Review on Synthesis of Bio-active Coumarin-fused Heterocyclic Molecules

2020 ◽  
Vol 24 (22) ◽  
pp. 2566-2587
Author(s):  
Geetika Patel ◽  
Subhash Banerjee
Keyword(s):  
Organic Chemistry ◽  
Heterocyclic Compounds ◽  
Multistep Method ◽  
Review Article ◽  
Literature Survey ◽  
Research Articles ◽  
One Pot ◽  
Physiochemical Properties ◽  
Heterocyclic Molecules ◽  
The Individual

The literature survey reveals that the individual coumarin and heterocyclic molecules have biological and pharmaceutical activities. Moreover, integrated coumarinfused heterocyclic compounds have shown interesting biological and physiochemical properties and thus, designing and development of coumarin-fused heterocyclic molecules are of great interest in the field of synthetic organic chemistry. Several coumarin-fused heterocyclic molecules have been synthesized by using different strategies such as multistep method, one-pot multi-component protocol, coupling and condensation method. The wide applications of integrated coumarin-fused heterocyclic molecules stimulated interest among researchers to develop different methodologies for the synthesis of novel fused molecules. As a consequence, several research articles, papers and review articles have been published in the literature. In this review article, we have presented various methods for the synthesis of different class of coumarin-fused heterocyclic molecules and their applications in chemical, optical, pharmaceutical and other useful applications.

Silver-assisted syntheses of fused five-membered N-heterocycles

2021 ◽  
Vol 25 ◽  
Author(s):  
Navjeet Kaur ◽  
Neha Ahlawat ◽  
Yamini Verma ◽  
Pooja Grewal ◽  
Pranshu Bhardwaj ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Heterocyclic Compounds ◽  
Stereoselective Synthesis ◽  
Review Article ◽  
Highly Efficient ◽  
Work Up ◽  
Detailed Work

: The metal-mediated formation of heterocycles is one of the most emerging and essential strategies in organic chemistry. The reactions utilized previously to synthesize heterocycles were less familiar to the scientists due to their detailed work-up, expensive nature, and complex operations. The silver-assisted cyclic reactions are highly efficient for both regioselective and stereoselective synthesis of five-membered fused N-heterocyclic compounds. The applications of silver in the preparation of five-membered fused N-heterocyclic compounds are covered in this review article.

scholarly journals A review on Indole and Benzothiazole derivatives its importance

2019 ◽  
Vol 9 (1-s) ◽  
pp. 505-509 ◽  
Author(s):  
Shaheen Sulthana ◽  
P. Pandian
Keyword(s):  
Heterocyclic Compounds ◽  
Structural Modification ◽  
Biological Activities ◽  
New Product ◽  
Review Article ◽  
Literature Survey ◽  
Pharmacological Activities ◽  
Benzothiazole Derivatives ◽  
Wide Range ◽  
Anti Inflammatory

In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Indole, Benzothiazole and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Indole, Benzothiazole and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. Hence, their extensive structural modification has result in different analogues of Indole and Benzothiazole derivatives depicting wide range of biological and pharmacological activities such as antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer. This review article literature survey summarizes the synthesis and pharmacological activities of Indole, Benzothiazole and its derivatives. Keywords: Indole, Benzothiazole, antiviral, anticonvulsant, anti-inflammatory, analgesic, antimicrobial and anticancer

Reactions Involving Aryl Methyl Ketone and Molecular Iodine: A Powerful Tool in the One-Pot Synthesis of Heterocycles

2021 ◽  
Author(s):  
Saideh Rajai-Daryasarei ◽  
Mohammad Hossein Gohari ◽  
Narges Mohammadi
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Heterocyclic Compounds ◽  
Methyl Ketone ◽  
Molecular Iodine ◽  
Bioactive Molecules ◽  
One Pot ◽  
Material Sciences ◽  
The One ◽  
Aryl Methyl

The preparation of heterocyclic compounds has attracted great attention in organic chemistry because of their extensive presence in bioactive molecules, material sciences, and natural products. Accordingly, the straightforward design and...

