scholarly journals Análise dos resultados do último laudo citopatológico de pacientes com Papanicolaou em atraso

2020 ◽  
Vol 11 (3) ◽  
Author(s):  
Nathanael De Souza Maciel ◽  
Francisco Jardsom Moura Luzia ◽  
Diego Da Silva Ferreira ◽  
Maria Charlianne de Lima Pereira Silva ◽  
Davide Carlos Joaquim ◽  
...  

Objetivo: Analisar os resultados do último laudo citopatológico de pacientes com o exame Papanicolaou em atraso. Metodologia: Estudo documental, retrospectivo, com abordagem quantitativa, realizado no município de Redenção–CE. Foram explorados 660 prontuários de mulheres com idade entre 25 e 64 anos. Para análise foram utilizadas medidas de tendência central e frequências absolutas e relativas. Resultados: O número de mulheres que nunca haviam realizado o exame Papanicolaou foi de 44,7% e as que haviam realizado, mas estavam em atraso, foi de 55,3%. A presença de células metaplásicas foi menos frequente (38,6%). Entre agentes infecciosos, houve prevalência dos resultados sugestivos de Gardnerella vaginalis e Mobiluncus (14,9%), Cândida sp (3,9%) e Trichomonas vaginalis (1,1%).  Os laudos indicaram presença de alterações celulares pré-malignas e malignas. Conclusão: Esta análise poderá motivar a implementação da busca de pacientes com exame atrasado, especialmente das que apresentam alguma infecção sexualmente transmissível ou alteração celular pré-maligna ou maligna.Descritores: Neoplasias do Colo do Útero; Teste de Papanicolaou; Programas de Rastreamento; Atenção Primária à Saúde, Enfermagem.ANALYSIS OF THE RESULTS OF THE LAST CYTOPATHOLOGICAL EXAM OF PATIENTS WITH DELAYED PAP SMEARObjective: To analyze the results of the last cytopathological report of patients with delayed Pap smear. Methodology: Documentary, retrospective study with quantitative approach, conducted in the city of Redenção-CE, from April to September 2018. Were explored 660 medical records of women aged 25 to 64 years. For analysis, measures of central tendency and absolute and relative frequencies were used. Results: The number of women who had never had the Pap smear was 44,7%, and those who had been submitted but were delayed were 55,3%. The presence of metaplastic cells was less frequent (38,6%). Among infectious agents, there was a prevalence of suggestive results of Gardnerella vaginalis and Mobiluncus (14,9%), Candida sp (3,9%) and Trichomonas vaginalis (1,1%). The reports indicated the presence of premalignant and malignant cellular alterations. Conclusion: There are a large number of women with delayed Pap tests and a deficiency in the quality of the tests, indicated by the absence of metaplastic tissue. This should motivate the active search of patients to interrupt the chain of transmission of Sexually Transmitted Infections and to treat cervical lesions early, reducing the chances of progression.KEYWORDS: Uterine Cervical Neoplasms, Papanicolaou Test, Mass Screening, Primary Health Care, Nursing. ANÁLISIS DE LOS RESULTADOS DEL ÚLTIMO EXAMEN CITOPATOLÓGICO DE PACIENTES CON PAPANICOLAOU EN RETRASOObjetivo: Analizar resultados del último examen citopatológico de pacientes con Papanicolaou en retraso. Metodología: Estudio documental, retrospectivo, con enfoque cuantitativo, realizado en la ciudad de Redenção-CE, de abril a septiembre de 2018. Fueron explorados 660 prontuarios de mujeres de 25 a 64 años. Para el análisis, se utilizaron medidas de tendencia central, frecuencias absolutas y relativas. Resultados: El número de mujeres que nunca se habían hecho la prueba de Papanicolaou fue del 44,7%, y las que se sometieron, pero estában en retraso, fueron 55,3%. La presencia de células metaplásicas fue menos frecuente (38,6%). Entre los agentes infecciosos, hubo una prevalencia de resultados sugestivos de Gardnerella vaginalis y Mobiluncus (14,9%), Candida sp (3,9%) y Trichomonas vaginalis (1,1%). Los informes indicaron presencia de alteraciones celulares premalignas y malignas. Conclusión: Hoy una gran cantidad de mujeres con pruebas de Papanicolaou retrasadas y una deficiencia en la calidad de los exámenes, indicada por la ausencia de tejido metaplásico. Esto debería motivar la búsqueda activa de pacientes para interrumpir la cadena de transmisión de las infecciones de transmisión sexual y para tratar las lesiones cervicales temprano, reduciendo las posibilidades de progresión.PALABRAS-CLAVE: Neoplasias del Cuello Uterino, Prueba de Papanicolaou, Tamizaje Masivo, Atención Primaria de Salud, Enfermería.

