Association of wheat Allergy and Coeliac Disease Through Pediatric and Adult Age: a Review of Literature

2020 ◽  
Vol 16 ◽  
Author(s):  
Ilenia Panasiti ◽  
Stefano Costa ◽  
Lucia Caminiti ◽  
Giuseppe Crisafulli ◽  
Giovanni Battista Pajno ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Autoimmune Disorder ◽  
Large Field ◽  
Wheat Allergy ◽  
Structural Protein ◽  
Adult Age ◽  
Distributed Components ◽  
Clinical Presentations ◽  
Wide Range ◽  
Allergic Disorders

: In recent years, the prevalence of large spectrum of gluten-related disorders (GRDs) has increased. Gluten is one of the most widely distributed components of food in both industrialized and developing countries. It is the main structural protein complex of wheat and its proteins are classified into albumins, salt-soluble globulins, and insoluble prolamins (gliadins and glutenins). Gluten is also included in other cereals, including rye and barley. GRDs can be classified in based on their pathogenic mechanism into: (i) Autoimmune disorders, (ii) Allergic disorders, (iii) No autoimmune not allergic disorders. Coeliac disease (CD) is an autoimmune disorder that occurs in genetically predisposed individuals who develop an immune reaction to gluten. It affects about 1% of people in most populations. The disease primarily interests the small intestine, but it is characterized by a wide range of clinical presentations, with both intestinal and extra-intestinal symptoms. Wheat allergy (WA) is an adverse immunologic reaction to wheat proteins. In the large field of WA a further classification can be made, distinguishing IgE-dependent WA, triggered by ingestion, inhalation or cutaneous and/or mucosal contact of wheat, and IgE-non-dependent WA. Its prevalence varies depending on the age and region, from 0.4% to 4%. Urticaria and/or angioedema, and anaphylaxis with or without exercise as a trigger, appear typically during childhood, asthma and/or rhinitis (Baker’s asthma) are more common during adulthood. Non-coeliac gluten sensitivity (NCGS) is a condition in which gluten ingestion leads to one or more of a variety of immunological, morphological or symptomatic (both gastrointestinal or extra gastrointestinal) manifestations in people in whom CD has been excluded. It is supposed it’s due to an activated innate immune response.

Primary amenorrhoea as a manifestation of coeliac disease

2021 ◽  
Vol 14 (1) ◽  
pp. e239260
Author(s):  
Sara Todo Bom Costa ◽  
Inês Salas Sanmarful
Keyword(s):  
Coeliac Disease ◽  
Clinical Manifestations ◽  
Autoimmune Disorder ◽  
Clinical History ◽  
Urogenital System ◽  
Primary Amenorrhoea ◽  
Secondary Sexual Characteristics ◽  
Wide Range ◽  
Sexual Characteristics ◽  
Detailed Clinical History

Coeliac disease is a systemic autoimmune disorder that has a wide range of clinical manifestations that include abdominal pain, diarrhoea, obstipation, weight loss, short stature and even primary amenorrhoea. It can be asymptomatic, which makes it an underdiagnosed disease. We present a case report of a 15-year-old girl who was referred to a paediatric consultation due to primary amenorrhoea. A detailed clinical history revealed poor weight gain. Physical examination showed that secondary sexual characteristics were present and there was a low body mass index. Ultrasonography images and laboratory tests revealed a normal urogenital system and an adequate gonadal function. Coeliac disease antibodies were positive and the diagnosis was confirmed through duodenal biopsy. The symptom resolved with a gluten-free diet. An approach to primary amenorrhoea should always include investigation of a systemic illness as it is a rare but treatable diagnosis.

Compression neuropathies of the forearm: anatomy, clinical features and management

2021 ◽  
pp. 1-10
Author(s):  
Alexander Scarborough ◽  
Robert J MacFarlane ◽  
Michail Klontzas ◽  
Rui Zhou ◽  
Mohammad Waseem
Keyword(s):  
Peripheral Nerve ◽  
Brachial Plexus ◽  
Upper Limb ◽  
Peripheral Nerves ◽  
Clinical Presentation ◽  
Permanent Damage ◽  
Peripheral Nerve Lesions ◽  
Clinical Presentations ◽  
Wide Range ◽  
Prompt Diagnosis

The upper limb consists of four major parts: a girdle formed by the clavicle and scapula, the arm, the forearm and the hand. Peripheral nerve lesions of the upper limb are divided into lesions of the brachial plexus or the nerves arising from it. Lesions of the nerves arising from the brachial plexus are further divided into upper (proximal) or lower (distal) lesions based on their location. Peripheral nerves in the forearm can be compressed in various locations and by a wide range of pathologies. A thorough understanding of the anatomy and clinical presentations of these compression neuropathies can lead to prompt diagnosis and management, preventing possible permanent damage. This article discusses the aetiology, anatomy, clinical presentation and surgical management of compressive neuropathies of the upper limb.

