Circulatory Cells as Tumortropic Carrier for Targetability Improvement

Background: How to achieve high targeting efficiency for drug delivery system is still one of the most important issues that tumor diagnosis and non-surgical therapies faced. Although nanoparticle-based drug delivery system made an amount of progress in extending circulation time, improving targetability, controlled drug release etc., yet the targeting efficiency remained low, and the development was limited to reduce side effects with overall survival rates unchanged or improved a little. Objective: This paper aims to review current researches on the cell-driven drug delivery systems, and discuss the potential obstacles and directions for cell-based cancer therapies and diagnosis. Methods: More than one hundred references were collected, and this paper focused on red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, mesenchymal stem cells, cell membrane, artificial cells and extracellular vesicles, then summarized 1) the utilizable properties, 2) balancing cargo-loading amounts and cell function, 3) cascade strategies for targetability improvement. Main findings: circulatory cells and their derivatives were featured by good biocompatibility, long circulation time in blood, unique chemo-migration and penetration ability. On the base of backpack and encapsulation approach, cargo loading amounts and cell function could be balanced through regulating membrane receptors, particle material/size/shape/structure and incubation temperature, etc. The cell-driven drug delivery system met most of the demands that nanoparticle-based delivery system failed to for effective tumortropic delivery. Conclusion: Despite of new challenges, cell-driven drug delivery system generally brought great benefits to and shed a light on for cancer therapy and diagnosis.

Download Full-text

Dual Targeted Red Blood Cell Hitchhiking: A Platform Liposomal Drug Delivery System to Improve Circulation Time and Increase Delivery to Target Organs

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2289 ◽

2020 ◽

Author(s):

L. Ferguson ◽

E. Hood ◽

T. Shuvaeva ◽

V. Shuvaev ◽

V. Muzykantov ◽

...

Keyword(s):

Drug Delivery ◽

Blood Cell ◽

Drug Delivery System ◽

Delivery System ◽

Red Blood Cell ◽

Circulation Time ◽

Liposomal Drug ◽

Target Organs ◽

Liposomal Drug Delivery

Download Full-text

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Nanotechnology Reviews ◽

10.1515/ntrev-2018-0029 ◽

2018 ◽

Vol 7 (4) ◽

pp. 291-301 ◽

Cited By ~ 16

Author(s):

Zepeng Jiao ◽

Bin Zhang ◽

Chunya Li ◽

Weicong Kuang ◽

Jingxian Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Drug Delivery System ◽

Delivery System ◽

Carboxymethyl Cellulose ◽

Drug Carrier ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Download Full-text

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

Journal of Materials Chemistry B ◽

10.1039/c8tb02952k ◽

2019 ◽

Vol 7 (14) ◽

pp. 2261-2276 ◽

Cited By ~ 3

Author(s):

Yufei Bian ◽

Zhiyong Wei ◽

Zefeng Wang ◽

Zhu Tu ◽

Liuchun Zheng ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Physical Properties ◽

Drug Delivery System ◽

Delivery System ◽

Controlled Drug Release ◽

Biodegradable Polyesters ◽

Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

Download Full-text

Safety assessment of a new nanoemulsion-based drug-delivery system reveals unexpected drug-free anticoagulant activity

Nanomedicine ◽

10.2217/nnm-2019-0447 ◽

2020 ◽

Vol 15 (14) ◽

pp. 1361-1373

Author(s):

James J Hobson ◽

Steve P Rannard ◽

Andrew Owen ◽

Neill J Liptrott

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Safety Assessment ◽

Cell Function ◽

Immune Cell ◽

Anticoagulant Activity ◽

Drug Free ◽

Preclinical Safety

Aim: A preclinical safety assessment of a novel nanoemulsion drug-delivery system, initially developed to improve the posology of efavirenz (EFV), was conducted with a specific focus on possible immunological and hematological complications. Materials & methods: Assessment of common acute toxicities, such as complement activation and cytokine secretion, was performed using validated assays known to have good correlation with in vivo end points. Results & conclusion: Compared with a standard aqueous solution of EFV, the EFV nanoemulsion showed no significant effect on immune cell function or phenotype. Prolongation of activated partial thromboplastin time was observed for EFV-loaded nanoemulsions (88% at 4 μg/ml) as well as unloaded nanoemulsions (52%) highlighting the potential for drug-free anticoagulant activity and warranting further investigation of the mechanism and utility of these materials.

Download Full-text

Synthesis of lipid–black phosphorus quantum dot bilayer vesicles for near-infrared-controlled drug release

Chemical Communications ◽

10.1039/c8cc03423k ◽

2018 ◽

Vol 54 (47) ◽

pp. 6060-6063 ◽

Cited By ~ 22

Author(s):

Shengyong Geng ◽

Lie Wu ◽

Haodong Cui ◽

Wenyong Tan ◽

Tianfeng Chen ◽

...

Keyword(s):

Drug Delivery ◽

Quantum Dots ◽

Drug Release ◽

Quantum Dot ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Controlled Drug Release ◽

Black Phosphorus ◽

Black Phosphorus Quantum Dots

Black phosphorus quantum dots are incorporated into liposomal bilayers to produce a drug delivery system with excellent near-infrared (NIR) photothermal properties and drug release capability controlled by light.

