Natural Hydrogels Applied in Photodynamic Therapy

2020 ◽  
Vol 27 (16) ◽  
pp. 2681-2703 ◽  
Author(s):  
Zhipan Feng ◽  
Shiying Lin ◽  
Andrew McDonagh ◽  
Chen Yu
Keyword(s):  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Drug Release ◽  
Three Dimensional ◽  
Controlled Drug Release ◽  
Natural Polymers ◽  
Current Review ◽  
Design Variables ◽  
Cd44 Targeting

Natural hydrogels are three-dimensional (3D) water-retaining materials with a skeleton consisting of natural polymers, their derivatives or mixtures. Natural hydrogels can provide sustained or controlled drug release and possess some unique properties of natural polymers, such as biodegradability, biocompatibility and some additional functions, such as CD44 targeting of hyaluronic acid. Natural hydrogels can be used with photosensitizers (PSs) in photodynamic therapy (PDT) to increase the range of applications. In the current review, the pertinent design variables are discussed along with a description of the categories of natural hydrogels available for PDT.

scholarly journals Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 628 ◽  
Author(s):  
João P. F. Carvalho ◽  
Ana C. Q. Silva ◽  
Verónica Bastos ◽  
Helena Oliveira ◽  
Ricardo J. B. Pinto ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
In Vitro Release ◽  
Three Dimensional ◽  
Human Keratinocytes ◽  
Controlled Drug Release ◽  
Dynamic Mechanical Properties ◽  
Aphthous Stomatitis ◽  
Release Mechanism ◽  
Porous Network

Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis.

Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake

2016 ◽  
Vol 143 ◽  
pp. 27-36 ◽  
Author(s):  
Shaohui Zheng ◽  
Zhen Jin ◽  
Jiwon Han ◽  
Sunghoon Cho ◽  
Van Du Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Cellular Uptake ◽  
Controlled Drug Release

Amorphous Polymer Networks Combining Three Functionalities–Shape-memory, Biodegradability, and Drug Release

2009 ◽  
Vol 1190 ◽  
Author(s):  
Christian Wischke ◽  
Axel Thomas Neffe ◽  
Susi Steuer ◽  
Andreas Lendlein
Keyword(s):  
Drug Release ◽  
Shape Memory ◽  
Amorphous Polymer ◽  
Polymer Networks ◽  
Three Dimensional ◽  
Hydrolytic Degradation ◽  
Functional Materials ◽  
Controlled Drug Release ◽  
Diffusion Controlled ◽  
Shape Programming

AbstractShape-memory polymers are of high scientific and technological interest in the biomedical field, e.g., as matrix for self-anchoring implantable devices. In this study, two different star-shaped copolyester tetroles, semi-crystalline oligo[(-caprolactone)-co-glycolide]tetrol (oCG) and amorphous oligo[(rac-lactide)-co-glycolide]tetrol (oLG), were synthesized and subsequently crosslinked by a low molecular weight diisocyanate resulting in copolyester urethane networks (N-CG, N-LG). Both networks could be loaded with model drugs and a diffusion controlled release of the drugs was observed without any effect on the mass loss as measure of hydrolytic degradation. However, the N-CG network’s capability of shape programming was disturbed as the crystallinity of the precursors got lost in the complex three dimensional architecture after crosslinking. By contrast, amorphous N-LG network showed an excellent shape-memory capability with a switching temperature around 36 °C corresponding to their glass transition temperature. This led to triple-functional materials combining biodegradability, shape-memory, and controlled drug release.

scholarly journals Novel amphiphilic hyaluronic acid derivatives as injectable hydrogels for controlled drug release

2016 ◽  
Vol 4 ◽  
Author(s):  
Borzacchiello Assunta ◽  
Palumbo Fabio ◽  
Agnello S ◽  
Pitarresi G ◽  
Giammona G ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Injectable Hydrogels

Controlled drug release from cross-linked κ-carrageenan/hyaluronic acid membranes

2015 ◽  
Vol 77 ◽  
pp. 322-329 ◽  
Author(s):  
M.R. El-Aassar ◽  
G.F. El Fawal ◽  
Elbadawy A. Kamoun ◽  
Moustafa M.G. Fouda
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Controlled Drug Release

scholarly journals Recent Developments in Lactone Monomers and Polymer Synthesis and Application

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2881
Author(s):  
Jakub Bińczak ◽  
Krzysztof Dziuba ◽  
Anna Chrobok
Keyword(s):  
Drug Release ◽  
Wide Spectrum ◽  
Three Dimensional ◽  
Controlled Drug Release ◽  
Tissue Scaffolds ◽  
Synthesis And Characterization ◽  
Medical Applications ◽  
High Importance ◽  
Recent Developments

Lactones are a group of compounds that have been known for several decades. The commercial importance of lactones results from the possibility of manufacturing of a broad scope of derivatives and polymers with a wide spectrum of applications. In this work the synthesis and characterization of simple lactones are described, which due to the easy methods of the synthesis are of high importance for the industry. The chemical as well as biochemical methods are included with special attention paid to the methods that avoid metal catalysts, initiators or toxic solvents, allowing the use of the final products for the medical applications, e.g., for controlled drug-release systems, resorbable surgical threads, implants, tissue scaffolds or for the production of drugs. Lactone-based derivatives, such as polymers, copolymers, composites or three-dimensional structures are also presented. The work is focused on the methods for the synthesis of lactones and lactones derivates, as well as on the special properties and application of the studied compounds.

Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation

2018 ◽  
Vol 6 (6) ◽  
pp. 1580-1591 ◽  
Author(s):  
Ankita R. Desai ◽  
Furqan A. Maulvi ◽  
Mihir M. Pandya ◽  
Ketan M. Ranch ◽  
Bhavin A. Vyas ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Circular Ring ◽  
In Vivo Evaluation

Controlled drug release from semi-circular drug-loaded ring-implanted contact lenses.

scholarly journals Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 290 ◽  
Author(s):  
Thao T. D. Tran ◽  
Phuong H. L. Tran
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Transdermal Drug Delivery ◽  
Drug Targeting ◽  
Controlled Drug Release ◽  
Control Drug ◽  
Current Review ◽  
Film Forming ◽  
New Generation ◽  
Control Drug Release

Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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