Possibilities of using phospho-soda in patients with complicated colon preparation for endoscopy

Endoscopic screening is the main method of colon examination. An important factor for the accurate diagnosis of various pathological changes in the mucous membrane of the lower part of the digestive tract is the degree of its visualization, which directly depends on the quality of preparation for colonoscopy. There are many colon cleansers, but the peristaltic motion of the gut slows down in various diseases and syndromes, which results in the reduced accuracy of endoscopy.The paper presents the analysis of colon preparation quality using Phospho-soda (Casen Recordati, S.L., Spain) for colonoscopy in 198 patients with pathological conditions that impedes passage of all bowel contents: inflammatory bowel disease, acromegaly, and hypotonia of the large intestine. The authors carried out a comparative analysis with a control group, which included 106 patients without factors that slowed down the peristaltic motion of the intestine, who were preparing for endoscopic examination according to a similar scheme.The study showed that using Phospho-soda to prepare for endoscopic examination in patients with decreased colonic tone resulted in the efficacy of the drug comparable with its efficacy in a group of patients without dysmotility.

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The visualization and assessment of the anterior surface of the cornea using video keratotopography

The Eye ◽

10.33791/2222-4408-2020-2-36-43 ◽

2020 ◽

Vol 22 (130) ◽

pp. 36-43

Author(s):

Gulnara Andrienko

Keyword(s):

Contact Lenses ◽

Corneal Topography ◽

Topographic Maps ◽

Specific Situation ◽

Main Method ◽

Pathological Conditions ◽

Quality Of Vision ◽

Corneal Shape ◽

Color Map

Corneal topography is the main method for assessing the regularity of the surface of the cornea. Corneal irregularity leads to a deterioration in its refractive properties and a decrease in the quality of vision. Learning the basics of corneal topography will help determine the choice of a color map for a specific situation, as well as understand and analyze the data associated with these maps. This article describes the main types of topographic maps, various patterns of corneal shape in normal and pathological conditions and how to use the data obtained to design and fit contact lenses. Despite the fact that images may vary depending on topographers used, the information presented in this article is universal.

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The visualization and assessment of the anterior surface of the cornea using video keratotopography

The Eye ◽

10.33791/2222-4408-2020-2-36-42 ◽

2020 ◽

Vol 22 (130) ◽

pp. 36-42

Author(s):

Gulnara Andrienko

Keyword(s):

Contact Lenses ◽

Corneal Topography ◽

Topographic Maps ◽

Specific Situation ◽

Main Method ◽

Pathological Conditions ◽

Quality Of Vision ◽

Corneal Shape ◽

Color Map

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Efficacy of the drug containing sodium picosulfate and magnesium citrate in bowel preparation for colonoscopy in children

Voprosy praktičeskoj pediatrii ◽

10.20953/1817-7646-2020-4-32-39 ◽

2020 ◽

Vol 15 (4) ◽

pp. 32-39

Author(s):

T.N. Budkina ◽

◽

V.I. Oldakovskiy ◽

A.V. Tupylenko ◽

V.S. Tsvetkova ◽

...

Keyword(s):

Bowel Preparation ◽

Key Words Children ◽

Control Group ◽

Magnesium Citrate ◽

Right Colon ◽

Bowel Diseases ◽

Sodium Picosulfate ◽

Inflammatory Bowel ◽

The Right

Objective. To evaluate the efficacy, safety, and tolerability of the drug containing sodium picosulfate and magnesium citrate (SPMC) used for bowel preparation in children. Patients and methods. We have assessed the quality of bowel preparation for colonoscopy in 80 children aged between 9 and 18 years (40 of them received SPMC for it and another 40 were prepared by cleansing enemas). The effectiveness of bowel preparation was evaluated using the Boston and Chicago Bowel Preparation Scales (BPS). Tolerability of the SPMC preparation scheme was estimated using a specially designed questionnaire. Results. Effective bowel preparation was achieved in 85% children receiving SPMC (excellent in 27.5% of cases and good in 57.5% of cases), whereas children in the control group have demonstrated significantly lower quality of bowel preparation (p = 0.021). We have observed that the right colon was significantly better prepared in the SPMC group than in the control group (p < 0.001). Ninety percent of children were satisfied with the SPMC preparation scheme and agreed to use it in the future. Conclusion. Preparation of children for colonoscopy with SPMC was effective, safe, and well tolerated by them; therefore, SPMC is preferable over traditional cleansing enemas. Key words: children, inflammatory bowel diseases, colonoscopy, bowel preparation, sodium picosulfate–magnesium citrate

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Lower Level of Bacteroides in the Gut Microbiota Is Associated with Inflammatory Bowel Disease: A Meta-Analysis

BioMed Research International ◽

10.1155/2016/5828959 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 63

Author(s):

