Peptide-mediated cationic micelles drug-delivery system applied on a VEGFR3-overexpressed tumor

Background: How to achieve high targeting efficiency for drug delivery system is still one of the most important issues that tumor diagnosis and non-surgical therapies faced. Although nanoparticle-based drug delivery system made an amount of progress in extending circulation time, improving targetability, controlled drug release etc., yet the targeting efficiency remained low, and the development was limited to reduce side effects with overall survival rates unchanged or improved a little. Objective: This paper aims to review current researches on the cell-driven drug delivery systems, and discuss the potential obstacles and directions for cell-based cancer therapies and diagnosis. Methods: More than one hundred references were collected, and this paper focused on red blood cells, monocytes, macrophages, neutrophils, natural killer cells, T lymphocytes, mesenchymal stem cells, cell membrane, artificial cells and extracellular vesicles, then summarized 1) the utilizable properties, 2) balancing cargo-loading amounts and cell function, 3) cascade strategies for targetability improvement. Main findings: circulatory cells and their derivatives were featured by good biocompatibility, long circulation time in blood, unique chemo-migration and penetration ability. On the base of backpack and encapsulation approach, cargo loading amounts and cell function could be balanced through regulating membrane receptors, particle material/size/shape/structure and incubation temperature, etc. The cell-driven drug delivery system met most of the demands that nanoparticle-based delivery system failed to for effective tumortropic delivery. Conclusion: Despite of new challenges, cell-driven drug delivery system generally brought great benefits to and shed a light on for cancer therapy and diagnosis.

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Construction of an exosome-functionalized graphene oxide based composite bionic smart drug delivery system and its anticancer activity

Nanotechnology ◽

10.1088/1361-6528/ac49bf ◽

2022 ◽

Author(s):

Qi Chen ◽

Chengchuan Che ◽

Jinfeng Liu ◽

Zhijin Gong ◽

Meiru Si ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Graphene Oxide ◽

Drug Delivery System ◽

Delivery System ◽

Functionalized Graphene Oxide ◽

Ph Response ◽

Drug Delivery Carrier ◽

Cancer Tumor

Abstract Graphene oxide has covalently modified by chito oligosaccharides and γ-polyglutamic acid to form GO-CO-γ-PGA, which exhibits excellent performance as a drug delivery carrier, but this carrier did not have the ability to actively target. In this study, the targeting property of breast cancer tumor cell exosomes was exploited to give GO-CO-γ-PGA the ability to target breast tumor cells (MDA-MB-231), and the drug mitoxantrone (MIT) was loaded to finally form EXO-GO-CO-γ-PGA-MIT with a loading capacity of 1.39 mg/mg. The pH response of EXO-GO-CO-γ-PGA showed a maximum cumulative release rate of 56.59% (pH 5.0) and 6.73% (pH 7.4) for MIT at different pH conditions. pH 7.4). In vitro cellular assays showed that EXO-GO-CO-γ-PGA-MIT was more potent in killing MDA-MB-231 cells due to its targeting ability and had a significantly higher pro-apoptotic capacity compared to GO-CO-γ-PGA-MIT. The results showed that this bionic nano-intelligent drug delivery system has good drug slow release function, can increase the local drug concentration of tumor and enhance the pro-apoptotic ability of MIT, so this newly synthesized bionic drug delivery carriers (EXO-GO-CO-γ-PGA-MIT) has potential application in breast cancer treatment.

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RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i1.28558 ◽

2019 ◽

Vol 12 (1) ◽

pp. 54

Author(s):

Jampala Rajkumar ◽

Radha Gv ◽

Trideva Sastri K ◽

Sadhana Burada

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Liquid Crystalline ◽

Minimal Amount ◽

Hydrophilic Drugs ◽

Drug Candidates ◽

Gel Texture ◽

Drug Delivery Carrier ◽

Semi Solid

An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

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RECENT UPDATE ON PRONIOSOMAL GEL AS TOPICAL DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v12i1.28558 ◽

2019 ◽

Vol 12 (1) ◽

pp. 54

Author(s):

Jampala Rajkumar ◽

Radha Gv ◽

Trideva Sastri K ◽

Sadhana Burada

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Liquid Crystalline ◽

Minimal Amount ◽

Hydrophilic Drugs ◽

Drug Candidates ◽

Gel Texture ◽

Drug Delivery Carrier ◽

Semi Solid

An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

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Surface Morphology and Hydrophilicity Evaluation of PLA Microspheres Treated with Boronhydride (NaBH4) at Different Concentrations

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.264.140 ◽

2017 ◽

Vol 264 ◽

pp. 140-143

Author(s):

Zuratul Ain Abdul Hamid ◽

Nurfatihin Ali

Keyword(s):

Drug Delivery ◽

Surface Modification ◽

Drug Delivery System ◽

Delivery System ◽

Poly Lactic Acid ◽

Major Drawback ◽

Drug Delivery Carrier ◽

System A ◽

Biodegradable Poly ◽

Effect Of Surface

In drug delivery system, a controlled drug delivery carrier is favorable to ensure the delivery of drug at suitable and required rate and dosage to the targeted area. Microsphere is one of the approaches used to deliver drug in a controlled manner. A biodegradable poly (lactic) acid (PLA) has been used widely for drug delivery due to the fact that the polymer was non-toxic with a biodegradable property. Therefore, PLA microspheres were utilized in this research works. On the other hand, the major drawback of PLA is its extremely hydrophobic properties which limit its application in drug delivery system. In order to overcome this problem, surface modification via alkaline hydrolysis has been made on PLA. This research investigated the effect of surface modification with sodium boronhydride (NaBH4) at different concentrations and temperatures on the properties of PLA microspheres. The enhancement of hydrophilicity of PLA microspheres has been evaluated using FTIR and SEM. From these evaluations, it was found that the hydrophilicity of PLA microspheres had increased as the concentration of NaBH4 and temperature increased.

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