International Publication Trends in Proteasome Inhibitors: From Tools for Cell Biologists to Anticancer Agents

2019 ◽  
Vol 16 (9) ◽  
pp. 1031-1039
Author(s):  
Peng Zhou ◽  
Minhui Zhu ◽  
Caiyun Zhang ◽  
Donghui Chen ◽  
Hongliang Zheng
Keyword(s):  
Anticancer Agents ◽  
Proteasome Inhibitors ◽  
Publication Trends ◽  
H Index ◽  
The Past ◽  
Dana Farber Cancer Institute ◽  
The Usa ◽  
The Subject ◽  
Number Of Publications ◽  
Scientific Fields

Background: There has been increased interest in the research of proteasome inhibitors for more than two decades. Hotspots in this field are constantly changing. Objective: This study aimed to investigate trends in proteasome inhibitors research from 1992 to 2018 and compare the contributions of such research from different countries and authors. Methods: We used Excel 2013 and VoSviewer to analyze bibliometric data on the subject of proteasome inhibitors, including the number of publications, citations frequency, H-index, and country contributions and hotspots (keywords of popular scientific fields). Results: A total of 3646 articles were included. The USA contributed the largest percentage of articles (1742), with the most citations (90666) and the highest H-index (139). The journal Blood had the most articles. Dana Farber Cancer Institute and Millennium Pharmaceuticals Incorporation were the most contributive institutions. Keywords could be divided into three clusters: Basic experiment, clinical research, and others. Conclusion: The number of proteasome inhibitors articles has been increasing for the past 27 years. The USA made the largest contribution in this field. Recent studies on the topic of “carfilzomib” are relatively new and should be closely followed in proteasome inhibitors research.

Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019

2020 ◽  
Vol 21 (9) ◽  
pp. 685-703
Author(s):  
Waseem Hassan ◽  
Jean Paul Kamdem ◽  
Mohammad Amjad Kamal ◽  
Joao Batista Teixeira da Rocha
Keyword(s):  
United States ◽  
Drug Metabolism ◽  
Bibliometric Analysis ◽  
Continuous Growth ◽  
H Index ◽  
Current Drug ◽  
The Usa ◽  
Twentieth Anniversary ◽  
Number Of Publications ◽  
Number Of Citations

Background: Scopus is regularly covering Current Drug Metabolism from 2000 onwards. Objective: The major objective is to perform the 1st bibliometric analysis of Current Drug Metabolism (CDM). Methods: The data was retrieved from Scopus in April-May 2020 for detail analysis. Results: The total number of publications was found to be 1551, with 955 reviews (61.57%) and 466 articles (30.05%). From 2000 onwards, we calculated the relative growth rate and doubling time. Based on the number of publications, total 4418 authors, 3235 institutions and 83 countries were directly involved in all publications. M.A. Kamal is the highly productive scientist with fifty-three (53 or 3.73%) publications, King Abdulaziz University is the top university with the highest number of publications (58 or 4.13%) and the USA is the top-ranked country with 365 publications (25.96%). We also provided the h-index, total citations (TC), h-index without self-citations (WSC) and total WSC of the top ten authors, universities and countries. In citations analysis, Prof. Zhou S.F. was the top scientist with the highest (1594) number of citations. In institutional category Department of Drug Metabolism, Merck Research Laboratories, Rahway, United States, is the top ranked institutes with 654 total citations. While, United States is the top-ranked country with 18409 total citations. In co-words analysis, 3387, 30564 and 17333 terms in titles of the manuscripts, abstracts and keywords were recorded, respectively. This indicated that CDM principally focused on understanding drug development ranging from its efficacy to delivery, metabolism, distribution, safety and mechanism of actions. Similarly, various specific drugs were thoroughly discussed in publications. Various enzymatic, genetics, proteins and cancer-related aspects were also described. For data presentations, we used VOSviewer graphical maps. Conclusion: The data confirm that CDM showed continuous growth in the number of publications and citations. However significant measures are needed to make overall progress and improve the rankings in relevant categories.

scholarly journals Global publication trends and hotspots of molecular biomarkers in DILI from 1991 to 2020: A 30-year bibliometric analysis

2021 ◽  
Vol 104 (1) ◽  
pp. 003685042110005
Author(s):  
Mingnan Cao ◽  
Li Wang ◽  
Lin Zhang ◽  
Jingli Duan
Keyword(s):  
Bibliometric Analysis ◽  
Research Collaboration ◽  
Citation Networks ◽  
Publication Trends ◽  
Drug Induced ◽  
Topic Area ◽  
The Past ◽  
Black Box Warnings ◽  
The Usa ◽  
Post Marketing

