Ethnopharmacology, Phytochemistry and Pharmacology of Lens culinaris Medikus Seeds: An Update

2019 ◽  
Vol 15 (2) ◽  
pp. 121-129 ◽  
Author(s):  
Kripi Vohra ◽  
Vandana Garg ◽  
Harish Dureja
Keyword(s):  
Lens Culinaris ◽  
Skin Diseases ◽  
Therapeutic Potential ◽  
North India ◽  
Nutritional Properties ◽  
Balanced Diet ◽  
Gastrointestinal Problems ◽  
Cardiac Disorders ◽  
Taxonomical Classification ◽  
Insight Into

Background: The seeds of Lens culinaris Medikus belong to family Leguminosae and are commonly known as masoor pulses, Lentils, and Lens esculenta Moench. Objective: The present review provides an up-to-date information on the therapeutic potential of Lentil seeds including its synonyms, taxonomical classification, geographical distribution, cultivation, pharmacognosy, phytochemistry, ethnopharmacology and reported biological uses. Updated Information: Geographically, L. culinaris seeds are grown throughout North India. They are lens shaped, grayish brown in color with mucilaginous taste and characteristic odor. They are well known for their nutritional properties and are also considered as a vital part of a balanced diet. Besides their contribution to health due to the presence of essential macro- and micro- nutrients, they also contain various bioactive phytochemicals such as phenolic compounds, saponins, etc. which are responsible for exhibiting various pharmacological properties. The Lentil seeds are traditionally used to treat gastrointestinal problems such as dysentery, diarrhea, constipation, strangury, cardiac disorders, skin diseases, anemia, etc. Due to such an attractive ethnopharmacological profile, various studies have been conducted on Lentil seeds which recommend the use of Lentil seeds as antioxidant, antibacterial, antifungal antihyperlipidemic, etc. Conclusion: This would assist the researchers to get a better insight into Lentil seeds.

scholarly journals Albizia Adianthifolia: Botany, Medicinal Uses, Phytochemistry, and Pharmacological Properties

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Alfred Maroyi
Keyword(s):  
Sexually Transmitted Infections ◽  
Literature Search ◽  
Skin Diseases ◽  
Therapeutic Potential ◽  
Pharmacological Properties ◽  
Ethnoveterinary Medicine ◽  
Medicinal Uses ◽  
Sexually Transmitted ◽  
Gastrointestinal Problems ◽  
Albizia Adianthifolia

The bark, leaves, and roots ofAlbizia adianthifoliaare highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties ofA. adianthifoliaso as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties ofA. adianthifoliawas undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis. Preelectronic literature search of conference papers, scientific articles, books, book chapters, dissertations, and theses was carried out at the University library. Literature search revealed thatA. adianthifoliais used as purgative and herbal medicine for diabetes, eye problems, gastrointestinal problems, haemorrhoids, headache, neurodegenerative disorders, reproductive problems in women, respiratory problems, wounds and pain, skin diseases, sexually transmitted infections, and ethnoveterinary medicine. Phytochemical compounds identified from the species include apocarotenoids, chalcone, dipeptide, elliptosides, essential oils, fatty acids, flavonoids, histamine, imidazolyl carboxylic acid, prosapogenins, steroids, triterpene saponins, and triterpenoids. Pharmacological studies revealed thatA. adianthifoliaextracts and compounds have acetylcholinesterase enzyme inhibitory, anthelmintic, antiamoebic, antibacterial, antimycobacterial, anti-sexually transmitted infections, antifungal, anti-inflammatory, antioxidant, anxiolytic, and antidepressant, cognitive-enhancing, haemolytic, hypoglycemic and antihyperglycemic, immunomodulatory, and cytotoxicity activities. Detailed studies on the pharmacokinetics, in vivo,and clinical research involving compounds isolated fromA. adianthifoliaand extracts of the species are required.

scholarly journals Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

2020 ◽  
Vol 3 (4) ◽  
pp. 285-299
Author(s):  
Yang Huang ◽  
Hui Sun ◽  
Hai Yu ◽  
Shaowei Li ◽  
Qingbing Zheng ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Therapeutic Potential ◽  
Therapeutic Interventions ◽  
Viral Escape ◽  
Global Burden ◽  
Health Crisis ◽  
The Us ◽  
Preclinical And Clinical Studies ◽  
Insight Into ◽  
Rapid Emergence

Abstract The rapid emergence of Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent human health crisis. Many SARS-CoV-2 neutralizing antibodies (NAbs) were developed with efficient therapeutic potential. NAbs-based therapeutics against SARS-CoV-2 are being expedited to preclinical and clinical studies with two antibody drugs, LY3819253 (LY-CoV555) and REGN-COV2 (REGN10933 and REGN10987), approved by the US Food and Drug Administration for emergency use authorization for treating COVID-19. In this review, we provide a systemic overview of SARS-CoV-2 specific or cross-reactive NAbs and discuss their structures, functions and neutralization mechanisms. We provide insight into how these NAbs specific recognize the spike protein of SARS-CoV-2 or cross-react to other CoVs. We also summarize the challenges of NAbs therapeutics such as antibody-dependent enhancement and viral escape mutations. Such evidence is urgently needed to the development of antibody therapeutic interventions that are likely required to reduce the global burden of COVID-19.

scholarly journals Insight into the Secondary Metabolites of Geum urbanum L. and Geum rivale L. Seeds (Rosaceae)

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1219
Author(s):  
Marek Bunse ◽  
Peter Lorenz ◽  
Florian C. Stintzing ◽  
Dietmar R. Kammerer
Keyword(s):  
Fatty Acids ◽  
Phenolic Compounds ◽  
Unsaturated Fatty Acids ◽  
Asiatic Acid ◽  
Cosmetic Products ◽  
Nutritional Properties ◽  
First Time ◽  
Derivatives Of ◽  
Geum Urbanum ◽  
Insight Into