Download Full-text

Polymer–paclitaxel conjugates based on disulfide linkers for controlled drug release

RSC Advances ◽

10.1039/c4ra12856g ◽

2015 ◽

Vol 5 (10) ◽

pp. 7559-7566 ◽

Cited By ~ 17

Author(s):

Wulian Chen ◽

Luqman Ali Shah ◽

Li Yuan ◽

Mohammad Siddiq ◽

Jianhua Hu ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Diblock Copolymer ◽

Controlled Drug Delivery ◽

Controlled Drug Release ◽

Controlled Drug Delivery System ◽

Disulfide Linkers ◽

Covalently Linked

Controlled drug delivery system based on hydrophilic diblock copolymer covalently linked paclitaxel (PTX) via a disulfide linker.

Download Full-text

Dual-functional SFP/PAN based nano drug release system for treatment and nutrients

Textile Research Journal ◽

10.1177/0040517520988094 ◽

2021 ◽

pp. 004051752098809

Author(s):

Ling Han ◽

Yingbo Ma ◽

Hao Dou ◽

Wei Fan

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Controlled Drug Release ◽

Order Kinetic ◽

Antimicrobial Drugs ◽

Dual Functional ◽

Nano Drug Delivery

Nano drug delivery systems can control the ordered release of drugs. To achieve the target of supplying therapeutics and nutrients at the same time, a novel nano drug delivery system with a core–shell structure was prepared by coaxial electrospinning. Polyacrylonitrile (PAN) has been used to produce a drug release scaffold in the shell section, mixed with absorbable silk fibroin peptide (SFP) as a nutrient. Ciprofloxacin (CPFX), a broad-spectrum antibiotic, was used as the core, as well as an antibacterial agent. Owing to its low molecular weight, using a pure SFP thin solution to manufacture nanofibers by electrospinning is still technically challenging. Thus, different ratios of PAN to SFP were used in the shell electrospinning solution. In this research, a novel nano dual-functionality drug delivery system has been successfully prepared. In vitro testing demonstrated that nanofibers could supply more nutrients with increasing SFP in shell solutions; however, the ability to maintain controlled release was reduced. It was found that the nanofiber membrane had the best controlled drug release capability for a PAN-to-SFP mass ratio of 95:5. Overall, most ciprofloxacin was released in the first 12 h, while the release of SFP was constant throughout the first 24 h. Our modeling demonstrated that the release of CPFX and SFP is best described using a first-order kinetic model. The developed drug delivery system is designed to release antimicrobial drugs in a controlled manner and provide absorbable nutrients simultaneously.

Download Full-text

Preparation and formulation optimization of methotrexate-loaded human serum albumin nanoparticles modified by mannose

Current Medicinal Chemistry ◽

10.2174/0929867328666210118112640 ◽

2021 ◽

Vol 28 ◽

Author(s):

Zhenyu Chen ◽

Zhongling Luo ◽

Jiayao Lyu ◽

Jianxin Wang ◽

Zhongbing Liu ◽

...

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Drug Delivery System ◽

Delivery System ◽

Circulation Time ◽

Independent Variables ◽

Albumin Nanoparticles

Background: Methotrexate (MTX) is the representative drug among the disease-modifying anti-rheumatic drugs. But the conventional treatment with MTX showed many limitations and side effects. Objective: To strengthen the targeting ability and circulation time of MTX in the treatment of rheumatoid arthritis, the present study focused on developing a novel drug delivery system of methotrexate-loaded human serum albumin nanoparticles (MTX-NPs) modified by mannose, which referred as MTX-M-NPs. Methods: Firstly, mannose-derived carboxylic acid was synthesized and further modified on the surface of MTX-NPs to prepare MTX-M-NPs. The formulation of nanoparticles was optimized by method of central composite design (CCD), with the drug lipid ratio, oil-aqueous ratio, and cholesterol or lecithin weight as the independent variables. The average particle size and encapsulation efficiency were the response variables. Response of different formulations was calculated and the response surface diagram, contour diagram and mathematical equation were used to relate the dependent and independent variables to predict the optimal formula ratio. The uptake of MTX-M-NPs by neutrophils was studied through the laser confocal detection. Further, MTX-M-NPs was subjected to assess the pharmacokinetics profile after intravenous injection with Sprague-Dawley rats. Results: This targeting drug delivery system was successfully developed. Results from Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy analysis can verify the successful preparation of this drug delivery system. Based on the optimized formula, MTX-M-NPs was prepared with a particle size of 188.17 ± 1.71 nm and an encapsulation rate of 95.55 ± 0.33%. MTX-M-NPs displayed significantly higher cellular uptake than MTX-NPs. The pharmacokinetic results showed that MTX-M-NPs could prolong the in vivo circulation time of MTX. Conclusion: This targeting drug delivery system laid a promising foundation for the treatment of RA.

Download Full-text

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

Chemical Communications ◽

10.1039/c6cc08241f ◽

2016 ◽

Vol 52 (95) ◽

pp. 13775-13778 ◽

Cited By ~ 39

Author(s):

Xin Wang ◽

Li-Li Tan ◽

Xi Li ◽

Nan Song ◽

Zheng Li ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Release ◽

On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

Download Full-text