Proteins: Sequence to Structure and Function – Current Status

2010 ◽  
Vol 11 (7) ◽  
pp. 498-514 ◽  
Author(s):  
Sandhya R. Shenoy ◽  
B. Jayaram
Keyword(s):  
Structure And Function ◽  
Current Status ◽  
And Function

scholarly journals Structure prediction of crystals, surfaces and nanoparticles

2020 ◽  
Vol 378 (2186) ◽  
pp. 20190600
Author(s):  
Scott M. Woodley ◽  
Graeme M. Day ◽  
R. Catlow
Keyword(s):  
Machine Learning ◽  
Energy Function ◽  
Structure Prediction ◽  
Search Algorithm ◽  
Structure And Function ◽  
Current Status ◽  
Organic Systems ◽  
And Function

We review the current techniques used in the prediction of crystal structures and their surfaces and of the structures of nanoparticles. The main classes of search algorithm and energy function are summarized, and we discuss the growing role of methods based on machine learning. We illustrate the current status of the field with examples taken from metallic, inorganic and organic systems. This article is part of a discussion meeting issue ‘Dynamic in situ microscopy relating structure and function’.

The structure and function of the brown fat uncoupling protein UCP1: current status

BioFactors ◽  
1998 ◽  
Vol 8 (3-4) ◽  
pp. 209-219 ◽  
Author(s):  
Eduardo Rial ◽  
M. Mar González-Barroso ◽  
Christophe Fleury ◽  
Frédéric Bouillaud
Keyword(s):  
Uncoupling Protein ◽  
Structure And Function ◽  
Brown Fat ◽  
Current Status ◽  
And Function

Current status of the molecular structure and function of the plasma sex steroid-binding protein (SBP)

1983 ◽  
Vol 19 (1) ◽  
pp. 699-706 ◽  
Author(s):  
Philip H. Petra ◽  
Frank Z. Stanczyk ◽  
Donald F. Senear ◽  
Pearl C. Namkung ◽  
Miles J. Novy ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Binding Protein ◽  
Structure And Function ◽  
Sex Steroid ◽  
Current Status ◽  
Steroid Binding ◽  
And Function ◽  
Molecular Structure And Function ◽  
Steroid Binding Protein

Structure and Function of the Myelin Proteins: Current Status and Perspectives in Relation to Multiple Sclerosis

2005 ◽  
Vol 12 (13) ◽  
pp. 1569-1587 ◽  
Author(s):  
Andreas Tzakos ◽  
Petri Kursula ◽  
Anastassios Troganis ◽  
Vassiliki Theodorou ◽  
Theodore Tselios ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Structure And Function ◽  
Myelin Proteins ◽  
Current Status ◽  
And Function

The current status of antiparasite chemotherapy

Parasitology ◽  
1997 ◽  
Vol 114 (7) ◽  
pp. 3-15 ◽  
Author(s):  
S. L. CROFT
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Sesquiterpene Lactones ◽  
Molecular Targets ◽  
Structure And Function ◽  
Current Status ◽  
Rational Approach ◽  
Pharmacological Properties ◽  
Antiparasitic Drugs ◽  
And Function

Currently used antiparasitic drugs, including benzimidazoles, nitroimidazoles, avermectins, polyene ionophores, hydroxynaphthoquinones and sesquiterpene lactones, were identified through the empirical route to drug discovery. The modern rational approach to drug design is focused upon the structure and function of biochemical and molecular targets. The requisite pharmacological properties for new anti-parasite drugs should not be ignored in this process.

scholarly journals Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions

2021 ◽  
Vol 9 ◽  
Author(s):  
Yao Lin ◽  
Liyun Chen ◽  
Mingjun Zhang ◽  
Sitian Xie ◽  
Lijie Du ◽  
...  
Keyword(s):  
Eccrine Sweat Gland ◽  
Structure And Function ◽  
Current Status ◽  
Sweat Glands ◽  
Future Directions ◽  
Hot Environment ◽  
And Function ◽  
Development Structure ◽  
Eccrine Sweat Glands ◽  
Eccrine Sweat

Eccrine sweat glands (ESGs) play an important role in temperature regulation by secreting sweat. Insufficiency or dysfunction of ESGs in a hot environment or during exercise can lead to hyperthermia, heat exhaustion, heatstroke, and even death, but the ability of ESGs to repair and regenerate themselves is very weak and limited. Repairing the damaged ESGs and regenerating the lost or dysfunctional ESGs poses a challenge for dermatologists and bum surgeons. To promote and accelerate research on the repair and regeneration of ESGs, we summarized the development, structure and function of ESGs, and current strategies to repair and regenerate ESGs based on stem cells, scaffolds, and possible signaling pathways involved.

scholarly journals Regenerative medicine in otorhinolaryngology

2015 ◽  
Vol 129 (8) ◽  
pp. 732-739 ◽  
Author(s):  
J C R Wormald ◽  
J M Fishman ◽  
S Juniat ◽  
N Tolley ◽  
M A Birchall
Keyword(s):  
Congenital Abnormality ◽  
Animal Studies ◽  
Structure And Function ◽  
Research Articles ◽  
Current Status ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Ovid Medline ◽  
And Function ◽  
Regenerative Therapies

AbstractBackground:Tissue engineering using biocompatible scaffolds, with or without cells, can permit surgeons to restore structure and function following tissue resection or in cases of congenital abnormality. Tracheal regeneration has emerged as a spearhead application of these technologies, whilst regenerative therapies are now being developed to treat most other diseases within otolaryngology.Methods and results:A systematic review of the literature was performed using Ovid Medline and Ovid Embase, from database inception to 15 November 2014. A total of 561 papers matched the search criteria, with 76 fulfilling inclusion criteria. Articles were predominantly pre-clinical animal studies, reflecting the current status of research in this field. Several key human research articles were identified and discussed.Conclusion:The main issues facing research in regenerative surgery are translation of animal model work into human models, increasing stem cell availability so it can be used to further research, and development of better facilities to enable implementation of these advances.

scholarly journals Nutritional Strategies to Prevent Lens Cataract: Current Status and Future Strategies

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1186 ◽  
Author(s):  
Andrea J Braakhuis ◽  
Caitlin I Donaldson ◽  
Julie C Lim ◽  
Paul J Donaldson
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Causative Factor ◽  
Structure And Function ◽  
Current Status ◽  
Cataract Formation ◽  
The World ◽  
And Function ◽  
Nutritional Strategies

Oxidative stress and the subsequent oxidative damage to lens proteins is a known causative factor in the initiation and progression of cataract formation, the leading cause of blindness in the world today. Due to the role of oxidative damage in the etiology of cataract, antioxidants have been prompted as therapeutic options to delay and/or prevent disease progression. However, many exogenous antioxidant interventions have to date produced mixed results as anti-cataract therapies. The aim of this review is to critically evaluate the efficacy of a sample of dietary and topical antioxidant interventions in the light of our current understanding of lens structure and function. Situated in the eye behind the blood-eye barrier, the lens receives it nutrients and antioxidants from the aqueous and vitreous humors. Furthermore, being a relatively large avascular tissue the lens cannot rely of passive diffusion alone to deliver nutrients and antioxidants to the distinctly different metabolic regions of the lens. We instead propose that the lens utilizes a unique internal microcirculation system to actively deliver antioxidants to these different regions, and that selecting antioxidants that can utilize this system is the key to developing novel nutritional therapies to delay the onset and progression of lens cataract.

Sign in / Sign up

Export Citation Format

Share Document