The Roles of β-Carotene in Cardiomyocytes

Author(s):  
Inez Felia Yusuf ◽  
Ronny Lesmana ◽  
Hanna Goenawan ◽  
Achadiyani ◽  
Astrid Feinisa Khairani ◽  
...  

: Cardiovascular disease is ranked one as the majority cause of mortality globally, approximately 17.9 million lives each year. There are risk factors of cardiovascular disease such as: behavioural factors, like tobacco use, unbalance diets, alcohol misuse and lack of physical activities, and other underlying health-related factors, like hypertension, dyslipidemia and hyperglycemia which are connected to pathophysiology determinants, such as ageing, and poor overall quality of life. One of the main strategies to prevent those risk is by encouraging healthy life style, including consuming natural supplement as one of a safe way to support health. Recently, β-carotene has gained some attention to the researchers because of its natural antioxidant properties as it is found in fruits and vegetables compounds. In this article we review the effects of β-carotene as an antioxidants that counteract free radicals, as well as cytoprotective agents that have positive benefits as anti-inflammatory for preventing several age-related disease especially in heart muscle cell health.

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 4
Author(s):  
I Re Heo ◽  
Ho Cheol Kim ◽  
Tae Hoon Kim

Background and Objectives: preserved ratio impaired spirometry (PRISm) is a common spirometric pattern that causes respiratory symptoms, systemic inflammation, and mortality. However, its impact on health-related quality of life (HRQOL) and its associated factors remain unclear. We aimed to identify these HRQOL-related factors and investigate the differences in HROOL between persons with PRISm and those with normal lung function. Materials and Methods: we reviewed the Korea National Health and Nutrition Examination Survey data from 2008 to 2013 to evaluate the HRQOL of persons with PRISm, as measured while using the Euro Quality of Life-5D (EQ-5D) and identify any influencing factors. PRISm was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1) <80% predicted and FEV1 to forced vital capacity (FVC) ratio (FEV1/FVC) ≥0.7. Individuals with FEV1 ≥80% predicted and FEV1/FVC ≥0.7 were considered as Controls. Results: of the 27,824 participants over the age of 40 years, 1875 had PRISm. The age- and sex-adjusted EQ-5D index was lower in the PRISm group than in the control group (PRISm, 0.930; control, 0.941; p = 0.005). The participants with PRISm showed a significantly higher prevalence of hypertension (p < 0.001), diabetes (p < 0.001), obesity (p < 0.001), low physical activity (p = 0.001), ever-smoker (p < 0.001), and low income (p = 0.034) than those in the control group. In participants with PRISm, lower EQ-5D index scores were independently associated with old age (p = 0.002), low income (p < 0.001), low education level (p < 0.001), and no economic activity (p < 0.001). Three out of five EQ-5D dimensions (mobility, self-care, and usual activity) indicated a higher proportion of dissatisfied participants in the PRISm group than the control group. Conclusions: the participants with PRISm were identified to have poor HRQOL when compared to those without PRISm. Old age and low socioeconomic status play important roles in HRQOL deterioration in patients with PRISm. By analyzing risk factors that are associated with poor HRQOL, early detection and intervention of PRISm can be done in order to preserve patients’ quality of life.


2015 ◽  
Vol 61 (3) ◽  
pp. 523-528 ◽  
Author(s):  
Eun-Jin Jang ◽  
Eun-Kyong Kim ◽  
Kyeong-Soo Lee ◽  
Hee-Kyung Lee ◽  
Youn-Hee Choi ◽  
...  

2013 ◽  
Vol 27 (2) ◽  
pp. NP681-NP690 ◽  
Author(s):  
In Cheol Hwang ◽  
Sang Min Park ◽  
Young Ho Yun ◽  
Kyoung Kon Kim

Author(s):  
Pratima Kaushik

Ageing is a universal phenomenon that has not only social but also economic, political, and health-related implications. With the advancement in healthcare facilities and better availability of health services, the geriatric population is gradually increasing. But, this group is at an increased risk of developing both physical and psychological co-morbidities due to age-related factors and changes in the social circumstances. The present chapter proposes the concept and issues related to co-morbidity in the geriatric population. After discussing the issues and consequences of medical and psychiatric co-morbidities, their effective treatment regime and care/management in relation to the geriatric population are addressed.


2019 ◽  
Vol 141 (1) ◽  
pp. 28-36
Author(s):  
Hyun Su Kim ◽  
Yoonjung Kim ◽  
Haejin Kwon

Aims: The purpose of this study was to investigate the health-related quality of life (HRQOL) of patients with cardiovascular disease and its relationship to hospital readmission. Methods: The cross-sectional study used data from 1037 adults aged ⩾19 years diagnosed with myocardial infarction or angina pectoris. Raw data were obtained from the fourth to sixth Korea National Health and Nutrition Examination Survey (2007–2014). Results: Readmission was found to be associated with age, living status, education level, unemployment, individual income level, stroke, osteoarthritis, diabetes, depression, low stress level, walking days per week, and activity limitations due to cardiovascular disease. Conclusion: In summary, readmission was related to HRQOL among patients with myocardial infarction. Interventions that consider efforts to reduce readmission through improved diagnosis and development of systematic management of cardiovascular disease symptoms are required.


PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171320 ◽  
Author(s):  
Alonso Montiel-Luque ◽  
Antonio Jesús Núñez-Montenegro ◽  
Esther Martín-Aurioles ◽  
Jose Carlos Canca-Sánchez ◽  
Maria Carmen Toro-Toro ◽  
...  

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