Pyrazole Carboxylic Acid and Derivatives: Synthesis and Biological Applications

2020 ◽  
Vol 17 ◽  
Author(s):  
Adnan Cetin
Keyword(s):  
Organic Chemistry ◽  
Biological Activity ◽  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Building Blocks ◽  
Literature Survey ◽  
Synthetic Methods ◽  
Biological Applications

: The heterocyclic compounds are the building blocks for synthesis of the different biological active compounds in the organic chemistry. Heterocyclic compounds have versatile synthetic applicability and biological activity. Pyrazole carboxylic acid derivatives are significant scaffold structures in heterocyclic compounds due to biologic activities such as antimicrobial, anticancer, inflammatory, antidepressant, antifungal anti-tubercular and antiviral etc. The aim of this mini-review is an overview synthesis of pyrazole carboxylic acid derivatives and their biologic applications. The summarized literature survey presents in detail biological activities of pyrazole carboxylic acid derivatives and their various synthetic methods. This mini-review can be guide to many scientists in medicinal chemistry.

scholarly journals Advances in Green Catalysis for the Synthesis of Medicinally Relevant N-Heterocycles

Catalysts ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1108
Author(s):  
A. Sofia Santos ◽  
Daniel Raydan ◽  
José C. Cunha ◽  
Nuno Viduedo ◽  
Artur M. S. Silva ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Heterogeneous Catalysts ◽  
Catalytic Synthesis ◽  
Biologically Active ◽  
Synthetic Methods ◽  
One Pot ◽  
Metal Catalyzed ◽  
The Individual ◽  
Green Catalysis ◽  
Synthetic Approaches

N-heterocycles, both saturated and unsaturated, are ubiquitous biologically active molecules that are extremely appealing scaffolds in drug discovery programs. Although classical synthetic methods have been developed to access many relevant N-heterocyclic scaffolds, representing well-established and reliable routes, some do not meet the needs of sustainability. In this context, several advances have been made towards the sustainable synthesis of N-heterocycles. This review focuses on the most recent examples from the last five years of catalytic synthesis of several heterocyclic compounds of medicinal relevance. Thus, the synthesis of isoindoloquinazolines, quinazolines and azaindoles, among others, are covered. The synthetic methods selected include the use of homogeneous and heterogeneous catalysts and the use of alternative and sustainable methods such as, for example, metal-catalyzed acceptorless coupling and one-pot reactions. The green aspects of the individual synthetic approaches are highlighted, and the scope of each methodology is described.

Recent developments in the synthesis of five- and six-membered N-heterocycles from dicarbonyl compounds

2021 ◽  
Vol 25 ◽  
Author(s):  
Navjeet Kaur ◽  
Pranshu Bhardwaj ◽  
Mansi Gupta
Keyword(s):  
Organic Chemistry ◽  
Transition Metals ◽  
Heterocyclic Compounds ◽  
Review Article ◽  
Chelating Ligands ◽  
Dicarbonyl Compounds ◽  
Synthetic Organic Chemistry ◽  
Material Chemistry ◽  
Recent Developments ◽  
Nitrogen Heterocyclic

: Various diketones such as 1,2-diketones, 1,3-diketones, 1,4-diketones, β-diketones and dicarbonyl compounds are used in the synthesis of core heterocyclic compounds such as pyrazoles, isoxazoles, triazoles and quinolones. They play an important role in synthetic organic chemistry. The diketones and dicarbonyl compounds also act as chelating ligands for the lanthanides and a large number of transition metals in material chemistry. 50% of drugs contain nitrogen heterocyclic compounds, so organic chemists have made efforts for the synthesis of nitrogen-containing heterocyclic compounds. This review article has compiled different methodologies for the synthesis of five- and six-membered nitrogen-containing heterocyclic compounds.

