scholarly journals Distress andneoangiogenesis in ovarian cancer patients

2019 ◽  
Vol 18 (2) ◽  
pp. 22-27
Author(s):  
G. P. Guens ◽  
I. N. Oleynikova ◽  
N. A. Sirota ◽  
N. I. Moiseeva ◽  
V. E. Shikina ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Cross Sectional ◽  
Early Diagnosis Of Cancer ◽  
Distress Level ◽  
Median Serum ◽  
Tumor Neoangiogenesis ◽  
Endothelial Growth Factor

Background.Previous pre-clinical and clinical trials showed that distress experienced by cancer patients can activate the sympathetic nervous system, resulting in the elevation of the level of catecholamines in tumor tissue. catecholamines activate tumor neoangiogenesis via binding to the adrenergic receptors of tumor cells and cells of tumor microenvironment. Vascular endothelial growth factor a(VEgF a) plays a key role in tumor neoangiogenesis.Objective.To evaluate the correlation between serum VEgF alevel and distress in ovarian cancer patients.Material and methods.The prospective cross-sectional study included 100 patients with stage i–iV ovarian cancer. the median age of the patients was 56 ± 9,56 years. Enzym-linked immunosorbent assay was used for the assessment of serum VEgF alevel. distress thermometer (validated self-reported questionnaire) was used for distress diagnosis.Results.The median serum VEgF alevel was 325.77 pg/ml. aclinically significant distress was diagnosed in 54 % of patients. We found the correlation between the serum VEgF alevel and distress level in ovarian cancer patients (spearman’s rho=0.33; 95 % ci, 0.11–0.52; р< 0.004). We also found the correlation between the serum VEgR alevel and disease stage (rho=0.30; 95 % ci0.02–0.53; p<0.05). However, there was no correlation between distress and disease stage. the regression analysis method revealed that distress was an independent factor of serum VEgF aelevation in ovarian cancer patients (p<0.05).Conclusion.Assessment and early diagnosis of cancer-related distress was shown to be important for the appropriate management of ovarian cancer.

scholarly journals Does the cancer patient's disease stage matter? A comparative study of caregivers' mental health and health related quality of life

2012 ◽  
Vol 10 (3) ◽  
pp. 189-196 ◽  
Author(s):  
Ellen Karine Grov ◽  
Berit Taraldsen Valeberg
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Cross Sectional ◽  
Health Related Qol ◽  
Health Related ◽  
The Impact

AbstractObjective:Cancer affects both patients and their caregivers. Caregiver burden may change during different stages of the patients' cancer trajectory. Limited research has focused on the impact of being a caregiver, assessed by the caregiver's mental health and quality of life (QOL) during the curative and the palliative phases of the patient's disease. The aim of this study is to compare caregivers of cancer patients during the curative and a palliative phases with respect to their mental health and health-related QOL.Method:This descriptive, cross-sectional study combines data from two studies. The first group consists of caregivers of patients with cancer in the late palliative phase and the second group consists of caregivers of outpatients with cancer who suffer from pain and/or use analgesics. Data were collected by means of standardized measures and analyzed with descriptive statistics.Results:Based on this material, no significant differences in mental health and health- related QOL were revealed for caregivers of cancer patients in the palliative and the curative phases, respectively. Neither education level in the caregivers, nor the patients' functional status influenced caregivers' mental health or QOL. Younger caregivers seem to have better physical QOL.Significance of results:Being caregivers of cancer patients seems to have a similar pattern of impact on caregivers' mental health and quality of life regardless of the patient's disease stage. We share some reflections about the way in which the cancer stage is divided and the appropriateness of such selection for measuring caregivers' mental health and QOL. Additionally, we discuss the use of generic instruments for measuring specific contexts and particular samples.

scholarly journals Presence of gastro-intestinal symptoms in ovarian cancer patients during survivorship: a cross-sectional study from the PROFILES registry

2018 ◽  
Vol 27 (6) ◽  
pp. 2285-2293 ◽  
Author(s):  
Mark J. A. Rietveld ◽  
Olga Husson ◽  
M. C. (Caroline) Vos ◽  
Lonneke V. van de Poll-Franse ◽  
P. B. (Nelleke) Ottevanger ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Intestinal Symptoms

scholarly journals The Prevalence of Occult Omental Metastases in Patients with Epithelial Ovarian Cancer