Df31 is a novel nuclear protein involved in chromatin structure in Drosophila melanogaster

2001 ◽  
Vol 114 (1) ◽  
pp. 37-47 ◽  
Author(s):  
G. Crevel ◽  
H. Huikeshoven ◽  
S. Cotterill
Keyword(s):  
Cell Types ◽  
Drosophila Embryo ◽  
Cell Fractionation ◽  
General Function ◽  
Structural Protein ◽  
Chromosomal Structure ◽  
Binding Characteristics ◽  
Wide Range ◽  
Cellular Dna

We originally isolated the Df31 protein from Drosophila embryo extracts as a factor which could decondense Xenopus sperm, by removing the sperm specific proteins and interacting with histones to facilitate their loading onto DNA. We now believe that this protein has a more general function in cellular DNA metabolism. The Df31 gene encodes a very hydrophilic protein with a predicted molecular mass of 18.5 kDa. Immunostaining showed that Df31 was present in a wide range of cell types throughout differentiation and in both dividing and non-dividing cells. In all cases the protein is present in large amounts, comparable with the level of nucleosomes. Injection of antisense oligonucleotides to lower the level of Df31 in embryos caused severe disruption of the nuclear structure. Large irregular clumps of DNA were formed, and in most cases the amount of DNA associated with each clump was more than that found in a normal nucleus. Immunofluorescence, cell fractionation, and formaldehyde cross-linking show that Df31 is associated with chromatin and that a significant fraction of it binds very tightly. It also shows the same binding characteristics when loaded onto chromatin in vitro. Chromatin fractionation shows that Df31 is tightly associated with nucleosomes, preferentially with oligonucleosomes. Despite this no differences were observed in the properties of nucleosomes loaded in the in vitro system in the presence and absence of Df31. These results suggest that Df31 has a role in chromosomal structure, most likely acting as a structural protein at levels of folding higher than that of nucleosomes.

scholarly journals FRATs: Searching for fast radio transient in real-time with LOFAR

2012 ◽  
Vol 8 (S291) ◽  
pp. 233-233
Author(s):  
Heino Falcke ◽  
Keyword(s):  
Time Scales ◽  
Search Space ◽  
Large Field ◽  
New Radio ◽  
Wide Range ◽  
Imaging Observation ◽  
Previous Decade ◽  
First Results ◽  
Single Radio ◽  
Radio Transients

AbstractLOFAR is an innovative new radio interferometer operating at low radio frequencies from 10 to 270 MHz. It combines a large field-of-view, high fractional bandwidth, rapid response, and a wide range of baselines from tens of meters to thousand kilometers. Its use of phased-array technology and its digital nature make LOFAR an extremely versatile instrument to search for transient radio phenomena on all time scales. Here we discuss in particular the search for fast radio transients (FRATs) at sub-second time scales. In fact, at these time scales the radio sky is rather dynamic due to coherent emission processes. Objects like pulsars, flaring stars, or planets like Jupiter are able to produce bright short flares. For pulsars, most previous detection strategies made use of the rotation of pulsars to detect them, using Fourier techniques, but it is also possible to detect pulsars and other objects through their single pulses. Such surveys have, e.g., led in the previous decade to the detection of Rapid Radio Transients (RRATS), but the unprobed search space is still rather large. LOFAR is now conducting a rather unique survey over the entire northern sky, searching for bright dispersed single radio pulses. This FRATs survey makes use of the LOFAR transient buffer boards (TBBs), which had initially been used to detect nanosecond radio pulses from cosmic rays. The TBBs store the radio data from each single receiver element of LOFAR and allow one to look back in time. A trigger system that runs parallel to normal imaging observation allows one to detect single pulses in an incoherent beam of all LOFAR stations, covering several tens to hundred square degrees at once. Once triggered, the data can be used to localize the pulse and to discriminate cosmic sources from terrestrial interference through 3D localization. The system has been successfully tested with known pulsars and first results of the ongoing survey will be presented.

