The Effect of Vitamin D Supplementation on Clinical Outcomes of Asthmatic Children with Vitamin D Insufficiency

2020 ◽  
Vol 20 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Rasoul N. Kalmarzi ◽  
Sivan Ahmadi ◽  
Ramesh Rahehagh ◽  
Asadollah Fathallahpour ◽  
Behzad Khalafi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Outcomes ◽  
Pulmonary Function Tests ◽  
Clinical Status ◽  
Serum Levels ◽  
Asthma Severity ◽  
Vitamin D Insufficiency ◽  
Forced Expiratory Volume ◽  
Enzyme Linked Immunosorbent Assay ◽  
Asthmatic Children

Background: The extensive impacts of vitamin D on the immune system has gathered the attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on clinical outcomes in asthmatic children with vitamin D insufficiency. Materials & Methods: This before-after interventional study was conducted on all asthmatic children who attended the Be'sat Hospital, Iran. Serum levels of 25(OH)D, asthma severity and pulmonary function tests before and after therapeutic prescription of vitamin D were evaluated. Serum levels of 25(OH)D were measured by enzyme-linked immunosorbent assay. Results: The mean age of the samples was 10.69±9.78 years and 39 subjects (57.4%) were male. The primary mean level of serum 25(OH)D (18.21±8.22, ng/mL) has significantly (p<0.05) increased after treatment (35.45±9.35, ng/mL). Also, asthma severity, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC indicators were significantly (p<0.05) increased after treatment. Conclusion: We can conclude that therapeutic prescription of vitamin D is very effective in improving the clinical status of asthmatic children.

The Effect of Adrenergic β2 Receptor Thr164Ile Gene Polymorphism on Asthma Risk, Severity and Response to Β2 Agonists in Egyptian Children

2020 ◽  
Vol 29 (3) ◽  
pp. 81-86
Author(s):  
Rania M. Amer ◽  
Samir Zamzam ◽  
Khalid M. Salah ◽  
Rana A. Waheed ◽  
Enas A. Tantawy
Keyword(s):  
Gene Polymorphism ◽  
Pulmonary Function Tests ◽  
Serum Levels ◽  
Asthma Severity ◽  
Amplification Refractory Mutation System ◽  
Asthmatic Children ◽  
Asthma Risk ◽  
Egyptian Children ◽  
Mutation System ◽  
Β2 Agonist

Background: Asthma is a global health problem affecting millions of adults and children. Pathogenesis of asthma is multifactorial and the genetic component is of particular importance. Objectives: To assess the role of ADRB2 Thr164Ile gene polymorphism in asthma risk, severity and response to β2 agonist therapy in Egyptian children. Methodology: The study enrolled 50 asthmatic and 50 control children. Pulmonary function tests and serum levels of IgE of asthmatic children were measured. The Thr164Ile genotypes were detected for all study subjects by Amplification Refractory Mutation System- Polymerase Chain Reaction (ARMS-PCR). Results: Serum IgE levels were significantly higher on comparing mild to moderate and severe cases (P=0.002& 0.02, respectively). The Ile/Ile genotype of Thr164Ile SNP was significantly present in asthmatic subjects (P=0.039). The Thr164Ile SNP was associated with lowered response to β2 agonist inhalation (P<0.001) but there was no association between the studied SNP and asthma severity. Conclusion: The Thr164Ile SNP can be linked to asthma risk and lowered response to β2 agonist treatment but not to asthma severity in asthmatic children.

scholarly journals Evaluation of the Relationship Between Serum levels of Zinc, Vitamin B12, Vitamin D and Clinical outcomes in Patients with COVID‐19

2021 ◽  
Author(s):  
Habibesadat Shakeri ◽  
Amir Azimian ◽  
Hamed Ghasemzadeh‐Moghaddam ◽  
Mohammadreza Safdari ◽  
Mehdi Haresabadi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Clinical Outcomes ◽  
Serum Levels ◽  
The Relationship

scholarly journals HUBUNGAN KADAR VITAMIN D SERUM DENGAN KUALITAS HIDUP PADA PASIEN EPILEPSI

2018 ◽  
Vol 35 (4) ◽  
Author(s):  
Edith Fitriyana Girsang ◽  
Aris Catur Bintoro ◽  
Dwi Pudjonarko
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Immunosorbent Assay ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Epilepsy Patient ◽  
Vitamin D Levels ◽  
Spearman Test