2018 ◽  
pp. 119
Author(s):  
Hariyono Winarto ◽  
Ken Indra
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Patients ◽  
Obstet Gynecol ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Occult Metastases ◽  
Keywords Cancer

Objective: Studies regarding omentectomy on epithelialovarian cancer are scarce with conflicting results; this study isaimed to investigate the prevalence of occult metastases inpatients with epithelial ovarian cancer of the omentum.Methods: A cross-sectional study design was used by evaluating themedical records of surgically staged ovarian cancer patients in Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia during the periodof January 2009 to December 2015.Results: A total of 51 subjects were involved in this study. One(2%) of 51 subjects was found to have occult metastases in theomentum. The prevalence of metastases of early stage epithelialovarian cancer in 2009-2015 is 33.3% (17 out of 51 subjects),whereas the omental involvement is found only in 2% subjects(1 out of 51).Conclusion: The prevalence of occult metastases of early stageepithelial ovarian cancer in Dr. Cipto Mangunkusumo Hospital,Jakarta, Indonesia, from 2009-2015 in 2% (1/51 subjects).[Indones J Obstet Gynecol 2018; 6-2: 119-122]Keywords: cancer, epithelial, metastases, omentum, ovarian cancer,ovary, prevalence

scholarly journals Demoralisation in Cancer Patients: The Association with Distress, Depression and Positive Emotion

2021 ◽  
Vol 16 (1) ◽  
pp. 108-122
Author(s):  
Thong Kai Shin ◽  
Keyword(s):  
Cancer Patients ◽  
Positive Emotion ◽  
Rating Scale ◽  
Cross Sectional Study ◽  
Epidemiologic Studies ◽  
University Hospital ◽  
Cross Sectional ◽  
Distress Level ◽  
High Level ◽  
Patients Experience

Cancer patients experience a high level of distress and depression. The understanding of its psychological correlates such as demoralisation and positive emotion helps in the management of these conditions. The study objectives are to examine the correlation between demoralisation and positive emotion, defined as discrete pleasant emotions, such as joy, pride, contentment or love, with depression and distress in cancer patients. The sociodemographic and clinical associated factors are also studied. This cross-sectional study recruited 178 cancer patients from a local university hospital. They were assessed using the Malay versions of the Demoralization Scales (DS-M), Positive Emotion Rating Scale (PERS), Centre for Epidemiologic Studies Depression (CESD) Scale, and Distress Thermometer. The mean age of the subjects was 53.6 + 16.51 years old, with 24% of them were in the advanced stage of cancer. Almost 38% of the subject were demoralised. Of them, 61.2% were depressed, 52.2% had low positive emotion, and 68.7% were distressed. Demoralisation was positively correlated with depression (r=0.78, p<0.01) and distress level (r=0.64, p<0.01) but negatively correlated with positive emotion (r=-0.69, p<0.01). In conclusion, demoralisation was highly prevalent and strongly associated with depression and distress in cancer patients. Assessment and early detection of demoralisation among cancer patients should receive more attention. Future studies on the management of this condition are needed.

Mental distress and need for psychosocial support in prostate cancer patients: An observational cross-sectional study

2020 ◽  
Vol 56 (1) ◽  
pp. 51-63
Author(s):  
Naomi Baba ◽  
Theresa Schrage ◽  
Armin Hartmann ◽  
Kenji Baba ◽  
Alexander Wuensch ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Mental Distress ◽  
Psychosocial Support ◽  
Cross Sectional Study ◽  
Coping Resources ◽  
Disease Stage ◽  
Depression And Anxiety ◽  
Sectional Study ◽  
Cross Sectional

Objective Prostate cancer is the most common cancer in German men and associated with various physical and psychosocial problems. This study investigated the association between mental distress and the subjective need for psychosocial support comparing subgroups of patients with different treatments and disease stages. Method We performed an observational, cross-sectional study including patients with four medical conditions: Active Surveillance, radical prostatectomy, biochemical relapse, metastasized disease. Mental distress (NCCN Distress-Thermometer), symptoms of depression and anxiety (PHQ-9, GAD-7), psychosocial needs and coping resources (self-designed questionnaire) were assessed. Results N = 130 patients were included. 33.3% showed distress, 16.5% symptoms of moderate depression and 13% symptoms of moderate anxiety. We found no significant differences between the four groups. An association was present between distress and wish for psychosocial support ( χ2 = 4.3; p < 0.05; ϕ = 0.19). Almost 90% lived with a partner, which represents a resource. Conclusions Prostate cancer patients showed low levels of mental distress, depression and anxiety with no difference in terms of disease stage and treatment modality. Therefore, careful psychosocial screening of all patients is essential to identify those in need for support. Distressed patients express a need for psychosocial support more often. Interpersonal relationships, most often wives and children, represent important coping resources.