scholarly journals Host-Directed Therapies for Cutaneous Leishmaniasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Fernanda O. Novais ◽  
Camila Farias Amorim ◽  
Phillip Scott
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Inflammatory Diseases ◽  
Wide Spectrum ◽  
Substantial Evidence ◽  
Novel Approach ◽  
Clinical Presentations ◽  
Wide Range ◽  
Parasite Replication ◽  
Inflammatory Drugs ◽  
Improve Clinical Outcome

Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude of the disease can result from an uncontrolled inflammatory response rather than unrestrained parasite replication. In these patients, host-directed therapies offer a novel approach to improve clinical outcome. Importantly, there are many anti-inflammatory drugs with known safety and efficacy profiles that are currently used for other inflammatory diseases and are readily available to be used for leishmaniasis. However, since leishmaniasis consists of a wide range of clinical entities, mediated by a diverse group of leishmanial species, host-directed therapies will need to be tailored for specific types of leishmaniasis. There is now substantial evidence that host-directed therapies are likely to be beneficial beyond autoimmune diseases and cancer and thus should be an important component in the armamentarium to modulate the severity of cutaneous leishmaniasis.

scholarly journals Shadow monochromatic backlighting: Large-field high resolution X-ray shadowgraphy with improved spectral tunability

2001 ◽  
Vol 19 (2) ◽  
pp. 285-293 ◽  
Author(s):  
T.A. PIKUZ ◽  
A. YA. FAENOV ◽  
M. FRAENKEL ◽  
A. ZIGLER ◽  
F. FLORA ◽  
...  
Keyword(s):  
High Resolution ◽  
High Spatial Resolution ◽  
Field Of View ◽  
Large Field ◽  
X Ray ◽  
Traditional Scheme ◽  
Wide Range ◽  
Wide Wavelength Range ◽  
Bent Crystals ◽  
First Time

The shadow monochromatic backlighting (SMB) scheme, a modification of the well-known soft X-ray monochromatic backlighting scheme, is proposed. It is based on a spherical crystal as the dispersive element and extends the traditional scheme by allowing one to work with a wide range of Bragg angles and thus in a wide spectral range. The advantages of the new scheme are demonstrated experimentally and supported numerically by ray-tracing simulations. In the experiments, the X-ray backlighter source is a laser-produced plasma, created by the interaction of an ultrashort pulse, Ti:Sapphire laser (120 fs, 3–5 mJ, 1016 W/cm2 on target) or a short wavelength XeCl laser (10 ns, 1–2 J, 1013 W/cm2 on target) with various solid targets (Dy, Ni + Cr, BaF2). In both experiments, the X-ray sources are well localized spatially (∼20 μm) and are spectrally tunable in a relatively wide wavelength range (λ = 8–15 Å). High quality monochromatic (δλ/λ ∼ 10−5–10−3) images with high spatial resolution (up to ∼4 μm) over a large field of view (a few square millimeters) were obtained. Utilization of spherically bent crystals to obtain high-resolution, large field, monochromatic images in a wide range of Bragg angles (35° < Θ < 90°) is demonstrated for the first time.

Cross-sectional analysis: clinical presentation of children with persistently low ALP levels

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Oliver Semler ◽  
Carl-Joachim Partsch ◽  
Anibh Martin Das ◽  
Andreas Prechtl ◽  
Corinna Grasemann
Keyword(s):  
Motor Development ◽  
Serum Alkaline Phosphatase ◽  
Body Height ◽  
Patient Records ◽  
Cross Sectional ◽  
Clinical Presentations ◽  
Wide Range ◽  
Z Scores ◽  
Sectional Analysis ◽  
Specific Symptoms

