scholarly journals Dose- and time-dependent systemic adverse reactions of sodium carboxy methyl cellulose after intraperitoneal application in rats

2021 ◽  
Vol 46 (5) ◽  
pp. 223-234
Author(s):  
Chunguang Fan ◽  
Li Hou ◽  
Guoxi Che ◽  
Yanping Shi ◽  
Xiangdong Liu ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Methyl Cellulose ◽  
Time Dependent ◽  
Carboxy Methyl Cellulose ◽  
Carboxy Methyl

scholarly journals Dose- and Time-Dependent Systemic Adverse Reactions of Sodium Carboxy Methyl Cellulose after Intraperitoneal Application in Rats

2020 ◽  
Author(s):  
Chunguang Fan ◽  
Li Hou ◽  
Guoxi Che ◽  
Yanping Shi ◽  
Xiangdong Liu ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Abdominal Cavity ◽  
Methyl Cellulose ◽  
Dose Dependence ◽  
Systemic Toxicity ◽  
Time Dependent ◽  
High Dose ◽  
Carboxy Methyl Cellulose ◽  
Carboxy Methyl ◽  
Medium Dose

Abstract Background: Sodium carboxy methyl cellulose (SCMC) is an important absorbable biomaterial for anti-adhesion and hemostasis medical devices used in the abdominal cavity. However, the systemic toxicity of SCMC following intraperitoneal route has not been revealed sufficiently. Results: 3 SCMC solutions with gradient concentrations were intraperitoneally injected into 3 group rats respectively all at once to observe the dose-dependence of systemic reactions of SCMC and 10 rats of each group were sacrificed 3d, 7d, 28d and 90d after injection to evaluate the time-dependence of the reactions. A range of adverse effects were shown in rats of high-dose(2000mg/kg) group which were found varied with time extending and virtually disappeared 90 days after injection. Slight reactions were observed in medium-dose(320mg/kg) group while negligible effects were found in low-dose(50mg/kg) group. Conclusion: The intraperitoneal application of SCMC can induce reversible systemic adverse effects to rats at the dose higher than 320mg/kg and it is essential to take both dose- and time-dependent effects into account while designing a systemic toxicity study for absorbable biomaterials.

Slip velocity and temperature jump of a non-Newtonian nanofluid, aqueous solution of carboxy-methyl cellulose/aluminum oxide nanoparticles, through a microtube

2019 ◽  
Vol 29 (5) ◽  
pp. 1606-1628 ◽  
Author(s):  
Marjan Goodarzi ◽  
Saeed Javid ◽  
Ali Sajadifar ◽  
Mehdi Nojoomizadeh ◽  
Seyed Hossein Motaharipour ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Aqueous Solution ◽  
Aluminum Oxide ◽  
Temperature Jump ◽  
Methyl Cellulose ◽  
Oxide Nanoparticles ◽  
Carboxy Methyl Cellulose ◽  
Aluminum Oxide Nanoparticles ◽  
Content Type ◽  
Carboxy Methyl

Purpose With respect to two new subjects, i.e. nanofluids and microchannels, in heat transfer systems and modern techniques used for building them, this paper aims to study on effect of using aluminum oxide nanoparticles in non-Newtonian fluid of aqueous solution of carboxy-methyl cellulose in microtube and through application of different slip coefficients to achieve various qualities on surface of microtube. Design/methodology/approach Simultaneously, the effect of presence of nanoparticles and phenomenon of slip and temperature jump has been explored in non-Newtonian nanofluid in this essay. The assumption of homogeneity of nanofluid and fixed temperature of wall in microtube has been used in modeling processes. Findings The results have been presented as diagrams of velocity, temperature and Nusselt Number and the investigations have indicated that addition of nanoparticles to the base fluid and increase in microtube slip coefficient might improve rate of heat transfer in microtube. Originality/value The flow of non-Newtonian nanofluid of aqueous solution of carboxy methyl cellulose-aluminum oxide has been determined in a microtube for the first time.

scholarly journals Isolasi Dan Karakteristik Fungi Lignoselulolitik Dari Limbah Sawit Sebagai Agen Pendegradasi Pakan Berserat

2019 ◽  
Vol 12 (2) ◽  
pp. 39-48
Author(s):  
Yunilas Yunilas ◽  
Lili Warly ◽  
Yetti Marlida ◽  
Irsan Ryanto
Keyword(s):  
Methyl Cellulose ◽  
Selective Medium ◽  
High Ability ◽  
Carboxy Methyl Cellulose ◽  
Fiber Degradation ◽  
Trichoderma Sp ◽  
Colony Color ◽  
Degradation Test ◽  
Palm Waste ◽  
Carboxy Methyl

