SARS-CoV-2 Infection in the Third Trimester Is Not an Independent Risk Factor for Immature Immune Function in Preterm Infants

2020 ◽  
Author(s):  
Zheng Junwen ◽  
Liu Pin ◽  
Wang Xia ◽  
Yang Pu ◽  
Wei Cong ◽  
...  
Keyword(s):  
Risk Factor ◽  
Immune Function ◽  
Preterm Infants ◽  
Independent Risk Factor ◽  
Third Trimester ◽  
The Third

Anemia in Preterm Infants

1996 ◽  
Vol 17 (10) ◽  
pp. 370-370
Author(s):  
Philip Roth
Keyword(s):  
Preterm Infants ◽  
Plasma Volume ◽  
Hemoglobin Concentration ◽  
Fetal Life ◽  
Combined Effects ◽  
Third Trimester ◽  
The Third ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Preterm Newborns

During fetal life, hemoglobin concentration increases from a level of 9 g/dL at l0 weeks' to 14 to 15 g/dL at 22 to 24 weeks' gestation. By the middle of the third trimester, concentrations close to those observed at birth (16 to 17 g/dL) are reached, and little additional change occurs. As a result, cord hemoglobin concentrations in term and preterm newborns are very similar, with the possible exception of the most extremely preterm infants. Immediately after birth, the hemoglobin concentration begins to rise from the combined effects of placental transfusion and the postnatal readjustment of plasma volume. At approximately 8 to 12 hours of life, the hemoglobin plateaus at levels 1 to 2 g/dL above those observed at birth (about 18 g/dL).

scholarly journals Blood pressure change across pregnancy in white British and Pakistani women: analysis of data from the Born in Bradford cohort

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Diane Farrar ◽  
Gillian Santorelli ◽  
Debbie A. Lawlor ◽  
Derek Tuffnell ◽  
Trevor A. Sheldon ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Ethnic Differences ◽  
Gestational Hypertension ◽  
Pressure Change ◽  
Third Trimester ◽  
Random Effects Models ◽  
The Third ◽  
Born In Bradford ◽  
Pakistani Women

Abstract The incidence of gestational hypertension (GH) and pre-eclampsia (PE) is increasing. Use of blood pressure (BP) change patterns may improve early detection of BP abnormalities. We used Linear spline random-effects models to estimate BP patterns across pregnancy for white British and Pakistani women. Pakistani women compared to white British women had lower BP during the first two trimesters of pregnancy, irrespective of the development of GH or PE or presence of a risk factor. Pakistani compared to white British women with GH and PE showed steeper BP increases towards the end of pregnancy. Pakistani women were half as likely to develop GH, but as likely to develop PE than white British women. To conclude; BP trajectories differ by ethnicity. Because GH developed evenly from 20 weeks gestation, and PE occurred more commonly after 36 weeks in both ethnic groups, the lower BP up to the third trimester in Pakistani women resulted in a lower GH rate, whereas PE rates, influenced by the steep third trimester BP increase were similar. Criteria for diagnosing GH and PE may benefit from considering ethnic differences in BP change across pregnancy.

Preeclampsia is an independent risk factor for spontaneous intestinal perforation in very preterm infants

2013 ◽  
Vol 27 (12) ◽  
pp. 1248-1251
Author(s):  
Yavuz Yılmaz ◽  
H. Gözde Kanmaz Kutman ◽  
Hülya Özkan Ulu ◽  
F. Emre Canpolat ◽  
Nurdan Uraş ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preterm Infants ◽  
Intestinal Perforation ◽  
Independent Risk Factor ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Spontaneous Intestinal Perforation

scholarly journals Homocysteine during the third trimester is a risk factor for preeclampsia: A prospective study

2020 ◽  
Author(s):  
Sha Chen ◽  
Hong Shen ◽  
Xueya Zhao ◽  
Jun Luo ◽  
Weiwei Cheng
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Folic Acid ◽  
Prospective Study ◽  
Vitamin B12 ◽  
Early Onset ◽  
Third Trimester ◽  
The Third ◽  
Early Onset Preeclampsia ◽  
A Prospective Study

Abstract Background: The purpose of this study was to investigate the risk factors for elevating homocysteine during pregnancy and the relative effects on preeclampsia, so as to further understand whether Hcy had predictive value for PE.Method: This is a prospective study that only covers pregnant women with singleton who received regular prenatal care from July to September 2018 exclusively at IPMCH (N=1142). Homocysteine, folic acid and vitamin B12 were tested in the 1st trimester (10-14 weeks), 2nd trimester (24-28 weeks), and 3rd trimester (30-34 weeks), respectively, and MTHFR genes (rs1801133, rs1801131, rs17367504) were detected. Therefore, the analysis of this case includes the variation in Hcy levels during pregnancy, risk factors for elevating homocysteine and the risk factors on preeclampsia.Results: (1) Homocysteine was lowest in the 1st trimester. (2) Homocysteine was negatively correlated with folic acid (r=-0.17, p<0.001) and vitamin B12 (r=-0.15, p<0.001) in the same trimester. (3) Both of heterozygous CT (p=0.025, 95% CI 0.018, 0.275) and homozygous TT (p<0.001, 95% CI 0.185, 0.501) in MTHFR rs1801133 might be risk factors that caused an increase in Hcy. G-spot mutations in MTHFR rs17367504 might be a risk factor that caused a decline in homocysteine. (4) Homocysteine in the 3rd trimester might be significantly correlated with increasing risk of preeclampsia (OR = 1.2, 95% CI 1.01,1.42), particularly early-onset preeclampsia (OR = 3.63, 95% CI 1.71,7.71) and severe preeclampsia (OR = 3.63, 95% CI 1.71,7.71).Conclusions: The variation in homocysteine level in the third trimester might be associated with preeclampsia, especially early-onset preeclampsia and severe preeclampsia, and MTHFR, folic acid and vitamin B12 might be the three critical factors responsible for the changing homocysteine levels during pregnancy.