Abstract Objectives Low activity of serum alkaline phosphatase (ALP) is a hallmark of hypophosphatasia (HPP), but low readings of ALP are not always recognized in clinical routine. Understanding the clinical presentations associated with low ALP may contribute to a timelier diagnosis of HPP. Methods Data from paediatric patients with low ALP, excluding patients in intensive care and with oncological/haematological disorders, were analysed. Most recent ALP values, previous diagnoses, medication and relevant symptoms were extracted from patient records at nine specialised centres and analysed descriptively. A relationship between body height and ALP values was scrutinised by linear regression. Results Of 370 children, 15 (4.1%) had a diagnosis of HPP. In the subgroup without a diagnosis of HPP, 241 (67.9%) out of 355 patients had one or more medical conditions known to be associated with low serum ALP. Of those, hypothyroidism, malnutrition and steroid administration were most frequent. Characteristic symptoms, particularly, short stature, muscle weakness and delay of motor development were more frequent and ALP values were lower in patients with documented HPP diagnosis compared to patients without diagnosis of HPP (Ø z-scores: −2.52) (interquartile range [IQR] = 0.20) vs. −1.96 (IQR = 0.87). A weak positive linear relationship between z-scores of ALP and body height was identified (p<0.001). Conclusions This analysis of paediatric patient records elucidates a wide range of disorders associated with low ALP activity. In case of additional specific symptoms, HPP should always be considered as a differential diagnosis.

Concomitant Burkholderiapseudomallei and Staphylococcus aureus Infection in a chronic kidney disease patient: A Case Report and Literature Review

2021 ◽  
Vol 20 (2) ◽  
pp. 456-458
Author(s):  
Norjihan Abdul Hamid ◽  
Mohd Zulfakar Mazlan ◽  
Zeti Norfidiyati Salmuna
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Patient ◽  
Medical Science ◽  
Disease Patient ◽  
Asymptomatic Infection ◽  
Clinical Presentations ◽  
Wide Range ◽  
Diagnostic Microbiology ◽  
And Staphylococcus Aureus

Melioidosis can happen in humans and animals. It has a wide range of clinical presentations that include asymptomatic infection, ulcers or abscesses of the skin, pneumonia, and multiple internal organ abscesses that may lead to fulminant septic shock. The organism presence in soil and surface of the water. We present a case of a non-diabetic chronic kidney disease patient presented with multiple carbuncles and respiratory melioidosis in which we are able to isolate B. pseudomallei after prolonging the plate incubation for 48-hours. We also suggested available tests in most diagnostic microbiology laboratory for identification of the organism. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.456-458

Pericardial disease

2010 ◽  
pp. 2790-2796
Author(s):  
Michael Henein
Keyword(s):  
Myocardial Infarction ◽  
Viral Infection ◽  
Pericardial Disease ◽  
Clinical Presentations ◽  
Wide Range

The most common clinical presentations of pericardial disease are pericarditis, effusion, tamponade, and constriction. The most common proven causes are viral infection or as a complication of myocardial infarction, but a wide range of other conditions including autoimmune rheumatic disorders and tuberculosis need to be considered. No firm cause is established in many cases, which are regarded as ‘idiopathic’ (presumed viral)....

scholarly journals Proximal Myopathy due to m.5835G>A Mutation in Mitochondrial MT-TY Gene

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
C. Simoncini ◽  
V. Montano ◽  
G. Alì ◽  
R. Costa ◽  
G. Siciliano ◽  
...  
Keyword(s):  
Clinical Phenotype ◽  
Gene Mutations ◽  
Mitochondrial Diseases ◽  
Leigh Syndrome ◽  
Phenotype Correlation ◽  
Mitochondrial Trna ◽  
Gene Coding ◽  
Clinical Presentations ◽  
Wide Range ◽  
Proximal Myopathy

Mitochondrial (mt) tRNA (MTT) gene mutations are an important cause of mitochondrial diseases and are associated with a wide range of clinical presentations. Most mutations fall into three mitochondrial tRNAs (tRNAIle, tRNALeu (UUR), and tRNALys) and are responsible for half of the mitochondrial diseasees associated with tRNA mutation, with MERRF, MELAS, mitochondrial myopathy, and Leigh syndrome being the most frequent phenotypes. More than 100 tRNA pathogenetic mutations are described, showing little correlation between the observed clinical phenotype and a specific mitochondrial tRNA mutation. Furthermore different mutation can manifest with similar clinical phenotypes, making the genotype-phenotype correlation difficult. Here we report the case of an Italian 53-year-old woman presenting with a proximal myopathy and the m.5835G>A mutation in MT-TY gene coding for the mitochondrial tRNA Tyrosine gene.

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