Administration of olive oil optimizes acetic acid induced colitis in CD1 mice

Background. In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases. This study investigates thein vivoantinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats.Materials and Methods. In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated. Acetylsalicylic acid and morphine were used as standard drugs, respectively. The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs. Last, the xenograft model in athymic mice was used to evaluate the anticancer effectin vivo.Results. EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test. It has also a better effect than Dexamethasone in the anti-inflammatory test. Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice.Conclusion. EVOO has a significant analgesic, anti-inflammatory, and anticancer properties. However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.

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Liquid-liquid equilibrium constant for acetic acid in an olive oil-epoxidized olive oil-acetic acid-hydrogen peroxide-water system

Hemijska industrija ◽

10.2298/hemind141210024j ◽

2016 ◽

Vol 70 (2) ◽

pp. 165-175 ◽

Cited By ~ 1

Author(s):

Milovan Jankovic ◽

Olga Govedarica ◽

Snezana Sinadinovic-Fiser ◽

Jelena Pavlicevic ◽

Vesna Teofilovic ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Acetic Acid ◽

Olive Oil ◽

Equilibrium Constant ◽

Water System ◽

Liquid Equilibrium ◽

Nrtl Model ◽

In Situ Epoxidation ◽

Flash Calculation ◽

Activity Coefficient Models

The liquid-liquid equilibrium constant for acetic acid in a quinary system olive oil-epoxidized olive oil-acetic acid-hydrogen peroxide-water was experimentally determined for temperatures and component ratios relevant for in situ epoxidation of plant oils. The values has the constant range from 1.52 to 2.73. To predict the equilibrium constant for acetic acid, the experimental data were correlated with UNIQUAC (universal quasi chemical) and NRTL (non-random two liquid) activity coefficient models. For simplified calculation of the phase equilibrium the insolubility of olive oil and epoxidized olive oil in the water, as well as insolubility of water and hydrogen peroxide in the olive oil and epoxidized olive oil, was assumed. The root mean square deviation (RMSD) of the experimental and calculated values of the liquid-liquid equilibrium constant for acetic acid is 0.1910 for the UNIQUAC model and 0.1815 for the NRTL model. For rigorous flash calculation, when the partitioning of all components between the phases was assumed, the RMSD for the NRTL model is 0.1749.

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The Inhibitory Effect of Extra Virgin Olive Oil and Its Active Compound Oleocanthal on Prostaglandin-Induced Uterine Hypercontraction and Pain—Ex Vivo and In Vivo Study

Nutrients ◽

10.3390/nu12103012 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3012

Author(s):

Yi-Fen Chiang ◽

Hui-Chih Hung ◽

Hsin-Yuan Chen ◽

Ko-Chieh Huang ◽

Po-Han Lin ◽

...

Keyword(s):

Oxidative Stress ◽

Acetic Acid ◽

Olive Oil ◽

Active Ingredient ◽

Active Compound ◽

Ex Vivo ◽

Virgin Olive Oil ◽

Extra Virgin Olive Oil ◽

Inhibitory Effect

Primary dysmenorrhea is a common occurrence in adolescent women and is a type of chronic inflammation. Dysmenorrhea is due to an increase in oxidative stress, which increases cyclooxygenase-2 (COX-2) expression, increases the concentration of prostaglandin F2α (PGF2α), and increases the calcium concentration in uterine smooth muscle, causing excessive uterine contractions and pain. The polyphenolic compound oleocanthal (OC) in extra virgin olive oil (EVOO) has been shown to have an anti-inflammatory and antioxidant effect. This study aimed to investigate the inhibitory effect of extra virgin olive oil and its active ingredient oleocanthal (OC) on prostaglandin-induced uterine hyper-contraction, its antioxidant ability, and related mechanisms. We used force-displacement transducers to calculate uterine contraction in an ex vivo study. To analyze the analgesic effect, in an in vivo study, we used an acetic acid/oxytocin-induced mice writhing model and determined uterus contraction-related signaling protein expression. The active compound OC inhibited calcium/PGF2α-induced uterine hyper-contraction. In the acetic acid and oxytocin-induced mice writhing model, the intervention of the EVOO acetonitrile layer extraction inhibited pain by inhibiting oxidative stress and the phosphorylation of the protein kinase C (PKC)/extracellular signal-regulated kinases (ERK)/ myosin light chain (MLC) signaling pathway. These findings supported the idea that EVOO and its active ingredient, OC, can effectively decrease oxidative stress and PGF2α-induced uterine hyper-contraction, representing a further treatment for dysmenorrhea.