The present study aimed at the identification and quantitation of phenolic compounds, fatty acids, and further characteristic substances in the seeds of Geum urbanum L. and Geum rivale L. For this purpose, individual components of extracts recovered with MeOH, CH2Cl2, and by cold-pressing, respectively, were characterized by HPLC-DAD/ESI-MSn and GC/MS and compared with reference compounds. For both Geum species, phenolic compounds, such as flavonoids and gallic acid derivatives, and triterpenes, such as saponins and their aglycones, were detected. Surprisingly, both Geum species revealed the presence of derivatives of the triterpenoid aglycons asiatic acid and madecassic acid, which were characterized for the first time in the genus Geum. Furthermore, the fatty acids of both species were characterized by GC–MS after derivatization. Both species showed a promising fatty-acid profile in terms of nutritional properties because of high proportions of unsaturated fatty acids. Linoleic acid and linolenic acid were most abundant, among other compounds such as palmitic acid and stearic acid. In summary, the present study demonstrates the seeds of G. urbanum and G. rivale to be a valuable source of unsaturated fatty acids and bioactive phenolics, which might be exploited for nutritional and cosmetic products and for phytotherapeutic purposes.

scholarly journals Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Xiaoyu Pu ◽  
Siyang Ma ◽  
Yan Gao ◽  
Tiankai Xu ◽  
Pengyu Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Radiation Damage ◽  
Therapeutic Potential ◽  
Damage Model ◽  
Bioactive Substances ◽  
Radiation Induced ◽  
Insight Into

Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.

Focal adhesion kinase: Insight into its roles and therapeutic potential in oesophageal cancer

2021 ◽  
Vol 496 ◽  
pp. 93-103
Author(s):  
Yumeng Zhang ◽  
Shu Liu ◽  
Shu Zhou ◽  
Dandan Yu ◽  
Junjie Gu ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Oesophageal Cancer ◽  
Therapeutic Potential ◽  
Insight Into

scholarly journals Traditional Medicine in Syria: Folk Medicine in Aleppo Governorate

2011 ◽  
Vol 6 (1) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Amal Alachkar ◽  
Ahmad Jaddouh ◽  
Muhammad Salem Elsheikh ◽  
Anna Rita Bilia ◽  
Franco Francesco Vincieri
Keyword(s):  
Weight Loss ◽  
Liver Diseases ◽  
Scientific Literature ◽  
Skin Diseases ◽  
Folk Medicine ◽  
Gastrointestinal Disorders ◽  
Herbal Preparations ◽  
The North ◽  
Cardiac Disorders ◽  
The City

The use of Traditional Arabic Medicine (TAM) for various diseases has been popular but scarcely studied in Syria. In the present study, we carried out ethnobotanical and ethnopharmacological research on the plants traditionally used to cure various diseases in northern Syria. The information was collected from the city and villages of the Aleppo governorate “Mohaafazah” in the north of Syria, collecting data directly on the basis of a detailed survey of inhabitants and herbalists. In this survey, we found that hundreds of plant species are still in use in TAM for the treatment of various diseases. We selected the most common 100 species, used in the treatment of more than 25 diseases. Among these plants, 53 are used for treating gastrointestinal disorders, 38 for respiratory system diseases, including asthma, bronchitis and cough, 34 for skin diseases, 21 for diabetes, 17 for kidney and urinary disorders, 16 for cardiac disorders, 14 for infertility and sexual impotency, 13 for treating liver diseases, 13 for several types of cancer, 9 for enhancing breast milk excretion, 8 for weight loss, 5 for reducing cholesterol, and three for weight gain. Plants were collected and identified: scientific Latin names, local names, the used parts of the plant, the herbal preparations and the local medical uses are described. Scientific literature concerning the activity of the investigated species is also reported and discussed according to their traditional uses.

Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees

2017 ◽  
Vol 21 (4) ◽  
pp. 288-298 ◽  
Author(s):  
Sophia Colantonio ◽  
Jason K. Rivers
Keyword(s):  
First Nations ◽  
Skin Diseases ◽  
Therapeutic Potential ◽  
Black Spruce ◽  
Birch Bark ◽  
Current Application ◽  
Balsam Poplar ◽  
Red Cedar ◽  
Graft Donor ◽  
First Nations People

Introduction: First Nations people have a long history of working with medicinal plants used to treat skin diseases. The purpose was to assess the dermatologic therapeutic potential of western red cedar, white spruce, birch, balsam poplar, and black spruce. Methods: Based on expert recommendations, 5 trees were selected that were used in First Nations medicine for cutaneous healing and have potential and/or current application to dermatology today. We searched several databases up to June 12, 2014. Results: Western red cedar’s known active principal compound, β-thujaplicin, has been studied in atopic dermatitis. White spruce’s known active principal compound, 7-hydroxymatairesinol, has anti-inflammatory activity, while phase II clinical trials have been completed on a birch bark emulsion for the treatment of actinic keratoses, epidermolysis bullosa, and the healing of split thickness graft donor sites. Balsam poplar has been used clinically as an anti-aging remedy. Black spruce bark contains higher amounts of the anti-oxidant trans-resveratrol than red wine. Discussion: North American traditional medicine has identified important botanical agents that are potentially relevant to both cosmetic and medical dermatology. This study is limited by the lack of good quality evidence contributing to the review. The article is limited to 5 trees, a fraction of those used by First Nations with dermatological properties.

Sign in / Sign up

Export Citation Format

Share Document