scholarly journals The Diagnostic Value of Plasma miRNA-497, cTnI, FABP3 and GPBB in Pediatric Sepsis Complicated with Myocardial Injury

2021 ◽  
Vol Volume 17 ◽  
pp. 563-570
Author(s):  
Chengjiao Huang ◽  
Shuna Xiao ◽  
Zhi Xia ◽  
Ying Cheng ◽  
Yong Li ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
Diagnostic Value ◽  
Pediatric Sepsis ◽  
Plasma Mirna

scholarly journals Kreatinkinazės MB frakcijos reikšmė perioperacinio miokardo infarkto diagnostikoje

2007 ◽  
Vol 5 (3) ◽  
pp. 0-0
Author(s):  
Gediminas Kitra ◽  
Gediminas Kundrotas ◽  
Vilija Jakumaitė
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Myocardial Injury ◽  
Postoperative Morbidity ◽  
Heart Surgery ◽  
Diagnostic Value ◽  
Perioperative Myocardial Infarction ◽  
Hospital Department ◽  
Routine Measurement ◽  
Creatine Kinase Mb

Gediminas Kitra1, Gediminas Kundrotas1, Vilija Jakumaitė1,21 Klaipėdos jūrininkų ligoninės Kardiochirurgijos skyrius,Liepojos g. 45, LT-92288 Klaipėda2 Kauno medicinos universiteto Psichofiziologijos ir reabilitacijos institutas,Vydūno al. 4, LT-00135 PalangaEl paštas: [email protected] Įvadas / tikslas Perioperacinis miokardo infarktas (PMI) po širdies operacijos didina pooperacinį sergamumą ir mirštamumą. Iki šiol nėra vienodų kriterijų PMI po aortos vainikinių jungčių operacijos diagnozuoti. Šio darbo tikslas – įvertinti kreatinkinazės MB frakcijos diagnostinę reikšmę. Ligoniai ir metodai Tirti 706 ligoniai, kuriems nuo 2004 m. sausio 2 d. iki 2007 m. vasario 22 d. buvo darytos aortos vainikinių jungčių operacijos naudojant dirbtinę kraujo apytaką (DKA). 69 (10%) ligoniams, remiantis elektrokardiograma ir kreatinkinazės MB koncentracijos padidėjimu, diagnozuotas PMI, 101 (14%) ligoniui nustatytas kreatinkinazės padidėjimas nesiekė diagnostinės ribos, jų miokardo pažeidimas vertintas kaip galimas perioperacinis miokardo pažeidimas. Rezultatai Ligoniams, kuriems yra PMI ir galimas PMI, pooperacinė eiga dažniau komplikavosi ūminiu širdies nepakankamumu. Šiose grupėse buvo didesnis hospitalinis mirštamumas, tačiau ligonių, kuriems buvo galimas PMI, mirštamumas dėl kardialinių priežasčių buvo mažesnis ir nesiskyrė nuo ligonių, kuriems miokardas nebuvo pažeistas. Išvados Rutininis kreatinkinazės MB frakcijos tyrimas po aortos vainikinių jungčių operacijos padeda diagnozuoti PMI ir prognozuoti tolesnę pooperacinę eigą. Kreatinkinazės MB frakcijos (CKMB) padidėjimas >100 u/l lemia didesnį hospitalinį mirštamumą. CKMB padidėjimas <100 u/l hospitaliniam mirštamumui įtakos neturi, tačiau lemia dažnesnį širdies nepakankamumą. Pagrindiniai žodžiai: perioperacinis miokardo infarktas, kreatinkinazės MB frakcija Significance of creatine kinase MB for the detection of perioperative myocardial infarction Gediminas Kitra1, Gediminas Kundrotas1, Vilija Jakumaitė1,21 Klaipėda Seamen’s Hospital, Department of Cardiosurgery,Liepojos str. 45, LT-92288 Klaipėda, Lithuania2 Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine,Vydūno ave. 4, LT-00135 Palanga, LithuaniaE-mail: [email protected] Background / objective Perioperative myocardial infarction (PMI) after heart surgery increases postoperative morbidity and mortality. Until now there are no universal criteria to confirm the diagnosis of PMI. We analysed the diagnostic value of creatine kinase MB fraction. Patients and methods 706 patients who underwent CABG with CPB from January 2, 2004 until February 22, 2007 were analyzed. 69 (10%) sustained PMI. The diagnosis was based on electrocardiogram and CKMB elevation. 101 (14%) were considered to have probable PMI, because their CKMB didn’t reach the diagnostic value. Results The postoperative course was complicated by acute heart failure more frequently in those with PMI and probable PMI. Hospital mortality was also higher in these patients. However, mortality from cardiac courses was lower in the group with probable PMI and similar to that in patients without perioperative myocardial injury. Conclusions Routine measurement of CKMB after CABG is of great importance in diagnosing PMI and predicts the clinical outcome. Key words: perioperative myocardial infarction, creatine kinase MB fraction