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Migration Model of Silver-Loaded Zeolite in Antibacterial Kraft Paper

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.200.271 ◽

2012 ◽

Vol 200 ◽

pp. 271-277 ◽

Cited By ~ 1

Author(s):

Ze Hui Zhong ◽

Yu Bian ◽

Ting Li ◽

Jun Xu ◽

Bai Long Hou

Keyword(s):

Acetic Acid ◽

Olive Oil ◽

Antibacterial Agent ◽

Experimental Results ◽

Silver Ion ◽

Distilled Water ◽

Migration Model ◽

Kraft Paper ◽

Predicted Model ◽

And Migration

Based on the Fick’s law, model about the migration of silver-loaded zeolite on antibacterial kraft paper was built, and migration of antibacterial agent in distilled water, 65 % ethanol and 4 % acetic acid at 2 h、24 h、96 h、240 h、480h、720h and 960 h under 40 °C were detected by AAS. The predicted and experimental results were compared using MATLAB software. The results are shown that the turns of migration in different foodstuff are that 65 % ethanol>4 % acetic acid>distilled water, while silver ion is not detected in olive oil and N-hexane. The migration in distilled water, 65 % ethanol and 4 % acetic acid can be well fitted with the predicted model, and the migration in 4 % acetic acid is similar with the model’s result in certain period of time, and migration of antibacterial agent from papers to food stimulants in different effective migration coefficient, depth of paper and time can be greatly predicted with.

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Ectodesmata as Revealed By Freeze-Etch Preparations of Plant Epidermal Cell Walls

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072782 ◽

1973 ◽

Vol 31 ◽

pp. 468-469

Author(s):

N.C. Lyon ◽

W. C. Mueller

Keyword(s):

Electron Microscopy ◽

Acetic Acid ◽

Nitric Acid ◽

Oxalic Acid ◽

Light Microscopy ◽

Epidermal Cell ◽

Cell Walls ◽

Plant Viruses ◽

Plant Leaves ◽

Thin Sections

Schumacher and Halbsguth first demonstrated ectodesmata as pores or channels in the epidermal cell walls in haustoria of Cuscuta odorata L. by light microscopy in tissues fixed in a sublimate fixative (30% ethyl alcohol, 30 ml:glacial acetic acid, 10 ml: 65% nitric acid, 1 ml: 40% formaldehyde, 5 ml: oxalic acid, 2 g: mecuric chloride to saturation 2-3 g). Other workers have published electron micrographs of structures transversing the outer epidermal cell in thin sections of plant leaves that have been interpreted as ectodesmata. Such structures are evident following treatment with Hg++ or Ag+ salts and are only rarely observed by electron microscopy. If ectodesmata exist without such treatment, and are not artefacts, they would afford natural pathways of entry for applied foliar solutions and plant viruses.

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A preliminary study on the potential of front face fluorescence spectroscopy for the discrimination of Moroccan virgin olive oils and the prediction of their quality

Analytical Methods ◽

10.1039/d0ay01746a ◽

2021 ◽

Author(s):

Hicham Zaroual ◽

El Mestafa El Hadrami ◽

Romdhane Karoui

Keyword(s):

Fluorescence Spectroscopy ◽

Olive Oil ◽

Virgin Olive Oil ◽

Front Face ◽

Virgin Olive Oils ◽

Olive Oils ◽

Preliminary Study

This study examines the feasibility of using front face fluorescence spectroscopy (FFFS) to authenticate 41 virgin olive oil (VOO) samples collected from 5 regions in Morocco during 2 consecutive crop seasons.

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