2020 ◽  
Vol 47 (1) ◽  
pp. 6104
Author(s):  
Andrea Alves Ribeiro ◽  
Sara Rosa Peixoto ◽  
Gabriel Henrique Martins de Almeida Araújo ◽  
Carolina Tonello dos Santos Pelá Alcanfor

O Trichomonas vaginalis é um protozoário que causa uma das principais infecções sexualmente transmissíveis. O objetivo foi estimar a prevalência de Trichomonas vaginalis em um Laboratório escola de Goiânia-GO. É um estudo retrospectivo utilizando as fichas de requisição dos exames citopatológicos realizados no Laboratório Clínico da Pontifícia Universidade Católica de Goiás (LC-PUCGO) entre janeiro de 2013 a dezembro de 2015. As variáveis foram categorizadas no programa Excel 2013 e tabulados no programa Epi Info™ versão 7, para avaliação da associação entre as variáveis foi realizado o cálculo do Odds Ratio (OR), considerando um intervalo de confiança (IC) de 95% e o valor de significância p< 0,05. Do total dos 4558 exames citopatológicos satisfatórios foi encontrada uma prevalência de Lactobacillus sp., de 46,97% (2141/4558) seguida por bacilos 24,62% (1122/4558), bacilos e cocos de 21,68% (988/4558), cocos de 3,86%(176/4558) e bacilos e lactobacilos de 2,87% (131/4558). Os agentes patogênicos encontrados foram Gardnerella vaginalis 79,6% (1141/1433), Candida sp. 17,7% (253/1433), Trichomonas vaginalis de 2,2% (32/1433), Herpes simplex de 0,4% (6/1433) e Chlamydia trachomatis de 0,1% (1/1433). Dentre os 4558 exames citopatológicos, 14,39% (656/4558) apresentaram anormalidades citológicas. As anormalidades encontradas foram ASC-US 2,57% (117/656), LSIL 1,78 % (81/656), ASC-H 3,52 % (160/656), HSIL 1,08% (48/656), AGC NEO 0,22% (10/656), Carcinoma invasor 0,02 % (1/656). Houve uma associação estatisticamente significante com a presença de Trichomonas vaginalis e o padrão anaeróbio OR 44,89 (IC 95 %: 10.5-271,8 p < 0,000). A detecção da manifestação por Trichomonas vaginalis é bastante sensível por meio do exame citopatológico. A presença de Trichomonas vaginalis, em um percentual relativamente baixo, indica a necessidade de identificação dos fatores de risco e aconselhamento em relação à proteção, transmissão e tratamento dessa infecção.


