Self-Assembling Peptides: Implications for Patenting in Drug Delivery and Tissue Engineering

Self-assembling short peptides have widespread applications in energy materials, tissue engineering, sensing and drug delivery. In this review we discuss the effect of functional N-terminal capping groups on peptide structure and function.

Download Full-text

Molecular Design and Applications of Self-Assembling Surfactant-Like Peptides

Journal of Nanomaterials ◽

10.1155/2013/469261 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Chengkang Tang ◽

Feng Qiu ◽

Xiaojun Zhao

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Molecular Design ◽

Structural Characteristics ◽

Protein Stabilization ◽

The Self ◽

Geometrical Shape ◽

Self Assembling ◽

Hydrophobic Moiety ◽

Potential Applications

Self-assembling surfactant-like peptides have been explored as emerging nanobiomaterials in recent years. These peptides are usually amphiphilic, typically possessing a hydrophobic moiety and a hydrophilic moiety. The structural characteristics can promote many peptide molecules to self-assemble into various nanostructures. Furthermore, properties of peptide molecules such as charge distribution and geometrical shape could also alter the formation of the self-assembling nanostructures. Based on their diverse self-assembling behaviours and nanostructures, self-assembling surfactant-like peptides exhibit great potentials in many fields, including membrane protein stabilization, drug delivery, and tissue engineering. This review mainly focuses on recent advances in studying self-assembling surfactant-like peptides, introducing their designs and the potential applications in nanobiotechnology.

Download Full-text

Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽

10.1039/c8sm02573h ◽

2019 ◽

Vol 15 (8) ◽

pp. 1704-1715 ◽

Cited By ~ 91

Author(s):

Jieling Li ◽

Ruirui Xing ◽

Shuo Bai ◽

Xuehai Yan

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Wound Healing ◽

Biomedical Applications ◽

3D Bioprinting ◽

Biological Applications ◽

Antitumor Therapy ◽

Self Assembling ◽

Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

Download Full-text

Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering

Polymer Chemistry ◽

10.1039/c4py00173g ◽

2014 ◽

Vol 5 (15) ◽

pp. 4431-4449 ◽

Cited By ~ 98

Author(s):

Jiban Jyoti Panda ◽

Virander Singh Chauhan

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Biomedical Applications ◽

Short Peptide ◽

Self Assembling ◽

Self Assembled

Self-assembling peptides with many potential biomedical applications.

Download Full-text

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

10.26434/chemrxiv.7157507 ◽

2018 ◽

Author(s):

Sarah Klass ◽

Matthew J. Smith ◽

Tahoe Fiala ◽

Jessica Lee ◽

Anthony Omole ◽

...

Keyword(s):

Drug Delivery ◽

Fusion Proteins ◽

Organic Molecules ◽

Intrinsically Disordered Protein ◽

Protein Domain ◽

Enzymatic Cleavage ◽

Intrinsically Disordered ◽

Disordered Protein ◽

Self Assembling ◽

Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

Download Full-text

Scaffolds for Drug Delivery in Tissue Engineering

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2008.1.2.1 ◽

2008 ◽

Vol 1 (2) ◽

pp. 113-123 ◽

Cited By ~ 2

Author(s):

Vikas V. Gaikwad ◽

Abasaheb B. Patil ◽

Madhuri V. Gaikwad

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Heart Diseases ◽

Cartilage Regeneration ◽

Tissue Growth ◽

The Body ◽

Patient Specific ◽

In Situ Gel ◽

Heart Muscle Cells

Scaffolds are used for drug delivery in tissue engineering as this system is a highly porous structure to allow tissue growth. Although several tissues in the body can regenerate, other tissue such as heart muscles and nerves lack regeneration in adults. However, these can be regenerated by supplying the cells generated using tissue engineering from outside. For instance, in many heart diseases, there is need for heart valve transplantation and unfortunately, within 10 years of initial valve replacement, 50–60% of patients will experience prosthesis associated problems requiring reoperation. This could be avoided by transplantation of heart muscle cells that can regenerate. Delivery of these cells to the respective tissues is not an easy task and this could be done with the help of scaffolds. In situ gel forming scaffolds can also be used for the bone and cartilage regeneration. They can be injected anywhere and can take the shape of a tissue defect, avoiding the need for patient specific scaffold prefabrication and they also have other advantages. Scaffolds are prepared by biodegradable material that result in minimal immune and inflammatory response. Some of the very important issues regarding scaffolds as drug delivery systems is reviewed in this article.

Download Full-text

Hydrogels as Antibacterial Biomaterials

Current Pharmaceutical Design ◽

10.2174/1381612824666180213122953 ◽

2018 ◽

Vol 24 (8) ◽

pp. 843-854 ◽

Cited By ~ 6

Author(s):

Weiguo Xu ◽

Shujun Dong ◽

Yuping Han ◽

Shuqiang Li ◽

Yang Liu

Keyword(s):

Mechanical Properties ◽

Drug Delivery ◽

Tissue Engineering ◽

Water Content ◽

Oxygen Permeability ◽

Structural Diversity ◽

High Water ◽

Clinical Applications ◽

High Water Content ◽

Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

Download Full-text