ANTIGEN 19.9) & CA125 (CARBOHYDRATE ANTIGEN 125) IN PATIENTS OF CANCER ( OVARIAN, ENDOMETRIAL & PANCREATIC)

2021 ◽  
Vol 9 (01) ◽  
pp. 1133-1137
Author(s):  
Farah Ahsan ◽  
◽  
Sonali Kukreti ◽  
Sumera Samreen ◽  
◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Pancreatic Tumor ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Control Group ◽  
Ovarian Endometriosis ◽  
Carbohydrate Antigen 125 ◽  
Ca 19.9

Purpose: To investigate the diagnostic value of CA 19.9 & CA125 in patients of cancer. Methods: 100 randomly selected patients coming to Medicine & Gynae OPD with symptoms of cancer. Serum was taken and CA19.9 & CA 125 was analyzed by Electrochemiluminescent Immunoassay. Results: It showed serum levels of CA19.9 & CA125 of patient with malignant ovarian, endometriosis & pancreatic tumor significantly higher than the control group. Out of total 50 patients for CA19.9, 45 were females & 5 males. Out of 45 females, 14 females & 3 males have raised value. All 3 males have significantly raised value more than 500 U/ml & All 3 had pancreatic carcinoma. Out of 14 females those had value more than 1000 had features of malignancy whereas rest females of value more than 100 had features of endometriosis. For CA125 total of 50 patients were taken out of which only 10 patients had raised CA125 level. All were females and 60% had value more than cut off that was 35u/ml. Out of the 10 females who had raised CA125, 6 had carcinoma & metastasis & rest 4 had endometriosis.

scholarly journals Metabolomic Profiling Identified Serum Metabolite Biomarkers and Related Metabolic Pathways of Colorectal Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Chengjian Zhang ◽  
Shengnan Zhou ◽  
Huijing Chang ◽  
Feng Zhuang ◽  
Yang Shi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Pathways ◽  
Roc Curves ◽  
Serum Levels ◽  
Serum Biomarkers ◽  
Healthy Controls ◽  
Dodecylbenzenesulfonic Acid ◽  
Metabolomic Profiling ◽  
Liquid Chromatography Tandem Mass ◽  
Healthy Control

Background. The screening and early detection of colorectal cancer (CRC) still remain a challenge due to the lack of reliable and effective serum biomarkers. Thus, this study is aimed at identifying serum biomarkers of CRC that could be used to distinguish CRC from healthy controls. Methods. A prospective 1 : 2 individual matching case-control study was performed which included 50 healthy control subjects and 98 CRC patients. Untargeted metabolomic profiling was conducted with liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify CRC-related metabolites and metabolic pathways. Results. In total, 178 metabolites were detected, and an orthogonal partial least-squares-discriminant analysis (OPLS-DA) model was useful to distinguish CRC patients from healthy controls. Nine metabolites showed significantly differential serum levels in CRC patients under the conditions of variable importance in projection VIP > 1 , p < 0.05 using Student’s t -test, and fold change FC ≥ 1.2 or ≤0.5. The above nine metabolites were 3-hydroxybutyric acid, hexadecanedioic acid, succinic acid semialdehyde, 4-dodecylbenzenesulfonic acid, prostaglandin B2, 2-pyrocatechuic acid, xanthoxylin, 12-hydroxydodecanoic acid, and formylanthranilic acid. Four potential biomarkers were identified to diagnose CRC through ROC curves: hexadecanedioic acid, 4-dodecylbenzenesulfonic acid, 2-pyrocatechuic acid, and formylanthranilic acid. All AUC values of these four serum biomarkers were above 0.70. In addition, the exploratory analysis of metabolic pathways revealed the activated states for the vitamin B metabolic pathway and the alanine, aspartate, and glutamate metabolic pathways associated with CRC. Conclusion. The 4 identified potential metabolic biomarkers could discriminate CRC patients from healthy controls, and the 2 metabolic pathways may be activated in the CRC tissues.

Preoperative Carbohydrate Antigen 195 (CA195) and CEA Serum Levels as Prognostic Factors in Patients with Colorectal Cancer

1998 ◽  
Vol 13 (3) ◽  
pp. 158-164 ◽  
Author(s):  
A. Andicoechea ◽  
F. Vizoso ◽  
E. Alexandre ◽  
E. Cuesta ◽  
M. Cruz Díez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Multivariate Analysis ◽  
Prognostic Value ◽  
Serum Levels ◽  
Tumor Location ◽  
Carbohydrate Antigen ◽  
Primary Colorectal Cancer ◽  
Preoperative Serum ◽  
The Mean

We evaluated in 214 patients with primary colorectal cancer the prognostic value of the preoperative serum levels of CEA and CA195. For CEA these levels were above the cutoff of 6 ng/ml in 31.3% of patients, whereas for CA195 they were higher than 12 U/ml in 35.9% of patients. The simultaneous use of both antigens increased the sensitivity to 49%, which was significantly higher than that of CEA (p<0.001) and CA195 (p<0.01) taken singly. The mean preoperative CEA levels were significantly (p<0.001) correlated with Dukes’ stage only, while there was a significant correlation between preoperative serum levels of CA195 and Dukes’ stage (p<0.001), grade of differentiation (p<0.01) and tumor location (p<0.05). The results indicated that high preoperative serum levels of CEA and CA195 were associated with a shorter overall survival (p<0.0001). In addition, separate Cox multivariate analysis showed that preoperative CA195 was, after Dukes’ stage, the strongest factor to predict overall survival (p<0.0001).

Sign in / Sign up

Export Citation Format

Share Document