Drug-induced liver injury (DILI) is one of the common adverse drug reactions and the leading cause of drug development attritions, black box warnings, and post-marketing withdrawals. Current biomarkers are suboptimal in detecting DILI and predicting its outcome. This study aimed to quantitatively and qualitatively investigate the research trends on DILI biomarkers using bibliometric analysis. All relevant publications were extracted from the Web of Science database. An online analysis platform of literature metrology, bibliographic item co-occurrence matrix builder, and CiteSpace software were used to analyze the publication trends. CitNetExplorer was used to construct direct citation networks and VOSviewer was used to analyze the keywords and research hotspots. We found a total of 485 publications related to DILI biomarkers published from 1991 to 2020. Toxicological Sciences had been the most popular journal in this field over the past 30 years. The USA maintained a top position worldwide and provided a pivotal influence, followed by China. Among all the institutions, the University of Liverpool was regarded as a leader for research collaboration. Moreover, Professors Paul B. Watkins and Tsuyoshi Yokoi made great achievements in topic area. We analyzed the citation networks and keywords, therefore identified five and six research hotspot clusters, respectively. We considered the publication information regarding different countries/regions, organizations, authors, journals, et al. by summarizing the literature on DILI biomarkers over the past 30 years. Notably, the subject of DILI biomarkers is an active area of research. In addition, the investigation and discovery of novel promising biomarkers such as microRNAs, keratin18, and bile acids will be future developing hotspots.

Idealists and Realists: British Views of Germany,1864–1939

1975 ◽  
Vol 25 ◽  
pp. 137-156 ◽  
Author(s):  
P. M. Kennedy
Keyword(s):  
Narrative Form ◽  
Past Century ◽  
General Survey ◽  
Small Segment ◽  
The Past ◽  
British Policy ◽  
History Of ◽  
The Subject ◽  
Number Of Publications ◽  
Sheer Number

Yet another survey of the much-traversed field of Anglo-German relations will seem to many historians of modern Europe to border on the realm of superfluity; probably no two countries have had their relationship to each other so frequently examined in the past century as Britain and Germany. Moreover, even if one restricted such a study to the British side alone, the sheer number of publications upon this topic, or upon only a section of it like the age of ‘appeasement’, is simply too great to allow a compression of existing knowledge into a narrative form that would be anything other than crude and sketchy. The following contribution therefore seeks neither to provide such a general survey, nor, by use of new and detailed archival materials, to concentrate upon a small segment of the history of British policy towards Germany in the period 1864–1939; but instead to consider throughout all these years a particular aspect, namely, the respective arguments of Germanophiles and Germanophobes in Britain and the connection between this dialogue and the more general ideological standpoints of both sides. In so doing, the author has produced a survey which remains embarrassingly summary in detail but does at least attempt to offer a fresh approach to the subject.

scholarly journals Is Candida auris here to stay? An interview with Dimitrios Kontoyiannis

2019 ◽  
Vol 14 (13) ◽  
pp. 1083-1085
Author(s):  
Dimitrios P Kontoyiannis
Keyword(s):  
Fungal Pathogen ◽  
Immunocompromised Host ◽  
Cancer Center ◽  
Candida Auris ◽  
Past President ◽  
H Index ◽  
The Past ◽  
The Usa ◽  
President Elect ◽  
Md Anderson

In this exclusive interview, Dimitrios P Kontoyiannis discusses current mycology hot topic, Candida auris. With a focus on the current knowns and unknowns for the pathogenesis, resistance and transmission of this emerging fungal pathogen, in addition to a look at therapeutics and future perspectives. This interview was conducted by Ellen Colvin, Commissioning Editor of Future Microbiology. Dimitrios P Kontoyiannis is the Texas 4000 distinguished endowed professor and deputy head in the Division of Internal Medicine at MD Anderson Cancer Center in Houston (TX, USA). Dr Kontoyiannis has authored over 550 peer-reviewed manuscripts and has given over 330 lectures in national and international conferences and academic institutions in the USA and abroad. He is considered a leading mycology expert world-wide with an H index of 101 and over 43,000 citations. His research group is credited for many and sustained contributions to clinical, translational and experimental mycology. He is the recipient of many national and international awards and is the past president elect of Immunocompromised Host Society (2016–2018).

scholarly journals A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 353 ◽  
Author(s):  
Ana Paunkov ◽  
Dionysios V. Chartoumpekis ◽  
Panos G. Ziros ◽  
Gerasimos P. Sykiotis
Keyword(s):  
Web Of Science ◽  
Research Field ◽  
Antioxidant Compounds ◽  
Nrf2 Pathway ◽  
The Past ◽  
Reverse Pattern ◽  
The Usa ◽  
Bibliometric Review ◽  
The Subject ◽  
Active Research

Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways. Currently in its third decade, research on Nrf2 has expanded to encompass not only basic but also clinical studies. In the present bibliometric review, we employed the VOSviewer tool to describe the existing Nrf2 literature landscape. As of July 2019, 11,931 papers on Nrf2 were listed in the “Web of Science” database, with more than 1000 new papers published each year. As expected, terms related to oxidative stress and antioxidant molecules occur very often in the Nrf2 literature throughout the years. Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway. Going beyond molecular biology/biochemistry and related fields, Nrf2 research has begun to spread into more clinical areas like endocrinology/metabolism, cardiology, and nephrology, likely reflecting an increased interest in clinical applications of Nrf2 pathway activators. China has become the most prolific producer of Nrf2 papers the last five years followed by the USA and Japan, a reverse pattern compared to the past. In conclusion, Nrf2 is the subject of a globally active research field that keeps growing and extends from bench to bedside.

scholarly journals Bibliometric Analysis of Global Scientific Research on lncRNA: A Swiftly Expanding Trend

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao Zhai ◽  
Jian Zhao ◽  
Yiran Wang ◽  
Xianzhao Wei ◽  
Gengwu Li ◽  
...  
Keyword(s):  
Overall Survival ◽  
Web Of Science ◽  
Epithelial Mesenchymal Transition ◽  
H Index ◽  
Mesenchymal Transition ◽  
The Usa ◽  
Rapid Pace ◽  
Number Of Publications ◽  
Cluster 2 ◽  
Research Hotspots

To investigate trends in long-noncoding (lnc) RNA research systematically, we compared the contribution of publications among different regions, institutions, and authors. Publications on lncRNA were retrieved from Web of Science (WoS) from 1975 to 2017. A total of 3879 papers were identified, and together they were cited 62967 times. The literature on lncRNA had been continuously growing since 2006, and the expansion might continue at a rapid pace until around 2021. China contributed the greatest proportion (63.47%) of lncRNA publications, and the USA ranked second in the number of publications (944 articles), while it had the highest citation frequency (43168 times) and H-index (97). The journal Oncotarget has the greatest number of publications on lncRNA research, with 305 papers. The keywords could be stratified into two clusters: cluster 1 (application) and cluster 2 (characteristics). Correspondingly, the “TNM stage,” “epithelial mesenchymal transition (EMT),” “cell apoptosis,” and “overall survival” are research hotspots since 2015. Thus, research on lncRNA showed a swiftly expanding trend, with China making the largest contribution. The focus on lncRNA is gradually shifting from “characteristics” to “application.”

scholarly journals Remote Sensing of Agricultural Greenhouses and Plastic-Mulched Farmland: An Analysis of Worldwide Research

2020 ◽  
Vol 12 (16) ◽  
pp. 2649
Author(s):  
Rafael Jiménez-Lao ◽  
Fernando J. Aguilar ◽  
Abderrahim Nemmaoui ◽  
Manuel A. Aguilar
Keyword(s):  
Biological Sciences ◽  
Remote Sensing ◽  
Temporal Dynamics ◽  
Research Topic ◽  
Relative Significance ◽  
Main Research ◽  
The Usa ◽  
The Subject ◽  
Spatio Temporal ◽  
Number Of Publications

The total area of plastic-covered crops of 3019 million hectares has been increasing steadily around the world, particularly in the form of crops maintained under plastic-covered greenhouses to control their environmental conditions and their growth, thereby increasing production. This work analyzes the worldwide research dynamics on remote sensing-based mapping of agricultural greenhouses and plastic-mulched crops throughout the 21st century. In this way, a bibliometric analysis was carried out on a total of 107 publications based on the Scopus database. Different aspects of these publications were studied, such as type of publication, characteristics, categories and journal/conference name, countries, authors, and keywords. The results showed that “articles” were the type of document mostly found, while the number of published documents has exponentially increased over the last four years, growing from only one document published in 2001 to 22 in 2019. The main Scopus categories relating to the topic analyzed were Earth and Planetary Sciences (53%), Computer Science (30%), and Agricultural and Biological Sciences (28%). The most productive journal in this field was “Remote Sensing”, with 22 documents published, while China, Italy, Spain, USA, and Turkey were the five countries with the most publications. Among the main research institutions belonging to these five most productive countries, there were eight institutions from China, four from Italy, one from Spain, two from Turkey, and one from the USA. In conclusion, the evolution of the number of publications on Remote Sensing of Agricultural Greenhouses and Plastic-Mulched Farmland found throughout the period 2000–2019 allows us to classify the subject studied as an emerging research topic that is attracting an increasing level of interest worldwide, although its relative significance is still very limited within the remote sensing discipline. However, the growing demand for information on the arrangement and spatio-temporal dynamics of this increasingly important model of intensive agriculture is likely to drive this line of research in the coming years.