Abstrak. Penelitian ini bertujuan untuk mengisolasi dan mengkarakteristik fungi lignoselulolitik dari limbah sawit sebagai pendegradasi serat (senyawa polisakarida). Penelitian ini menggunakan metode eksplorasi melalui isolasi, karakteristik, uji degradasi lignoselulosa dan identifikasi. Isolasi menggunakan medium selektif yang dimodifikasi mengandung carboxy methyl cellulose (CMC), xylan, lignin dan manan. Dari hasil isolasi diperoleh 16 isolat fungi lignoselulolitik dan 4 diantaranya memiliki kemampuan tinggi dalam mendegradasi lignoselulosa yaitu isolate fungi YLF2, YLF3, YLF4 dan YLF8. Isolat fungi yang diperoleh memiliki karakteristik yang bervariasi meliputi bentuk, permukaan, tepi dan warna koloni. Hasil uji degradasi (hidrolitik) menunjukkan bahwa isolat fungi YLF8 menghasilkan indeks hidrolitik lebih tinggi dibanding fungi lainnya. Berdasarkan hasil dapat disimpulkan bahwa isolat fungi YLF8 termasuk pada strain Trichoderma sp berpotensi sebagai isolat pendegradasi serat dan dapat digunakan sebagai bioktivator dalam fermentasi pakan berserat.Isolation And Characteristic Of Lignocellulolitic Fungi Of Palm Waste As a Fiber Feed Degrading AgentAbstract. This study aims to isolate and characterize lignocellulolytic fungi from palm wastes as fiber degradation (polysaccharide compounds). This research uses exploration method through isolation, characteristic, lignocellulosic degradation test and identification. Isolation using modified selective medium contains carboxy methyl cellulose (CMC), xylan, lignin and manan. From isolation result obtained 16 isolates of lignocellulolytic fungi and 4 of them have high ability in degrading lignocellulose that is fungi YLF2, YLF3, YLF4 and YLF8. The obtained fungi isolates have varying characteristics including shape, surface, edges and colony color. The result of degradation test (hydrolytic) showed that YLF8 fungi isolates yielded higher hydrolytic index than other fungi. Based on the results it can be concluded that the isolates of YLF8 fungi belong to the Trichoderma sp strain potentially as fiber degrading isolates and can be used as bioctivators in fibrous fermentation feed. 

scholarly journals HEPATOPROTECTIVE ACTIVITY OF VERNONIA AMYGDALINA LEAF ETHANOLIC EXTRACT IN WHITE RATS INDUCED BY PARACETAMOL

2018 ◽  
Vol 11 (10) ◽  
pp. 562
Author(s):  
Panal Sitorus ◽  
Nerdy Nerdy
Keyword(s):  
Body Weight ◽  
Methyl Cellulose ◽  
Ethanolic Extract ◽  
Scientific Data ◽  
Control Group ◽  
Carboxy Methyl Cellulose ◽  
Vernonia Amygdalina ◽  
White Rats ◽  
Significant Difference ◽  
Carboxy Methyl

Objectives: A study on the hepatoprotective effect of Vernonia amygdalina leaves ethanolic extract on white rats induced by paracetamol was aimed to obtaining scientific data and evidence the hepatoprotective ability of the extract.Methods: The research was a complete randomized design, using 36 white rats which were divided into 6 groups. The normal control group was given 1% carboxy methyl cellulose for 7 days and followed by distilled water 8 hours after treatment. The positive control group was given 100 mg curcumin per kg body weight of rats for 7 days and followed by 2.5 g paracetamol per kg body weight after treatment. The negative control group was given 1% carboxy methyl cellulose for 7 days and followed by 2.5 g paracetamol per kg body weight after treatment. The test group was given 50, 100 and 200 mg extract per kg body weight of rats for 7 days and followed by 2.5 g paracetamol per kg body weight after treatment. Blood sampling was carried out 3 times (before treatment, after treatment and after induction).Results: With doses of 50, 100, and 200 mg extract per kg body weight of rats give significant difference on the decrease of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) levels after paracetamol administration.Conclusions: It can be concluded that Vernonia amygdalina leaves ethanolic extract were potentially hepatoprotective.

Addition of methyl cellulose enema to double-contrast barium imaging of sigmoid diverticulosis

1997 ◽  
Vol 38 (1) ◽  
pp. 73-75 ◽  
Author(s):  
R. Olsson ◽  
I. Adnerhill ◽  
P. Björkdahl ◽  
O. Ekberg ◽  
F. T. Fork
Keyword(s):  
Diagnostic Imaging ◽  
Barium Enema ◽  
Methyl Cellulose ◽  
Lumen Diameter ◽  
Carboxy Methyl Cellulose ◽  
Double Contrast ◽  
Double Contrast Barium Enema ◽  
Carboxy Methyl

Double-contrast barium enema has a reduced sensitivity in patients with severe sigmoid diverticulosis. Therefore a carboxy methyl cellulose enema was employed after the conventional double-contrast examination in 15 patients with sigmoid diverticulosis. A significant increase in lumen diameter and a superior removal of barium residue from the diverticulas facilitated the interpretation of the sigmoid loops. Conclusion: The addition of methyl cellulose enema to double-contrast barium imaging improves diagnostic imaging in diverticulosis by expanding the lumen and emptying the diverticulas.

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