scholarly journals On the functioning mechanism of an ATP-driven molecular motor

2021 ◽  
Author(s):  
Masahiro Kinoshita
Keyword(s):  
Molecular Motor ◽  
Functioning Mechanism

scholarly journals A model of processive walking and slipping of kinesin-8 molecular motors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ping Xie
Keyword(s):  
Single Molecule ◽  
Molecular Motors ◽  
External Load ◽  
Molecular Motor ◽  
Velocity Versus ◽  
Stick Slip ◽  
Load Dependence ◽  
Chemomechanical Coupling ◽  
Similarities And Differences ◽  
Stick Slip Motion

AbstractKinesin-8 molecular motor can move with superprocessivity on microtubules towards the plus end by hydrolyzing ATP molecules, depolymerizing microtubules. The available single molecule data for yeast kinesin-8 (Kip3) motor showed that its superprocessive movement is frequently interrupted by brief stick–slip motion. Here, a model is presented for the chemomechanical coupling of the kinesin-8 motor. On the basis of the model, the dynamics of Kip3 motor is studied analytically. The analytical results reproduce quantitatively the available single molecule data on velocity without including the slip and that with including the slip versus external load at saturating ATP as well as slipping velocity versus external load at saturating ADP and no ATP. Predicted results on load dependence of stepping ratio at saturating ATP and load dependence of velocity at non-saturating ATP are provided. Similarities and differences between dynamics of kinesin-8 and that of kinesin-1 are discussed.

Skeletal Muscle of Molecular Motor and Its Application in Active Rehabilitation of Human Lower Limbs

2021 ◽  
Vol 217 (1) ◽  
pp. 54-68
Author(s):  
Feng Han ◽  
Zhi Yan ◽  
Minjia Wang ◽  
Tong Li ◽  
Jiaqing Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Molecular Motor ◽  
Lower Limbs ◽  
Active Rehabilitation

A Bacterial Transcription Terminator with Inefficient Molecular Motor Action but with a Robust Transcription Termination Function

2010 ◽  
Vol 395 (5) ◽  
pp. 966-982 ◽  
Author(s):  
Nisha C. Kalarickal ◽  
Amitabh Ranjan ◽  
B. Sudha Kalyani ◽  
Megha Wal ◽  
Ranjan Sen
Keyword(s):  
Molecular Motor ◽  
Transcription Termination ◽  
Motor Action ◽  
Transcription Terminator ◽  
Bacterial Transcription ◽  
Termination Function

scholarly journals Studies of Conformational Changes of Tubulin Induced by Interaction with Kinesin Using Atomistic Molecular Dynamics Simulations

2021 ◽  
Vol 22 (13) ◽  
pp. 6709
Author(s):  
Xiao-Xuan Shi ◽  
Peng-Ye Wang ◽  
Hong Chen ◽  
Ping Xie
Keyword(s):  
Molecular Dynamics ◽  
High Resolution ◽  
Binding Energy ◽  
Molecular Dynamics Simulations ◽  
Conformational Changes ◽  
Weak Interactions ◽  
Molecular Motor ◽  
Structural Data ◽  
Calculated Binding Energy ◽  
Dynamics Simulations

The transition between strong and weak interactions of the kinesin head with the microtubule, which is regulated by the change of the nucleotide state of the head, is indispensable for the processive motion of the kinesin molecular motor on the microtubule. Here, using all-atom molecular dynamics simulations, the interactions between the kinesin head and tubulin are studied on the basis of the available high-resolution structural data. We found that the strong interaction can induce rapid large conformational changes of the tubulin, whereas the weak interaction cannot. Furthermore, we found that the large conformational changes of the tubulin have a significant effect on the interaction of the tubulin with the head in the weak-microtubule-binding ADP state. The calculated binding energy of the ADP-bound head to the tubulin with the large conformational changes is only about half that of the tubulin without the conformational changes.

scholarly journals Optoregulated force application to cellular receptors using molecular motors

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yijun Zheng ◽  
Mitchell K. L. Han ◽  
Renping Zhao ◽  
Johanna Blass ◽  
Jingnan Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Molecular Motor ◽  
Membrane Receptors ◽  
Polymer Chains ◽  
Cell Junctions ◽  
Force Application ◽  
Molecular Scale ◽  
Applied Forces

AbstractProgress in our understanding of mechanotransduction events requires noninvasive methods for the manipulation of forces at molecular scale in physiological environments. Inspired by cellular mechanisms for force application (i.e. motor proteins pulling on cytoskeletal fibers), we present a unique molecular machine that can apply forces at cell-matrix and cell-cell junctions using light as an energy source. The key actuator is a light-driven rotatory molecular motor linked to polymer chains, which is intercalated between a membrane receptor and an engineered biointerface. The light-driven actuation of the molecular motor is converted in mechanical twisting of the entangled polymer chains, which will in turn effectively “pull” on engaged cell membrane receptors (e.g., integrins, T cell receptors) within the illuminated area. Applied forces have physiologically-relevant magnitude and occur at time scales within the relevant ranges for mechanotransduction at cell-friendly exposure conditions, as demonstrated in force-dependent focal adhesion maturation and T cell activation experiments. Our results reveal the potential of nanomotors for the manipulation of living cells at the molecular scale and demonstrate a functionality which at the moment cannot be achieved by other technologies for force application.

scholarly journals Cardiac Myosin-Binding Protein C Modulates the Tuning of the Molecular Motor in the Heart

2008 ◽  
Vol 95 (2) ◽  
pp. 720-728 ◽  
Author(s):  
Yves Lecarpentier ◽  
Nicolas Vignier ◽  
Patricia Oliviero ◽  
Aziz Guellich ◽  
Lucie Carrier ◽  
...  
Keyword(s):  
Protein C ◽  
Molecular Motor ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding

A Molecular Lock with Hydrogen Sulfate as “Key” and Fluoride as “Hand”: Computing Based Insights on the Functioning Mechanism

2016 ◽  
Vol 1 (17) ◽  
pp. 5547-5553 ◽  
Author(s):  
Suvendu Paul ◽  
Monaj Karar ◽  
Swastika Mitra ◽  
Selim A. Sher Shah ◽  
Tapas Majumdar ◽  
...  
Keyword(s):  
Hydrogen Sulfate ◽  
Functioning Mechanism
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