scholarly journals A REVIEW OF CHALLENGES AND POSSIBILITIES OF BILAYER TABLET TECHNOLOGY

2021 ◽  
Vol 9 (08) ◽  
pp. 676-681
Author(s):  
Sunitha Reddy M. ◽  
◽  
Lavanya Muppa ◽  
Keyword(s):  
Weight Control ◽  
Review Article ◽  
Controlled Delivery ◽  
Delivery Rate ◽  
Improve Treatment ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Subsequent Layer ◽  
Viable Treatment

Bilayer tablet making process involves certain challenges as well as advantages. Bilayer tablets are the prescriptions which comprise of two same or various medications consolidated in a solitary portion for viable treatment of the illness. Persistent consistence and cost measure are two significant boundaries in treatments. Bilayer tablets manage these focuses adequately. To deliver a decent quality bi-layer tablet, the apparatus should be built according to GMP. Different hardware are accessible to beat normal bi-layer issues, for example, layer detachment, lacking hardness, weight control, cross defilement between the layers and so forth. Bilayer tablets give one of the significant plan approaches where inconsistent medications, with an alternate sign, and same medication with various delivery rate can be combined in a solid unit. Bilayer tablet is reasonable for consecutive arrival of two medications in blend, and for supported delivery tablets in which one layer is promptly delivered as introductory portion and the subsequent layer is a controlled portion. Controlled delivery dose structures have been broadly used to improve treatment with a few significant medications. Utilization of bilayer tablet is an altogether different viewpoint for calming and pain relieving drugs. This review article clarifies what are the outcomes to be looked and how to be faced during bilayer tablet production.

scholarly journals ONCE DAILY IMMEDIATE-AND EXTENDED-RELEASE BILAYER TABLETS OF ETORICOXIB: A STUDY ON THE RELEASE KINETICS

2019 ◽  
pp. 230-235
Author(s):  
BIBASWAN MISHRA ◽  
BISWARANJAN MOHANTY
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Extended Release ◽  
Fourier Transform Infrared ◽  
Once Daily ◽  
N Value ◽  
Ftir Study ◽  
Bilayer Tablets ◽  
Bilayer Tablet

Objective: In the present work, the main objective was to develop bilayer extended release matrix tablets of etoricoxib by providing a loading dose followed by maintenance dose that expected to improve the therapeutic efficacy of the medication with less toxic effect. Methods: Bilayer tablets of etoricoxib was developed successfully with the meticulous proportion of release controlling Hydroxy propyl methyl cellulose K100 (HPMC K100) and lactose. The tablets were prepared by wet granulation technique. Granules for immediate layer and extended layer for different formulations were prepared separately. The formulations were developed and evaluations were performed to examine the parameters that affect the in vitro performance of the tablets. The drug-excipient compatibility was ensured by Fourier transform infrared spectroscopy (FTIR) study. Results: The values of physical parameters of all formulations were found within appreciable limit. Formulation containing HPMC K 100 and lactose in the proportion of 2:1 in the extended release layer was able to release 26.22% of drug in 15 min and shown a steady release of drug for an extended period of 12 h. The dissolution data was put in Korsemeyer–Peppas model in order to find out n value, which describes the drug release mechanism. The n-value of different formulations were found to be variable. The Fourier transform infrared spectroscopy (FTIR) study revealed absence of any other new peaks and also no differences in the positions of the absorption bands in the bilayer tablet F8 that indicate the lack of significant interactions between etoricoxib and other excipients. Conclusion: It had been concluded that once daily immediate-and extended release bilayer tablet of etoricoxib can be formulated with profound physical characteristics and dissolution properties. This resulted in reducing the daily dose and thus minimise the cardiovascular toxicity of etoricoxib.

scholarly journals A REVIEW ON AN EMERGIN TREND BILAYER FLOATING DRUG DELIVERY SYSTEM

2021 ◽  
Vol 11 (2) ◽  
pp. 44-49
Author(s):  
ANJALI CHOURASIYA ◽  
◽  
NARENDRA GEHALOT ◽  
SURESH CHANDRA MAHAJAN ◽  
◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Conventional Drug ◽  
Gastro Retentive

NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue. Novel drug delivery system have been developed to overcome the limitation of conventional drug delivery systems, such as of gastric retention by decreasing fluctuations in the concentration of the drug in blood,resulting in the reduction in unwanted toxicity and poor efficiency. As compared to traditional dosage forms bilayer tablets are more efficient for sequential release of two drugs that can be different or identical. Bilayer tablet is also capable of separating two incompatible substances and also for sustained release. Gastro retentive drug delivery system retains the period of dosage forms in the stomach or upper gastro intes-tinal tract ,as to improve bioavailability and the therapeutic efficacy of the drugs. Mainly the bilayer drug delivery system is suitable for drugs whose therapethic windows are narrow in the gastrointestinal tract (GIT) and also they have low elimination half life: 3-4 h. The purpose of this review is to disclose the challenges faced during the formulation of bilayer tablets. Finally, the whole article is firmly analyzed in a concluding paragraph. KEYWORDS: Conventional drug delivery systems, Bilayer tablet, Gastro retentive, Bioavailability

scholarly journals Formulation, Development and Evaluation of Bilayer Tablet of Flurbiprofen

2019 ◽  
pp. 246-251
Author(s):  
Nitin A Gaikwad ◽  
Indrjeet V Mane ◽  
Manohar D Kengar ◽  
Ranjeet S Jadhav
Keyword(s):  
Immediate Release ◽  
Wet Granulation ◽  
Content Uniformity ◽  
Formulation Development ◽  
Sodium Starch Glycolate ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Weight Variation ◽  
Initial Release ◽  
Higuchi Model

In the Study of Formulation of Bilayer Tablet of Flurbiprofen the Following Materials Using sodium starch glycolate as immediate release and HPMC K15 in different ratios as release retardant materials using a wet granulation method. All tablets exhibited good physical properties with Respect to appearance, content uniformity, hardness, weight variation and Invitro dissolution data show at increasing proportions Of sodium starch glycolate for immediate release whereas HPMC K15sustaineddrugreleaserate. The bilayer tablets showed an initial release of drug In about1hr, then sustaining the release for 12h, The kinetic analysis of dissolution data showed that release was observe din these tablets. When data was fitted to the Higuchi model. Bilayer tablets of flurbiprofen can be successfully formulated Using sodium starch glycolate and HPMC K15 in different ratios as release retardant materials employing a wet granulation method.

scholarly journals Formulation and In-vitro Evaluation of Bilayer Tablets of Atenolol and Amlodipine

2019 ◽  
Vol 22 (2) ◽  
pp. 153-169
Author(s):  
KM Yasif Kayes Sikdar ◽  
Ahad Ahamed ◽  
Md Mahbubul Alam ◽  
Md Raihan Sarkar ◽  
BK Sajeeb
Keyword(s):  
Release Kinetics ◽  
Antihypertensive Agents ◽  
Fixed Dose ◽  
Compatibility Study ◽  
In Vitro Evaluation ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Tablet Properties ◽  
Hcl Medium

The present investigation was focused on formulation and in-vitro evaluation of a fixed dose bilayer tablet of two prominent antihypertensive agents, atenolol and amlodipine. The tablets were designed to immediately release atenolol (ATF1-ATF5) by using different percentage of sodium starch glycolate as super-disintegrant for prompt blood pressure lowering activity and sustain release amlodipine (AMF1- AMF5) by varying the percentage of hydroxy propyl methylcellulose (HPMC) for prolonged activity. After evaluation of the physical and chemical parameters of the formulations according to United States Pharmacopoeia (USP) guidelines, the best immediate release formulation was found in ATF1 in terms of dissolution (99.87% after 45 minutes) and other tablet properties like hardness, disintegration time, good flow properties etc. However, the best sustained release activity was found in AMF3 in terms of dissolution (99.98% after 24 hours with constant release) and other tablet properties. After optimization of the formulations, both atenolol and amlodipine parts were successfully compressed into bilayer tablets and post-compression parameters were evaluated. In 0.1 N HCl medium, the release of atenolol from bilayer tablet was found 98.97% after 45 minutes and in case of amlodipine it was found 98.12% in 0.1 N HCl medium followed by phosphate buffer medium after 24 hours. Drug release kinetics showed that the atenolol layer followed Case I, QasiFickian transport and amlodipine layer followed Anomalous (non-Fickian) transport. Compatibility study was conducted by using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Moreover, crystalline nature of substances and extent of its conversion to amorphous form was studied using X-ray Diffractometry (X-RD). Bangladesh Pharmaceutical Journal 22(2): 153-169, 2019