Yingting Zhou ◽

Fachao Zhi

Keyword(s):

Inflammatory Bowel Disease ◽

Gut Microbiota ◽

Bowel Disease ◽

Meta Analysis ◽

Active Phase ◽

Cochrane Library ◽

Control Group ◽

Inflammatory Bowel ◽

Normal Controls

Background and Aims. Multiple studies have reported associations between inflammatory bowel disease (IBD) and the flora disequilibrium of Bacteroides. We performed a meta-analysis of the available data to provide a more precise estimate of the association between Bacteroides level in the gut and IBD. Methods. We searched PubMed/MEDLINE, EMBASE, Cochrane Library, Wiley Library, BIOSIS previews, Web of Science, CNKI, and ScienceDirect databases for published literature on IBD and gut microbiota from 1990 to 2016. Quality of all eligible studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). We compared the level of Bacteroides in IBD patients with that in a control group without IBD, different types of IBD patients, and IBD patients with active phase and in remission. Results. We identified 63 articles, 9 of which contained sufficient data for evaluation. The mean level of Bacteroides was significantly lower in Crohn’s disease (CD) and ulcerative colitis (UC) patients in active phase than in normal controls. The level of Bacteroides in remission CD and UC patients was much lower than patients in the control group. Bacteroides level was even lower in patients with CD and UC in active phase than in remission. Conclusions. This analysis suggests that lower levels of Bacteroides are associated with IBD, especially in active phase.

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Specific quality of life factors in patients with inflammatory bowel disease

Orvosi Hetilap ◽

10.1556/oh.2012.29369 ◽

2012 ◽

Vol 153 (38) ◽

pp. 1511-1519 ◽

Cited By ~ 5

Author(s):

Beáta Nagy ◽

Réka Laczkóné Majer

Keyword(s):

Quality Of Life ◽

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Content Analysis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Bowel Disease ◽

Control Group ◽

Inflammatory Bowel

Introduction: Inflammatory bowel disease is a chronic disease with a fluctuating course and unknown origin. Its two major forms are Crohn’s disease and ulcerative colitis. Objective: The authors attempted to analyse the quality of life of patients with inflammatory bowel disease as compared to healthy persons and patients with asthma in order to identify specific factors which most significantly affect the quality of life of these patients. Method: 269 subjects participated in the study (control group, 115 subjects; Crohn’s disease, 67 patients; ulcerative colitis, 25 patients; asthma, 62 patients). The following methods were used: WHO-5, IIRS, SIBDQ and AQLQ(S) questionnaires and content analysis. Results: Patients with inflammatory bowel disease had the worst quality of life with respect to both subjective well-being and burden of disease. The results obtained from questionnaires developed for the analysis of quality of life indicated that extraintestinal symptoms and emotional problems are the major factors which interfere with the quality of life of patients with inflammatory bowel disease. These findings were confirmed by content analysis of interviews with patients. Conclusions: The authors recommend that more attention should be paid to improving the quality of life of patients with inflammatory bowel disease and helping them to live with the illness, especially at the level of interpersonal relations. Orv. Hetil., 2012, 153, 1511–1519.

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Muscle function and quality of life in the Crohn’s disease

Fisioterapia em Movimento ◽

10.1590/1980-5918.030.002.ao14 ◽

2017 ◽

Vol 30 (2) ◽

pp. 337-345 ◽

Cited By ~ 2

Author(s):

Andrea Lemos Cabalzar ◽

Diana Junqueira Fonseca Oliveira ◽

Maycon de Moura Reboredo ◽

Fernando Azevedo Lucca ◽

Júlio Maria Fonseca Chebli ◽

...

Keyword(s):