The diagnostic value of GDF-15 for myocardial involvement in idiopathic inflammatory myopathy

Rheumatology ◽  
2020 ◽  
Author(s):  
Mengqian Qiu ◽  
Xiaoxuan Sun ◽  
Xiaoqing Qi ◽  
Xianfang Liu ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
Cardiac Involvement ◽  
Inflammatory Myopathy ◽  
Area Under The Curve ◽  
Idiopathic Inflammatory Myopathy ◽  
Diagnostic Value ◽  
Control Group ◽  
Cellular Volume ◽  
Potential Biomarker ◽  
Myocardial Involvement

Abstract Background Cardiac involvement is a serious complication of idiopathic inflammatory myopathy (IIM). GDF-15 can predict the risk and the prognosis of cardiovascular disease, but its value is unclear in IIM. Objective To investigate the diagnostic value of GDF-15 for myocardial involvement in IIM. Methods A total of 77 IIM patients from May 2018 to August 2020 were included in this retrospective study. Of these, 43 patients underwent cardiac magnetic resonance (CMR) examination. There were 33 SLE patients and 16 healthy people were used as the control group. The concentration of GDF-15 of these groups was measured by ELISA. Results There were significant differences in GDF-15 levels in patients with IIM, SLE and healthy controls (H = 45.291, P&lt;0.001). GDF-15 levels were statistically significant different between IIM patients with the myocardial injury [1484.88(809.07 2835.50) pg/ml] and without myocardial injury [593.26(418.61 784.59) pg/ml, P =0.001]. After adjusted for age, renal function, the risk of myocardial injury in IIM patients increased an average of 0.3% by per increased unit of GDF-15 (odds ratio=1.003, 95% CI: 1.000, 1.007). The level of GDF-15 was positively correlated with extra-cellular volume (ECV) (rs = 0.348, P =0.028). GDF-15 ≥ 929.505 pg/ml (area under the curve=0.856, 95% CI: 0.744, 0.968) predicted myocardial injury in IIM with a sensitivity of 0.75 and specificity of 0.90. Conclusion GDF-15 could serve as a potential biomarker to predict myocardial injury in IIM patients.

scholarly journals Use of high-sensitivity cardiac troponin I levels for early diagnosis of myocardial injury after neonatal asphyxia

2019 ◽  
Vol 47 (7) ◽  
pp. 3234-3242 ◽  
Author(s):  
Li Jiang ◽  
Yuning Li ◽  
Zhi Zhang ◽  
Lixing Lin ◽  
Xiaoli Liu
Keyword(s):  
Early Diagnosis ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Early Stage ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Cardiac Troponin I ◽  
Roc Curve Analysis ◽  
Neonatal Asphyxia