Author(s):  
Fatemeh Rahmani ◽  
Yahya Ehteshaminia ◽  
Hamid Mohammadi ◽  
Seif Ali Mahdavi

Introduction: Trichomoniasis is the most common non-viral sexually transmitted infection in the world, caused by the protozoan parasite Trichomonas vaginalis, which infects the urogenital tract of men and women. Approximately, 250 million new cases of Trichomonas vaginalis Infection are reported worldwide each year. Trichomoniasis is also considered an important HIV co-infection. The infection is often asymptomatic but can be accompanied by symptoms such as severe inflammation, itching and irritation, foamy discharge, and malodorous smell mucus, but the signs and symptoms of the disease are not sufficient for specific diagnosis. Material and Methods: In this study, the websites of PubMed, Google Scholar, SID, and Margiran were searched and related articles were reviewed. Results: Only screening and the use of highly sensitive and specific diagnostic methods can identify asymptomatic individuals. Today, the most common way to diagnose the infection is to use wet slide, Pap smear and culture methods that do not have high sensitivity and specificity. Also, due to the increase in infection and its complications, finding an efficient, rapid, and easy test to detect the parasite and differentiate Trichomoniasis vaginitis from other sexually transmitted diseases is considered important and necessary. Conclusion: Nowadays, there are several diagnostic methods that differentiate trichomoniasis infection from other sexually transmitted infections with high accuracy and sensitivity. Of course, existing diagnostic methods mostly use women's urine and vaginal samples for diagnosis, and methods that specifically diagnose the infection in men are more limited.


Author(s):  
Mercy Mrudula Dasari ◽  
Venkatalakshmi Anem ◽  
Sirisha Gunta ◽  
Satish Kumar Seeram ◽  
Bhagyalakshmi Atla

Background: Cervical cancer is a leading cause of morbidity and mortality among women worldwide and more over in the developing countries, so there is a need to develop screening test with high specificity and sensitivity. Aim of the study was to evaluate the effectiveness of Papanicolaou (PAP) smear versus visual inspection acetic acid (VIA) for screening cervical lesions in patients and to determine and compare their sensitivity and specificity.Methods: The present study is a hospital based prospective study for a period of two years at the department of pathology from August 2014 to July 2016 consisting of 500 patients attending gynaecology outpatient clinic. Papanicolaou (Pap) smear tests and visual inspection acetic acid were employed along with complete clinical history record. The results of VIA were correlated with that of pap smear on the basis of sensitivity, specificity and positive and negative predictive value.Results: Out of 500 cases, most common age group was 21 to 40 years of age consisting of 305 cases - 61%. VIA was positive in 156 cases-31.2%, PAP smear positive for epithelial cell abnormalities were 60 cases-12%. VIA showed higher sensitivity (52.38%) compared to Pap smear (40%) whereas Pap smear showed higher specificity (93.2%) compared to VIA (92.4%).Conclusions: Papanicolaou test is a better screening test for epithelial cell abnormality than VIA. However, in countries with low resource settings where cytology-based screening programs are not available, VIA is a promising alternative.


Mycoses ◽  
2002 ◽  
Vol 45 (S2) ◽  
pp. 24-24
Author(s):  
U.-C. Hipler ◽  
C. Greif ◽  
U. Metzner ◽  
C. Hipler ◽  
P. Elsner

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Ana Paula Almeida Cunha ◽  
Ilka Kassandra Pereira Belfort ◽  
Francisco Pedro Belfort Mendes ◽  
Gerusinete Rodrigues Bastos dos Santos ◽  
Lucas Henrique de Lima Costa ◽  
...  

Objective. To verify the association between HPV infection and the presence of coinfections (Chlamydia trachomatis, Trichomonas vaginalis, and Neisseria gonorrhoeae) in women in the state of Maranhão. Methods. HPV-DNA detection was performed by the nested PCR, using the primers PGMY09/11 and GP + 5/GP + 6. For the identification of sexually transmitted agents, conventional PCR was performed using the following primers: KL1/KL2 (Chlamydia trachomatis), TVA5/TVA6 (Trichomonas vaginalis), and HO1/HO3 (Neisseria gonorrhoeae). DNA-HPV positive samples were subjected to automated sequencing for genotyping. Results. Among the 353 women evaluated, 204 (57.8%) had HPV-DNA, of which 140 (68.6%) exhibited HPV/STIs, while 64 (31.4%) had the only HPV. T. vaginalis infection showed a positive association with HPV ( p = 0.003 ). Women without cervical lesions were predominant (327/92.6%); however, the largest number of lesions was reported in women who had HPV/coinfections (18/8.8%). Multiple regression analysis showed that both HPV only and the concomitant presence of HPV/STI were able to indicate the occurrence of epithelial lesions (R = 0.164; R2 = 0.027). Conclusion. The findings suggest that the presence of T. vaginalis can contribute to HPV infection, and HPV/IST association may influence the development of cervical intraepithelial lesions that are precursors of cervical cancer.