Quality Of Life ◽

Muscle Strength ◽

Muscle Function ◽

Respiratory Muscle ◽

Control Group ◽

Respiratory Muscle Strength ◽

Peripheral Muscle ◽

Sf 36 ◽

Inflammatory Bowel

Abstract Introduction: Crohn’s disease (CD) is an inflammatory bowel disease, marked by exacerbations and remissions periods. Peripheral manifestations in CD may be present with the syndrome of skeletal muscle dysfunction (SMD), which is characterized by loss of muscle strength, fatigue complain, limited exercise capacity and impaired quality of life of these patients. Objective: Evaluate muscle strength, physical capacity and quality of life of patients with CD and compare them with healthy controls. Methods: 18 patients CD and 12 healthy controls matched for age and sex were involved. Peripheral muscle strength evaluated by handgrip strength of the dominant hand and respiratory muscle strength by measures of respiratory muscle strength (maximal inspiratory/expiratory pressure - MIP and MEP). Exercise capacity evaluated by Shuttle test (ST) and the quality of life by the Short-form 36 (SF-36) and by the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: Patients with CD presented a lower respiratory muscle strength (MIP = -68.93 ± 26.61 vs 29.63 ± -100 cmH2O, p = 0.0013 and MEP = 81.07 ± 30.26 vs 108 ± 25.30 cmH2O, p = 0.032) and a tendency the lower peripheral muscle strength (31.72 ± 8.55 vs 39.00 ± 13.37 kgf, p = 0.09). In addition, CD patients presented worse physical capacity on the ST compared to the control group (513.7 ± 237m vs 983.0 ± 263m, p < 0.05) and worse quality of life in 7 of 8 domains of the SF-36 and in all dimensions of the IBDQ. Conclusion: Patients with CD showed muscle functional impairment and poorer quality of life compared to healthy control group. These findings suggest that the assessment and maybe interventions in the muscle function must be used in clinical practice.

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Impact of BMGIM Music Therapy on Emotional State in Patients with Inflammatory Bowel Disease: A Randomized Controlled Trial

Journal of Clinical Medicine ◽

10.3390/jcm10081591 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1591

Author(s):

Vicente Alejandro March-Luján ◽

Vicente Prado-Gascó ◽

José María Huguet ◽

Xavier Cortés ◽

José María Paredes Arquiola ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Emotional State ◽

Control Group ◽

Acute And Chronic Stress ◽

State Of Mind ◽

Inflammatory Bowel ◽

The Impact

Background. Patients with inflammatory bowel disease (IBD) have a high prevalence of emotional disturbances which worsen the symptoms of the disease. As a therapeutic alternative that is part of a comprehensive care alongside medication, the Bonny Method of Guided Imagery and Music (BMGIM) music-assisted therapy has achieved promising emotional improvements in patients with chronic diseases. The objective of the study was to determine the impact of a treatment based on a BMGIM group adaptation on patients with inflammatory bowel disease (IBD) and their emotional state, therefore analyzing state of mind, quality of life, anxiety, depression, immunocompetence as a marker of well-being, and levels of acute and chronic stress. Methods. Longitudinal, prospective, quantitative, and experimental study including 43 patients with IBD divided into an intervention group (22 patients), who received eight sessions over eight weeks, and a control group (21 patients). A saliva sample was taken from each patient before and after each session in order to determine cortisol and IgA levels. Similarly, a hair sample was taken before the first and after the last session to determine the cumulative cortisol level. All molecules were quantified using the ELISA immunoassay technique. In addition, patients completed several emotional state questionnaires: HADS, MOOD, and CCVEII. Results. An improvement was observed in the following states of mind: sadness, fear, anger, and depression. No significant effect was observed in state of mind in terms of happiness or anxiety, in the levels of cortisol in hair, and in patients’ perceived quality of life. A reduction in cortisol was observed in saliva, although this did not significantly affect the IgA titer. Conclusions. BMGIM seems to improve the emotional state of patients with IBD.

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Genotype-Guided Thiopurine Dosing Does not Lead to Additional Costs in Patients With Inflammatory Bowel Disease

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz009 ◽

2019 ◽

Vol 13 (7) ◽

pp. 838-845 ◽

Cited By ~ 6

Author(s):

Reinier L Sluiter ◽

Corine van Marrewijk ◽

Dirk de Jong ◽

Hans Scheffer ◽

Henk-Jan Guchelaar ◽

...

Keyword(s):

Quality Of Life ◽

Inflammatory Bowel Disease ◽

Incremental Cost ◽

Bowel Disease ◽

Healthcare Costs ◽

Cost Savings ◽

Control Group ◽

Life Years ◽

Inflammatory Bowel

Abstract Background and Aims Decreased thiopurine S-methyltransferase [TPMT] enzyme activity increases the risk of haematological adverse drug reactions [ADRs] in patients treated with thiopurines. Clinical studies have shown that in patients with inflammatory bowel disease [IBD], pharmacogenetic TPMT-guided thiopurine treatment reduces this risk of ADRs. The aim of this study was to investigate whether this intervention impacts on healthcare costs and/or quality of life. Methods An a priori defined cost-effectiveness analysis was conducted in the Thiopurine response Optimization by Pharmacogenetic testing in Inflammatory bowel disease Clinics [TOPIC] trial, a randomized controlled trial performed in 30 Dutch hospitals. Patients diagnosed with IBD [age ≥18 years] were randomly assigned to the intervention [i.e. pre-treatment genotyping] or control group. Total costs in terms of volumes of care, and effects in quality-adjusted life years [QALYs], based on EuroQol-5D3L utility scores, were measured for 20 weeks. Mean incremental cost savings and QALYs with confidence intervals were calculated using non-parametric bootstrapping with 1000 replications. Results The intervention group consisted of 381 patients and the control group 347 patients. The mean incremental cost savings were €52 per patient [95% percentiles −682, 569]. Mean incremental QALYs were 0.001 [95% percentiles −0.009, 0.010]. Sensitivity analysis showed that the results were robust for potential change in costs of screening, costs of biologicals and costs associated with productivity loss. Conclusions Genotype-guided thiopurine treatment in IBD patients reduced the risk of ADRs among patients carrying a TPMT variant, without increasing overall healthcare costs and resulting in comparable quality of life, as compared to standard treatment.