Objective Low-cost diagnostic and prognostic biomarkers could help guide clinical management of neonates with myocardial injury after asphyxia. This study aimed to assess the utility of creatine kinase (CK)-MB, high-sensitivity cardiac troponin I (hs-cTnI), brain natriuretic peptide (BNP), and myoglobin in the early diagnosis of myocardial injury following neonatal asphyxia. Methods Eighteen neonates with asphyxia and myocardial injury, 22 neonates with asphyxia and no myocardial injury, and 19 neonates without asphyxia (controls) were enrolled consecutively at the Neonatology Department, First Hospital of Lanzhou University (August 2013 to December 2014). Serum CK-MB, hs-cTnI, BNP, and myoglobin levels were evaluated at 12 hours and 7 days after birth. Their diagnostic value for myocardial injury was assessed by receiver operating characteristic (ROC) curve analysis. Results Levels of all four markers were higher in neonates with asphyxia and myocardial injury than in neonates with asphyxia and no myocardial injury or controls 12 hours after birth. The marker hs-cTnI had the highest diagnostic value. Using a cutoff value of 0.087 µg/L for hs-cTnI, the sensitivity, specificity, and diagnostic accuracy for asphyxia-induced myocardial injury were 55.6%, 95.5%, and 77.5%, respectively. Conclusions Serum hs-cTnI levels can predict myocardial injury caused by neonatal asphyxia at an early stage.

scholarly journals Plasma-Derived miRNA-222 as a Candidate Marker for Papillary Thyroid Cancer

2020 ◽  
Vol 21 (17) ◽  
pp. 6445
Author(s):  
Aistė Kondrotienė ◽  
Albertas Daukša ◽  
Daina Pamedytytė ◽  
Mintautė Kazokaitė ◽  
Aurelija Žvirblienė ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Characteristic Curve ◽  
Nodular Goiter ◽  
Diagnostic Value ◽  
The Cancer Genome Atlas ◽  
Papillary Thyroid ◽  
Potential Marker ◽  
Cancer Genome Atlas ◽  
Plasma Mirna

We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. Preoperative PTC plasma miRNA expression (n = 49) was compared with plasma miRNA in the HC group (n = 57) and patients with NG (n = 23). It was demonstrated that miR-221; miR-222; miR-146b; miR-21 and miR-181b were overexpressed in preoperative PTC plasma samples compared to HC (p < 0.0001; p < 0.0001; p < 0.0001; p < 0.0001; p < 0.002; respectively). The upregulation in tumor tissue of these miRNAs was consistent with The Cancer Genome Atlas Thyroid Carcinoma dataset. A significant decrease in miR-21; miR-221; miR-146b and miR-181b expression was observed in the plasma of PTC patients after total thyroidectomy (p = 0.004; p = 0.001; p = 0.03; p = 0.036; respectively). The levels of miR-222 were significantly higher in the preoperative PTC compared to the NG group (p = 0.004). ROC curve (receiver operating characteristic curve) analysis revealed miR-222 as a potential marker in distinguishing PTC from NG (AUC 0.711; p = 0.004). In conclusion; circulating miR-222 profiles might be useful in discriminating PTC from NG.

scholarly journals Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Shuling Dong ◽  
Huiqing Yin ◽  
Cuicui Dong ◽  
Kaiyan Sun ◽  
Pin Lv ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Roc Curve ◽  
Diagnostic Value ◽  
Expression Level ◽  
Roc Curve Analysis ◽  
Plasma Microrna ◽  
Plasma Mirna

Esophageal squamous cell carcinoma (ESCC) is a common human malignancy with poor survival, which was usually diagnosed at an advanced stage. MicroRNAs (miRNAs), a class of single stranded noncoding RNAs with only 17–25 ribonucleotides, were demonstrated to play an important role in lots of cancers. In the recent years, increasing evidence revealed that circulating miRNAs exhibited great potential in the diagnosis of various types of cancers. The present study was designed to evaluate the diagnostic value of plasma miRNA-216a/b for ESCC. Our results showed that the expression level of plasma miRNA-216a/b was significantly lower in ESCC patients compared with that of healthy controls. The receiver operating characteristic (ROC) curve analysis yielded an area under the ROC curve (AUC) value of 0.877 [95% CI (confidence interval): 0.818–0.922] for miRNA-216a and 0.756 (95% CI: 0.685–0.819) for miRNA-216b. Clinical data indicated that plasma miRNA-216a/b were inversely correlated with lymph node metastasis and TNM stage. Additionally, the plasma miRNA-216b expression level was significantly upregulated in postoperative samples compared to preoperative samples. Our study, for the first time, demonstrated that plasma miRNA-216a/b might serve as potential biomarkers for the diagnosis of ESCC and dysregulation of miRNA-216a/b might be involved in the progression of ESCC.

