Phytosome Drug Delivery of Natural Products: A Promising Technique for Enhancing Bioavailability

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Rani Anjana ◽  
Kumar Sunil ◽  
Sharma Hitender ◽  
Khar R. K.
Keyword(s):  
Drug Delivery ◽  
Natural Products ◽  
Plant Extract ◽  
Herbal Extract ◽  
Present Review ◽  
Absorption Profile ◽  
Promising Technique ◽  
Characterization Techniques ◽  
Advanced Form

The phytosome technology was developed by Indena markedly enhancing the bioavailability of selected phytomedicines, by incorporating phospholipids into standardized plant extract, which improve their absorption and utilization. Phytosome are advanced form of herbal extract that shows better absorption profile than conventional herbal extract. The present review focus on the preparation and characterization techniques of phytosomes, merits and various landmarks in the field of phytosomes.

Prevalence of Listeria species in raw milk, ice cream and yogurt and effect of selected natural herbal extract on its survival

2020 ◽  
Vol 21 (3) ◽  
pp. 99-106
Author(s):  
Mona Yousef ◽  
Hazem Ramadan ◽  
Maha Al-Ashmawy
Keyword(s):  
Plant Extract ◽  
Reduction Rate ◽  
Ice Cream ◽  
Raw Milk ◽  
Inhibitory Effect ◽  
Food Preservation ◽  
Herbal Extract ◽  
Listeria Species ◽  
Soft Cheese ◽  
High Reduction

Objective: This study aimed to detect the prevalence of Listeria species in raw milk, ice cream and yogurt, and to evaluate the effect of extract of clove, thyme and pomegranate peel on such organism. Design: Descriptive study. Procedures: One hundred and fifty samples of milk, ice cream and yogurt were examined for isolation, identification and molecular identification of Listeria spp. Extraction of natural plant extract as clove, thyme and pomegranate peels and detection of their inhibitory effect on Listeria spp. Results: The prevalence of Listeria spp. in milk was 36% where 14% as L. monocytogenes, 6% L. innocua and 16% and other Listeria spp. was 16%. In yogurt, Listeria spp. was 6% as L. innocua was 2% and other Listeria spp. was 4%, while no L. monocytogenes was detected. In ice cream, Listeria spp. was 8% where L. monocytogenes was 2% and other Listeria spp. was 6% while no L. innocua was detected. The concentration of plant extract was 2.5% which showed high reduction rate on L. innocua and L. monocytogenes during shelf life of soft cheese. Conclusion and clinical relevance: Listeria is widely isolated from milk than from ice cream and yogurt. Plant extracts play role in food preservation and consider as a natural antimicrobial agent where most effective one was clove extract.

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

scholarly journals Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Freeze Drying ◽  
Recent Progress ◽  
Present Review ◽  
Porous Structures ◽  
Air Filtration ◽  
Future Outlook ◽  
Synthetic Process

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

scholarly journals Electrospinning: A promising technique for drug delivery systems

2020 ◽  
Vol 59 (1) ◽  
pp. 441-454
Author(s):  
Carlos A. Martínez-Pérez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Delivery Systems ◽  
Extrinsic Factor ◽  
Promising Technique ◽  
Physical Chemical ◽  
Set Up ◽  
Final System ◽  
Intense Research

AbstractIn the last years, electrospinning has become a technique of intense research to design and fabricate drug delivery systems (DDS), during this time a vast variety of DDS with mainly electrospun polymers and many different active ingredient(s) have been developed, many intrinsic and extrinsic factor have influence in the final system, there are those that can be attributed to the equipment set up and that to the physical-chemical properties of the used materials in the fabrication of DDS. After all, this intense research has generated a great amount of DDS loaded with one or more drugs. In this manuscript a review with the highlights of different kind of systems for drug delivery systems is presented, it includes the basic concepts of electrospinning, types of equipment set up, polymer/drug systems, limitations and challenges that need to be overcome for clinical applications.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

Electrospun Biomaterials’ Applications and Processing

2021 ◽  
Vol 49 ◽  
pp. 91-100
Author(s):  
Lucie Depeigne ◽  
Emilija Zdraveva
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Review Paper ◽  
Electrospinning Process ◽  
Post Processing ◽  
Natural Polymers ◽  
Main Aspect ◽  
Promising Technique ◽  
Biomedical Field ◽  
Set Up

One of the largest fields of application of electrospun materials is the biomedical field, including development of scaffolds for tissue engineering, drug delivery and wound healing. Electrospinning appears as a promising technique in terms of scaffolds composition and architecture, which is the main aspect of this review paper, with a special attention to natural polymers including collagen, fibrinogen, silk fibroin, chitosan, chitin etc. Thanks to the adaptability of the electrospinning process, versatile hybrid, custom tailored structure scaffolds have been reported. The same is achieved due to the vast biomaterials’ processability as well as modifications of the basic electrospinning set-up and its combination with other techniques, simultaneously or by post-processing.

scholarly journals CONNECTION APPROACHES BETWEEN TRADITIONAL AND MODERN PHARMACOLOGICAL PROFILE OF SHOREA ROBUSTA GAERTN. F.: A REVIEW

2018 ◽  
Vol 11 (9) ◽  
pp. 37
Author(s):  
Manish Pal Singh ◽  
Ravi Kumar
Keyword(s):  
Plant Extract ◽  
Therapeutic Potential ◽  
Present Review ◽  
Pharmacological Effects ◽  
Pharmacological Profile ◽  
Active Ingredients ◽  
Pharmacological Activities ◽  
Shorea Robusta ◽  
The Rich ◽  
Different Parts

Shorea robusta is regarded as an important medicine in Ayurveda. S. robusta Gaertn. f. belongs to family Dipterocarpaceae, and traditionally, it is used to treat wounds, ulcers, leprosy, cough, gonorrhea, earache, and headache and many more. The use of different parts of this plant such as leaves, resin, and bark as a medicament for the treatment of various conditions is well documented in literature. It is the rich source of flavonoids, saponins, steroids, tannins, phenols, etc. mainly triterpenoids, which play the prominent role for their therapeutic potential in the drug. These compounds are believed to be responsible for the pharmacological activities of plant extract. The present review clarified the main active ingredients and pharmacological effects of S. robusta as a promising plant as a result of effectiveness and safety. Further studies should be carried out this plant to discover the unrevealed part of it which may serve for the welfare of humankind.

scholarly journals GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

2017 ◽  
Vol 4 (2) ◽  
pp. 10 ◽  
Author(s):  
Harshil P. Shah ◽  
Shailesh T. Prajapati ◽  
C. N. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Route ◽  
Delivery Systems ◽  
Present Review ◽  
Gastric Residence Time ◽  
In Vivo Characterization ◽  
Absorption Window

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

scholarly journals Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1803
Author(s):  
Vivek Puri ◽  
Ameya Sharma ◽  
Pradeep Kumar ◽  
Inderbir Singh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Efficient Method ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Review Article ◽  
Present Review ◽  
Tabular Form ◽  
Thiolated Polymers ◽  
Drug Delivery Applications

Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.

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