1995 ◽  
Vol 113 (6) ◽  
pp. 1009-1011 ◽  
Author(s):  
Edenilson Eduardo Galore ◽  
Maria José Cavaliere ◽  
Neuza Kasumi Shirata ◽  
Maria de Fátima Araújo

It has been described that women infected with the human immunodeffciency virus (HIV) present more frequent cytological abnormalities in cervicovaginal smears, generally related to infection by human papillomavirus (HPV). The present work is a study of cervicovaginal smears of 147 HIV-seropositive women submitted to routine gynecological examinations. The smears were stained by the Papanicolaou method. Cytopathic effects of HPV were found in 38 (25.8%) cases. Nuclear atypias of cervical intraepithelial neoplasia (CIN) were evident in 36 (24.5%) of these cases: 27 (18.4%), CIN I; 6 (4.0%), CIN II and 3 (2.0%) CIN III. Also 2 (1.4%) invasive carcinomas and one (0.7%) endocervical dysplasia were found. Other agents observed were: Candida sp, 19 (12.9%) cases, Gardnerella vaginalis, 19 (12.9%), Trichomonas vaginalis, 13 (8.4%), Chlamydia trachomatis 5 (3.4%), Mobiluncus sp 2 (1.4%) and Herpes simplex virus 1 (0.7%). This study emphasizes the high frequency of HPV/CIN cervicovaginal abnormalities in HIV-seropositive in our population. It is possible that immunological factors and sexual promiscuity are involved in this phenomenon.


2017 ◽  
Vol 145 (11) ◽  
pp. 2341-2351 ◽  
Author(s):  
T. N. LOBÃO ◽  
G. B. CAMPOS ◽  
N. N. SELIS ◽  
A. T. AMORIM ◽  
S. G. SOUZA ◽  
...  

SUMMARYUreaplasma urealyticumandU. parvumhave been associated with genital infections. The purpose of this study was to detect the presence of ureaplasmas and other sexually transmitted infections in sexually active women from Brazil and relate these data to demographic and sexual health, and cytokines IL-6 and IL-1β. Samples of cervical swab of 302 women were examined at the Family Health Units in Vitória da Conquista. The frequency of detection by conventional PCR was 76·2% forMollicutes. In qPCR, the frequency found was 16·6% forU. urealyticumand 60·6%U. parvumand the bacterial load of these microorganisms was not significantly associated with signs and symptoms of genital infection. The frequency found forTrichomonas vaginalis,Neisseria gonorrhoeae,Gardnerella vaginalisandChlamydia trachomatiswas 3·0%, 21·5%, 42·4% and 1·7%, respectively. Higher levels of IL-1βwere associated with control women colonized byU. urealyticumandU. parvum. Increased levels of IL-6 were associated with women who exhibitedU. parvum. Sexually active women, with more than one sexual partner in the last 3 months, living in a rural area were associated with increased odds of certainU. parvumserovar infection.