scholarly journals Role of E-selectin for diagnosing myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia

2016 ◽  
Vol 54 (1) ◽  
pp. 49-54
Author(s):  
Ming-Hong Deng ◽  
Chun-Wang Lin ◽  
Yan-Na Sun ◽  
Xiang-Lin Zeng ◽  
Fang Wen
Keyword(s):  
Receiver Operating Characteristic ◽  
Mycoplasma Pneumoniae ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Operating Characteristic ◽  
Troponin I ◽  
Diagnostic Value ◽  
Healthy Children ◽  
Paediatric Patients ◽  
Mycoplasma Pneumoniae Pneumonia

Backgrounds Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia. Methods In this prospective and blinded clinical study, plasma E-selectin, cardiac troponin I, creatine kinase isoenzyme MB, interleukin-6 and tumor necrosis factor alpha concentrations were measured in paediatric patients with mycoplasma pneumoniae pneumonia (MPP group, n = 138). The control group comprised 120 healthy children. The definition of cardiac injury was based on cardiac troponin I or CK-MB (with or possibly without abnormal electrocardiogram evidence). Diagnostic value of E-selectin for myocardial injury was determined by analysing receiver operating characteristic curves. Results Among the 138 mycoplasma pneumoniae pneumonia patients, 40 patients were identified with myocardial injury, while 98 patients were identified without myocardial injury. Plasma E-selectin concentrations were: 40.22 ± 4.80 ng/mL, in patients with myocardial injury; 18.55 ± 2.16 ng/mL, in patients without myocardial injury and 12.39 ± 3.27 ng/mL, in healthy children. For the 40 patients identified with myocardial injury, area under the receiver operating characteristic curve value for plasma E-selectin concentrations was 0.945 (95% CI: 0.899–0.991), and optimal diagnostic cut-off value was 29.93 ng/mL (positive likelihood ratio = 72.5). Conclusion E-selectin was shown to be an effective index for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia, and its role in other causes of myocardial injury warrants further investigation.

scholarly journals A Novel Graphene-Based Nanomaterial Modified Electrochemical Sensor for the Detection of Cardiac Troponin I

2021 ◽  
Vol 9 ◽  
Author(s):  
Jing Li ◽  
Shenwei Zhang ◽  
Li Zhang ◽  
Yu Zhang ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Electrochemical Sensor ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
High Sensitivity ◽  
High Specificity ◽  
Diagnostic Value ◽  
Cardiac Troponin I

Acute myocardial infarction has a high clinical mortality rate. The initial exclusion or diagnosis is important for the timely treatment of patients with acute myocardial infarction. As a marker, cardiac troponin I (cTnI) has a high specificity, high sensitivity to myocardial injury and a long diagnostic window. Therefore, its diagnostic value is better than previous markers of myocardial injury. In this work, we propose a novel aptamer electrochemical sensor. This sensor consists of silver nanoparticles/MoS2/reduced graphene oxide. The combination of these three materials can provide a synergistic effect for the stable immobilization of aptamer. Our proposed aptamer electrochemical sensor can detect cTnl with high sensitivity. After optimizing the parameters, the sensor can provide linear detection of cTnl in the range of 0.3 pg/ml to 0.2 ng/ml. In addition, the sensor is resistant to multiple interferents including urea, glucose, myoglobin, dopamine and hemoglobin.

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

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