Current Advances in Drug Delivery Systems for Capsule Endoscopy

2020 ◽  
Vol 21 (11) ◽  
pp. 838-843
Author(s):  
Ivan Lyutakov ◽  
Plamen Penchev
Keyword(s):  
Drug Delivery ◽  
Capsule Endoscopy ◽  
Drug Delivery Systems ◽  
Microelectromechanical Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Once Daily ◽  
New Approach ◽  
Delivery Routes ◽  
Wireless Capsule

Background: Oral administration of medications and current oral modified-release systems are the most preferred drug delivery routes, but they provide efficacy up to 12-24 hours per administration and are not useful when the patient has short transit time. The once-daily administered formulations are the endpoint of many types of drug development, and some innovations in capsule endoscopy (CE) can solve this problem. Objective: This review aims to reveal recent advances in drug delivery systems (DDS) for CE as an essential field of research for more precise drug targeting at the gastrointestinal (GI) tract. Methods: We performed a narrative overview of the MEDLINE database from 1991-2020 using the keywords of DDS and CE with synthesizing the findings, hand searches, and authoritative articles. Results: There are microelectromechanical systems and non-mechanical patent technologies for DDS for CE, and the implementation of wireless-capsule medical devices into the human body will provide new diagnostic and therapeutic options. Integrating biomedical CE with DDS and the cloud technology will bring remote real-time feedbackbased automated treatment or responsive medication. Conclusion: Swallowable drug delivery systems for capsule endoscopy brings an entirely new approach for diagnostic and therapeutic methods in digestive diseases.

FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy

2017 ◽  
Vol 8 (11) ◽  
pp. 957-966 ◽  
Author(s):  
Marcilio Cunha-Filho ◽  
Maísa RP Araújo ◽  
Guilherme M Gelfuso ◽  
Tais Gratieri
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Hot Melt Extrusion ◽  
Delivery Systems ◽  
Individualized Therapy ◽  
Melt Extrusion ◽  
New Approach ◽  
Hot Melt

scholarly journals Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

2021 ◽  
Vol 2 (3) ◽  
pp. 626-647
Author(s):  
Yubia De Anda-Flores ◽  
Elizabeth Carvajal-Millan ◽  
Alma Campa-Mada ◽  
Jaime Lizardi-Mendoza ◽  
Agustin Rascon-Chu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Colonic Delivery ◽  
Drug Degradation ◽  
Non Invasive ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

A Review of Niosomes as Novel Drug Delivery Systems

2021 ◽  
Vol 14 (6) ◽  
pp. 5654-5664
Author(s):  
Anil Kumar Chilka ◽  
Vadithe Vasu Naik
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Ionic Surfactant ◽  
Target Tissue ◽  
New Approach ◽  
Surfactant Vesicles ◽  
Novel Drug ◽  
Subcellular Level

The aim of this review is to present the structure of niosome, benefits and drawbacks, fundamentals of niosome preparation and characterization as well as a description of their applications in drug delivery. This review will provide an overview on the increasing interest on niosomes in the field of drug delivery. Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area of action within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosomes. Niosomes are the type of non-ionic surfactant vesicles, which are biodegradable, non-toxic, more stable and inexpensive, a new approach to liposomes. Their structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes. The niosomes have the tendency to load different type of drugs.

A new approach for the evaluation of niosomes as effective transdermal drug delivery systems

2011 ◽  
Vol 79 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Rita Muzzalupo ◽  
Lorena Tavano ◽  
Roberta Cassano ◽  
Sonia Trombino ◽  
Teresa Ferrarelli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Approach ◽  
Transdermal Drug Delivery Systems

A Selectively Anodic Bonded Micropump for Implantable Medical Drug Delivery Systems

2002 ◽  
Author(s):  
Shane Ridgeway ◽  
Junho Song ◽  
Li Cao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Microelectromechanical Systems ◽  
Actuation Voltage ◽  
Delivery Systems ◽  
Maximum Pressure ◽  
Glass Wafer ◽  
Medical Drug

Microelectromechanical Systems (MEMS) fabrication techniques offer a unique solution for implantable medical drug delivery systems. An implantable medical drug delivery system can relieve the pain associated with frequent injections and deliver a localized dosage. An implantable drug delivery system can also avoid contamination and infection better than conventional injection methods (such as intravenous injection). The major advantage of microfabricated drug delivery systems is the possibility of mass production at low cost. A silicon based peristaltically actuated implantable medical drug delivery system consisting of three pumping chambers was microfabricated and tested. The unique features of this microfabricated drug delivery system include the design of a selectively anodic bonded micropump. The selectively anodic bonded Pyrex glass wafer was used to seal the pump chambers and allow for a view of fluid movement. Chromium was used as a selective bonding material. A 20 nm thick chromium film deposited on the top surface of the silicon valves successfully prevented bonding between the valve and the glass wafer. The pump operates with a normally closed valve which consists of a silicon mesa located at the center of each chamber. This mesa makes intimate contact with the glass wafer. Three 180 μm deep and 12 mm diameter circular chambers were etched into the top surface of the silicon wafer using deep reactive ion etching (DRIE) and connected by two 1 mm wide channels. Directly opposite the chambers, three 12 mm diameter circular features were etched 320 μm deep using DRIE to create a 50 μm thick silicon membrane and provide an attachment point for piezoelectric actuating disks. The piezoelectric disks were applied using a conductive silver epoxy. A positive potential was applied to the gold layer that was e-beam deposited on the substrate, with the negative terminal applied to each individual actuator. The three pump chambers were actuated in a peristaltic motion with driving frequencies ranging from 0.5 to 4 Hz and actuation voltages ranging from 10–130 V. The design goal of 10 μL/min was met at driving frequencies of 2 and 4 Hz where the maximum flowrate was 10.1 and 11.4 μL/min for the 2 and 4 Hz actuation frequencies respectively at an actuation voltage of 130 V. The maximum pressure achieved by the pump was 35.8 mmH20 for the 2 and 4 Hz actuation frequencies at an actuation voltage of 130 V.

Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems

2012 ◽  
Vol 3 (1) ◽  
pp. 105-124 ◽  
Author(s):  
Jean-Claude Bakala N’Goma ◽  
Sawsan Amara ◽  
Kaouthar Dridi ◽  
Vincent Jannin ◽  
Frédéric Carrière
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Lipid Digestion

Advances of Smart Nano-drug Delivery Systems in Osteosarcoma Treatment

2021 ◽  
Author(s):  
Ying Liu ◽  
Qing Li ◽  
Qian Bai ◽  
Wei Jiang
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Approach ◽  
Stimulus Response ◽  
Nano Drug Delivery

Nanotechnology has recently gained great interest due to its potential for biomedical applications, which provides a new approach for the treatment of cancer. Especially, nanotechnology, featuring stimulus response and stability...

Feasibility of Capsule Endoscopy for Direct Imaging of Drug Delivery Systems in the Fasted Upper-Gastrointestinal Tract

2014 ◽  
Vol 31 (8) ◽  
pp. 2044-2053 ◽  
Author(s):  
Pernille Barbre Pedersen ◽  
Daniel Bar-Shalom ◽  
Stefania Baldursdottir ◽  
Peter Vilmann ◽  
Anette Müllertz
Keyword(s):  
Drug Delivery ◽  
Gastrointestinal Tract ◽  
Capsule Endoscopy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Upper Gastrointestinal Tract ◽  
Direct Imaging ◽  
Upper Gastrointestinal
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