scholarly journals Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer

2021 ◽  
Vol 11 (1) ◽  
pp. 23-31
Author(s):  
Neha Singh ◽  
Durga Pandey ◽  
Nilesh Jain ◽  
Surendra Jain
Keyword(s):  
Sustained Release ◽  
Immediate Release ◽  
Flow Property ◽  
Wet Granulation ◽  
Formulation Development ◽  
In Vitro Evaluation ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Sustained Release Tablets

The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer. Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release

scholarly journals Analysis on the evaluation of aceclofenac bilayer tablets and its formulation using FT-IT method

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 323-328
Author(s):  
Umamaheswara Rao T ◽  
Smitha M ◽  
Maghiben M ◽  
Damodara Velayudham A
Keyword(s):  
Immediate Release ◽  
Research Progress ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Dissolution Studies ◽  
Bilayer Tablets ◽  
Ir Studies ◽  
Bilayer Tablet ◽  
Ft Ir

The detached of the current research progress a bilayer tablet of aceclofenac utilizing sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as super disintegrants for the formulation of immediate-release layer whereas polymers such as methocel K15M, Lubrizol 971P were utilized by the formulation of sustaining layer. The tablets were equipped by straight density technique. The organized tablets were estimated for pre-compressed parameters like micromeritic properties and post compressed parameters like bulk variation, aceclofenac satisfied and in-vitro dissolution studies. The in-vitro dissolution studies showed about 86.78 % of aceclofenac release from the bilayer tablet, indicating that a preliminary burst release of aceclofenac followed by sustaining action up to 12 h by the sustained layer of the tablets. In-Vitro kinetic data revealed that all the formulations surveyed the Higuchi prototype via fickian dispersal as announcement device subsequently the preliminary rupture announcement. FT-IR studies exposed here is no communication among the drug and polymers utilized in the study. The errand of medication is to safeguard and reestablish wellbeing and to soothe languishing. In this context, the most commonly used pain-relieving agent is aceclofenac an NSAID. In the present investigation, aceclofenac bilayer tablets were prepared to provide sustain effect for better therapeutic effect. These points of interest, clarify the requirement for the planning of changed medication conveyance framework.

scholarly journals Treatment of COVID-19 in Patients With Sarcoidosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Shreya Kondle ◽  
Titus Hou ◽  
Michael Manansala ◽  
Christian Ascoli ◽  
Richard M. Novak ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Case Reports ◽  
Case Series ◽  
Review Article ◽  
Hospitalization Rate ◽  
Treatment Modalities ◽  
Tnf Alpha ◽  
Disease Course ◽  
Improve Treatment ◽  
Management Algorithm

Recent case reports and studies on treating COVID-19 in patients with chronic sarcoidosis describe different treatment modalities ranging from glucocorticoids to biologic medications. This review article summarizes seven case series and reports totaling 46 patients. While one case report suggested that sarcoidosis medications such as glucocorticoids may lengthen the COVID-19 disease course, another study with a larger registry suggests they do not. More studies are needed to elucidate an improvement in outcomes. It is possible that addition of TNF-alpha inhibitors at COVID-19 diagnosis decreases hospitalization rate. Overall, it is difficult to make firm conclusions regarding treatment given the heterogeneity of treatment modalities in the current literature. Our summarized findings are outlined with the opinions of sarcoidosis, pulmonary, and infectious disease experts in a flow chart that provides clinicians with our proposed management algorithm for sarcoidosis patients who develop COVID-19. We emphasize a need for exchange of information regarding management of COVID-19 in the setting of sarcoidosis to further improve treatment in this vulnerable population of patients.

Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview

2019 ◽  
Vol 13 (2) ◽  
pp. 74-82 ◽  
Author(s):  
Sourav Thakur ◽  
Bhupendra Singh ◽  
Vijay Mishra ◽  
Nishika Yadav ◽  
Namita Giri ◽  
...  
Keyword(s):  
Relevant Literature ◽  
Biomedical Literature ◽  
Warning Sign ◽  
Matrix Tablet ◽  
Night Time ◽  
Nocturnal Asthma ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Wide Range

Background: Asthma is a common ailment with a larger circadian difference. Nocturnal Asthma (NA) is an inconstant exacerbation of asthmatic condition related to the rise in warning sign during the night time and there is a need for its treatment addressing air route alertness and decline in lung functions. These symptoms are linked to sleep or known as circadian events. Chronotherapeutics is a management system based on an in-vivo drug accessibility programmed to check the rhythms of ailment in a direction to improve the therapeutic outcomes by suppressing the side effects. This review aims to provide an overview of NA, chronotherapeutics for the treatment of NA, bilayer tablets, and advanced techniques involved in the fabrication of bilayer tablets. The review also discusses some of the related patents. Methods: Relevant literature about the latest developments and updated information related to NA, chronotherapeutics and bilayer tablets has been very widely searched on different biomedical literature programs such as Google, Web of Science, PubMed portals, etc. Bilayer tablet mediated chronotherapy has gained significant attention and consideration as it is developed and fabricated based on the body’s circadian rhythm. Bilayer tablets can deliver the bioactive compounds at an appropriate time, place as well as amount and site. Results: Available literature advocated that the bilayer matrix tablet containing a single drug in the sustained release film and fast releasing film, may be beneficial for the chronic diseases like asthma, migraine, diabetes, hypertension and inflammation which usually require immediate as well as maintained therapeutic effect. Conclusion: The application of nanotechnology in the arena of medicine will transform the diagnosis and treatment strategies of a wide range of diseases in the upcoming years. The findings of this review confirm the importance of bilayer tablet based chronotherapy in nocturnal asthma.

scholarly journals Development of a Robust Control Strategy for Fixed-Dose Combination Bilayer Tablets with Integrated Quality by Design, Statistical, and Process Analytical Technology Approach

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1443
Author(s):  
Myung-Hee Chun ◽  
Ji Yeon Kim ◽  
Eun-Seok Park ◽  
Du Hyung Choi
Keyword(s):  
Robust Control ◽  
Control Strategy ◽  
Quality By Design ◽  
Process Analytical Technology ◽  
Fixed Dose ◽  
Bilayer Tablets ◽  
Bilayer Tablet ◽  
Dose Combination ◽  
Analytical Technology ◽  
Metformin Hcl

Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of high-dose metformin HCl in a sustained-release layer and low-dose dapagliflozin l-proline in an immediate-release layer. The formulation and process of each layer were optimized using the QbD approach. A d-optimal mixture design and response surface design were applied to optimize critical material attributes and critical process parameters, respectively. The robust design space was developed using Monte Carlo simulations by evaluating the risk of uncertainty in the model predictions. Multivariate analysis showed that there were significant correlations among impeller speed, massing time, granule bulk density, and dissolution in the metformin HCl layer, and among roller pressure, ribbon density, and dissolution in the dapagliflozin l-proline layer. Process analytical technology (PAT) was used with in–line transmittance near-infrared spectroscopy to confirm the bulk and ribbon densities of the optimized bilayer tablet. Moreover, the in vitro drug release and in vivo pharmacokinetic studies showed that the optimized test drug was bioequivalent to the reference drug. This study suggested that integrated QbD, statistical, and PAT approaches can develop a robust control strategy for FDC bilayer tablets by implementing real-time release testing based on the relationships among various variables.

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