  THE CORRELATION BETWEEN VITAMIN D SERUM LEVELS WITH QUALITY OF LIFE IN EPILEPSY PATIENTABSTRACTIntroduction: Epilepsy affects overall health status and decreases the life quality of epilepsy patient. Seizure frequency, seizure type, daily activity disorder, depression and anxiety also affect the quality of life epilepsy patient. Vitamin D is considered as a neurosteroid modulator of nerve excitability and seizure susceptibility. Studies of vitamin D direct role in epilepsy are limited. Nevertheless, some studies show the role of vitamin D as an anticonvulsant that reduces the incidence of seizures.Aim: To determine the correlation between vitamin D serum levels with quality of life in epilepsy patient.Method: A cross sectional observational study on people with epilepsy in neurology clinic at Dr. Soeselo Hospital, Slawi, Dr Kariadi Hospital, and Tugurejo Hospital, Semarang in July 2017-January 2018. The quality of life was assessed with Quality of Life in Epilepsy 31 (QOLIE-31). Vitamin D serum levels measured using enzyme-linked immunosorbent assay (ELISA) method. Data were analyzed using Spearman test. Results were considered significant if p<0.05.Results: There was no correlation between vitamin D serum levels with quality of life in epilepsy. There was significant correlation between anxiety with quality of life and there were difference between age group with quality of life. Discussion: There was no correlation between serum vitamin D levels and  quality of life in epilepsy patient.Keywords: Epilepsy,quality of life epilepsy, vitamin DABSTRAKPendahuluan: Epilepsi mempengaruhi status kesehatan secara keseluruhan dan menurunkan kualitas hidup pasien epilepsi. Frekuensi bangkitan, tipe bangkitan, gangguan aktivitas harian, depresi dan ansietas, juga memengaruhi kualitas hidup pasien epilepsi. Vitamin D dianggap neurosteroid, sebagai modulator eksitabilitas saraf dan kerentanan bangkitan. Bukti langsung untuk peran vitamin D dalam epilepsi terbatas. Namun beberapa penelitian menunjukkan peran vitamin D sebagai antikonvulsan yang mengurangi kejadian bangkitan.Tujuan: Mengetahui hubungan kadar vitamin D serum dengan kualitas hidup pada pasien epilepsi.Metode: Penelitian potong lintang terhadap pasien epilepsi yang berobat ke Poliklinik Saraf RSUD Dr. Soeselo, Slawi, RSUP Dr. Kariadi, Semarang, dan RS Tugurejo, Semarang pada bulan Juli 2017-Januari 2018. Kualitas hidup dinilai menggunakan kuesioner Quality of Life in Epilepsy 31 (QOLIE-31), pengukuran kadar vitamin D serum menggunakan metode enzyme-linked immunosorbent assay (ELISA). Data dianalisis dengan uji Spearman, hasil dianggap bermakna jika p<0,05.Hasil: Tidak didapatkan hubungan antara kadar vitamin D serum dengan kualitas hidup serta domainnya pada pasien epilepsi. Didapatkan hubungan yang bermakna antara ansietas dengan kualitas hidup dan antara kelompok usia dengan kualitas hidup.Diskusi: Tidak terdapat hubungan bermakna antara kadar vitamin D serum dengan kualitas hidup pada pasien epilepsi.Kata kunci: Epilepsi, kualitas hidup, vitamin D

scholarly journals Association of admission serum levels of vitamin D, calcium, Phosphate, magnesium and parathormone with clinical outcomes in neurosurgical ICU patients

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Seyed Hossein Ardehali ◽  
Salman Dehghan ◽  
Ahmad Reza Baghestani ◽  
Aynaz Velayati ◽  
Zahra Vahdat Shariatpanahi
Keyword(s):  
Vitamin D ◽  
Calcium Phosphate ◽  
Clinical Outcomes ◽  
Serum Levels ◽  
Icu Patients ◽  
Phosphate Magnesium

Cardiovascular Fitness in Children With Asthma Correlates With Psychologic Functioning of the Child

PEDIATRICS ◽  
1989 ◽  
Vol 84 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Robert C. Strunk ◽  
David A. Mrazek ◽  
Jolene T. Fukuhara ◽  
Jim Masterson ◽  
Susan K. Ludwick ◽  
...  
Keyword(s):  
Global Assessment ◽  
Child Behavior Checklist ◽  
Asthma Severity ◽  
Forced Expiratory Volume ◽  
Cardiovascular Fitness ◽  
Assessment Scale ◽  
Bicycle Ergometry ◽  
Global Assessment Scale ◽  
Asthmatic Children ◽  
Children With Asthma

