CASC15：A tumor-associated long non-coding RNA

Background: CASC15, one of long non-coding RNA, is involved in the regulation of many tumor biological processes, and is expected to become a new biological therapeutic target. This paper aims to elucidate the pathophysiological function of CASC15 in various tumors. Methods: The relationship between CASC15 and tumors was analyzed by searching references, and summarizes the specific pathophysiological mechanism of CASC15. Results: LncRNA CASC15 is closely related to tumor development, and has been shown to be abnormally high expressed in all kinds of tumors, including breast cancer, cervical cancer, lung cancer, hepatocellular carcinoma, gastric cancer, bladder cancer, colon cancer, colorectal cancer, cardiac hypertrophy, intrahepatic cholangiocarcinoma, leukemia, melanoma, tongue squamous cell carcinoma, nasopharyngeal carcinoma. However, CASC15 has been found to be downexpressed abnormally in ovarian cancer, glioma and neuroblastoma. Besides, it is identified that CASC15 can affect the proliferation, invasion and apoptosis of tumors. Conclusion: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors.

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Association Between Long Non-Coding RNA POLR2E rs3787016 Polymorphism and Cancer Susceptibility: A Meta-analysis of 8725 Cancer Cases and 10710 Controls

Shiraz E-Medical Journal ◽

10.5812/semj.102065 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Saeid Ghavami ◽

Mohsen Taheri ◽

Mohammad Hashemi

Keyword(s):

Breast Cancer ◽

Web Of Science ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Positive Association ◽

Cancer Development ◽

Non Coding Rna ◽

Stratified Analysis ◽

The Relationship ◽

Long Non Coding Rna

Objectives: Several studies have reported a correlation between the POLR2E rs3787016 polymorphism and cancer development, but findings are inconsistent. Therefore, we designed the current study to understand how rs3787016 polymorphism impacts cancer susceptibility. Methods: We searched the Scopus, Web of Science, and PubMed databases for studies related to the topic of interest published up to March 2019. A total of 11 relevant studies, encompassing 8,761 cancer cases and 10,534 controls, were retrieved and subject to quantitative analysis. The strength of the relationship was evaluated using the pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results: Overall, the findings proposed a positive association between rs189037 polymorphism and susceptibility to cancer in homozygous (OR = 1.32, 95% CI = 1.11 - 1.57, P = 0.002, TT vs. CC), recessive (OR = 1.21, 95% CI = 1.06-1.39, P = 0.005, TT vs. CT + CC), and allele (OR = 1.12, 95% CI = 1.02-1.22, P = 0.021, T vs. C) genetic models. Stratified analysis showed that rs3787016 increased the risk of prostate and breast cancer. In addition, we found a significant association between the variant and increased cancer risk in Asian and Caucasian populations. Conclusions: In summary, the findings of the current meta-analysis suggest that the POLR2E rs3787016 polymorphism is an indicator of cancer susceptibility.

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The Role of lncRNA PCAT6 in Cancers

Frontiers in Oncology ◽

10.3389/fonc.2021.701495 ◽

2021 ◽

Vol 11 ◽

Author(s):

Siying Wang ◽

Zhenyao Chen ◽

Jingyao Gu ◽

Xin Chen ◽

Zhaoxia Wang

Keyword(s):

Breast Cancer ◽

Prognostic Biomarker ◽

Malignant Tumors ◽

Vital Role ◽

Cancer Breast ◽

Non Coding Rna ◽

Different Types ◽

Cancer Côlon ◽

Long Non Coding Rna

Long non-coding RNA (lncRNA) PCAT6 is a member of the Prostate Cancer Associated Transcripts family of molecules. In this review, we focus on the latest studies involving PCAT6 in the diagnosis, treatment, and prognosis of malignant tumors of the digestive, respiratory, urinary, reproductive, motion, and nervous systems. PCAT6 was found to be highly expressed in gastric cancer, colon cancer, hepatocellular carcinoma, lung cancer, bladder cancer, ovarian cancer, breast cancer, cervical cancer, osteosarcoma, glioblastoma, and other tumors. PCAT6 can promote the development and progression of different types of malignant tumors through various mechanisms. Overall, these findings suggest that PCAT6 may play an increasingly vital role in the clinical assessment of these malignant tumors. It can function as an oncogene and may be used as a potential new prognostic biomarker of these tumors.

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Bioinformatics Analysis of Long Non-coding RNA and Related Diseases: An Overview

Frontiers in Genetics ◽

10.3389/fgene.2021.813873 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yuxin Gong ◽

Wen Zhu ◽

Meili Sun ◽

Lei Shi

Keyword(s):

