Theranostic Nanoparticles for Pancreatic Cancer Treatment

2020 ◽  
Vol 20 ◽  
Author(s):  
LR Jaidev ◽  
Laxmi Shanthi Chede ◽  
Hemanth Kumar Kandikattu
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Mortality Rate ◽  
Cancer Treatment ◽  
High Mortality ◽  
Therapeutic Agents ◽  
Present Review ◽  
Survival Period ◽  
New Novel ◽  
Theranostic Nanoparticles

: Pancreatic cancer is one of the low vascular permeable tumors with a high mortality rate. The five-year survival period is ~5%. The field of drug delivery is at its pace in developing unique drug delivery carriers to treat high mortality rate cancers such as pancreatic cancer. Theranostic nanoparticles are the new novel delivery carriers where the carrier is loaded with both diagnostic and therapeutic agents. The present review discusses various therapeutic and theranostic nanocarriers for pancreatic cancer.

scholarly journals Advanced pancreatic cancer: The standard of care and new opportunities

2018 ◽  
Author(s):  
Amrallah A. Mohammad
Keyword(s):  
Pancreatic Cancer ◽  
Mortality Rate ◽  
Cancer Treatment ◽  
Molecular Analysis ◽  
Therapeutic Approach ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Standard Of Care

Presentation of pancreatic cancer is localized, locally advanced or metastatic. With the later represented the main bulk (more than 80%). Despite the significant innovation in molecular analysis and therapeutic approach in many types of cancer in the last two decades, still the outcome of advanced pancreatic cancer is disappointing and the mortality rate approximately unchanged. In this mandated review we intended to highlight the standard of care and emerging agents for advanced pancreatic cancer treatment.

Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain

2020 ◽  
Vol 3 (5) ◽  
pp. 3005-3014
Author(s):  
Taishi Higashi ◽  
Tetsuya Kogo ◽  
Nana Sato ◽  
Tatsunori Hirotsu ◽  
Shogo Misumi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

scholarly journals Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 11553-11573 ◽  
Author(s):  
Aziliz Hervault ◽  
Nguyễn Thị Kim Thanh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Treatment ◽  
Magnetic Nanoparticle ◽  
Therapeutic Agents ◽  
Chemotherapy Treatment

Magnetic nanoparticles have great potential as mediators of localised heat as well as vehicles for drug delivery to have synergistic effect of thermo-chemotherapy for cancer treatment.

scholarly journals Recent advancesin the development of novel drug delivery systems for the prophylaxis of malaria

2018 ◽  
Vol 9 (3) ◽  
pp. 49
Author(s):  
Sahil Kumar ◽  
Kulvinder Singh ◽  
Rajesh K Singh ◽  
DN Prasad ◽  
TR Bhardwaj
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methyl Cellulose ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Polyvinyl Pyrrolidone ◽  
Present Review ◽  
Targeted Drug ◽  
Novel Drug

<p>The present review high-lights the advancement in nanoparticles formulations for the prophylaxis of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metal like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulation have improved the targeted drug delivey of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and lumefantrine etc.</p>

Emamectin benzoate is a safe and effective anthelmintic against coelomic nematode Philometra rubra in striped bass Morone saxatilis

2020 ◽  
Vol 142 ◽  
pp. 47-53
Author(s):  
K Béland ◽  
G Séguin ◽  
S Lair
Keyword(s):  
Mortality Rate ◽  
Striped Bass ◽  
High Mortality ◽  
Morone Saxatilis ◽  
Treatment Results ◽  
Emamectin Benzoate ◽  
Once Daily ◽  
Fish Hatchery ◽  
Parasitic Burden

An unusually high mortality rate due to verminous (Philometra rubra) coelomitis was documented in wild-hatched striped bass Morone saxatilis raised in a fish hatchery as part of a stock restoration program. To decrease the parasitic burden and therefore potentially minimize mortality, the effectiveness of 2 different anthelmintics was evaluated. Two trials were conducted on wild-collected fingerlings naturally infected by P. rubra. In 2006, 144 yearling fish were randomly assigned to 4 experimental groups: (1) levamisole (Levasol®) at 2 mg l-1 via immersion for 8 h once weekly for 3 wk; (2) levamisole at a dose of 2.5 mg kg-1 biomass via feed once daily for 7 d; (3) emamectin benzoate (Slice®) at a dose of 0.05 mg kg-1 biomass via feed once daily for 7 d; and (4) control. Emamectin successfully eliminated live nematodes in 84.9% of the fish, whereas the administration of levamisole, either via immersion or feed, was not successful in significantly reducing the number of live P. rubra. In 2007, the administration of the same dosage of emamectin to approximately 1000 naturally infected yearling striped bass was associated with a 100% mortality rate of P. rubra in the 30 fish randomly examined 5 wk after the beginning of the treatment. Results of these trials indicate that, at the dosage used, the administration of emamectin at the end of the summer is safe for striped bass yearlings and considerably reduces the prevalence and intensity of the infection by this parasite.

Phytosome Drug Delivery of Natural Products: A Promising Technique for Enhancing Bioavailability

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Rani Anjana ◽  
Kumar Sunil ◽  
Sharma Hitender ◽  
Khar R. K.
Keyword(s):  
Drug Delivery ◽  
Natural Products ◽  
Plant Extract ◽  
Herbal Extract ◽  
Present Review ◽  
Absorption Profile ◽  
Promising Technique ◽  
Characterization Techniques ◽  
Advanced Form

The phytosome technology was developed by Indena markedly enhancing the bioavailability of selected phytomedicines, by incorporating phospholipids into standardized plant extract, which improve their absorption and utilization. Phytosome are advanced form of herbal extract that shows better absorption profile than conventional herbal extract. The present review focus on the preparation and characterization techniques of phytosomes, merits and various landmarks in the field of phytosomes.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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