Design of Metal-Organic Frameworks for pH-Responsive Drug Delivery Application

2019 ◽  
Vol 19 (20) ◽  
pp. 1644-1665 ◽  
Author(s):  
Xin Shen ◽  
Ying Pan ◽  
Zhihao Sun ◽  
Dong Liu ◽  
Hongjia Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Future Challenges ◽  
Metal Organic ◽  
Good Biocompatibility ◽  
And Function ◽  
Controllable Particle Size ◽  
Selection Of

Metal-Organic Frameworks (MOFs) have aroused great interest in the field of nanoscience and nanotechnology particularly in biomedical domains, such as Drug Delivery System (DDS), Biomedical Imaging (BI) and Photodynamic Therapy (PDT). As an emerging material, MOFs possess extraordinarily high surface area, controllable particle size and good biocompatibility. With extraordinary flexibility in the selection of organic and inorganic components, MOFs can rationally be tuned to obtain the materials having versatile structures and porosities. MOFs can serve as ideal vehicles for DDS, BI and PDT through modification and function. In this review, we summarized the design and synthetic strategies for preparing MOFs and introduced their recent advanced usage in DDS, BI and PDT. Finally, the prospect and future challenges of these nanomaterials are also documented.

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

scholarly journals MIL-53 (Al) metal-organic frameworks as potential drug carriers

2021 ◽  
Vol 2058 (1) ◽  
pp. 012015
Author(s):  
O Yu Griaznova ◽  
I V Zelepukin ◽  
G V Tikhonowski ◽  
V N Kolokolnikov ◽  
S M Deyev
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Loading ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Drug Carriers ◽  
Microwave Assisted Synthesis ◽  
Promising Candidate ◽  
Metal Organic

Abstract One of the challenges of the medicine is to improve the chemical stability of drugs and to prevent their premature biodegradation before reaching the therapeutic target. Various nanoparticles were used to solve this problem, but low drug loading efficiency limited their biomedical applications. Metal organic frameworks are promising candidates for drug delivery since they have extremely high surface area and regular porosity. In this study, we prepared high-crystalline MIL-53 frameworks based on aluminium and 2-aminoterephtalic acid by microwave-assisted synthesis and evaluated their properties as drug carriers. Drug loading of chemotherapeutic and diagnostic molecules of different nature riches value of 34% by particle weight, significantly higher than those of other reported solid nanoparticles. Therefore, our results make MIL-53 (Al) frameworks promising candidate for drug delivery.

scholarly journals Recent Improvement Strategies on Metal-Organic Frameworks as Adsorbent, Catalyst, and Membrane for Wastewater Treatment

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5261
Author(s):  
Arie Wibowo ◽  
Maradhana A. Marsudi ◽  
Edi Pramono ◽  
Jeremiah Belva ◽  
Ade W. Y. P. Parmita ◽  
...  
Keyword(s):  
Wastewater Treatment ◽  
Environmental Problem ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
High Porosity ◽  
Comprehensive Description ◽  
Metal Organic ◽  
Accumulation Of Pollutants ◽  
And Function

The accumulation of pollutants in water is dangerous for the environment and human lives. Some of them are considered as persistent organic pollutants (POPs) that cannot be eliminated from wastewater effluent. Thus, many researchers have devoted their efforts to improving the existing technology or providing an alternative strategy to solve this environmental problem. One of the attractive materials for this purpose are metal-organic frameworks (MOFs) due to their superior high surface area, high porosity, and the tunable features of their structures and function. This review provides an up-to-date and comprehensive description of MOFs and their crucial role as adsorbent, catalyst, and membrane in wastewater treatment. This study also highlighted several strategies to improve their capability to remove pollutants from water effluent.

scholarly journals Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 271 ◽  
Author(s):  
Yaoyao Han ◽  
Weicong Liu ◽  
Jianjing Huang ◽  
Shuowen Qiu ◽  
Huarui Zhong ◽  
...  
Keyword(s):  
Real World ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Internal Surface ◽  
Aqueous Solubility ◽  
Research Area ◽  
Drug Molecules ◽  
Future Challenges ◽  
Metal Organic

Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed.

Metal-organic-framework derived hollow manganese nickel selenide spheres confined with nanosheets on nickel foam for hybrid supercapacitors

2021 ◽  
Author(s):  
Bahareh ameri ◽  
Akbar Mohammadi Zardkhoshoui ◽  
Saied Saeed Hosseiny Davarani
Keyword(s):  
Active Sites ◽  
Nickel Foam ◽  
Metal Organic Framework ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Supercapacitive Performance ◽  
Hybrid Supercapacitors ◽  
Porous Networks ◽  
Metal Organic

Metal-organic frameworks (MOFs) derived nanoarchitectures have special features, such as high surface area (SA), abundant active sites, exclusive porous networks, and remarkable supercapacitive performance when compared to traditional nanoarchitectures. Herein,...

