<p>Long-Term Continuous Antimicrobial Resistance Surveillance Among Nosocomial Gram-Negative Bacilli in China from 2010 to 2018 (CMSS)</p>

ZusammenfassungDie Ausbreitung von resistenten Gram-negativen Erregern weltweit ist besorgniserregend. Von besonderem Interesse ist die Verbreitung von Resistenzen gegen Beta-Laktam-Antibiotika, die in vielen Fällen Mittel der Wahl zur Therapie sind. Im European Antimicrobial Resistance Surveillance Network (EARS-Net) wird die Resistenzentwicklung bei schweren Infektionskrankheiten in Europa regelmäßig überwacht. In Deutschland können Isolate zur Abklärung und/oder Bestätigung von Carbapenemasen an das Nationale Referenzzentrum (NRZ) für Gram-negative Krankenhauserreger an der Uniklinik Bochum eingeschickt werden.Im ersten Teil der Arbeit werden die aktuell publizierten Daten für Europa ausgewertet und dargestellt sowie mit den aktuell verfügbaren Daten aus Deutschland verglichen. Im zweiten Teil werden Therapieoptionen von Infektionen durch resistente Erreger dargestellt.

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Progress towards a coordinated, national paediatric antimicrobial resistance surveillance programme: Staphylococcus aureus, enterococcal and Gram-negative bacteraemia in Australia

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkaa065 ◽

2020 ◽

Vol 75 (6) ◽

pp. 1639-1644

Author(s):

Anita J Campbell ◽

Denise A Daley ◽

Jan M Bell ◽

Stanley Pang ◽

Geoffrey W Coombs ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Antimicrobial Resistance ◽

Bloodstream Infections ◽

Negative Resistance ◽

Data Set ◽

Surveillance Programme ◽

Gram Negative ◽

Antimicrobial Resistance Surveillance ◽

Nationally Representative ◽

Molecular Phenotypes

Abstract Background There is increasing knowledge of antimicrobial usage in children yet limited availability of nationally representative paediatric-specific data on antimicrobial resistance. Objectives Paediatric data from this national surveillance programme are presented to explore differences between childhood and adult bloodstream infections and antimicrobial resistance surveillance. Methods Using information collected from a prospective coordinated antimicrobial resistance surveillance programme, children ≤18 years and adults >18 years with a positive blood culture for Staphylococcus aureus, Enterococcus spp. or Gram-negative spp. presenting to one of 34 Australian hospitals during 2013–16 were evaluated. Consistent methodologies for key sepsis pathogens were employed and a comparative analysis between children and adults was conducted. Results There are stark contrasts between children and adults in this national antimicrobial resistance (AMR) data set. Notable differences include lower rates of AMR, different clinical and molecular phenotypes and lower mortality amongst children. The burden of Gram-negative resistance is disproportionately experienced in children, with higher odds of death with an ESBL versus non-ESBL bacteraemia in comparison with adults. Conclusions These data support that children are not just ‘little adults’ in the AMR era, and analyses by age group are important to detect differences in antibiotic susceptibility, clinical phenotype and genetic virulence factors. Antimicrobial surveillance incorporated into routine laboratory practice is vital to inform an array of wider applications including antimicrobial guidelines, stewardship and direction for prioritization of novel antimicrobial development.

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Surveillance of antimicrobial resistance of invasive pathogens: the Estonian experience

Eurosurveillance ◽

10.2807/esm.11.02.00601-en ◽

2006 ◽

Vol 11 (2) ◽

pp. 9-10 ◽

Cited By ~ 2

Author(s):

K Loivukene ◽

K Kermes ◽

E Sepp ◽

V Adamson ◽

P Mitt ◽

...

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Antimicrobial Resistance ◽

Surveillance System ◽

Gram Negative ◽

E Coli ◽

Invasive Pathogens ◽

Susceptibility Data ◽

Antimicrobial Resistance Surveillance ◽

Klebsiella Spp

The aim of the present study was to evaluate the needs for surveillance of invasive Gram-negative pathogens in Estonia. The antimicrobial susceptibility data of invasive isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella spp, Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae and enterococci were collected in accordance with EARSS (European Antimicrobial Resistance Surveillance System) protocols. Despite the higher rate of Gram positive pathogens, their resistance to antimicrobials was low in contrast to the elevated resistance established for Gram negative pathogens. The higher resistance to antimicrobials was particularly associated with A. baumannii and P. aeruginosa. Also, the proportion of extended spectrum betalactamase (ESBL)-producing strains was 23% among Klebsiella spp. and 3.6% among E. coli. The inclusion of invasive Gram negative pathogens in antimicrobial resistance surveillance provides useful information concerning local pathogen susceptibility, as well as for the empirical treatment of suspected infections.

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