The Fungal Metabolites with Potential Antiplasmodial Activity

2018 ◽  
Vol 25 (31) ◽  
pp. 3796-3825 ◽  
Author(s):  
Bin Yang ◽  
Jingxia Huang ◽  
Xuefeng Zhou ◽  
Xiuping Lin ◽  
Juan Liu ◽  
...  
Keyword(s):  
Natural Products ◽  
Antimicrobial Agents ◽  
Antimalarial Activity ◽  
Management Strategies ◽  
Marine Fungus ◽  
Chemical Diversity ◽  
Biologically Active ◽  
Antiplasmodial Activity ◽  
Marine Environments ◽  
Tropical Regions

Malaria caused by Plasmodium parasites is amongst many prevalent public health concerns in several tropical regions of the world. Nowadays, the parasite resistance patterns to most currently used drugs in therapy and insecticides have created an urgent need for new chemical entities exhibiting new modes of action and management strategies. Fungus has been proven to be an excellent source of biologically active compounds, which have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review summarizes the current 255 natural products from fungus, which may possess antimalarial activity and can be classified as sesquiterpenes, diterpenes, sesterterpenes, alkaloids, peptides depsipeptides, xanthones, anthraquinones, anthrones, bioxanthracenes, bixanthones, preussomerins, depsidones, phenols, trichothecenes, azaphliones, macrolides, and steroids. However, the treatments available for malaria are limited. Thus, the identification of novel antimicrobial agents should be continued, and all possible strategies should be explored. Carrying forward the antimalarial screening in exited terrestrial and marine natural products library, and finding the new natural products in new resources, particularly those living in marine environments, are still important approaches to find new antimalarial agents. Unusual marine environments are associated with chemical diversity, leading to a resource of novel active substances for the development of bioactive products. Finding new antimalarial natural products in marine fungus, particularly those living in deep-sea and special marine environments, is an important approach to identify novel active agents.

scholarly journals Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents

Marine Drugs ◽  
2022 ◽  
Vol 20 (1) ◽  
pp. 62
Author(s):  
Lesley-Ann Giddings ◽  
David J. Newman
Keyword(s):  
Natural Products ◽  
Antitumor Agents ◽  
Marine Fungi ◽  
Gene Clusters ◽  
Biologically Active ◽  
Bioactive Metabolites ◽  
Marine Environments ◽  
Environmental Pressures ◽  
Symbiotic Associations ◽  
Extremophilic Fungi

Marine environments are underexplored terrains containing fungi that produce a diversity of natural products given unique environmental pressures and nutrients. While bacteria are commonly the most studied microorganism for natural products in the marine world, marine fungi are also abundant but remain an untapped source of bioactive metabolites. Given that their terrestrial counterparts have been a source of many blockbuster antitumor agents and anti-infectives, including camptothecin, the penicillins, and cyclosporin A, marine fungi also have the potential to produce new chemical scaffolds as leads to potential drugs. Fungi are more phylogenetically diverse than bacteria and have larger genomes that contain many silent biosynthetic gene clusters involved in making bioactive compounds. However, less than 5% of all known fungi have been cultivated under standard laboratory conditions. While the number of reported natural products from marine fungi is steadily increasing, their number is still significantly lower compared to those reported from their bacterial counterparts. Herein, we discuss many varied cytotoxic and anti-infective fungal metabolites isolated from extreme marine environments, including symbiotic associations as well as extreme pressures, temperatures, salinity, and light. We also discuss cultivation strategies that can be used to produce new bioactive metabolites or increase their production. This review presents a large number of reported structures though, at times, only a few of a large number of related structures are shown.

1,2,3-Triazole- and Quinoline-Based Hybrids with Potent Antiplasmodial Activity

2021 ◽  
Vol 18 ◽  
Author(s):  
Isabela A. Graciano ◽  
Alcione S. de Carvalho ◽  
Fernando de Carvalho da Silva ◽  
Vitor F. Ferreira
Keyword(s):  
Antimalarial Activity ◽  
Biological Activities ◽  
Review Article ◽  
Pharmaceutical Market ◽  
Biologically Active ◽  
New Drugs ◽  
Synthetic Methods ◽  
Antiplasmodial Activity ◽  
New Chemical Entities ◽  
Active Substances

Background: Malaria is a disease causing millions of victims every year and requires new drugs, often due to parasitic strain mutations. Thus, the search for new molecules that possess antimalarial activity is constant and extremely important. However, the potential that an antimalarial drug possesses cannot be ignored, and molecular hybridization is a good strategy to design new chemical entities. Objective: This review article aims to emphasize recent advances in the biological activities of new 1,2,3-triazole- and quinoline-based hybrids and their place in the development of new biologically active substances. More specifically, it intends to present the synthetic methods that have been utilized for the syntheses of hybrid 1,2,3-triazoles with quinoline nuclei. Method: We have comprehensively and critically discussed all the information available in the literature regarding 1,2,3-triazole- and quinoline-based hybrids with potent antiplasmodial activity. Results: The quinoline nucleus has already been proven to lead to new chemical entities in the pharmaceutical market, such as drugs for the treatment of malaria and other diseases. The same can be said about the 1,2,3-triazole heterocycle, which has been shown to be a beneficial scaffold for the construction of new drugs with several activities. However, only a few triazoles have entered the pharmaceutical market as drugs. Conclusion: Many studies have been conducted to develop new substances that may circumvent the resistance developed by the parasite that causes malaria, thereby improving the therapy currently used.