Abnormalities in fitness in asthmatic children are assumed to derive from illness severity. We studied 90 children with moderately severe to severe but stable asthma for (1) fitness levels using bicycle ergometry, (2) measures of asthma severity, (3) clinician's impression of child (Child Global Assessment Scale), and (4) mother's rating of child's behavior (Child Behavior Checklist). Fitness values ranged from 15% to 120% of normal values for age, sex, and body surface area: 48% were abnormal (&lt;2 SD below mean) and 5% were borderline (1 to 2 SD below mean). Associations between levels of fitness and medical and psychologic criteria were tested using regression analyses. Of the 11 medical variables used to define the severity of asthma, recent exacerbation of disease, forced expiratory volume in 1 second, and specific airway conductance together accounted for 8.1% of the variability in the workload ratios (ie, R2 = 0.081). The importance of the psychologic factors in determining the variability in the workload ratios was tested after the importance of the medical variables had been considered: Child Global Assessment Scale accounted for a significant amount of variability, improving the R2 to 0.180 (an increase to 0.100, P = .003). These data suggest that, within the spectrum of disease presented by the patients in this study, adjustment to the disease is at least as important as severity of disease in determining fitness.

scholarly journals Serum vitamin D status and biochemical parameters of asthmatic children in Sokoto Metropolis, North-western Nigeria

2019 ◽  
Vol 11 (2) ◽  
pp. 64-70
Author(s):  
Mohammed Haruna Yeldu ◽  
Mohammed Danjuma ◽  
Mainasara Abdullahi Sulaiman ◽  
Jiya Nma Muhammad ◽  
Garba Balkisu Illah ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Immunoglobulin E ◽  
Airflow Obstruction ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Asthma Severity ◽  
Vitamin D Status ◽  
Asthmatic Children ◽  
Serum Vitamin D

Background: Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms. It is characterized by the occurrence of bronchial hyper responsiveness, airflow obstruction and an underlying inflammation. Several studies have proposed the association of vitamin D with increased incidence of asthma symptoms. Aims and Objectives: This study aimed at determining the serum vitamin D status and biochemical parameters among asthmatic children in Sokoto-Nigeria. Materials and Methods: The study population consisted of 120 subjects including 80 asthmatic children and 40 age-and sex-matched apparently healthy controls from two tertiary Hospitals in Sokoto Metropolis. Serum vitamin D, calcium, parathyroid hormone (PTH), immunoglobulin E (IgE) and magnesium were measured using standard techniques. Results: Mean serum vitamin D and magnesium were significantly (p ˂ 0.05) lower, while serum PTH and IgE were significantly higher (p˂0.001) in asthmatic children than in controls. Vitamin D insufficiency was found to be prevalent among the asthmatic children. There was no significant relationship between the low level of vitamin D and asthma severity. Conclusion: This study observed that, hypovitaminosis D and hypomagnesaemia occurred among asthmatic children, and asthma was more prone in the younger children than in their older counterpart. It is recommended that in order to avoid or limit the rate of children having asthmatic episodes, vitamin D and magnesium supplements should be used in the management of asthmatic children.

scholarly journals Relationship Between Advanced Glycation End Products and Their Receptor, sRAGE and Cardiovascular Diseases Risk in Adults with T2D and Vitamin D Insufficiency/deficiency (FS12-08-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Justina Owusu ◽  
Fatma Huffman ◽  
Juan Liuzzi ◽  
Tan Li ◽  
Vijaya Narayanan
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Advanced Glycation End Products ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
The Relationship

Abstract Objectives Advanced Glycation End Products, (AGEs) and their soluble receptor (sRAGE) have been implicated in the development of complications and mortality among individuals with type 2 diabetes (T2D). There is limited information on the relationship between AGEs and sRAGE and risk of cardiovascular diseases (CVD) in minority groups, who have a higher burden of T2D. The relationship between AGEs and sRAGE and CVD risks in adults with T2D and vitamin D insufficiency/deficiency was assessed in a minority population. Methods A cross sectional study of Hispanics and African Americans with T2D (n = 64, 41 women and 23 men, mean age = 54 ± 9) recruited from two clinics in Miami Dade. Systolic (SBP) and diastolic blood pressure (DBP), weight and height measurement and serum lipid profile were completed. ELISA kits were used to assess serum levels of AGEs (Biotang Inc/TSZ Elisa, Waltham, MA, USA) and sRAGE (Biotang Inc/TSZ Elisa, Waltham, MA, USA). Multiple linear regression was used to assess association between AGEs, sRAGE and CVD risks. Results A negative and significant association between AGEs and high-density lipoprotein cholesterol (HDL-C)(B = −0.551, P = 0.029) was found. The relationship between AGEs and HDL-C persisted after adjusting for covariates (P < 0.05). sRAGE was significantly associated with SBP (B = 0.015, P = 0.025) and diastolic blood pressure DBP (B = 0.0271, P = 0.037). Results loss significance when association between sRAGE and DBP and SBP were adjusted for covariates such as age, body mass index (BMI), smoking and alcohol intake. Conclusions Our results suggest that AGEs and sRAGE are related to markers of cardiovascular risk such as HDL-C, SBP and DBP in the study population of African Americans and Hispanics with T2D and vitamin D insufficiency/deficiency. Measures on reducing serum levels of AGEs and improving sRAGE and vitamin D are warranted in these populations for risk reduction of CVD. Funding Sources Partial funding for this research was provided through an NIH/NIDDK sponsored grant.