scholarly journals Cobalt-Based Metal Organic Frameworks as Solids Catalysts for Oxidation Reactions

Catalysts ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 95
Author(s):  
Amarajothi Dhakshinamoorthy ◽  
Eva Montero Lanzuela ◽  
Sergio Navalon ◽  
Hermenegildo Garcia
Keyword(s):  
Aerobic Oxidation ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Acid Sites ◽  
Crystalline Lattice ◽  
Oxidation Reactions ◽  
Solid Catalysts ◽  
Long Term Stability ◽  
Metal Organic

Metal organic frameworks (MOFs) are porous crystalline solids whose frameworks are constituted by metal ions/nodes with rigid organic linkers leading to the formation of materials having high surface area and pore volume. One of the unique features of MOFs is the presence of coordinatively unsaturated metal sites in their crystalline lattice that can act as Lewis acid sites promoting organic transformations, including aerobic oxidation reactions of various substrates such as hydrocarbons, alcohols, and sulfides. This review article summarizes the existing Co-based MOFs for oxidation reactions organized according to the nature of substrates like hydrocarbon, alcohol, olefin, and water. Both aerobic conditions and peroxide oxidants are discussed. Emphasis is placed on comparing the advantages of using MOFs as solid catalysts with respect to homogeneous salts in terms of product selectivity and long-term stability. The final section provides our view on future developments in this field.

scholarly journals Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1598 ◽  
Author(s):  
Tahir Rasheed ◽  
Komal Rizwan ◽  
Muhammad Bilal ◽  
Hafiz M. N. Iqbal
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
High Surface ◽  
High Surface Area ◽  
Co2 Reduction ◽  
Biological Species ◽  
Crystalline Materials ◽  
Potential Applications ◽  
Metal Organic ◽  
Catalytic Chemistry

Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

Synthesis and Electrochemical Properties of Ternary Co-, Cu- and Ni- Based Metal-Organic Frameworks Electrode for Battery Supercapacitor Hybrid Application

2020 ◽  
Vol 981 ◽  
pp. 17-22
Author(s):  
Amir Luqman Sanusi ◽  
Nurul Khairiyyah Mohd Zain ◽  
Izan Izwan Misnon ◽  
Ahmad Salihin Samsudin ◽  
Rajan Jose
Keyword(s):  
Electrochemical Properties ◽  
Metal Ion ◽  
Electrochemical Impedance ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
High Specific Capacitance ◽  
Electrochemical Analysis ◽  
Benzenedicarboxylic Acid ◽  
Metal Organic

Metal-organic frameworks (MOFs) composed by coordination bonds between metal ion with organic linker has a uniform combination of micro and mesoporous structures has been used for several application including battery supercapacitor hybrid. (BSH). In BSH, MOF offer several advantages including high surface area, porous, and structure tunability. This paper reports the synthesis of ternary MOF of copper (Cu), nickel (Ni) and cobalt (Co) with 1,4-benzenedicarboxylic acid. The Co/Cu/Ni-MOF is synthesized using hydrothermal method at 160 °C for 12h and further develop as a BSH electrode. The physicochemical properties of MOF were characterized using FESEM, FTIR, XRD, BET and the electrochemical properties were evaluated using cyclic voltammetry (CV), charge-discharge cycling (CDC) and electrochemical impedance spectroscopy (EIS). Electrochemical analysis indicated that the MOF has high specific capacitance (CS) of 591 F g-1 at a current density of 1 A g-1 and 519 F g-1 at scan rate of 2 mV s-1, and possess low series resistance (RS) of 0.44 Ω and equivalent distributed resistance (Rd) of 1.07 Ω.

scholarly journals Recent Trends in Covalent and Metal Organic Frameworks for Biomedical Applications

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 916 ◽  
Author(s):  
Georges Chedid ◽  
Ali Yassin
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Materials Science ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
Great Promise ◽  
Surface Areas ◽  
Metal Organic ◽  
New Type ◽  
Recent Trends

Materials science has seen a great deal of advancement and development. The discovery of new types of materials sparked the study of their properties followed by applications ranging from separation, catalysis, optoelectronics, sensing, drug delivery and biomedicine, and many other uses in different fields of science. Metal organic frameworks (MOFs) and covalent organic frameworks (COFs) are a relatively new type of materials with high surface areas and permanent porosity that show great promise for such applications. The current study aims at presenting the recent work achieved in COFs and MOFs for biomedical applications, and to examine some challenges and future directions which the field may take. The paper herein surveys their synthesis, and their use as Drug Delivery Systems (DDS), in non-drug delivery therapeutics and for biosensing and diagnostics.

Exploring frontiers of high surface area metal–organic frameworks

2013 ◽  
Vol 4 (4) ◽  
pp. 1781 ◽  
Author(s):  
Richard Luis Martin ◽  
Maciej Haranczyk
Keyword(s):  
Surface Area ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Metal Organic
Sign in / Sign up

Export Citation Format

Share Document