2021 ◽  
Vol 2 (3) ◽  
pp. 340-352
Author(s):  
Andrea Karime González Silva ◽  
Nadia Velázquez Hernández ◽  
Alma Rosa Pérez Álamos ◽  
Marisela Aguilar Durán

La tricomoniasis representa el 30% de las infecciones de transmisión sexual no virales en el mundo; su agente etiológico es el protozoario parásito Trichomonas vaginalis. Frecuentemente la infección es asintomática, lo que dificulta su tratamiento y detección y facilita su transmisión. La implementación de pruebas específicas, sensibles y económicamente accesibles que permitan mejorar la capacidad de detección de este patógeno, es importante ya que los métodos de diagnóstico que se utilizan tradicionalmente (examen en fresco, cultivo vaginal, papanicolaou, etc.) no cumplen con estos requisitos. En este proyecto se incluyeron 197 mujeres sexualmente activas entre los 17 y los 67 años; se tomaron muestras cérvicovaginales para realizar examen en fresco, tinción Papanicolaou y para la identificación molecular se amplificó una región conservada en el gen de adhesina AP65 de T. vaginalis. Se obtuvo una prevalencia del 35.5% de Trichomonas vaginalis identificada por de PCR de punto final, confirmando que esta última es la técnica con mayor sensibilidad y especificidad con respecto al examen en fresco y Papanicolaou.   Trichomoniasis represents 30% of non-viral sexually transmitted infections worldwide; its etiological agent is the protozoan parasite Trichomonas vaginalis. The infection is often asymptomatic, which makes it difficult to treat and detect and facilitates its transmission. The implementation of specific, sensitive and economically accessible tests to improve the detection capacity of this pathogen is important because the diagnostic methods traditionally used (fresh examination, vaginal culture, pap smears, etc.) do not meet these requirements. 197 sexually active women between 17 and 67 years of age were included in this project; cervicovaginal samples were taken for fresh test, Papanicolaou staining, and for molecular identification, a conserved region in the AP65 adhesin gene of T. vaginalis was amplified. A prevalence of 35.5% of Trichomonas vaginalis identified by end-point PCR was obtained, confirming that the latter is the technique with greater sensitivity and specificity with respect to the fresh test and Papanicolaou.


2021 ◽  
Vol 9 (9) ◽  
pp. 1864
Author(s):  
Shu-Fang Chiu ◽  
Po-Jung Huang ◽  
Wei-Hung Cheng ◽  
Ching-Yun Huang ◽  
Lichieh Julie Chu ◽  
...  

The three most common sexually transmitted infections (STIs) are Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC) and Trichomonas vaginalis (TV). The prevalence of these STIs in Taiwan remains largely unknown and the risk of STI acquisition affected by the vaginal microbiota is also elusive. In this study, a total of 327 vaginal swabs collected from women with vaginitis were analyzed to determine the presence of STIs and the associated microorganisms by using the BD Max CT/GC/TV molecular assay, microbial cultures, and 16S rRNA sequencing. The prevalence of CT, TV, and GC was 10.8%, 2.2% and 0.6%, respectively. A culture-dependent method identified that Escherichia coli and Streptococcus agalactiae (GBS) were more likely to be associated with CT and TV infections. In CT-positive patients, the vaginal microbiota was dominated by L. iners, and the relative abundance of Gardnerella vaginalis (12.46%) was also higher than that in TV-positive patients and the non-STIs group. However, Lactobacillus spp. was significantly lower in TV-positive patients, while GBS (10.11%), Prevotella bivia (6.19%), Sneathia sanguinegens (12.75%), and Gemella asaccharolytica (5.31%) were significantly enriched. Using an in vitro co-culture assay, we demonstrated that the growth of L. iners was suppressed in the initial interaction with TV, but it may adapt and survive after longer exposure to TV. Additionally, it is noteworthy that TV was able to promote GBS growth. Our study highlights the vaginal microbiota composition associated with the common STIs and the crosstalk between TV and the associated bacteria, paving the way for future development of health interventions targeting the specific vaginal bacterial taxa to reduce the risk of common STIs.


2011 ◽  
Vol 5 (7) ◽  
pp. 1677
Author(s):  
Roberto Wagner Júnior Freire de Freitas ◽  
Niciane Bandeira Pessoa Marinho ◽  
Camila Félix Américo ◽  
Marta Maria Coelho Damasceno ◽  
Ana Fátima Carvalho Fernandes ◽  
...  