scholarly journals A significant decrease in hemoglobin concentrations may predict occurrence of necrotizing enterocolitis in preterm infants with late-onset sepsis

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095227
Author(s):  
Na Cai ◽  
Wenting Fan ◽  
Min Tao ◽  
Wei Liao
Keyword(s):  
Risk Factor ◽  
Blood Cell ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Independent Risk Factor ◽  
Late Onset ◽  
Demographic Data ◽  
Red Blood Cell Transfusion ◽  
Clinical Value ◽  
Late Onset Sepsis

Objective This study aimed to examine the clinical value of a decrease in hemoglobin concentration (HC) after the onset of sepsis for predicting occurrence of necrotizing enterocolitis (NEC) in preterm infants with late-onset sepsis. Methods We performed a retrospective cohort study between January 2015 and January 2020. Premature neonates (gestational age <37 weeks) with late-onset sepsis (age >3 days) were enrolled. According to the degree of reduction in HC, neonates were divided into the non-decrease group, mild decrease group, and severe decrease group. Demographic data, perinatal conditions, blood cell count analysis, blood culture, and treatment measures were compared. Results Eighty premature infants with sepsis were studied. The mortality rate and incidence of NEC were significantly higher in the severe decrease group than in the non-decrease and mild decrease groups. Significant differences were observed in the decrease in HC, red blood cell transfusion, and ventilator application between the NEC and non-NEC groups. A significant decrease in HC was an independent risk factor for NEC in preterm infants with sepsis. Conclusion A significant decrease in HC is an independent risk factor for NEC and may predict the occurrence of NEC in preterm infants with sepsis.

Relation between neutrophil-to-lymphocyte ratio and mortality in patients with hypertrophic cardiomyopathy

2020 ◽  
Vol 14 (18) ◽  
pp. 1693-1701
Author(s):  
Ziqiong Wang ◽  
Liming Zhao ◽  
Sen He
Keyword(s):  
Risk Factor ◽  
Hypertrophic Cardiomyopathy ◽  
Mortality Rate ◽  
Subgroup Analysis ◽  
Prognostic Value ◽  
Independent Risk Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Third ◽  
All Cause Mortality

Aim: We assessed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for all-cause mortality in patients with hypertrophic cardiomyopathy (HCM). Methods & results: A total of 354 HCM patients were enrolled. There were 44 all-cause mortality in total. Patients in the third tertile of NLR had the highest all-cause mortality rate of 5.2 per 100 person-years. Patients in tertile 3 had a significantly higher risk of all-cause mortality with adjusted hazard ratio of 2.4 (95% CI: 1.0–5.4; p = 0.040) when compared with that of patients in tertile 1. No significant interactions between NLR and other variables were observed during subgroup analysis. Conclusion: NLR was an independent risk factor for all-cause mortality in HCM patients.

scholarly journals Gambaran Faktor Risiko pada Wanita Hamil Trimester 3 yang Terkonfirmasi Positif SARS-CoV-2

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Aurelia S. Posumah ◽  
Mayer F. Wowor ◽  
Glady I. Rambert
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Close Contact ◽  
Secondary Data ◽  
Third Trimester ◽  
Travel History ◽  
The Third ◽  
Diabetes Melitus

Abstract: Coronavirus Disease 2019 (COVID-19) a infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There are several groups that are susceptible to infection with SARS-CoV-2, one of which is pregnant women. This can be attributed to changes in the physiology and immune system that occur in pregnant women. This study aimed to determine the most risk factors that cause pregnant women in Prof. Dr. R. D. Kandou was infected with SARS-CoV-2. This type of research is descriptive with a retrospective approach, using secondary data in the form of data from the patient's medical record status. From 5 patients studied, there were 4 patients with risk factors for hypertension (80%) and 1 patient with close contact risk factors (20%), but other risk factors such as diabetes mellitus, travel history in transmission areas, obesity and smoking are not found. In conclusion, from 5 patients studied, the most risk factor that causes pregnant women in the third trimester to be infected with SARS-CoV-2 is hypertension (80%).Keywords: 3rd trimester pregnant women, SARS-CoV-2, risk factor  Abstrak: Coronavirus Disease 2019 (COVID-19) penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Terdapat beberapa kelompok yang rentan terinfeksi SARS-CoV-2, salah satunya wanita hamil. Hal ini dapat dikaitkan dengan perubahan fisiologi dan sistem imunitas tubuh yang terjadi pada wanita hamil. Tujuan penelitian ini untuk mengetahui faktor risiko terbanyak yang menyebabkan wanita hamil di RSUP Prof. Dr. R. D. Kandou terinfeksi SARS-CoV-2. Jenis penelitian yang digunakan bersifat deskriptif dengan pendekatan retrospektif, yaitu menggunakan data sekunder berupa data dari status rekam medik pasien. Dari 5 pasien yang diteliti, didapatkan 4 pasien dengan faktor risiko hipertensi (80%) dan 1 pasien dengan faktor risiko kontak erat (20%), namun pada faktor risiko lain seperti diabetes melitus, riwayat perjalanan di daerah transmisi, obesitas dan merokok tidak ditemukan. Sebagai simpulan, dari 5 pasien yang diteliti, faktor risiko terbanyak yang menyebabkan wanita hamil trimester 3 terinfeksi SARS-CoV-2 adalah hipertensi (80%).Kata Kunci: wanita hamil trimester 3, SARS-CoV-2, faktor risiko

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