Vitamin D insufficiency together with high serum levels of vitamin A increases the risk for osteoporosis in postmenopausal women

2013 ◽  
Vol 8 (1-2) ◽  
Author(s):  
J. M. Mata-Granados ◽  
J. R. Cuenca-Acevedo ◽  
M. D. Luque de Castro ◽  
M. F. Holick ◽  
J. M. Quesada-Gómez
Keyword(s):  
Vitamin D ◽  
Vitamin A ◽  
Postmenopausal Women ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
High Serum

scholarly journals Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Maryam Moghaddassi ◽  
Marzieh Pazoki ◽  
Ahmad Salimzadeh ◽  
Tayeb Ramim ◽  
Zahra Alipour
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Pulmonary Function ◽  
Vitamin D Deficiency ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Serum Levels ◽  
Forced Expiratory Volume ◽  
Healthy Individuals ◽  
25 Hydroxy Vitamin D

Background. Besides the extensive regulatory role in growing number of biologic processes, vitamin D has been recently considered essential for lungs function as well as protective against exacerbation of chronic obstructive pulmonary diseases. We assessed the correlation between vitamin D serum levels with pulmonary function in healthy individuals. Methods. In a cross-sectional study, healthy volunteer (n=92) participants underwent the following laboratory procedures: a blood test, a 24-hour urine collection test, and the serum level of 25-hydroxy vitamin D before undergoing spirometry. Linear correlation coefficient was calculated to detect the association between serum level of 25-hydroxy vitamin D and pulmonary volumes. Results. The mean age of participants was 39.95±9.98 years. 48% of participants showed different levels of 25-hydroxy vitamin D deficiency. We recognized a consistent direct positive correlation between serum levels of 25-hydroxy vitamin D and lung function volumes. The coefficient for forced vital capacity, forced expiratory volume in 1 second, forced expiratory flow 25–75%, and forced expiratory volume in 1 second/forced vital capacity ratio were 0.610, 0.509, 0.454, and 0.551, respectively. Conclusions. Our findings suggest correlation between higher serum levels of 25-hydroxy vitamin D and improved pulmonary function. Accordingly, supplemental vitamin D might significantly improve treatment response.

Insulin resistance and lung function in obese asthmatic pre-pubertal children

2018 ◽  
Vol 31 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Paola Di Filippo ◽  
Alessandra Scaparrotta ◽  
Daniele Rapino ◽  
Tommaso de Giorgis ◽  
Marianna Immacolata Petrosino ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lung Function ◽  
Statistical Significance ◽  
Serum Levels ◽  
Forced Expiratory Volume ◽  
Normal Weight ◽  
Model Assessment ◽  
Obese Children ◽  
Asthmatic Children ◽  
Insulin Resistant

AbstractBackground:Recent findings have supposed that the underlying association between the increased prevalence of both asthma and obesity may be insulin resistance (IR).Methods:Insulin and glucose serum levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) for IR in 98 pre-pubertal children. Lung function and allergy status evaluation were performed. The study population was divided into four groups: (1) obese asthmatic children (ObA); (2) normal-weight asthmatic children (NwA); (3) normal-weight non-asthmatic children (Nw) and (4) obese non-asthmatic children (Ob).Results:Forced expiratory volume in 1 s (FEV1) was slightly lower in obese subjects compared with normal-weight subjects and forced vital capacity (FVC) appeared lower in asthmatics, whereas between non-asthmatics subjects, it was lower in the obese group than in the normal-weight one. The post hoc analysis revealed a statistically significant reduction in FEV1, peak expiratory flow (PEF), forced expiratory flows (FEF) between 50% and 25% of the FVC (FEF50and FEF25) between ObA and Nw and in FEV1, FVC, PEF, FEF50and FEF25between NwA and Nw, but no statistically significant differences of lung function parameters were observed between ObA and NwA. We found an inverse relationship between HOMA-IR and all spirometric parameters, although without any statistical significance. We also observed a significantly lower FVC in insulin-resistant children (HOMA-IR>95th percentile) (p=0.03).Conclusions:This study suggests that lung function could be early altered in obese children, already in pre-pubertal age. Although IR should not manifest its effects on lungs in pre-pubertal obese children, the prevention or treatment of obesity in the pre-pubertal period may prevent definitive negative effects on lungs.

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