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Neutrophil to Lymphocyte Ratio in Diagnosis of Inflammatory Bowel Disease and Correlation with Disease Severity Assessed by Ultrasound and Colonoscopy

QJM ◽

10.1093/qjmed/hcab100.049 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Wesam A Ebrahem ◽

Shereen A Saleh ◽

Mohamed O Aly ◽

Dina S Mohamed

Keyword(s):

Inflammatory Bowel Disease ◽

Sensitivity And Specificity ◽

Bowel Disease ◽

Complete Blood Count ◽

High Sensitivity ◽

Endoscopic Examination ◽

Control Group ◽

Moderate Activity ◽

Lymphocyte Ratio ◽

Inflammatory Bowel

Abstract Background Inflammatory bowel disease (IBD) is a chronic idiopathic disease affecting author the gastrointestinal tract that is comprised of two separate, but related intestinal disorders; Crohn’ s disease (CD) and ulcerative colitis (UC). The diagnosis of IBD is most commonly made on the basis of clinical features in combination with findings on ultrasonography, endoscopy and histopathology. Patients and Methods This is a crosssectional prospective observational study. This study included 40 IBD patients (19 females and 21 males), presented to Internal Medicine department, El-Demerdash Hospital, Ain Shams University from June 2018 to June 2019. Patients were matched with 10 healthy subjects (7 females and 3 males) as a control group. All patients subjected to the following: Thorough medical history, clinical examination (general and local) and laboratory investigations including complete blood count with calculation of neutrophils to lymphocyte ratio, ESR and CRP on the day of the colonoscopic procedure. US examination and endoscopic examination were done for every patient. Results Mean value of NLR in IBD patients was significantly higher than those in control group representing 3.12±1.87 and 1.88±0.42 respectively but it was statisitically insignificant between active and inactive IBD patients with best cut off >2,01 to differentiate active from inactive patient.THE NLR value was correllating with CRP only with no correlation with ESR,NLR value also has association with US findings that suggesting activity with best cut off >2.5 to detect these findings by US in active patients.US has high sensitivity and specificity in discriminating patients with moderate and severe activity from those with mild activity or those in remission but it was unable to discriminate patient of moderate activity from patients with severe activity with strong assossiation with endoscopic scores of activity. Conclusion NLR values had higher sensitivity and specificity than CRP and ESR with the benefit of being readily available with an affordable price. They are more useful when utilized together with serum laboratory inflammatory indices (CRP and ESR).

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Remote Monitoring Empowerment of Patients with IBDs during the SARS-CoV-2 Pandemic

Healthcare ◽

10.3390/healthcare8040377 ◽

2020 ◽

Vol 8 (4) ◽

pp. 377

Author(s):

Mauro Mastronardi ◽

Margherita Curlo ◽

Maurizio Polignano ◽

Natalino Vena ◽

Daniela Rossi ◽

...

Keyword(s):

Lower Number ◽

Control Group ◽

Control Room ◽

Clinical Control ◽

The World ◽

Bowel Diseases ◽

Monitoring Group ◽

Inflammatory Bowel ◽

Tele Monitoring

Once the WHO declared the Sars-CoV-2 pandemic, the world had to reprogram numerous clinical activities, particularly those related to highly disabling diseases such as inflammatory bowel diseases (IBDs). In this study, 1083 IBD patients were assessed, affected by Crohn’s Disease (CD) and Ulcerative Colitis (UC), and subdivided into two groups. The first group included patients who needed treatment in person at the outpatients clinic, while the second group could be tele-monitored because they were able to self-administer therapy. The tele-monitoring was based on telecommunication applications via smartphone, driven by a dedicated clinical control room in the IBD Clinic. The aim of this study was to assess the quality of life (using IBDQ32) of UC patients and tele-monitored CD patients (tele-monitoring group) as compared to those patients who underwent assessment in person in the outpatients clinic (control group). Despite observing a lower number of relapses in the control group than the tele-monitoring group, there were no statistically significant differences between the groups in terms of the IBD32Q scores. Tele-monitoring of patients who are able to self-administer the IBD therapy can be an effective vicarious system as compared to the clinical evaluation in person, that could lead to important changes to avoid the overcrowding of the IBD outpatients clinic, especially during public health crises like the present pandemic.

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