Academic impact and rankings of American and Canadian neurosurgical departments as assessed using the h index

2010 ◽  
Vol 113 (3) ◽  
pp. 447-457 ◽  
Author(s):  
Francisco A. Ponce ◽  
Andres M. Lozano
Keyword(s):  
Web Of Science ◽  
Neurosurgical Department ◽  
Academic Impact ◽  
H Index ◽  
Residency Programs ◽  
The Past ◽  
Size Number ◽  
The Us ◽  
Number Of Publications ◽  
Number Of Citations

Object The authors undertook a study to estimate the relative academic impact of neurosurgical departments in Canada and the US using the h index, a measure of the number of citations received by a collection of work. Methods The study included 99 departments of neurosurgery with residency programs participating in the US National Residency Matching Program, and the 14 analogous Canadian programs. Three types of h indices were determined—one reflecting the cumulative work attributed to a neurosurgical department, h(c); one restricted to the cumulative work published over the past 10 years, h(10); and one limited to work published in 2 major North American neurosurgical journals, hNS(10). For an article to be included, attribution to a neurosurgical department had to appear in the address field in the database Thomson's ISI Web of Science. The three h indices were compared with each other, and their relation to other measures such as size of the department, degrees held by the faculty, and research funding was examined. Results Significant correlations were found between the citation indices and faculty size, number of publications and the types of degrees held by the faculty, and funding by the US NIH. Three types of authorship were identified: neurosurgeon, nonclinician researcher, and nonneurosurgeon clinical affiliate. The degree to which the latter 2 nonneurosurgeon categories contributed to the departmental h index varied among departments and can confound interdepartmental comparison. Limiting articles to those published in neurosurgical journals appeared to correct for the influence of nonneurosurgeons in departmental impact and reflect neurosurgeon-driven scholarship. Conclusions The h index may be useful in evaluating output across neurosurgery departments.

Roundtable: The Progress of Heterodox Economics

2000 ◽  
Vol 22 (2) ◽  
pp. 145-148 ◽  
Author(s):  
A. W. Bob Coats ◽  
Roger E. Backhouse ◽  
Sheila C. Dow ◽  
Daniel R. Fusfeld ◽  
Craufurd D. Goodwin ◽  
...  
Keyword(s):  
Status Quo ◽  
Central Theme ◽  
Heterodox Economics ◽  
The Past ◽  
Graduate Curricula ◽  
The Status ◽  
The Usa ◽  
The Subject ◽  
Methodological Approaches ◽  
High Degree

The central theme of this session is the changing relationship between “orthodox” (i.e., mainstream, neoclassical) and “heterodox” economics, especially in the USA, during the past two or three decades. Economics is such a large and heterogeneous discipline that it cannot be characterized both briefly and accurately. Alongside the growth of formalization and mathematization, and the high degree of uniformity in the undergraduate and graduate curricula and in the leading textbooks, there are also within the subject a number of dissenting or deviant doctrinal schools, rival methodological approaches, and innovative developments designed to remedy its defects and/or overcome its limitations. Moreover, many of the outspoken criticisms of the status quo, proposed remedies, and innovations, originate with or are endorsed by prominent economists with impeccable professional credentials. Indeed, in some cases their contributions threaten the discipline's foundations and can, therefore, be considered a species of “orthodox subversion.”

scholarly journals Doctoral dissertations in Chinese Interpreting Studies: A scientometric survey using topic modeling

2015 ◽  
Author(s):  
Ziyun Xu
Keyword(s):  
Topic Modeling ◽  
Latent Dirichlet Allocation ◽  
Cognitive Resources ◽  
The Past ◽  
Career Trajectories ◽  
Probabilistic Topic Modeling ◽  
The Subject ◽  
Number Of Publications ◽  
Doctoral Dissertations ◽  
In Cis

Despite being a relatively new discipline, Chinese Interpreting Studies (CIS) has witnessed tremendous growth in the number of publications and diversity of topics investigated over the past two decades. The number of doctoral dissertations produced has also increased rapidly since the late 1990s. As CIS continues to mature, it is important to evaluate its dominant topics, trends and institutions, as well as the career development of PhD graduates in the subject. In addition to traditional scientometric techniques, this study’s empirical objectivity is heightened by its use of Probabilistic Topic Modeling (PTM), which uses Latent Dirichlet Allocation (LDA) to analyze the topics covered in a near-exhaustive corpus of CIS dissertations. The analysis reveals that the topics of allocation of cognitive resources, deverbalization, and modeling the interpreting process attracted most attention from doctoral researchers. Additional analyses were used to track the research productivity of institutions and the career trajectories of PhD holders: one school was found to stand out, accounting for more than half of the total dissertations produced, and a PhD in CIS was found to be a highly useful asset for new professional interpreters.

Sign in / Sign up

Export Citation Format

Share Document