Nanocomposites: A New Tendency of Structure in Nanotechnology and Material Science

2021 ◽  
Vol 7 (1) ◽  
pp. 937-941
Author(s):  
Altaf Rajani ◽  
Priyanka Chauhan ◽  
Pranav Y. Dave
Keyword(s):  
Material Science ◽  
Electronic Devices ◽  
Optoelectronic Devices ◽  
Review Article ◽  
Literature Survey ◽  
Nano Composites ◽  
Preparation Methods ◽  
Plasmonic Structures ◽  
New Challenges ◽  
The Individual

Nanoscience has become a diverse and unique field of scientific and technical activity. Over the last few years, the research interest in nanomaterials/nanoparticles and their various applications in various electronic devices, effective optoelectronic devices, bio-sensors, photodetectors, solar cells, nanodevices and plasmonic structures have been increasing tremendously. The reasons are-the unique properties of nanostructures and the outstanding performance of nanoscale devices. At the nanoscale, a material’s property can change dramatically, with unique design possibilities and properties; they attract the attention of researchers worldwide. Nano-composites are those materials with a Nano-scale structure which improves the microscopic property of the products. Composite materials have combinations of two or several nanocomponents, which acquire new and unique characteristic properties that the individual constituents, by themselves, cannot obtain. There are number of various methods to synthesis various Nano-composites. Based on the literature survey, this review article explains a brief introduction of nanocomposites and their types, preparation methods and different diverse properties. It also describes the benefits and limitations of it and new challenges/future scope of the nanocomposites for the better future applications in different sectors.

One-pot access to 2-oxazolines via a Castro-Stephens coupling and intramolecular cyclization

2021 ◽  
Vol 08 ◽  
Author(s):  
Dnyaneshwar Nighot ◽  
Arvind Kumar Jain ◽  
Imran Ali ◽  
Varun Rawat
Keyword(s):  
Organic Chemistry ◽  
Biological Activity ◽  
Intramolecular Cyclization ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
One Pot ◽  
Alcohol Group ◽  
Xrd Studies ◽  
Oxazoline Derivatives

Aim: Here, we have reported easy one-pot access to a series of oxazolines using a modified Castro-Stephens coupling protocol. Background: 2-oxazolines have been shown to have significant biological activity and wide-ranging applications in organic chemistry. These properties make oxazolines as heterocyclic compounds of immense importance. Objective: The objective of this study is to synthesize oxazoline derivatives via an economical and one-pot protocol. Method: 2-oxazoline has been synthesized through Cu-powder mediated Castro-Stephens coupling and intramolecular cyclization route. The mechanism involves a rearrangement in which one of the oxygen from the N-acylamino alcohol group is liberated as water and then transferred to alkyne functionality to form 2-oxazoline derivatives. The oxazolines were characterized by NMR, mass, and XRD studies. Result: The protocol is economically viable and uses readily available Cu-powder along with DMF for cross-coupling and cyclization steps.

Heterocycle Compounds with Antimicrobial Activity

2020 ◽  
Vol 26 (8) ◽  
pp. 867-904 ◽  
Author(s):  
Maria Fesatidou ◽  
Anthi Petrou ◽  
Geronikaki Athina
Keyword(s):  
Heterocyclic Compounds ◽  
Bacterial Infections ◽  
Scientific Community ◽  
Antimicrobial Agents ◽  
Fungal Infections ◽  
Biological Activities ◽  
Literature Survey ◽  
New Findings ◽  
Wide Range ◽  
Number Of Microorganisms

Background: Bacterial infections are a growing problem worldwide causing morbidity and mortality mainly in developing countries. Moreover, the increased number of microorganisms, developing multiple resistances to known drugs, due to abuse of antibiotics, is another serious problem. This problem becomes more serious for immunocompromised patients and those who are often disposed to opportunistic fungal infections. Objective: The objective of this manuscript is to give an overview of new findings in the field of antimicrobial agents among five-membered heterocyclic compounds. These heterocyclic compounds especially five-membered attracted the interest of the scientific community not only for their occurrence in nature but also due to their wide range of biological activities. Method: To reach our goal, a literature survey that covers the last decade was performed. Results: As a result, recent data on the biological activity of thiazole, thiazolidinone, benzothiazole and thiadiazole derivatives are mentioned. Conclusion: It should be mentioned that despite the progress in the development of new antimicrobial agents, there is still room for new findings. Thus, research still continues.

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