Small Rnas ◽

Bioinformatics Analysis ◽

Regulation Of Gene Expression ◽

Research Progress ◽

Biological Processes ◽

Existing Problems ◽

Non Coding Rna ◽

Non Coding Rnas ◽

Cancer Côlon ◽

Long Non Coding Rna

Long non-coding RNAs (lncRNAs) are usually located in the nucleus and cytoplasm of cells. The transcripts of lncRNAs are >200 nucleotides in length and do not encode proteins. Compared with small RNAs, lncRNAs have longer sequences, more complex spatial structures, and more diverse and complex mechanisms involved in the regulation of gene expression. LncRNAs are widely involved in the biological processes of cells, and in the occurrence and development of many human diseases. Many studies have shown that lncRNAs can induce the occurrence of diseases, and some lncRNAs undergo specific changes in tumor cells. Research into the roles of lncRNAs has covered the diagnosis of, for example, cardiovascular, cerebrovascular, and central nervous system diseases. The bioinformatics of lncRNAs has gradually become a research hotspot and has led to the discovery of a large number of lncRNAs and associated biological functions, and lncRNA databases and recognition models have been developed. In this review, the research progress of lncRNAs is discussed, and lncRNA-related databases and the mechanisms and modes of action of lncRNAs are described. In addition, disease-related lncRNA methods and the relationships between lncRNAs and human lung adenocarcinoma, rectal cancer, colon cancer, heart disease, and diabetes are discussed. Finally, the significance and existing problems of lncRNA research are considered.

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Long Non-Coding RNA and Breast Cancer

Technology in Cancer Research & Treatment ◽

10.1177/1533033819843889 ◽

2019 ◽

Vol 18 ◽

pp. 153303381984388 ◽

Cited By ~ 13

Author(s):

Tianzhu Zhang ◽

Hui Hu ◽

Ge Yan ◽

Tangwei Wu ◽

Shuiyi Liu ◽

...

Keyword(s):

Breast Cancer ◽

Molecular Mechanisms ◽

Biological Function ◽

Tumor Development ◽

Health Concern ◽

Sequencing Technologies ◽

Non Coding Rna ◽

Non Coding Rnas ◽

Long Non Coding Rna ◽

Generation Sequencing

Breast cancer, one of the most common diseases among women, is regarded as a heterogeneous and complicated disease that remains a major public health concern. Recently, owing to the development of next-generation sequencing technologies, long non-coding RNAs have received extensive attention. Numerous studies reveal that long non-coding RNAs are playing important roles in tumor development. Although the biological function and molecular mechanisms of long non-coding RNAs remain enigmatic, recent researchers have demonstrated that an array of long non-coding RNAs express abnormally in cancers, including breast cancer. Herein, we summarized the latest literature about long non-coding RNAs in breast cancer, with a particular focus on the multiple molecular roles of regulatory long non-coding RNAs that regulate cell proliferation, invasion, metastasis, and apoptosis.

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The Relationship Between Long Non-Coding RNA Expressions and Ponatinib in Breast Cancer

Cyprus Journal of Medical Sciences ◽

10.5152/cjms.2019.819 ◽

2019 ◽

Vol 4 (2) ◽

pp. 125-130

Author(s):

Tugce Balci Okcanoglu ◽

◽

Cagla Kayabasi ◽

Sunde Yilmaz Susluer ◽

Cumhur Gunduz ◽

...

Keyword(s):

Breast Cancer ◽

Non Coding Rna ◽

The Relationship ◽

Long Non Coding Rna

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Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma

Experimental and Molecular Pathology ◽

10.1016/j.yexmp.2021.104638 ◽

2021 ◽

pp. 104638

Author(s):

Chao Guo ◽

Shuhuang Zhou ◽

Weimin Yi ◽

Pingzhou Yang ◽

Ou Li ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Therapeutic Target ◽

Antisense Rna ◽

Prognostic Biomarker ◽

Non Coding Rna ◽

Long Non Coding Rna

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Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1

Oncogene ◽

10.1038/s41388-021-01845-y ◽

2021 ◽

Author(s):

Yina Qiao ◽

Ting Jin ◽

Shengdong Guan ◽

Shaojie Cheng ◽

Siyang Wen ◽

...

Keyword(s):

Breast Cancer ◽

Noncoding Rna ◽

Causes Of Death ◽

Invasion And Metastasis ◽

Lymphatic Metastases ◽

Non Coding Rna ◽

Promising Target ◽

Mesenchymal Transformation ◽

Long Non Coding Rna ◽

Mcf 7

AbstractInvasion and metastasis are the leading causes of death in patients with breast cancer (BC), and epithelial-mesenchymal transformation (EMT) plays an essential role in this process. Here, we found that Lnc-408, a novel long noncoding RNA (lncRNA), is significantly upregulated in BC cells undergoing EMT and in BC tumor with lymphatic metastases compared with those without lymphatic metastases. Lnc-408 can enhance BC invasion and metastasis by regulating the expression of LIMK1. Mechanistically, Lnc-408 serves as a sponge for miR-654-5p to relieve the suppression of miR-654-5p on its target LIMK1. Knockdown or knockout of Lnc-408 in invasive BC cells clearly decreased LIMK1 levels, and ectopic Lnc-408 in MCF-7 cells increased LIMK1 expression to promote cell invasion. Lnc-408-mediated enhancement of LIMK1 plays a key role in cytoskeletal stability and promotes invadopodium formation in BC cells via p-cofilin/F-actin. In addition, the increased LIMK1 also facilitates the expression of MMP2, ITGB1, and COL1A1 by phosphorylating CREB. In conclusion, our findings reveal that Lnc-408 promotes BC invasion and metastasis via the Lnc-408/miR-654-5p/LIMK1 axis, highlighting a novel promising target for the diagnosis and treatment of BC.

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