ABSTRACTObjective: to estimate the prevalence of microbiological agents in cytology reports. Method: this is a documentary and retrospective study, carried out in a Normal Delivery Center in the city of Fortaleza, Ceara, Brazil. Information were collected from 300 medical records of women treated within the period from August 2008 to March 2009, who attended the health service to undertake the cytological collection for the preventive examination of uterine cervix cancer. The data were collected on the first half of 2009, statistically analyzed, and presented in tables. The project was sent to the Research Ethics Committee of Universidade Federal do Ceara and approved under the Protocol 315/05. Results: the prevalence of Gardnerella sp., Candida sp., and Trichomonas vaginalis was 18.6%, 5.7%, and 3.0%, respectively. The microbiological agents were present in higher proportions in married women, aged between 18 and 29 years, and who completed elementary education. Trichomoniasis was found in a greater proportion in women who were not using any contraceptive method. Conclusion: measures of health education should be designed to this public in order to promote a greater knowledge on the microbiological agents, modes of transmission, and prevention. Descriptors: women’s health; sexually transmitted infections; prevalence.RESUMOObjetivo: estimar a prevalência de agentes microbiológicos em laudos de citologia. Método: trata-se de um estudo documental e retrospectivo, desenvolvido em um Centro de Parto Natural da cidade de Fortaleza-CE. Foram colhidas informações em 300 prontuários de mulheres atendidas no período de agosto de 2008 a março de 2009, que compareceram ao serviço de saúde para a realização da coleta citológica do exame preventivo do câncer de colo uterino. Os dados foram coletados no primeiro semestre de 2009, analisados estatisticamente e apresentados em tabelas. O projeto foi encaminhado ao Comitê de Ética em Pesquisa da Universidade Federal do Ceará e aprovado sob o Protocolo n. 315/05. Resultados: a prevalência de Gardnerella sp., Candida sp. e Trichomonas vaginallis foi de 18,6%, 5,7% e 3,0%, respectivamente. Os agentes microbiológicos estiveram presentes em maiores proporções nas mulheres casadas, com idade entre 18 e 29 anos e com ensino fundamental completo. A Tricomoníase esteve presente em maior proporção nas mulheres que não usavam nenhum método contraceptivo. Conclusão: medidas de educação em saúde devem ser traçadas a essa clientela com a finalidade de promover maiores conhecimentos sobre os agentes microbiológicos, modos de transmissão e prevenção. Descritores: saúde da mulher; infecções sexualmente transmissíveis; prevalência. RESUMENObjetivo: estimar la prevalencia de agentes microbiológicos en laudos de citología. Método: esto es un estudio documental y retrospectivo, desarrollado en un Centro de Parto Normal en la ciudad de Fortaleza, Ceará, Brasil. Se recogió informaciones en 300 prontuarios de mujeres tratadas en el periodo de agosto de 2008 a marzo de 2009, que comparecieron al servicio de salud para llevar a cabo la recogida citológica del examen preventivo del cáncer de cuello uterino. Los dados fueron recogidos en el primero semestre de 2009, estadísticamente analizados y presentados em tablas. El proyecto fue enviado al Comité de Ética en Investigación de la Universidade Federal do Ceará y aprobados por medio del Protocolo 315/05. Resultados: la prevalencia de Gardnerella sp., Candida sp. y Trichomonas vaginalis fue de 18,6%, 5,7% y 3,0%, respectivamente. Los agentes microbiológicos estuvieron presentes em mayor proporción em las mujeres casadas, con edad entre los 18 y 29 años y con educación primaria completa. La Trichomoniasis está presente en mayor proporción entre las mujeres que no estaban usando ningún método anticonceptivo. Conclusión: medidas de educación en salud deben ser trazadas para ese público visando promover mayores conocimientos acerca de los agentes microbiológicos, modos de transmisión y prevención. Descriptores: salud de la mujer; enfermedades transmitidas sexualmente; prevalencia.


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