scholarly journals Anxiety and depression symptoms among ovarian cancer patients in China: a cross-sectional study

2021 ◽  
Vol 7 (4) ◽  
pp. 321-327
Author(s):  
Jing Chen ◽  
De-Rong Long ◽  
Xiu-Jing Guo ◽  
Yi Liu ◽  
Hua-Xuan You
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Influencing Factors ◽  
Coping Style ◽  
Cross Sectional Study ◽  
Education Level ◽  
Depression And Anxiety ◽  
Sectional Study ◽  
Cross Sectional ◽  
And Coping

AbstractObjectiveTo investigate the prevalence of cancer-related depression and anxiety in western China among patients with ovarian cancer and analyze their influencing factors.MethodsIn this prospective cross-sectional study, qualified patients were asked to fill in questionnaires. Multivariate analysis and binary logistic regression analysis were used to test the associations among symptoms of depression and anxiety, coping styles, and influencing factors.ResultsA total of 270 ovarian cancer inpatients who met the criteria for participation in the study completed the questionnaires. The levels of depression and anxiety that prevailed in ovarian cancer patients were 47.03% and 57.77%, respectively. Among them, 90.38% of cancer-related anxiety patients and 91.33% of cancer-related depression patients showed mild symptoms. The chi-square test showed that there were statistically significant differences (P < 0.05) in the fields of education level and income. T-test showed that cancer-related depression and anxiety were associated with coping style, and the difference had statistical significance (P < 0.05). Furthermore, multivariate analysis showed that the education level and coping style were the independent influencing factors of depression and anxiety.ConclusionsThe present study suggested that about half of the ovarian cancer patients had with depression and anxiety symptoms. The majority of the cancer-related depression and symptoms were mild. Educational level and coping style should be considered during the interventions of cancer-related depression and anxiety.

scholarly journals The trends of complementary alternative medicine use among cancer patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Abdul Rahman Jazieh ◽  
Khadega A. Abuelgasim ◽  
Husam I. Ardah ◽  
Mohammad Alkaiyat ◽  
Omar B. Da’ar
Keyword(s):  
Alternative Medicine ◽  
Cancer Patients ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Complementary Alternative Medicine ◽  
Cultural Changes ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
Cam Use ◽  
The Individual

Abstract Background The use of complementary and alternative medicine (CAM) is common among cancer patients and it may reflect the individual and societal beliefs on cancer therapy. Our study aimed to evaluate the trends of CAM use among patients with cancer between 2006 and 2018. Methods We included 2 Cohorts of patients with cancer who were recruited for Cohort 1 between 2006 and 2008 and for Cohort 2 between 2016 and 2018. The study is a cross-sectional study obtaining demographic and clinical information and inquiring about the types of CAM used, the reasons to use them and the perceived benefits. We compared the changes in the patterns of CAM use and other variables between the two cohorts. Results A total of 1416 patients were included in the study, with 464 patients in Cohort 1 and 952 patients in Cohort 2. Patients in Cohort 2 used less CAM (78.9%) than Cohort 1 (96.8%). Cohort 1 was more likely to use CAM to treat cancer compared to Cohort 2 (84.4% vs. 73%, respectively, p < 0.0001,); while Cohort 2 used CAM for symptom management such as pain control and improving appetite among others. Disclosure of CAM use did not change significantly over time and remains low (31.6% in Cohort 1 and 35.7% for Cohort 2). However, physicians were more likely to express an opposing opinion against CAM use in Cohort 2 compared to Cohort 1 (48.7% vs. 19.1%, p < 0.001, respectively). Conclusion There is a significant change in CAM use among cancer patients over the decade, which reflects major societal and cultural changes in this population. Further studies and interventions are needed to improve the disclosure to physicians and to improve other aspects of care to these patients.

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