scholarly journals Determination of Antiplasmodial Activity and Binding Affinity of Selected Natural Products towards PfTrxR and PfGR

2013 ◽  
Vol 8 (8) ◽  
pp. 1934578X1300800
Author(s):  
Ranjith Munigunti ◽  
Katja Becker ◽  
Reto Brun ◽  
Angela I. Calderón
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Ligand Binding ◽  
Binding Assay ◽  
Antimalarial Activity ◽  
Antiplasmodial Activity ◽  
Binding Affinities ◽  
Ligand Binding Assay

In our study, the binding affinities of selected natural products towards PfTrxR, PfGR, human TrxR and human GR were determined using a mass spectrometry based ligand binding assay. The in vitro antimalarial activity and cytotoxicity of these ligands were also determined. Catharanthine, 11-(OH)-coronaridine, hernagine, vobasine and hispolone displayed antiplasmodial activity against PfK1 (IC50 = 0.996–3.63 μg/mL).

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity

2016 ◽  
Vol 33 (2) ◽  
pp. 348-364 ◽  
Author(s):  
Karin Kleigrewe ◽  
Lena Gerwick ◽  
David H. Sherman ◽  
William H. Gerwick
Keyword(s):  
Natural Products ◽  
Chemical Diversity ◽  
Biologically Active ◽  
Biosynthetic Genes ◽  
Biochemical Pathways ◽  
Active Natural

Cyanobacteria are a prolific source of structurally unique and biologically active natural products that derive from intriguing biochemical pathways.

scholarly journals Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Siti Junaidah Ahmad ◽  
Mohd Badrin Hanizam Abdul Rahim ◽  
Syarul Nataqain Baharum ◽  
Mohd Shukri Baba ◽  
Noraziah Mohamad Zin
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Bioactive Compounds ◽  
Antimalarial Activity ◽  
Classical Method ◽  
Biologically Active ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Wide Range ◽  
Bioassay Guided Fractionation

Natural products continue to play an important role as a source of biologically active substances for the development of new drug.Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.

Biologically active natural products from Cassine viburnifolia

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Grkovic ◽  
R Akee ◽  
J Evans ◽  
JM Collins ◽  
B O'Keefe
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Active Natural

Antistaphylococcal activity of carbonic acid extract of hops

2018 ◽  
Vol 22 (2) ◽  
pp. 297-300
Author(s):  
V.V. Nevmerzhitsky ◽  
V.Yu. Ivannik ◽  
V.V. Kazmirchuk ◽  
T.N. Moiseenko ◽  
T.A. Volkov ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Antimicrobial Agents ◽  
Carbonic Acid ◽  
Inflammatory Diseases ◽  
Acquired Resistance ◽  
Biologically Active ◽  
Antibacterial Drugs ◽  
Antistaphylococcal Activity ◽  
Prevention And Treatment ◽  
Main Disadvantage

The fight against staphylococcal infection, increasing the effectiveness of methods of prevention and treatment of diseases of staphylococcal etiology is of interest to scientists and practitioners, both in Ukraine and around the world. The urgency of this problem is growing rapidly, as there is a tendency to increase the resistance of not only staphylococci, but also other gram-positive bacteria. The spread of methicillin-resistant staphylococci restricts the choice of antibiotics for the treatment of diseases of staphylococcal etiology. Staphylococcus aureus is the most common and dangerous type, which is one of the main factors of purulent-inflammatory lesions of the skin and mucous membranes. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. One of the unique and promising medicinal plants, which contains a rich complex of biologically active substances (BAS), is common hops (Humulus lupulus L.). The complex of BAS (flavonoids, hormones, vitamins, bitter, phenolic compounds, essential oils) causes anti-inflammatory, bactericidal, hyposensitizing and analgesic action of hops. The purpose of this work is to determine the antistaphylococcal activity of the carbon dioxide extract of hops and to justify the development on its basis of new antimicrobial agents for the prevention and treatment of infectious and purulent-inflammatory diseases. The following methods were used: microbiological (method of diffusion into agar (well method)) and mathematical and statistical. The high antimicrobial activity of the carbon dioxide extract of hops has been established for museum test strains of the genus Staphylococcus. The results of the studies testify to the prospects of further study of the bactericidal properties of the extract of hops carbon dioxide with the aim of creating effective antimicrobial agents on its basis for the prevention and treatment of infectious and purulent-inflammatory diseases of staphylococcal etiology.

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